BACKGROUND Frailty is a complex aging-related syndrome characterized by a cumulative loss of physiological reserve and increased vulnerability to adverse clinical outcomes,including falls,disability,incapacity and dea...BACKGROUND Frailty is a complex aging-related syndrome characterized by a cumulative loss of physiological reserve and increased vulnerability to adverse clinical outcomes,including falls,disability,incapacity and death.While an increasing number of studies suggest that the gut microbiota may play a key role in the pathophy-siology of frailty,direct evaluation of the association between gut microbiome alterations and frailty in older adults remains limited.AIM Seven electronic databases(China National Knowledge Infrastructure,VIP,SinoMed,Wanfang,PubMed,Web of Science and EMBASE)were searched for articles published before October 31,2023 to identify observational studies that compared the microbiomes of older adults with and without frailty.The diversity and composition of the gut microbiota were the main outcomes used to analyze the associations of changes in the gut microbiota with frailty in older adults.The quality of the included studies was assessed via the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality.RESULTS Eleven observational studies with 912 older adults were included in this review.Consistent results revealed a significant difference in the gut microbiota composition between frail and non-frail older adults,with a significant decrease inαdiversity and a significant increase inβdiversity in frail older adults.The pooled results revealed that at the phylum level,four microbiota(Actinobacteria,Proteo-bacteria,Verrucomicrobia and Synergistetes)were significantly enriched,and two microbiota(Firmicutes and Fusobacteria)were significantly depleted in frail older adults.At the family level,the results consistently revealed that the abundances of 6 families,most of which belong to the Actinobacteria or Proteo-bacteria phylum,were greater in frail than in non-frail older adults.At the genus or species level,consistent results from more than two studies revealed that the abundances of the genera Prevotella,Faecalibacterium,and Roseburia were significantly lower in frail older adults;individual studies revealed that the abundances of some genera or species(e.g.,Megamonas,Blautia,and Megasphaera)were significantly lower,whereas those of other genera or species(e.g.,Bifidobacterium,Oscillospira,Ruminococcus and Pyramidobacter)were significantly greater in frail older adults.CONCLUSION This systematic review suggests that changes in the gut microbiota are associated with frailty in older adults,which is commonly reflected by a reduction in beneficial species and an increase in pathogenic species.However,further studies are needed to confirm these findings.展开更多
Purpose:Current Direct Observation(DO)methods are burdensome to the observer and relevant limitations can be identified on the outcome information.This study aims to characterize DO from the observers’point of view a...Purpose:Current Direct Observation(DO)methods are burdensome to the observer and relevant limitations can be identified on the outcome information.This study aims to characterize DO from the observers’point of view and to analyze the feasibility and usefulness of visual information in the form of video.Method:data collection was done with ten adult males,observed while performing different physical activities in an indoor court.Sessions were video recorded by two cameras.Three observers performed systematic observation,using SOPLAY,with different sampling rates.Inter observer’s agreement and with reference data was analyzed by Cohen’s Kappa statistic.Results:SOPLAY highest agreement between observers was 0.611 on vigorous category and walking category had the lowest 0.188.It doubles the time needed to annotate the video with pauses,but half of player’s behavior is preserved.Conclusion(s):using video to support DO permits to collect more accurate data and a more detailed behavior categorization is warranted.Developments in computer vision are expected to reduce the human efforts in DO methods.展开更多
To solve the problem that external systematic errors of the optical camera cannot be fully estimated due to limited computing resources,a unified dimensionality reduction representation method for the external systema...To solve the problem that external systematic errors of the optical camera cannot be fully estimated due to limited computing resources,a unified dimensionality reduction representation method for the external systematic errors of the optical camera is proposed,and autonomous relative optical navigation is realized.The camera translational and misalignment errors are converted into a three-dimensional rotation error,whose differential model can be established through specific attitude control and appropriate assumption.Then,the rotation error and the relative motion state are jointly estimated in an augmented Kalman filter framework.Compared with the traditional method that estimates the camera translational and misalignment errors,the proposed method reduces the computational complexity in that the estimated state dimension is reduced.Furthermore,as demonstrated by numerical simulation,the estimation accuracy is improved significantly.展开更多
文摘BACKGROUND Frailty is a complex aging-related syndrome characterized by a cumulative loss of physiological reserve and increased vulnerability to adverse clinical outcomes,including falls,disability,incapacity and death.While an increasing number of studies suggest that the gut microbiota may play a key role in the pathophy-siology of frailty,direct evaluation of the association between gut microbiome alterations and frailty in older adults remains limited.AIM Seven electronic databases(China National Knowledge Infrastructure,VIP,SinoMed,Wanfang,PubMed,Web of Science and EMBASE)were searched for articles published before October 31,2023 to identify observational studies that compared the microbiomes of older adults with and without frailty.The diversity and composition of the gut microbiota were the main outcomes used to analyze the associations of changes in the gut microbiota with frailty in older adults.The quality of the included studies was assessed via the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality.RESULTS Eleven observational studies with 912 older adults were included in this review.Consistent results revealed a significant difference in the gut microbiota composition between frail and non-frail older adults,with a significant decrease inαdiversity and a significant increase inβdiversity in frail older adults.The pooled results revealed that at the phylum level,four microbiota(Actinobacteria,Proteo-bacteria,Verrucomicrobia and Synergistetes)were significantly enriched,and two microbiota(Firmicutes and Fusobacteria)were significantly depleted in frail older adults.At the family level,the results consistently revealed that the abundances of 6 families,most of which belong to the Actinobacteria or Proteo-bacteria phylum,were greater in frail than in non-frail older adults.At the genus or species level,consistent results from more than two studies revealed that the abundances of the genera Prevotella,Faecalibacterium,and Roseburia were significantly lower in frail older adults;individual studies revealed that the abundances of some genera or species(e.g.,Megamonas,Blautia,and Megasphaera)were significantly lower,whereas those of other genera or species(e.g.,Bifidobacterium,Oscillospira,Ruminococcus and Pyramidobacter)were significantly greater in frail older adults.CONCLUSION This systematic review suggests that changes in the gut microbiota are associated with frailty in older adults,which is commonly reflected by a reduction in beneficial species and an increase in pathogenic species.However,further studies are needed to confirm these findings.
基金This work was funded by the Portuguese Foundation for Science and Technology(FCT),grant SFRH/BPD/71332/2010,Pest-OE/SAU/UI0617/2011 and UIDB/50014/2020The work was also developed in the context of Project QREN 33910 ARENA,a R&D project funded by ERDF through ON2 as part of the NSRF,and managed by IAPMEI-Agência para a Competitividade e Inovação,I.P..
文摘Purpose:Current Direct Observation(DO)methods are burdensome to the observer and relevant limitations can be identified on the outcome information.This study aims to characterize DO from the observers’point of view and to analyze the feasibility and usefulness of visual information in the form of video.Method:data collection was done with ten adult males,observed while performing different physical activities in an indoor court.Sessions were video recorded by two cameras.Three observers performed systematic observation,using SOPLAY,with different sampling rates.Inter observer’s agreement and with reference data was analyzed by Cohen’s Kappa statistic.Results:SOPLAY highest agreement between observers was 0.611 on vigorous category and walking category had the lowest 0.188.It doubles the time needed to annotate the video with pauses,but half of player’s behavior is preserved.Conclusion(s):using video to support DO permits to collect more accurate data and a more detailed behavior categorization is warranted.Developments in computer vision are expected to reduce the human efforts in DO methods.
基金supported by National Natural Science Foundation of China(Nos.U20B2055 and 61525301)Graduate Research Innovation Projects of Hunan Province,China(No.CX20210013)。
文摘To solve the problem that external systematic errors of the optical camera cannot be fully estimated due to limited computing resources,a unified dimensionality reduction representation method for the external systematic errors of the optical camera is proposed,and autonomous relative optical navigation is realized.The camera translational and misalignment errors are converted into a three-dimensional rotation error,whose differential model can be established through specific attitude control and appropriate assumption.Then,the rotation error and the relative motion state are jointly estimated in an augmented Kalman filter framework.Compared with the traditional method that estimates the camera translational and misalignment errors,the proposed method reduces the computational complexity in that the estimated state dimension is reduced.Furthermore,as demonstrated by numerical simulation,the estimation accuracy is improved significantly.
