A general atom-economical approach for the synthesis of a-halomethyl ketones is demonstrated through Ce（SO4）z/acid co-catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient ...A general atom-economical approach for the synthesis of a-halomethyl ketones is demonstrated through Ce（SO4）z/acid co-catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent yields, with broad substrate scope. This protocol is an alternative to conventional a-halogenation of ketones.展开更多
A convenient and efficient method was developed for the synthesis of naphtho[2,1-blfurans via 4-dimethylaminopyridine（DMAP）-catalyzed cascade reaction of 2-hydroxy-l-naphthaldehydes and a-halogenated ketones in mode...A convenient and efficient method was developed for the synthesis of naphtho[2,1-blfurans via 4-dimethylaminopyridine（DMAP）-catalyzed cascade reaction of 2-hydroxy-l-naphthaldehydes and a-halogenated ketones in moderate to good yields in the presence of Na2CO3 at 80 ~C for 6 h. The mechanism for this process was briefly discussed with a tentative catalytic cycle proposed. Moreover, this method features organocatalysts and high step-economy, which makes it practical and attractive.展开更多
文摘A general atom-economical approach for the synthesis of a-halomethyl ketones is demonstrated through Ce（SO4）z/acid co-catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent yields, with broad substrate scope. This protocol is an alternative to conventional a-halogenation of ketones.
基金Supported by the National Natural Science Foundation of China（Nos.21172001, 21372008）, the Program for the New Century Excellent Talents in University of China（No.NCET-10-0004） and the Natural Science Foundation of Anhui Province of China（No. 1308085QB39）.
文摘A convenient and efficient method was developed for the synthesis of naphtho[2,1-blfurans via 4-dimethylaminopyridine（DMAP）-catalyzed cascade reaction of 2-hydroxy-l-naphthaldehydes and a-halogenated ketones in moderate to good yields in the presence of Na2CO3 at 80 ~C for 6 h. The mechanism for this process was briefly discussed with a tentative catalytic cycle proposed. Moreover, this method features organocatalysts and high step-economy, which makes it practical and attractive.
