Considering the present situation, the aim of English teaching in middle schools in our country, according to the teaching syllabus, is to train the students to listen, speak, read and write ; to lay particular emphas...Considering the present situation, the aim of English teaching in middle schools in our country, according to the teaching syllabus, is to train the students to listen, speak, read and write ; to lay particular emphasis on the students’ reading skill so as to pave the way for their further learning and using the language properly. How can the readers make improvements in reading? There are many skills to improve one’s ability of reading comprehension. I. The knowledge of words. One of the most important skills in reading is the knowledge of word. The number of the words you know determines the difficulty and complexity of the material you can read and understand. If you have an extremely limited reading vocabulary, you will be able to read only very simple material. Obviously, vocabulary forms a stumbling block for the poor reader. The more words you memorize, the faster you read the article. So, it is necessary to memorize words as much as you can.展开更多
目的了解国内外干预项目的内容及成果经验,为以后在我国慢性病防控从业群体中推广循证慢性病防控提供参考。方法检索知网、万方、维普、PubMed、Web of Science和Scopus数据库中1995年1月1日—2019年11月31日发表的与慢性病防控循证能...目的了解国内外干预项目的内容及成果经验,为以后在我国慢性病防控从业群体中推广循证慢性病防控提供参考。方法检索知网、万方、维普、PubMed、Web of Science和Scopus数据库中1995年1月1日—2019年11月31日发表的与慢性病防控循证能力干预相关的文献,最终纳入45篇文献进行分析。结果国内极为缺乏针对提升公共卫生从业者慢性病防控循证能力的干预项目。发达国家较早实践提升医务人员慢性病能力的干预措施,包括各类面对面课程、研讨会、网络课程、书籍等,但干预课程设置普遍遇到的问题包括慢性病防控机构缺乏数据库权限,未对不同循证认知层次和工作环境的从业者进行有针对性的分类。结论我国应积极借鉴慢性病防控的国外经验,开发各类干预途径并加以推广和应用。展开更多
BACKGROUND： Transplantation of fetal cell suspension or blocks of fetal tissue can ameliorate the nerve function after the injury or disease in the central nervous system, and it has been used to treat neurodegenerat...BACKGROUND： Transplantation of fetal cell suspension or blocks of fetal tissue can ameliorate the nerve function after the injury or disease in the central nervous system, and it has been used to treat neurodegenerative disorders induced by Parkinson disease. OBJECTIVE： To observe the effects of the transplantation of neuron-like cells derived from bone marrow stromal cells （rMSCs） into the brain in restoring the dysfunctions of muscle strength and balance as well as learning and memory in rat models of cerebral infarction. DESIGN ： A randomized controlled experiment.SETTING ： Department of Pathophysiology, Zhongshan Medical College of Sun Yat-sen University.MATERIALS ： Twenty-four male SD rats （3-4 weeks of age, weighing 200-220 g） were used in this study （Certification number：2001A027）. METHODS： The experiments were carried out in Zhongshan Medical College of Sun Yat-sen University between December 2003 and December 2004. ① Twenty-four male SD rats randomized into three groups with 8 rats in each： experimental group, control group and sham-operated group. Rats in the experiment al group and control group were induced into models of middle cerebral artery occlusion （MCAO）. After in vitro cultured, purified and identified with digestion, the Fischer344 rMSCs were induced to differentiate by tanshinone IIA, which was locally injected into the striate cortex （18 area） of rats in the experimental group, and the rats in the control group were injected by L-DMEM basic culture media （without serum） of the same volume to the corresponding brain area. In the sham-operated group, only muscle and vessel of neck were separated. ② At 2 and 8 weeks after the transplantation, the rats were given the screen test, prehensile-traction test, balance beam test and Morris water-maze test. ③ The survival and distribution of the induced cells in corresponding brain area were observed with Nissl stained with toluidine blue and hematoxylin and eosin （HE） staining in the groups.MAIN OUTCOME MEASURES ： ① Results of the behavioral tests （time of the Morris water-maze test screen test, prehensile-traction test, balance beam test）; ② Survival and distribution of the induced cells.RESULTS： All the 24 rats were involved in the analysis of results. ① Two weeks after transplantation, rats with neuron-like cells grafts in the experimental group had significant improvement on their general muscle strength than those in the control group [screen test： （9.4±1.7）, （4.7±1.0） s, P 〈 0.01]; forelimb muscle strength [prehensile-traction test： （7.6±1.4）, （5.2±1.2） s, P 〈 0.01], ability to keep balance [balance beam test： （7.9±0.74）, （6.1±0.91） s, P 〈 0.01] and abilities of learning and memory [latency to find the platform： （35.8±5.9）, （117.5±11.6） s, P 〈 0.01; distance： （623.1±43.4）, （1 902.3±98.6） cm, P 〈 0.01] as compared with those in the control group. The functional performances in the experimental group at 8 weeks were better than those at two weeks, which were still obviously different from those in the sham-operated group （P 〈 0.05）. ② The HE and Nissl stained brain tissue section showed that there was nerve cell proliferation at the infarcted cortex in the experiment group, the density was higher than that in the control group, plenty of aggregative or scattered cells could be observed at the site where needle was inserted for transplantation, the cells migrated directively towards the area around them, the cerebral vascular walls were wrapped by plenty of cells; In the control group, most of the cortices were destroyed, karyopyknosis and necrosis of neurons were observed, normal nervous tissue structure disappeared induced by edema, only some nerve fibers and glial cells remained.CONCLUSION： The rMSCs transplantation can obviously enhance the motor function and the abilities of learning and memory in rat models of cerebral infarction.展开更多
文摘Considering the present situation, the aim of English teaching in middle schools in our country, according to the teaching syllabus, is to train the students to listen, speak, read and write ; to lay particular emphasis on the students’ reading skill so as to pave the way for their further learning and using the language properly. How can the readers make improvements in reading? There are many skills to improve one’s ability of reading comprehension. I. The knowledge of words. One of the most important skills in reading is the knowledge of word. The number of the words you know determines the difficulty and complexity of the material you can read and understand. If you have an extremely limited reading vocabulary, you will be able to read only very simple material. Obviously, vocabulary forms a stumbling block for the poor reader. The more words you memorize, the faster you read the article. So, it is necessary to memorize words as much as you can.
文摘目的了解国内外干预项目的内容及成果经验,为以后在我国慢性病防控从业群体中推广循证慢性病防控提供参考。方法检索知网、万方、维普、PubMed、Web of Science和Scopus数据库中1995年1月1日—2019年11月31日发表的与慢性病防控循证能力干预相关的文献,最终纳入45篇文献进行分析。结果国内极为缺乏针对提升公共卫生从业者慢性病防控循证能力的干预项目。发达国家较早实践提升医务人员慢性病能力的干预措施,包括各类面对面课程、研讨会、网络课程、书籍等,但干预课程设置普遍遇到的问题包括慢性病防控机构缺乏数据库权限,未对不同循证认知层次和工作环境的从业者进行有针对性的分类。结论我国应积极借鉴慢性病防控的国外经验,开发各类干预途径并加以推广和应用。
基金the National Natural Science Foundation of China, No. 03030307 the Great Special Fund of Guangdong Province, No. 2004A30201002
文摘BACKGROUND： Transplantation of fetal cell suspension or blocks of fetal tissue can ameliorate the nerve function after the injury or disease in the central nervous system, and it has been used to treat neurodegenerative disorders induced by Parkinson disease. OBJECTIVE： To observe the effects of the transplantation of neuron-like cells derived from bone marrow stromal cells （rMSCs） into the brain in restoring the dysfunctions of muscle strength and balance as well as learning and memory in rat models of cerebral infarction. DESIGN ： A randomized controlled experiment.SETTING ： Department of Pathophysiology, Zhongshan Medical College of Sun Yat-sen University.MATERIALS ： Twenty-four male SD rats （3-4 weeks of age, weighing 200-220 g） were used in this study （Certification number：2001A027）. METHODS： The experiments were carried out in Zhongshan Medical College of Sun Yat-sen University between December 2003 and December 2004. ① Twenty-four male SD rats randomized into three groups with 8 rats in each： experimental group, control group and sham-operated group. Rats in the experiment al group and control group were induced into models of middle cerebral artery occlusion （MCAO）. After in vitro cultured, purified and identified with digestion, the Fischer344 rMSCs were induced to differentiate by tanshinone IIA, which was locally injected into the striate cortex （18 area） of rats in the experimental group, and the rats in the control group were injected by L-DMEM basic culture media （without serum） of the same volume to the corresponding brain area. In the sham-operated group, only muscle and vessel of neck were separated. ② At 2 and 8 weeks after the transplantation, the rats were given the screen test, prehensile-traction test, balance beam test and Morris water-maze test. ③ The survival and distribution of the induced cells in corresponding brain area were observed with Nissl stained with toluidine blue and hematoxylin and eosin （HE） staining in the groups.MAIN OUTCOME MEASURES ： ① Results of the behavioral tests （time of the Morris water-maze test screen test, prehensile-traction test, balance beam test）; ② Survival and distribution of the induced cells.RESULTS： All the 24 rats were involved in the analysis of results. ① Two weeks after transplantation, rats with neuron-like cells grafts in the experimental group had significant improvement on their general muscle strength than those in the control group [screen test： （9.4±1.7）, （4.7±1.0） s, P 〈 0.01]; forelimb muscle strength [prehensile-traction test： （7.6±1.4）, （5.2±1.2） s, P 〈 0.01], ability to keep balance [balance beam test： （7.9±0.74）, （6.1±0.91） s, P 〈 0.01] and abilities of learning and memory [latency to find the platform： （35.8±5.9）, （117.5±11.6） s, P 〈 0.01; distance： （623.1±43.4）, （1 902.3±98.6） cm, P 〈 0.01] as compared with those in the control group. The functional performances in the experimental group at 8 weeks were better than those at two weeks, which were still obviously different from those in the sham-operated group （P 〈 0.05）. ② The HE and Nissl stained brain tissue section showed that there was nerve cell proliferation at the infarcted cortex in the experiment group, the density was higher than that in the control group, plenty of aggregative or scattered cells could be observed at the site where needle was inserted for transplantation, the cells migrated directively towards the area around them, the cerebral vascular walls were wrapped by plenty of cells; In the control group, most of the cortices were destroyed, karyopyknosis and necrosis of neurons were observed, normal nervous tissue structure disappeared induced by edema, only some nerve fibers and glial cells remained.CONCLUSION： The rMSCs transplantation can obviously enhance the motor function and the abilities of learning and memory in rat models of cerebral infarction.
