Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cogniti...Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive deficits.The pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or degradation.In most cases,展开更多
基金supported by Ministero dell’Istruzione,dell’Università e della Ricerca of Italy (PRIN 20109MXHMR_001)Associazione Italiana Ricerca sul Cancro (AIRC,IG#15221)
文摘Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive deficits.The pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or degradation.In most cases,
