Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

Euglobal-IIIa (1), a novel acylphloroglucinol-sesquiterpene derivative, and a known analogue, have been isolated from leaves of Eucalyptus robusta. The structures was elucidated by extensive spectroscopic data and by comparison with data reported in literature, while the absolute configuration of 1 was determined by the X-ray diffraction analysis. Compound 1 exhibited comparable cytotoxicity with that of cisplatin against five human cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC50 values of 15.7, 15.5, 17.6, 14.3, and 21.8 μM, respectively.

Gravity observation at continental borderlands (Russia, Primorie, Cape Shults)

The paper is focused on different kinds of gravity results obtained in Shults Cape Observatory for 2010 -2015. Gravity observation is interpreted together with GPS observation data which was obtained from 2012 to 2015 at the same station, The station is situated on Gamov peninsular （42.58° N, 131.15° E, Russia） at the coast of Japan Sea, This region constitutes the eastern boundary of Eurasia. This major continental tectonic feature is associated with a seismic activity, high heat flow and anomalous thickness of earth＇s crust. The goal of the observation was the investigation of gravity variation with time and seismicity situation monitoring. Gravity observation was developed at special basement by absolute gravimeter （GABL type） and by spring gravimeter （SCINREX CG-5and gPhone type）. Tidal models were tested by results of observation with spring gravimeters. Reduction task was solved, as the experimental data received from different points of Shults Cape Observatory was used. Applied reduction coefficient is 203.3 12Gal m l, and agrees with theoretical calculation. Next goal was studying structure of earth＇s crust by means of gravity models. Gravity anomaly varied from 30 mGal to 46 mGal, which also depend on difference reference system, Experimental results were used for testing of the structure of continental boundary, which also depends on the sea bottom flexion. Thickness of elastic layer was estimated from 12 km to 18 km by using different models.

Absolute Structure Determination of Chiral Organic Nanocrystals Using Zone-Axis Electron Diffraction

Enantiomorphic identification of chiral molecules is essential in organic chemistry and the pharmaceutical industry,as two enantiomorphic structures can show distinctively different properties.Here,we illustrate the absolute structural determination of organic nanocrystals using zone-axis electron diffraction by taking advantage of electron multiple scattering.Two enantiomorphs are distinguished by comparing the reflection intensities of Friedel pairs in the zone-axis electron diffraction pattern,after confirming the absolute indices of reflections by locating relative positions of diffraction spots from two patterns that deviate from a certain angle.We demonstrate the protocol with successful applications in two chiral drug nanocrystals.