Dynamic thermal modeling and parameter identification for a monolithic laser diode module

We improved the thermal equivalent-circuit model of the laser diode module（LDM） to evaluate its thermal dynamic properties and calculate the junction temperature of the laser diode with a high accuracy.The thermal parameters and the transient junction temperature of the LDM are modeled and obtained according to the temperature of the thermistor integrated in the module.Our improved thermal model is verified indirectly by monitoring the emission wavelength of the laser diode against gas absorption lines,and several thermal parameters are obtained with the temperature uncertainty of 0.01 K in the thermal dynamic process.

Effect of cooling time t8/5 on microstructure and toughness of Nb-Ti- Mo microalloyed C-Mn steel

In order to further optimize welding process of Nb-Ti-Mo microalloyed steel, welding thermal cycles on coarse-grained heat-affected zone （CGHAZ） of welded joints were simulated using Gleeble 1500. The microstructure and low-temperature impact fracture were investigated using a scanning electron microscope and a pendulum impact machine, respectively. Moreover, the relationship between cooling time ts/5 and the microstructure of CGHAZ was discussed, and the effect of microstructure on impact toughness was also studied. As cooling time increased, martensite fraction decreased from 97.8% （3 s） to 3.0% （60 s）. The fraction of martensite/austenite （M/A） constituent increased from 2.2% （3 s） to 39.0% （60 s）, its shape changed from granular to strip, and the maximum length increased from 2.4 μm （3 s） to 7.0 μm （60 s）. As cooling time increased, the prior austenite grain size increased from 34.0 μm （3 s） to 49.0 gm （60 s）, the impact absorption energy reduced from 101.8 J （5 s） to 7.2 J （60 s）, and the fracture mechanism changed from quasi-cleavage fracture to cleavage fracture. The decreased toughness of CGHAZ was due to the reduction of lath martensite-content, coarsening of original austenite grain, and increase and coarsening of M/A constituent. The heat input was controlled under 7 kJ cm-1 during actual welding for these steels.

A nomogram for prediction of absorption rate coefficient

Background Previous studies have suggested that nomogram can simplize complicated calculations of several varibles. A simple nomogram was constructed to estimate absorption rate coefficient (k a) by using the peak time (t peak ) and the elimination rate coefficient (k e) of drugs administered orally Methods The nomogram was based on the plasma concentration-time (C-T) curve equation and the function relation between t peak , k a and k e A mathematical analysis was presented for the construction of single chart nomogram To check the degree of accuracy of the developed nomogram, we used it to analyze retrospective profiles of 46 drugs and compared the k a values obtained graphically and those calculated by numerically solving the descriptive equation In addition, we measured the carbocisteine concentration of 18 healthy volunteers by HPLC with fluorescence detection To analyze performance error, the measured carbocisteine concentrations were compared with predicted concentrations by the k a obtained from the nomograms along with the other pharmacokinetic parameters Results The estimated of k a values from nomograms were in very close proximity with the numerical values The performance error was as follows: median performance error (MDPE) and median absolute performance error (MDAPE) were 1 32% and 18 15%, respectively Conclusions The developed nomogram is accurate and reliable The size of performance error meets the demand of clinical pharmacokinetics Therefore, the nomograms can offer another convenient and easy method for rational individualized dosage regimens