A novel t(3;12)(q21;p13) translocation in a patient with accelerated chronic myeloid leukemia after imatinib and nilotinib therapy

The acquisition of secondary chromosomal aberrations in chronic myeloid leukemia (CML) patients with Philadelphia chromosome-positive (Ph+) karyotype signifies clonal evolution associated with the progression of the disease to its accelerated or blastic phase. Therefore, these aberrations have clinical and biological significance. T(3;12)(q26;p13), which is a recurrent chromosomal aberration observed in myeloid malignancies, is typically associated with dysplasia of megakaryocytes, multilineage involvement, short duration of any blastic phase, and extremely poor prognosis. We have identified a recurrent reciprocal translocation between chromosomes 3 and 12 with different breakpoint at bands 3q21 in the malignant cells from a 28-year-old man. The patient was initially diagnosed as having Ph+ CML in the chronic phase. The t(3;12)(q21;p13) translocation occurred 4 years after the patient was first diagnosed with CML while undergoing tyrosine kinase inhibitor therapy. We confirmed the t(3;12)(q21;p13) translocation via fluorescence in situ hybridization assay by using whole-chromosome paint probes for chromosomes 3 and 12. Our findings demonstrate that, similar to other recurrent translocations involving 3q26 such as t(3;3) and t(3;21), the t(3;12)(q21;p13) translocation is implicated not only in myelodysplastic syndrome and acute myeloid leukemia but also in the progression of CML. These findings extend the disease spectrum of this cytogenetic aberration.

Optimal motion cueing algorithm for accelerating phase of manned spacecraft in human centrifuge

This paper presents a novel optimal Motion Cueing Algorithm(MCA)to control the rotations of a Human Centrifuge(HC)and achieve the best simulation of a Space Craft(SC)motion.Relations of the specific forces sensed by astronauts of the SC and the HC have been derived and linearized.A Linear Quadratic Regulator(LQR)controller is implemented for the problem which tends to minimize the error between the two sensed specific forces as well as control input in a cost function.It results in control inputs of the HC to generate its sensed specific force as close as possible to the one in the SC.The algorithm is implemented for both linearized and nonlinear portions of a US space shuttle mission trajectory as a verification using MATLAB.In longitudinal direction,the proposed MCA,works well when the acceleration is less than 2 g in which the tracking error does not exceed 12%.In lateral direction the tracking is much better even in nonlinear region since the error remains less than 7%for tilting up to 50°.Finally,the effect of weight matrixes in the LQR cost function on overall weight and power of the HC motion system is discussed.

Particle Measurement Sensor for in situ determination of phase structure of fluidized bed

Based on three-dimensional （3D） acceleration sensing, an intelligent particle spy capable of detecting, transferring, and storing data, is proposed under the name of Particle Measurement Sensor （PMS）. A prototype 60-mm-dia PMS was tested to track its freefall in terms of velocity and displacement, and served as a particle spy in a fluidized bed delivering the in situ acceleration information it detects. With increasing superficial gas velocity in the fluidized bed, the acceleration felt by PMS was observed to increase. The variance of the signals, which reflect the fluctuation, increased at first, reaching a maximum at the gas velocity （Uc） which marks the transition from bubbling to turbulent fluidization. Through probability density distribution （PDD） analysis, the PDD peak can be divided into the emulsion phase peak and the bubble phase peak. The average acceleration of emulsion and bubble phase increased, while the variance of both phases reached a maximum at Uc, at the same time. However, the difference between the variances of two phases reached the maximum at Uc. Findings of this study indicate that PMS can record independent in situ information. Further, it can provide other in situ measurements when equipped with additional multi-functional sensors.

Generating monoenergetic proton beam by using circularly polarized laser

The interaction of ultrashort intense circularly polarized laser with ultra thin overdense foil is studied by particle-in-cell simulation and analytic model. It is found that with the balance between pondermotive force and electrostatic force, highly quasi-monoenergetic proton beam can be generated by Phase Stable Acceleration (PSA) process. As in conventional accelerators, ion will be accelerated and bunched up in the longitudinal direction at the same time.