Most current biotechnology industries are based on batch or fed-batch fermentation processes,which often show low productivity and high production costs compared to chemical processes.To increase the economic competit...Most current biotechnology industries are based on batch or fed-batch fermentation processes,which often show low productivity and high production costs compared to chemical processes.To increase the economic competitiveness of biological processes,continuous fermentation technologies are being developed that offer significant advantages in comparison with batch/fed-batch fermentation processes,including:(1)removal of potential substrates and product inhibition,(2)prolonging the microbial exponential growth phase and enhancing productivity,and(3)avoiding repeated fermentation preparation and lowering operation and installation costs.However,several key challenges should be addressed for the industrial application of continuous fermentation processes,including(1)contamination of the fermentation system,(2)degeneration of strains,and(3)relatively low product titer.In this study,we reviewed and discussed metabolic engineering and synthetic biology strategies to address these issues.展开更多
近五年随着消费者对“天然、绿色、安全”化妆品的关注度日益提高,发酵源化妆品的开发得到了长足发展。对于发酵源化妆品原料的开发,中外研究人员从不同角度入手,提高了相关发酵产物的活性、产量以及有效成分的含量。文章基于中国知网(C...近五年随着消费者对“天然、绿色、安全”化妆品的关注度日益提高,发酵源化妆品的开发得到了长足发展。对于发酵源化妆品原料的开发,中外研究人员从不同角度入手,提高了相关发酵产物的活性、产量以及有效成分的含量。文章基于中国知网(CNKI)数据库以及Web of Science核心数据库,借助文献计量方法和知识图谱可视化软件VOSviewer,以“化妆品”、“发酵”、“cosmetic”、“fermentation”或“fermented”为关键词构建近五年发酵源化妆品文献库,根据可视化分析知识图谱中的关键词共现频率分析近期发酵源化妆品领域的研究热点,并对目前化妆品相关的发酵菌种、发酵产物及功效宣称进行了汇总分析,同时对未来发酵源化妆品的发展与研发提出展望,为发酵源化妆品领域研究提供理论基础。展开更多
基金supported by the National Key R&D Program of China(Grant No.2021YFC2100900)the National Natural Science Foundation of China(Grant Nos.21938004,22078172,and 21878172)DongGuan Innovative Research Team Program(Grant No.201536000100033).
文摘Most current biotechnology industries are based on batch or fed-batch fermentation processes,which often show low productivity and high production costs compared to chemical processes.To increase the economic competitiveness of biological processes,continuous fermentation technologies are being developed that offer significant advantages in comparison with batch/fed-batch fermentation processes,including:(1)removal of potential substrates and product inhibition,(2)prolonging the microbial exponential growth phase and enhancing productivity,and(3)avoiding repeated fermentation preparation and lowering operation and installation costs.However,several key challenges should be addressed for the industrial application of continuous fermentation processes,including(1)contamination of the fermentation system,(2)degeneration of strains,and(3)relatively low product titer.In this study,we reviewed and discussed metabolic engineering and synthetic biology strategies to address these issues.
文摘近五年随着消费者对“天然、绿色、安全”化妆品的关注度日益提高,发酵源化妆品的开发得到了长足发展。对于发酵源化妆品原料的开发,中外研究人员从不同角度入手,提高了相关发酵产物的活性、产量以及有效成分的含量。文章基于中国知网(CNKI)数据库以及Web of Science核心数据库,借助文献计量方法和知识图谱可视化软件VOSviewer,以“化妆品”、“发酵”、“cosmetic”、“fermentation”或“fermented”为关键词构建近五年发酵源化妆品文献库,根据可视化分析知识图谱中的关键词共现频率分析近期发酵源化妆品领域的研究热点,并对目前化妆品相关的发酵菌种、发酵产物及功效宣称进行了汇总分析,同时对未来发酵源化妆品的发展与研发提出展望,为发酵源化妆品领域研究提供理论基础。
