The new title compound 4-chloro-N-(2-(2-nitrophenyl)acetoxy)-N-(m-tolyl)benza- mide (C:2HI7C1N2Os, Mr = 424.82) has been synthesized via the reaction of 4-chloro-N-hydroxy-N- (m-tolyl)benzamide with 2-(2-n...The new title compound 4-chloro-N-(2-(2-nitrophenyl)acetoxy)-N-(m-tolyl)benza- mide (C:2HI7C1N2Os, Mr = 424.82) has been synthesized via the reaction of 4-chloro-N-hydroxy-N- (m-tolyl)benzamide with 2-(2-nitrophenyl)acetyl chloride. The structure of the product was confirmed by 1H NMR, 13C NMR, IR, HRMS (ESI) and single-crystal X-ray diffraction. The title compound crystallizes in the monoclinic system, space group P21/c with a = 13.0269(10), b =6.7251(6), c = 23.9313(16) A, β = 99.931(6)°, V = 2065.1(3) A3, Z = 4, Dc = 1.366 g/cm3, F(000) = 880,μ = 0.221 mm-1, the final R = 0.0600 and wR = 0.1754 for 1981 observed reflections (I〉 20(/)). X-ray analysis indicates that the chloro-phenyl ring (C(10)℃(15)) and the methyl-substituted benzene ring (C(16)℃(21)) are not coplanar with the nitro-substituted benzene ring (C(1)--C(6)), with the dihedral angle to be 70.78° and 63.72°, respectively. Hydrogen bonds C(2)-H(2)...O(2) and C(7)-H(7B)...O(5) are observed.展开更多
A concise synthesis of the mosquito oviposition attractant pheromone, (-)-(5R, 6S)- and (+)-(5S 6R)-6-acetoxy hexadecanolide from L-glutamic acid is described. The key steps are the inversion of the configuration at C...A concise synthesis of the mosquito oviposition attractant pheromone, (-)-(5R, 6S)- and (+)-(5S 6R)-6-acetoxy hexadecanolide from L-glutamic acid is described. The key steps are the inversion of the configuration at C-4 of 7, and the formation of δ-lactone from the γ-lactone through ring enlargement.展开更多
Intramolecular transfer of both singlet and triplet electronic excitation between the naphthalene moiety and the carbonyl group in 3β-(1-naphthyl)acetoxy-⊿~5-androsten-17-one was studied.Irradiation with 280 nm ligh...Intramolecular transfer of both singlet and triplet electronic excitation between the naphthalene moiety and the carbonyl group in 3β-(1-naphthyl)acetoxy-⊿~5-androsten-17-one was studied.Irradiation with 280 nm light selectively leads to excitation of the naphthalene moiety. Transfer of the singlet excitation from the naphthalene moiety to the carbonyl group occurs by dipole- dipole resonance interaction.The measured rates for such energy transfer in several solvents agree with that calculated from Frster equation.After efficient intersystem crossing,the carbonyl group transfers triplet excitation back to the naphthalene moiety via electron exchange mechanism.The combination of singlet and triplet energy transfer with the high efficiency of intersystcm crossing of carbonyl group results in the phosphorescence enhancement of naphthalene moiety.展开更多
AIM: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography(HPLC) ...AIM: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography(HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods. RESULTS: Five 9, 19-cycloartane triterpenes,(3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside(1), actein(2), 23-epi-26-deoxyactein(3), asiaticoside B(4), and 12β-hydroxycimigenol(5) were isolated from the roots of Cimicifuga foetida. CONCLUSION: Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12.展开更多
Gibberellin A<sub>5</sub> (GA<sub>5</sub>) (9) is a C<sub>19</sub>-gibberellin which was originally isolated from Phaselous mutiflorus in 1960 by MacMillan et al. This letter re...Gibberellin A<sub>5</sub> (GA<sub>5</sub>) (9) is a C<sub>19</sub>-gibberellin which was originally isolated from Phaselous mutiflorus in 1960 by MacMillan et al. This letter reports the synthesis of Gibberellin A<sub>5</sub> methyl ester(8) from Gibberellic acid (1).展开更多
基金Supported by the Fundamental Research Funds for the Central Universities(lzujbky-2010-137)Lanzhou Science and Technology Bureau Program Funds(2012-2-90)
文摘The new title compound 4-chloro-N-(2-(2-nitrophenyl)acetoxy)-N-(m-tolyl)benza- mide (C:2HI7C1N2Os, Mr = 424.82) has been synthesized via the reaction of 4-chloro-N-hydroxy-N- (m-tolyl)benzamide with 2-(2-nitrophenyl)acetyl chloride. The structure of the product was confirmed by 1H NMR, 13C NMR, IR, HRMS (ESI) and single-crystal X-ray diffraction. The title compound crystallizes in the monoclinic system, space group P21/c with a = 13.0269(10), b =6.7251(6), c = 23.9313(16) A, β = 99.931(6)°, V = 2065.1(3) A3, Z = 4, Dc = 1.366 g/cm3, F(000) = 880,μ = 0.221 mm-1, the final R = 0.0600 and wR = 0.1754 for 1981 observed reflections (I〉 20(/)). X-ray analysis indicates that the chloro-phenyl ring (C(10)℃(15)) and the methyl-substituted benzene ring (C(16)℃(21)) are not coplanar with the nitro-substituted benzene ring (C(1)--C(6)), with the dihedral angle to be 70.78° and 63.72°, respectively. Hydrogen bonds C(2)-H(2)...O(2) and C(7)-H(7B)...O(5) are observed.
文摘A concise synthesis of the mosquito oviposition attractant pheromone, (-)-(5R, 6S)- and (+)-(5S 6R)-6-acetoxy hexadecanolide from L-glutamic acid is described. The key steps are the inversion of the configuration at C-4 of 7, and the formation of δ-lactone from the γ-lactone through ring enlargement.
文摘Intramolecular transfer of both singlet and triplet electronic excitation between the naphthalene moiety and the carbonyl group in 3β-(1-naphthyl)acetoxy-⊿~5-androsten-17-one was studied.Irradiation with 280 nm light selectively leads to excitation of the naphthalene moiety. Transfer of the singlet excitation from the naphthalene moiety to the carbonyl group occurs by dipole- dipole resonance interaction.The measured rates for such energy transfer in several solvents agree with that calculated from Frster equation.After efficient intersystem crossing,the carbonyl group transfers triplet excitation back to the naphthalene moiety via electron exchange mechanism.The combination of singlet and triplet energy transfer with the high efficiency of intersystcm crossing of carbonyl group results in the phosphorescence enhancement of naphthalene moiety.
基金supported by the National Natural Science Foundation of China(No.U1132604)Knowledge Innovation Program of the CAS(No.KZCX2-XB2-15-03)Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2008-ZZ05)
文摘AIM: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography(HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods. RESULTS: Five 9, 19-cycloartane triterpenes,(3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside(1), actein(2), 23-epi-26-deoxyactein(3), asiaticoside B(4), and 12β-hydroxycimigenol(5) were isolated from the roots of Cimicifuga foetida. CONCLUSION: Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12.
基金Project supported by the National Natural Science Foundation of China
文摘Gibberellin A<sub>5</sub> (GA<sub>5</sub>) (9) is a C<sub>19</sub>-gibberellin which was originally isolated from Phaselous mutiflorus in 1960 by MacMillan et al. This letter reports the synthesis of Gibberellin A<sub>5</sub> methyl ester(8) from Gibberellic acid (1).