The patterns of acetylator phenotypes has been determined in 102 women with breast tumors, including 25 with benign breast disease and 77 with breast cancer, and compared to that in 59 healthy controls. There was sign...The patterns of acetylator phenotypes has been determined in 102 women with breast tumors, including 25 with benign breast disease and 77 with breast cancer, and compared to that in 59 healthy controls. There was significant increase (16.2%) of rapid acetylators in 77 patients with breast cancer, P<0.05. As a result of the effect of therapy on the rate of acetylation, it was found that in 39 patients with breast cancer the level of acetylation was decreased after mastectomy. The difference of percentage acetylation between preoperation and post-operation was statistically significant, P<0.05. A similar change in 8 patients with breast cancer could be observed after chemotherapy, P<0.01. The results obtained in the present study indicated that there was a significant association between rapid phcnotype and breast cancer of women. The mastectomy or inhibition of tumor growth may bring about a decrease in the level of acetylation.展开更多
To study the relationship between metabolic phenotype of acetylation and bladder cancer Methods Totally 203 healthy volunteers and 67 patients with bladder cancer were investigated with caffeine as a metabolic probe...To study the relationship between metabolic phenotype of acetylation and bladder cancer Methods Totally 203 healthy volunteers and 67 patients with bladder cancer were investigated with caffeine as a metabolic probe Urine samples were collected in 2-6 hours after a cup of 140?mg coffee was taken, and the caffeine metabolites, 5 acetylamino 6 formylamino 1 methyluracil (AFMU) and 1 methylxanthine (1X) were analyzed by high performance liquid chromatography (HPLC) The frequency histogram and probit plot were constructed to select the critical value which was used to assess slow and fast acetylation status both in healthy volunteers and patients with bladder cancer Results The peak height ratios of AFMU and 1X (AFMU/1X) were from 0 06 to 6 50 for healthy volunteers and 0 10 to 6 31 for patients with bladder cancer, both with the critical value of 1 10 Of 203 healthy volunteers involved in this study, 26 3% were slow acetylacors, as compared to 46 3% with slow acetylacors in patients with bladder cancer The odds ratio is 2 376, and the gene frequency for healthy volunteers and patients with urinary bladder cancer were 0 5218 and 0 6804, respectively Conclusions N acetylation status in the Chinese population is polymorphic and completely concordant with that determined with other metabolic probes Slow acetylators are significantly associated with bladder cancer展开更多
文摘The patterns of acetylator phenotypes has been determined in 102 women with breast tumors, including 25 with benign breast disease and 77 with breast cancer, and compared to that in 59 healthy controls. There was significant increase (16.2%) of rapid acetylators in 77 patients with breast cancer, P<0.05. As a result of the effect of therapy on the rate of acetylation, it was found that in 39 patients with breast cancer the level of acetylation was decreased after mastectomy. The difference of percentage acetylation between preoperation and post-operation was statistically significant, P<0.05. A similar change in 8 patients with breast cancer could be observed after chemotherapy, P<0.01. The results obtained in the present study indicated that there was a significant association between rapid phcnotype and breast cancer of women. The mastectomy or inhibition of tumor growth may bring about a decrease in the level of acetylation.
文摘To study the relationship between metabolic phenotype of acetylation and bladder cancer Methods Totally 203 healthy volunteers and 67 patients with bladder cancer were investigated with caffeine as a metabolic probe Urine samples were collected in 2-6 hours after a cup of 140?mg coffee was taken, and the caffeine metabolites, 5 acetylamino 6 formylamino 1 methyluracil (AFMU) and 1 methylxanthine (1X) were analyzed by high performance liquid chromatography (HPLC) The frequency histogram and probit plot were constructed to select the critical value which was used to assess slow and fast acetylation status both in healthy volunteers and patients with bladder cancer Results The peak height ratios of AFMU and 1X (AFMU/1X) were from 0 06 to 6 50 for healthy volunteers and 0 10 to 6 31 for patients with bladder cancer, both with the critical value of 1 10 Of 203 healthy volunteers involved in this study, 26 3% were slow acetylacors, as compared to 46 3% with slow acetylacors in patients with bladder cancer The odds ratio is 2 376, and the gene frequency for healthy volunteers and patients with urinary bladder cancer were 0 5218 and 0 6804, respectively Conclusions N acetylation status in the Chinese population is polymorphic and completely concordant with that determined with other metabolic probes Slow acetylators are significantly associated with bladder cancer
