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Synthesis and Acetylcholinesterase Inhibitory Activity of Polymethoxyflavone Mannich Base Derivatives
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作者 SHI Ling ZHANG Yanhua +2 位作者 WANG Caifang LIU Haoran WANG Qiuan 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2017年第4期594-597,共4页
A series of novel polymethoxyflavone Marmich base derivatives 1--8 was synthesized by Mannich reaction of 5-hydroxy-3,7,3',4'-tetramethoxyflavone 9 with various secondary aliphatic amines and formaldehyde. Their ace... A series of novel polymethoxyflavone Marmich base derivatives 1--8 was synthesized by Mannich reaction of 5-hydroxy-3,7,3',4'-tetramethoxyflavone 9 with various secondary aliphatic amines and formaldehyde. Their acetylcholmesterase(AChE) inhibitory activities were evaluated. The results showed that most of them exhibited AChE inhibitory activity and especially piperidin-l-yl methyl substituent derivative 5(IC50=0.238 μmol/L) demon- strated stronger activity comparable with the positive control, neoeserinemethyl sulfate(IC50=1.39 μmol/L), which is worthy of further development as an agent for Alzheimer's disease treatment. 展开更多
关键词 Polymethoxyflavone Mannich base derivative acetylcholinesterase inhibitory activity
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New spinosin derivatives from the seeds of Ziziphus mauritiana 被引量:3
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作者 Bin WANG Hong-Tao ZHU +3 位作者 Dong WANG Chong-Ren YANG Min XU Ying-Jun ZHANG 《Natural Products and Bioprospecting》 CAS 2013年第3期93-98,共6页
Three new acylated flavonoid C-glycosides,6'''-(-)-phaseoylspinosin(1),6'''-(3'''',4'''',5''''-trimethoxyl)-(E)-cinnamoylspinosin(2),and 6'&#... Three new acylated flavonoid C-glycosides,6'''-(-)-phaseoylspinosin(1),6'''-(3'''',4'''',5''''-trimethoxyl)-(E)-cinnamoylspinosin(2),and 6'''-(4''''-O-β-D-gluco-pyranosyl)-benzoylspinosin(3),were isolated from the seeds of Ziziphus mauritiana(Rhamnaceae).A further 19 known compounds including eight spinosin analogues(4-11)were also isolated.Their structures were elucidated by means of spectroscopic analysis and chemical method.Among spinosin derivatives 1,2,4,7,8,and triterpenoid saponin 14,jujuboside A(14)displayed moderate acetylcholinesterase(AchE)inhibitory activity with an inhibition value of 46.2%at a concentration of 1μM. 展开更多
关键词 Ziziphus mauritiana RHAMNACEAE SEEDS spinosin derivatives jujuboside A acetylcholinesterase inhibitory
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New Lycopodium alkaloids from Lycopodium obscurum 被引量:2
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作者 Xue-Yuan ZHANG Liao-Bin DONG +5 位作者 Fei LIU Xing-De WU Juan HE Li-Yan PENG Huai-Rong LUO Qin-Shi ZHAO 《Natural Products and Bioprospecting》 CAS 2013年第2期52-55,共4页
Three new Lycopodium alkaloids,obscurumines C-E(1-3),along with nine known compounds,were isolated from the club moss Lycopodium obscurum L.Structures of the new compounds were determined on the basis of their spectro... Three new Lycopodium alkaloids,obscurumines C-E(1-3),along with nine known compounds,were isolated from the club moss Lycopodium obscurum L.Structures of the new compounds were determined on the basis of their spectroscopic analysis and the relative configurations of 1 were established by X-ray crystallographic analysis.All the new isolates were tested for the acetylcholinesterase(AChE)inhibitory activity. 展开更多
关键词 obscurumines Lydopodium alkaloids Lycopodium obscurum acetylcholinesterase(AChE)inhibitory activity
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Carinatines A and B,Lycopodium Alkaloids from Phlegmariurus carinatus 被引量:2
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作者 Fei Liu Yu-Cheng Liu +6 位作者 Wei-Wei Jiang Juan He Xing-De Wu Li-Yan Peng Jia Su Xiao Cheng Qin-Shi Zhao 《Natural Products and Bioprospecting》 CAS 2014年第4期221-225,共5页
Carinatine A(1),a C16N2-type Lycopodium alkaloid possessing a 5/6/6/6 ring system formed by a new C-4/C-12 bond,and carinatine B(2),the first derivative of lycojaponicumin C,along 16 known compounds,were isolated from... Carinatine A(1),a C16N2-type Lycopodium alkaloid possessing a 5/6/6/6 ring system formed by a new C-4/C-12 bond,and carinatine B(2),the first derivative of lycojaponicumin C,along 16 known compounds,were isolated from the whole plant of Phlegmariurus carinatus.Their structures were elucidated based on the spectroscopic data.The two new isolates were no inhibitory activity for the acetylcholinesterase(AChE). 展开更多
关键词 Lycopodium alkaloid Phlegmariurus carinatus Carinatines A and B acetylcholinesterase(AChE)inhibitory activity
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