Is Dor fundoplication optimum after laparoscopic Heller myotomy for achalasia? A meta-analysis

AIM:To compare the outcome of acid reflux prevention by Dor fundoplication after laparoscopic Heller myotomy(LHM)for achalasia.METHODS:Electronic database PubMed,Ovid(Evidence-Based Medicine Reviews,EmBase and Ovid MEDLINE)and Cochrane Library were searched between January 1995 and September 2012.Bibliographic citation management software(EndNote X3)was used for extracted literature management.Quality assessment of random controlled studies(RCTs)and non-RCTs was performed according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0and a modification of the Newcastle-Ottawa Scale,respectively.The data were analyzed using Review Manager(Version 5.1),and sensitivity analysis was performed by sequentially omitting each study.RESULTS:Finally,6 studies,including a total of 523achalasia patients,compared Dor fundoplication with other types of fundoplication after LHM(Dor-other group),and 8 studies,including a total of 528 achalasia patients,compared Dor fundoplication with no fundoplication after LHM(Dor-no group).Dor fundoplication was associated with a significantly higher recurrence rate of clinical regurgitation and pathological acid reflux compared with the other fundoplication group(OR=7.16,95%CI:1.25-40.93,P=0.03,and OR=3.79,95%CI:1.23-11.72,P=0.02,respectively).In addition,there were no significant differences between Dor fundoplication and no fundoplication in all subjects.Other outcomes,including complications,dysphagia,postoperative physiologic testing,and operation-related data displayed no significant differences in the two comparison groups.CONCLUSION:Dor fundoplication is not the optimum procedure after LHM for achalasia.We suggest more attention should be paid on quality of life among different fundoplications.

Direct cost variance analysis of peroral endoscopic myotomy vs heller myotomy for management of achalasia:A tertiary referral center experience

BACKGROUND Laparoscopic Heller myotomy(LHM)has been the traditional surgical treatment for achalasia.Recently,peroral endoscopic myotomy(POEM)has demonstrated similar clinical outcomes with shorter procedure times.Studies comparing the direct cost-effectiveness of POEM vs LHM are limited.AIM To compare costs of POEM vs LHM.METHODS Haider SA et al.Comparing costs:POEM vs Heller myotomy WJGE https://www.wjgnet.com 594 October 16,2023 Volume 15 Issue 10 This retrospective chart review aimed to compare the outcomes and cost of clinical care between patients who underwent POEM and LHM procedures for achalasia.The study was conducted at a tertiary academic center from January 2019 to December 2020.Clinical outcomes,including post-operative Eckardt scores and adverse events,were assessed and compared between the two groups.Direct cost variance analysis was utilized to evaluate the cost of clinical care incurred by patients undergoing POEM in the year preceding the procedure,during the index admission,and one year post-procedure,in comparison to patients undergoing LHM.RESULTS Of 30 patients were included(15 POEM and 15 LHM)in the study.Patients in the POEM group had a mean Eckardt score of 0.5±0.5 post-procedure,which was no different from patients in the LHM group(0.7±0.6,P=0.17)indicating comparative efficacy.However,the total costs of the admission for the procedure in the LHM group were on average$1827 more expensive than in the POEM group(P<0.01).Total healthcare costs one year prior to index procedure were$7777 higher in the LHM group,but not statistically different(P=0.34).The patients in the LHM group one year after the index procedure had accrued$19730.24 larger total cost,although this was not statistically different from POEM group(P=0.68).CONCLUSION Despite similar clinical outcomes,the cost of the index procedure admission for POEM was significantly lower than for LHM.The difference was primarily related to shorter time increments utilized in the operating room during the index procedure,and shorter length of hospital stay following POEM.

Navigating reflux disease after achalasia treatments:Balancing risks and benefits

The peroral endoscopic myotomy(POEM)procedure has revolutionized the management of achalasia in many centres around the world as it offers patients a minimally invasive endoscopic solution to their dysphagia caused by achalasia.Alongside its success in alleviating dysphagia,concerns regarding postoperative gastroesophageal reflux disease have emerged as a pertinent issue which are not fully resolved.In this study,Nabi et al have comprehensively reviewed the topic of the prediction,prevention and management of gastroesophageal reflux after POEM.POEM is a purely endoscopic procedure which is usually performed without any anti-reflux procedure.Certain patients may be better served by a laparoscopic Heller’s myotomy and fundoplication and it is important that gastroenterologists and surgeons provide comprehensive risks and benefits of each achalasia treatment option so that patients can decide what treatment is best for them.This article by Nabi et al provides a comprehensive review of the current status of this issue to allow these discussions to occur.

Laparoscopic Heller myotomy with or without partial fundoplication: A matter of debate

AIM: To present our experience of laparoscopic Heller stretching myotomy followed by His angle reconstruction as surgical approach to esophageal achalasia.METHODS: Thirty-two patients underwent laparoscopic Heller myotomy; an anterior partial fundoplication in 17,and angle of His reconstruction in 15 cases represented the antireflux procedure of choice.RESULTS: There were no morbidity and mortality recorded in both anterior funduplication and angle of His reconstruction groups. No differences were detected in terms of recurrent dysphagia, p.o. reflux or medical therapy.CONCLUSION: To reduce the incidence of recurrent achalasia after laparoscopic Heller myotomy, we believe that His' angle reconstruction is a safe and effective alternative to the anterior fundoplication.

Gastroesophageal reflux following per-oral endoscopic myotomy:Can we improve outcomes?

This editorial is an analysis the review article by Nabi et al recently published in this journal.Achalasia Cardia is a disease whose pathophysiology is still unclear.It is known that there is inflammation of unknown aetiology leading to loss of ganglion cells in the muscularis propria.The end result is lower oesophageal sphincter spasm,loss of receptive relaxation,decreased oesophageal peristalsis,all leading on to varying degrees of dysphagia.The treatment of this condition is palliative in nature,performed by myotomy of the lower oesophagus either surgically or endoscopically.Gastroesophageal reflux disease(GERD)has been associated with the myotomy performed,particularly with the Peroral Endoscopic Myotomy(POEM)procedure.Nabi et al have provided an excellent overview of the latest developments in predicting,preventing,evaluating,and managing GERD subsequent to POEM.Based on this theme,this review article explores the concept of using histology of the oesophageal muscle layer,to grade the disease and thereby help tailoring the length/type of myotomy performed during the POEM procedure.In the future,will a histology based algorithm available preoperatively,help modify the POEM procedure,thereby decreasing the incidence of GERD associated with POEM?

腹腔镜Heller肌切开术与经口内镜下肌切开术治疗贲门失弛缓症疗效及安全性的meta分析

目的系统评价腹腔镜Heller肌切开术(LHM)与经口内镜下肌切开术(POEM)治疗贲门失弛缓症的疗效及安全性。方法计算机检索PubMed、EMbase、The Cochrane Library、Web of Science及万方数据库、维普数据库、中国知网数据库(CNKI),搜索建库至2023年11月公开发表的相关文献,采用RevMan 5.0软件进行meta分析。结果共纳入15篇文献,其中1篇是随机对照试验,8篇是回顾性队列研究,6篇是前瞻性非随机对照试验。共1439例患者,LHM组696例,POEM组743例。Meta分析结果显示,与LHM组相比,POEM组术后吞咽困难复发率更低[OR=2.01,95%CI(1.17,3.44),P=0.01]、手术时间更短[MD=22.66,95%CI(5.57,39.75),P=0.009]、住院时间更短[MD=0.55,95%CI(0.38,0.71),P<0.01]、术后恢复正常生活天数更少[MD=4.49,95%CI(4.00,4.97),P<0.01],在胃食管反流病发生率和术后皮下气肿发生率上LHM低于POEM[OR=0.64,95%CI(0.45,0.90),P=0.009;OR=0.33,95%CI(0.11,0.99),P=0.05];而在术后总并发症发生率、术后质子泵抑制剂使用率、术后6个月Eckardt评分等方面,两个术式差异无统计学意义(P>0.05)。结论与LHM相比,POEM术后吞咽困难复发率、手术时间、住院时间、术后恢复正常生活天数更具优势。

Submucosal tunnel endoscopy:Peroral endoscopicmyotomy and peroral endoscopic tumor resection

Peroral endoscopic myotomy(POEM) is an innovative,minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy(LHM), not only for all types of esophageal achalasia [classical(Ⅰ), vigorous(Ⅱ), spastic(Ⅲ), Chicago Classification], but also for advanced sigmoid type achalasia(S1 and S2), failed LHM, or other esophageal motility disorders(diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction(EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection(POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors(submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives.

腹腔镜Heller手术与经口内镜下肌切开术治疗贲门失弛缓症的临床效果比较

目的比较腹腔镜Heller手术(laparoscopic heller myotomy,LHM)和经口内镜下肌切开术(peroral endoscopic myotomy,POEM)治疗贲门失弛缓症的临床疗效,探讨POEM术后胃食管反流并发症的治疗策略。方法采用回顾性队列研究的方法,收集2012年10月至2017年4月我院收治的61例贲门失弛缓症患者的临床资料,其中30例行腹腔镜Heller手术加部分胃底折叠术(Dor)为腹腔镜组(LHM组);31例行经口内镜下肌切开术为内镜组(POEM组),随访至2019年4月,比较两组患者的基本资料、手术情况、临床疗效以及胃食管反流并发症(包括胃食管反流症状、病理性酸反流、食管炎)的情况。结果患者均顺利完成手术,无围术期死亡。LHM组和POEM组患者在手术时间、术中出血量、围术期并发症、平均住院日、住院费用等方面差异无统计学意义。LHM组和POEM组的治疗有效率分别为86.7%(26/30)和90.3%(28/31),差异无统计学意义。两组患者术后Ecardt评分、下段食管静息压较术前均明显下降(P<0.001),但两组之间比较,差异无统计学意义;POEM组术后胃食管反流症状(3/27 vs 11/20,P=0.018)、病理性酸反流(4/26 vs 12/18,P=0.024)、食管炎(2/28 vs 9/22,P=0.023)发生率显著高于LHM组。临床相关胃食管反流发生率在POEM组更高(1/29 vs 7/24,P=0.026)。结论 LHM与POEM治疗贲门失弛缓症的安全性及中远期疗效相近,但是POEM手术缺乏抗反流措施,可导致胃食管反流发生率升高,术后应密切随访并积极干预。

腹腔镜Heller括约肌切开术治疗贲门失弛缓症

目的:探讨采用腹腔镜微创手术治疗贲门失弛缓症的可行性及临床效果。方法:对5例患者在术中行胃镜定位、监视下行腹腔镜Heller括约肌切开术治疗。结果:4例手术顺利,1例患者由于粘连严重,术中分破远端食管,经胃镜证实后即行腹腔镜下修补术,术后1d,4例症状明显改善,1例术后1周吞咽困难症状逐渐改善。随访5～17个月,均未再发生吞咽困难、返流、胸骨后疼痛等症状。结论:腹腔镜Heller括约肌切开术治疗贲门失弛缓症创伤小、恢复快,并可作为内科治疗失败后的补救治疗。

腹腔镜下Heller肌切开加Dor胃底折叠术治疗贲门失弛缓症的临床体会

目的:探讨腹腔镜下Heller肌切开加Dor胃底折叠术治疗贲门失迟缓症的治疗效果以及折叠术对术后返流症状的预防作用。方法:回顾性分析我院自2010年12月至2012年7月行腹腔镜下Heller肌切开加Dor胃底折叠术治疗贲门失迟缓症的患者资料,随访患者术后吞咽困难、反酸等症状,总结临床体会。结果:10例贲门失弛缓症患者顺利完成腹腔镜下Heller肌切开术并加做胃底折叠术,患者平均住院天数(13.2±4.1)d,术后住院天数(7.1±2.6)d,术中出血(5.2±1.9)mL,手术时间(78.5±26.8)min;术后无1人死亡,随访患者1例6个月时出现反酸症状,1例1年后出现吞咽困难症状。结论:腹腔镜下heller肌切开加Dor胃底折叠术应作为治疗贲门失迟缓症推荐方式。

Impact of minimally invasive surgery on the treatment of benign esophageal disorders

Thanks to the development of minimally invasive surgery, the last 20 years have witnessed a change in the treatment algorithm of benign esophageal disorders. Today a laparoscopic operation is the treatment of choice for esophageal achalasia and for most patients with gastroesophageal reflux disease. Because the pathogenesis of achalasia is unknown, treatment is palliative and aims to improve esophageal emptying by decreasing the functional obstruction at the level of the gastro-esophageal junction. The refinement of minimally invasive techniques accompanied by large, multiple randomized control trials with long-term outcome has allowed the laparoscopic Heller myotomy and partial fundoplication to become the treatment of choice for achalasia compared to endoscopic procedures, including endoscopic botulinum toxin injection and pneumatic dilatation. Patients with suspected gastroesophageal reflux need to undergo a thorough preoperative workup. After establishing diagnosis, treatment for gastroesophageal reflux should be individualized to patient characteristics and a decision about an operation made jointly between surgeon and patient. The indications for surgery have changed in the last twenty years. In the past, surgery was often considered for patients who did not respond well to acid reducing medications. Today, the best candidate for surgery is the patient who has excellent control of symptoms with proton pump inhibitors. The minimally invasive approach to antireflux surgery has allowed surgeons to control reflux in a safe manner, with excellent long term outcomes. Like achalasia and gastroesophageal reflux, the treatment of patients with paraesophageal hernias has also seen a major evolution. The laparoscopic approach has been shown to be safe, and durable, with good relief of symptoms over the long-term. The most significant controversy with laparoscopic paraesophageal hernia repair is the optimal crural repair. This manuscript reviews the evolution of these techniques.

POEM手术与腹腔镜Heller手术治疗贲门失驰缓症的有效性及安全性观察

目的探讨经口内镜下肌切开术（POEM手术）与腹腔镜Helle手术治疗贲门失驰缓症的有效性及安全性。方法选取本院2015年1月至2017年1月收治的109例贲门失弛缓症患者进行研究，按随机数字表法将其分为研究组与对照组，对照组患者采用POEM手术治疗，研究组患者采用腹腔镜Heller手术治疗，治疗后比较两组患者手术时间、住院时间、术中出血量、住院费用、贲门失驰缓症评分量表（Eckardt评分）、食管最大宽度、复发及并发症发生情况。结果研究组患者手术时间[（54．17±26．35）min比（125．63±31．76）min]与住院时间[（5．76±1．08）d比（7．64±1．47）d]均较对照组短，术中出血量[（11．28±3．12）ml比（73．61±38．29）ml]与住院费用[（1．68±0．71）万元比）2．19±0．54）万元]较对照组低，差异均有统计学意义（均P〈0．05）。手术前后两组患者Eckardt评分及食管最大宽度比较差异均无统计学意义（均P〉0．05）。术后两组患Eckardt评分及食管最大宽度均下降，与术前比较差异有统计学意义（P〈0．05）。研究组发生5例（9．09％）并发症，对照组发生3例（5．56％）并发症．两组比较差异无统计学意义（χ^2=0．501，P〉0．05）。随访中发现，研究组3例（5．56％）患者复发，对照组未见复发，两组比较差异无统计学意义（χ^2=1.334，P〉0．05）。结论POEM手术与腹腔镜Heller手术均可有效改善贲门失弛缓症患者临床症状，POEM手术在经济效益和减少创伤方面存在一定优势。

腹腔镜Heller肌切开术与内镜下气囊扩张比较治疗贲门失弛缓症的Meta分析

目的系统评价腹腔镜Heller术与气囊扩张比较治疗贲门失弛缓症的疗效和安全性。方法计算机检索Cochrane图书馆RCT数据库、Pub Med、EMbase、CBM、VIP、和Wan Fang等数据库建库至2016年12月。收集全世界腹腔镜Heller术与气囊扩张比较治疗贲门失弛缓症的RCT。采用Rev Man 5.2软件进行Meta分析。结果纳入4个RCT(437例)患者。Meta分析显示:(1)总体症状缓解率:LHM优于PD(78.38%和68.52%,P=0.04)。(2)手术相关穿孔发生率:LHM优于PD(0.50%和4.63%,P=0.02);(3)长期总体症状缓解率(24个月)、胃食管反流发生率、术后LES压力改善,两组差异无统计学意义。结论目前的证据表明,LHM和PD均有较好的长期疗效,但LHM在疗效和安全性上更有优势,建议根据医疗水平和患者具体情况选择使用。

腹腔镜下Heller肌切开+Dor胃底折叠术在贲门失弛缓症治疗中的应用

目的:探讨腹腔镜下Heller肌切开+Dor胃底折叠术治疗贲门失弛缓症的临床价值。方法:对1999年5月-2013年5月本院收治的16例贲门失弛缓症患者施行腹腔镜Heller肌切开联合Dor胃底折叠术,进行回顾性统计分析。结果:手术平均时间(105.2±25.6)min,术中平均出血(32.3±12.0)mL。其中术中食管黏膜穿破2例;反流性食管炎2例;1例仍有轻度吞咽困难。手术效果优良率87.5%(14/16)。结论:腹腔镜Heller肌切开联合Dor胃底折叠术是治疗贲门失弛缓症的首选治疗方式,术中精细操作,术后严密检查,可预防并发症的发生。

免气腹辅助3D腹腔镜改良Heller肌切开联合Dor胃底折叠治疗贲门失弛缓症

目的：探讨免气腹辅助3D腹腔镜改良 Heller 肌切开联合 Dor 胃底折叠治疗贲门失弛缓症的临床价值。方法2013年7月～2015年11月对32例贲门失弛缓症行免气腹辅助3D腹腔镜下贲门食管肌层切开，联合Dor胃底折叠术（前部180＆#176;胃底折叠缝合术）。结果32例均成功完成免气腹腹腔镜手术，手术时间（71．6±36．8） min，术中出血量（23．6±18．4）ml，住院时间（8．2±2．6）d，无食管漏等并发症及死亡。32例术后随访6～34个月，平均15．3月，Eckardt评分Ⅰ级20例（62．5％），Ⅱ级9例（28．1％），Ⅲ级3例（9．4％）；手术有效29例（90．6％），失败3例（9．4％）。23例术后6个月复查食管吞钡造影，食管最大横径（31．1±5．2）mm，较术前（45．3±8．0）mm明显改善（t＝11．064，P＝0．000）。结论免气腹辅助3D腹腔镜改良Heller联合Dor胃底折叠术治疗贲门失弛缓症疗效满意。

腹腔镜食管下段贲门肌层切开联合Dor胃底折叠术治疗贲门失弛缓症

目的:探讨腹腔镜食管下段贲门肌层切开联合Dor胃底折叠术治疗贲门失弛缓症的临床应用价值。方法:回顾性分析31例行腹腔镜食管下段贲门肌层切开联合Dor胃底折叠术治疗的贲门失弛缓症患者术前与术后3个月的临床数据。结果:31例均成功行腹腔镜手术,27例术前与术后3个月吞咽困难评分(1.10±0.18与0.91±0.12,P<0.01)、术前与术后胸骨后疼痛评分(0.38±0.04与0.36±0.03,P<0.05)症状得到有效缓解,体质量指数(21.32±1.26与20.47±1.34,P<0.05)及生活质量指数(85.69±7.78与80.43±9.19,P<0.05)明显优于术前。结论:腹腔镜食管下段贲门肌层切开联合Dor胃底折叠术对于改善贲门失弛缓症患者临床症状及提高生活质量具有重要的意义。

贲门失驰缓症外科治疗术式的改进

目的：评价手术治疗贲门失驰缓症的方法；方法：外科治疗贲门失驰缓症２２例，其中改良Ｈｅｌｅｒ手术１２例，Ｈｅｌｅｒ手术附加胃底折叠术４例，Ｈｅｌｅｒ手术加转移膈肌瓣手术４例，胸腔镜手术１例，食管胃弓上吻合１例；结果：随访１月至８年，疗效满意，５例有返流性食管炎的症状；结论：作者认为附加抗返流术式疗效确切，转移膈肌瓣手术优于胃底折叠术，胸腔镜手术创伤小，恢复快，值得推荐。

POEM与LHM在贲门失弛缓症治疗有效性和安全性的Meta分析

目的比较经口内镜下食管肌层切开术(per-oral endoscopic myotomy,POEM)与腹腔镜Heller肌切开术(laparoscopic Heller's myotomy,LHM)临床有效性和安全性,为贲门失弛缓症最佳治疗提供证据.方法检索PubMed、EMBASE、the Cochrane Library、SCI数据库、CNKI和维普中文科技期刊数据库,检索语言为中英文,检索时间为各数据库建库时间至2016-02-20截止.采用Review Manager version5.3软件进行数据分析.各研究间的异质性通过Q检验和I2来检验.结果总共有8篇非随机对照研究纳入统计分析,共574例患者,其中POEM组245例,LHM组329例.Meta分析结果显示:(1)临床有效率:相比LHM组,POEM组有更高的临床有效率(RR=1.14,95%CI:1.02-1.27,P=0.02),异质性检验P=0.60,I^2=0%;(2)主要并发症:POEM组和LHM组,两者在主要并发症上没有统计学差异(RR=1.16,95%CI:0.76-1.78,P=0.49),异质性检验P=0.43,I^2=0%;(3)全部并发症:两组间全部并发症没有显著的统计学差异(RR=0.99,95%CI:0.72-1.36,P=0.94],异质性检验P=0.12,I^2=39%;(4)住院时间:两组间住院时间没有统计学意义(MD=-0.46,95%CI:-1.09-0.16,P=0.14),异质性检验P=0.0007,I^2=76%;(5)手术时间:两组间手术时间没有统计学意义(MD=-35.45,95%CI:-87.01-16.10,P=0.18),异质性检验:P<0.00001,I^2=98%.结论 POEM优于LHM,但本文还无法明确POEM是否是贲门失弛缓症的最佳治疗方法 ,需要进一步验证.

腹腔镜Heller手术治疗贲门失弛缓症疗效和安全性的Meta分析

目的系统评价腹腔镜Heller手术与内镜下球囊扩张术治疗贲门失弛缓症的临床安全性和疗效。方法计算机检索PubMed、EMbase、The Cochrane Library（2015年8期）、Web of Knowledge、CBM、CNKI、VIP和WanFang Data,搜集腹腔镜Heller手术与内镜下球囊扩张术治疗贲门失弛缓症的相关随机对照试验（RCT）,检索时限均为从建库至2015年8月26日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入5个RCT,包括446例患者。Meta分析结果显示：与内镜下球囊扩张术治疗贲门失弛缓症相比,腹腔镜Heller手术可提高治疗后3个月有效率[OR=2.66,95%CI（1.08,6.60）,P=0.03]和1年有效率[OR=2.24,95%CI（1.29,3.87）,P=0.004],但在治疗后2~3年有效率[OR=1.749,95%CI（0.99,3.23）,P=0.05]和并发症发生率[OR=0.27,95%CI（0.06,1.13）,P=0.07]方面,二者差异无统计学意义。结论现有证据表明,与内镜下球囊扩张术相比,腹腔镜Heller手术治疗贲门失弛缓症可以提高治疗后短期（3个月及1年）有效率,但两种治疗方式在治疗2年以上的有效率及并发症发生率方面无显著差异。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。

经腹腔镜Heller肌切开治疗贲门失弛缓症的远期结果及影响因素

目的评价经腹腔镜食管下段与贲门肌层切开术(LHM)附加胃前壁180°包绕抗反流手术(Dor手术)治疗贲门失弛缓症的远期结果及影响因素。方法回顾性分析2011年1月至2019年12月单一术者应用LHM+Dor手术治疗贲门失弛缓症的连续病例共54例,已除外术后复发再手术和合并癌变者。术前、术后应用症状问询、食管造影检查评价手术疗效;术前应用胃镜检查除外食管黏膜癌变,食管测压检查进行分型,24 h食管pH监测观察食管酸暴露。分析上述术前因素对手术疗效的影响。结果所有患者均有不同程度的吞咽困难,症状持续6.5年(0.5~30.0年)。术中4例(7.4%)黏膜穿孔,无术后并发症和手术死亡。随访中位值5.2年(0.5~9.0年),吞咽困难症状由术前100%降至5.6%(P<0.001),术后烧心症状发生率3.7%,Eckardt临床症状评分由术前4.85±1.64降至0.71±1.08(P=0.000),手术疗效优良率94.4%。术后5年无症状(Eckardt评分≤1)率88.8%。术前有、无夜间呛咳症状患者相比,术后5年无症状率分别为54.6%和91.7%(P=0.047)。术前Ⅰ、Ⅱ度食管扩张与Ⅲ、Ⅳ度食管扩张患者相比,术后5年无症状率分别为92.3%和79.0%(P=0.027)。多因素分析结果显示:术前食管扩张程度较重是术后症状控制较差的独立预测因素(P=0.026)。结论LHM+Dor手术治疗贲门失弛症安全可靠、症状缓解率高且疗效持久,术前食管扩张程度是手术疗效的独立预测因素。