A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibo...A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with pernicious anemia. In their absence, since the disappearance of the Schilling tests, the gastric tubage currently used for the study of gastric acid secretion, is obligatory for the simultaneous study of intrinsic factor output. This study is important to eliminate another disease much more frequent than pernicious anemia, the protein bound to cobalamin malabsorption was observed in achlorhydric simple atrophic gastritis in the presence of intrinsic factor secretion.展开更多
Detailed analysis of intragastric acidity,bacterial parameters in the gastric content including total viable bacterial count(TVBC),oral bacterial count(OBC),intestinal bacterial count(IBC) and nitrate-reducing bacteri...Detailed analysis of intragastric acidity,bacterial parameters in the gastric content including total viable bacterial count(TVBC),oral bacterial count(OBC),intestinal bacterial count(IBC) and nitrate-reducing bacterial count(NRBC) and bacterial identifications were performed on 43 samples of gastric juice obtained at endoscopy of 13 cases with Billroth Ⅰ subtotal gastrectomy(BⅠ),19 cases with Billroth Ⅱ operation(BⅡ) and 11 cases with pylorus and antroseromuscular flap preserving gastrectomy (PAFPG). Eight normal subjects were studied likewise to serve as the control.No significant difference was found in OBC among the 4 groups while the average of TVBC,IBC and NRBC and the PH value were much higher in BⅡ(P<0. 001) and BⅠ(P<0. 05) than in PAFPG and the control but no significant difference of the above mentioned parameters was found between the latter 2 groups. Large amounts of gut bacilli and enteroanaerobes such as Veillonella spp. , Bacteriodes fragilis and Clostridium spp. were identified in the gastric remnants after BⅡ or BⅠ operation but not in those after PAFPG.These findings suggest that intragastric bacterial overgrowth can exist in the hypoacidic stumps in the first 1 to 3 years aftr conventional subtotal gastrectomy especially after B Ⅱ but it cannot exist in the stumps after PAFPG since it only moderately reduces the intrastump acidity.展开更多
文摘A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with pernicious anemia. In their absence, since the disappearance of the Schilling tests, the gastric tubage currently used for the study of gastric acid secretion, is obligatory for the simultaneous study of intrinsic factor output. This study is important to eliminate another disease much more frequent than pernicious anemia, the protein bound to cobalamin malabsorption was observed in achlorhydric simple atrophic gastritis in the presence of intrinsic factor secretion.
文摘Detailed analysis of intragastric acidity,bacterial parameters in the gastric content including total viable bacterial count(TVBC),oral bacterial count(OBC),intestinal bacterial count(IBC) and nitrate-reducing bacterial count(NRBC) and bacterial identifications were performed on 43 samples of gastric juice obtained at endoscopy of 13 cases with Billroth Ⅰ subtotal gastrectomy(BⅠ),19 cases with Billroth Ⅱ operation(BⅡ) and 11 cases with pylorus and antroseromuscular flap preserving gastrectomy (PAFPG). Eight normal subjects were studied likewise to serve as the control.No significant difference was found in OBC among the 4 groups while the average of TVBC,IBC and NRBC and the PH value were much higher in BⅡ(P<0. 001) and BⅠ(P<0. 05) than in PAFPG and the control but no significant difference of the above mentioned parameters was found between the latter 2 groups. Large amounts of gut bacilli and enteroanaerobes such as Veillonella spp. , Bacteriodes fragilis and Clostridium spp. were identified in the gastric remnants after BⅡ or BⅠ operation but not in those after PAFPG.These findings suggest that intragastric bacterial overgrowth can exist in the hypoacidic stumps in the first 1 to 3 years aftr conventional subtotal gastrectomy especially after B Ⅱ but it cannot exist in the stumps after PAFPG since it only moderately reduces the intrastump acidity.
