A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigati...A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression.Nonetheless,nonpharmacological interventions aimed at inducing adult neurogenesis are currently limited.Although individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully explored.In this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 months.Amyloid deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease progressed.However,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus decreased.These findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 mice.Furthermore,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice following multifactor stimulation,as evidenced by Morris water maze,novel object recognition,forced swimming test,and tail suspension test results.Notably,the efficacy of multifactor stimulation in consolidating immature neurons persisted for at least 2weeks after treatment cessation.At the molecular level,multifactor stimulation upregulated the expression of neuron-related proteins(NeuN,doublecortin,postsynaptic density protein-95,and synaptophysin),anti-apoptosis-related proteins(Bcl-2 and PARP),and an autophagyassociated protein(LC3B),while decreasing the expression of apoptosis-related proteins(BAX and caspase-9),in the hippocampus of amyloid precursor protein/presenilin 1 mice.These observations might be attributable to both the brain-derived neurotrophic factor-mediated signaling pathway and antioxidant pathways.Furthermore,serum metabolomics analysis indicated that multifactor stimulation regulated differentially expressed metabolites associated with cell apoptosis,oxidative damage,and cognition.Collectively,these findings suggest that multifactor stimulation is a novel non-invasive approach for the prevention and treatment of Alzheimer's disease.展开更多
Acousto-optic system for performing basic operations of vector-matrix multiplication with digital(16-bit)accuracy are described.The system comprised of two multi-transducer Bragg cells that can perform at least 1×...Acousto-optic system for performing basic operations of vector-matrix multiplication with digital(16-bit)accuracy are described.The system comprised of two multi-transducer Bragg cells that can perform at least 1×10 8 operation/s of basic vector-matrix multiplication with digital (16-bit ) accuracy and which is simple and compact.展开更多
Optical spectrometer of the Guillermo Haro astrophysical observatory (Mexico) realizes investigations in the visible and near-infrared range 350 - 800 nm and exploits mechanically removable traditional static diffract...Optical spectrometer of the Guillermo Haro astrophysical observatory (Mexico) realizes investigations in the visible and near-infrared range 350 - 800 nm and exploits mechanically removable traditional static diffraction gratings as dispersive elements. There is a set of the static gratings with slit-densities 150 - 600 lines/mm and optical apertures 9 cm × 9 cm that provide the first order spectral resolution from 0.8 to 3.2 A/pixel, respectively. However, the needed mechanical manipulations, namely, replacing the static diffraction gratings with various resolutions and following recalibration of spectrometer within studying even the same object are practically inconvenient and lead to wasting rather expensive observation time. We suggest exploiting an acousto-optical cell, i.e. the dynamic diffraction grating tunable electronically, as dispersive element in that spectrometer. Involving the acousto-optical technique, which can potentially provide electronic control over the spectral resolution and the range of observations, leads to eliminating the abovementioned demerits and improving the efficiency of analysis.展开更多
The designed practically prototype of an advanced acousto-optical radio-wave spectrometer is presented in a view of its application to investigating the Milky Way star formation problems. The potential areas for obser...The designed practically prototype of an advanced acousto-optical radio-wave spectrometer is presented in a view of its application to investigating the Milky Way star formation problems. The potential areas for observations of the cold interstellar medium, wherein such a spectrometer can be exploited successfully at different approximations, are: 1) comparison of the Milky Way case with extragalactic ones at scale of the complete galactic disk;2) global studies of the Galactic spiral arms;and 3) characterization of specific regions like molecular clouds or star clusters. These aspects allow us to suggest that similar instrument will be really useful. The developed prototype of spectrometer is able to realize multi-channel wideband parallel spectrum analysis of very-high-frequency radio-wave signals with an improved resolution power exceeding 103. It includes the 1D-acousto-optic wide-aperture cell as the input device for real-time scale data processing. Here, the current state of developing this acousto-optical spectrometer in frames of the astrophysical instrumentation is briefly discussed, and the data obtained experimentally with a tellurium dioxide crystalline acousto-optical cell are presented. Then, we describe a new technique for more precise spectrum analysis within an algorithm of the collinear wave heterodyning. It implies a two-stage integrated processing, namely, the wave heterodyning of a signal in an acoustically square-law nonlinear medium and then the optical processing in the same solid-state cell. Technical advantage of this approach lies in providing a direct multi-channel parallel processing of ultra-high-frequency radio-wave signals with the resolution power exceeding 104. This algorithm can be realized on a basis of exploiting a large-aperture effective acousto-optical cell, which operates in the Bragg regime and performs the ultra-high-frequency co-directional collinear acoustic wave heterodyning. The general concept and basic conclusions here are confirmed by proof-of-principle experiments with the specially designed cell of a new type based on a lead molybdate crystal.展开更多
We present an advanced schematic arrangement of the radio-wave spectrometer with a few parallel optical arms for processing the data flow. This arrangement includes two principal novelties. First of them consists in t...We present an advanced schematic arrangement of the radio-wave spectrometer with a few parallel optical arms for processing the data flow. This arrangement includes two principal novelties. First of them consists in the proposed design, where each individual optical arm exhibits its original performances providing parallel multi-band observations within a few different scales simultaneously. These optical arms have the beam shapers providing both the needed incident light polarization and apodization to increase the dynamic range. After parallel acousto-optical processing, data flows of all the optical arms are united by the joint CCD matrix on the stage of the combined electronic data processing. The second novelty is in usage of unique wide-aperture bastron-based acousto-optical cell providing one of the best performances at the middle-frequencies (about 500 MHz) in comparison with the other available crystalline materials in this range. Such multi-band capabilities have a number of applications in astrophysical scenarios at different scales: from objects in the distant universe to planetary atmospheres in the Solar system. Thus one yields the united versatile instrument, which provides comprehensive studies of astrophysical objects simultaneously with precise synchronization in various frequency ranges.展开更多
A fiber Bragg grating temperature sensor network was designed to implement the real-time health monitoring of the aluminum reduction cell. The heat transfer process was simulated using software ANSYS, and an on-line s...A fiber Bragg grating temperature sensor network was designed to implement the real-time health monitoring of the aluminum reduction cell. The heat transfer process was simulated using software ANSYS, and an on-line shell monitoring system was established based on optical sensing technology. According to aluminum reduction cell heat transfer theory, the 2D slice finite element model was developed. The relationship between shell temperature and cell status was discussed. Fiber Bragg grating （FBG） was chosen as the temperature sensor in light of its unique advantages. The accuracy of designed FBG temperature sensors exceeds 2 ~C, and good repeatability was exhibited. An interrogation system with 104 sensors based on VPG （volume phase grating） filter was established. Through the long-term monitoring on running state, the status of the aluminum reduction cell, including security and fatigue life could be acquired and estimated exactly. The obtained results provide the foundation for the production status monitoring and fault diagnosis. Long-term test results show good stability and repeatability which are compatible with electrolysis process.展开更多
In this paper, multilayer antireflection coatings are designed by modifying the thickness of two and three paired layer distributed Bragg reflector （DBR） structure. Our proposed DBR-based structures show antireflect...In this paper, multilayer antireflection coatings are designed by modifying the thickness of two and three paired layer distributed Bragg reflector （DBR） structure. Our proposed DBR-based structures show antireflection behaviors, in spite of the reflection treatment in traditional DBR structures. Firstly, the proposed structures are designed to be equivalent to the theoretical ideal triple-layer （TL） antireflection coating （ARC）. Therefore, the problem of finding a suitable material for the middle layer of triple structure is solved. Simulation results show the significant equivalency for the reflectance of proposed structures to the ideal TL ARC at the same wavelengths and incident angles. Also, the design of the structure is changed in order to present the constant reflectance coefficient over a wide range of wavelengths. This structure enhances the omni-directionality of the multilayer ARC.展开更多
基金supported by the National Natural Science Foundation of China,No.82001155(to LL)the Natural Science Foundation of Zhejiang Province,No.LY23H090004(to LL)+5 种基金the Natural Science Foundation of Ningbo,No.2023J068(to LL)the Fundamental Research Funds for the Provincial Universities of Zhejiang Province,No.SJLY2023008(to LL)the College Students'Scientific and Technological Innovation Project(Xin Miao Talent Plan)of Zhejiang Province,No.2022R405A045(to CC)the Student ResearchInnovation Program(SRIP)of Ningbo University,Nos.20235RIP1919(to CZ),2023SRIP1938(to YZ)the K.C.Wong Magna Fund in Ningbo University。
文摘A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression.Nonetheless,nonpharmacological interventions aimed at inducing adult neurogenesis are currently limited.Although individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully explored.In this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 months.Amyloid deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease progressed.However,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus decreased.These findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 mice.Furthermore,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice following multifactor stimulation,as evidenced by Morris water maze,novel object recognition,forced swimming test,and tail suspension test results.Notably,the efficacy of multifactor stimulation in consolidating immature neurons persisted for at least 2weeks after treatment cessation.At the molecular level,multifactor stimulation upregulated the expression of neuron-related proteins(NeuN,doublecortin,postsynaptic density protein-95,and synaptophysin),anti-apoptosis-related proteins(Bcl-2 and PARP),and an autophagyassociated protein(LC3B),while decreasing the expression of apoptosis-related proteins(BAX and caspase-9),in the hippocampus of amyloid precursor protein/presenilin 1 mice.These observations might be attributable to both the brain-derived neurotrophic factor-mediated signaling pathway and antioxidant pathways.Furthermore,serum metabolomics analysis indicated that multifactor stimulation regulated differentially expressed metabolites associated with cell apoptosis,oxidative damage,and cognition.Collectively,these findings suggest that multifactor stimulation is a novel non-invasive approach for the prevention and treatment of Alzheimer's disease.
文摘Acousto-optic system for performing basic operations of vector-matrix multiplication with digital(16-bit)accuracy are described.The system comprised of two multi-transducer Bragg cells that can perform at least 1×10 8 operation/s of basic vector-matrix multiplication with digital (16-bit ) accuracy and which is simple and compact.
文摘Optical spectrometer of the Guillermo Haro astrophysical observatory (Mexico) realizes investigations in the visible and near-infrared range 350 - 800 nm and exploits mechanically removable traditional static diffraction gratings as dispersive elements. There is a set of the static gratings with slit-densities 150 - 600 lines/mm and optical apertures 9 cm × 9 cm that provide the first order spectral resolution from 0.8 to 3.2 A/pixel, respectively. However, the needed mechanical manipulations, namely, replacing the static diffraction gratings with various resolutions and following recalibration of spectrometer within studying even the same object are practically inconvenient and lead to wasting rather expensive observation time. We suggest exploiting an acousto-optical cell, i.e. the dynamic diffraction grating tunable electronically, as dispersive element in that spectrometer. Involving the acousto-optical technique, which can potentially provide electronic control over the spectral resolution and the range of observations, leads to eliminating the abovementioned demerits and improving the efficiency of analysis.
文摘The designed practically prototype of an advanced acousto-optical radio-wave spectrometer is presented in a view of its application to investigating the Milky Way star formation problems. The potential areas for observations of the cold interstellar medium, wherein such a spectrometer can be exploited successfully at different approximations, are: 1) comparison of the Milky Way case with extragalactic ones at scale of the complete galactic disk;2) global studies of the Galactic spiral arms;and 3) characterization of specific regions like molecular clouds or star clusters. These aspects allow us to suggest that similar instrument will be really useful. The developed prototype of spectrometer is able to realize multi-channel wideband parallel spectrum analysis of very-high-frequency radio-wave signals with an improved resolution power exceeding 103. It includes the 1D-acousto-optic wide-aperture cell as the input device for real-time scale data processing. Here, the current state of developing this acousto-optical spectrometer in frames of the astrophysical instrumentation is briefly discussed, and the data obtained experimentally with a tellurium dioxide crystalline acousto-optical cell are presented. Then, we describe a new technique for more precise spectrum analysis within an algorithm of the collinear wave heterodyning. It implies a two-stage integrated processing, namely, the wave heterodyning of a signal in an acoustically square-law nonlinear medium and then the optical processing in the same solid-state cell. Technical advantage of this approach lies in providing a direct multi-channel parallel processing of ultra-high-frequency radio-wave signals with the resolution power exceeding 104. This algorithm can be realized on a basis of exploiting a large-aperture effective acousto-optical cell, which operates in the Bragg regime and performs the ultra-high-frequency co-directional collinear acoustic wave heterodyning. The general concept and basic conclusions here are confirmed by proof-of-principle experiments with the specially designed cell of a new type based on a lead molybdate crystal.
文摘We present an advanced schematic arrangement of the radio-wave spectrometer with a few parallel optical arms for processing the data flow. This arrangement includes two principal novelties. First of them consists in the proposed design, where each individual optical arm exhibits its original performances providing parallel multi-band observations within a few different scales simultaneously. These optical arms have the beam shapers providing both the needed incident light polarization and apodization to increase the dynamic range. After parallel acousto-optical processing, data flows of all the optical arms are united by the joint CCD matrix on the stage of the combined electronic data processing. The second novelty is in usage of unique wide-aperture bastron-based acousto-optical cell providing one of the best performances at the middle-frequencies (about 500 MHz) in comparison with the other available crystalline materials in this range. Such multi-band capabilities have a number of applications in astrophysical scenarios at different scales: from objects in the distant universe to planetary atmospheres in the Solar system. Thus one yields the united versatile instrument, which provides comprehensive studies of astrophysical objects simultaneously with precise synchronization in various frequency ranges.
基金Project(61174018) supported by National Natural Science Foundation, ChinaProject(ZR2011FQ025) supported by the Natural Science Foundation of Shandong Province ChinaProject(2010GN066) supported by the Independent Innovation Foundation of Shandong University, China
文摘A fiber Bragg grating temperature sensor network was designed to implement the real-time health monitoring of the aluminum reduction cell. The heat transfer process was simulated using software ANSYS, and an on-line shell monitoring system was established based on optical sensing technology. According to aluminum reduction cell heat transfer theory, the 2D slice finite element model was developed. The relationship between shell temperature and cell status was discussed. Fiber Bragg grating （FBG） was chosen as the temperature sensor in light of its unique advantages. The accuracy of designed FBG temperature sensors exceeds 2 ~C, and good repeatability was exhibited. An interrogation system with 104 sensors based on VPG （volume phase grating） filter was established. Through the long-term monitoring on running state, the status of the aluminum reduction cell, including security and fatigue life could be acquired and estimated exactly. The obtained results provide the foundation for the production status monitoring and fault diagnosis. Long-term test results show good stability and repeatability which are compatible with electrolysis process.
文摘In this paper, multilayer antireflection coatings are designed by modifying the thickness of two and three paired layer distributed Bragg reflector （DBR） structure. Our proposed DBR-based structures show antireflection behaviors, in spite of the reflection treatment in traditional DBR structures. Firstly, the proposed structures are designed to be equivalent to the theoretical ideal triple-layer （TL） antireflection coating （ARC）. Therefore, the problem of finding a suitable material for the middle layer of triple structure is solved. Simulation results show the significant equivalency for the reflectance of proposed structures to the ideal TL ARC at the same wavelengths and incident angles. Also, the design of the structure is changed in order to present the constant reflectance coefficient over a wide range of wavelengths. This structure enhances the omni-directionality of the multilayer ARC.
