尿激酶型纤溶酶原激活物(urokinase type plasminogen activator,uPA)是纤溶酶原的重要激活物之一,其特异性受体为纤溶酶原激活物受体(urokinase type plasminogen activator receptor,uPAR).大量研究表明,uPA/uPAR系统对纤溶酶原活性...尿激酶型纤溶酶原激活物(urokinase type plasminogen activator,uPA)是纤溶酶原的重要激活物之一,其特异性受体为纤溶酶原激活物受体(urokinase type plasminogen activator receptor,uPAR).大量研究表明,uPA/uPAR系统对纤溶酶原活性起调控作用,参与多种与基细胞外基质降解、重塑相关的病理生理过程.肿瘤组织中,在uPA/uPAR系统的作用下将纤溶酶原激活为纤溶酶,促进基底膜和细胞外基质内相关成分的降解,为肿瘤的侵袭、转移提供有利微环境.此外,uPA/uPAR系统对于肿瘤的增殖及肿瘤血管形成也具有调控作用.本文就uPA/uPAR系统在肿瘤中的作用及其临床意义做一综述.展开更多
The expression of signal transducer and activator of transcription 6(STAT6)and nuclear factor-κB(NF-κB)in the colonic mucosa of patients with ulcerative colitis(UC)was examined.Real-time polymer-ase chain reaction a...The expression of signal transducer and activator of transcription 6(STAT6)and nuclear factor-κB(NF-κB)in the colonic mucosa of patients with ulcerative colitis(UC)was examined.Real-time polymer-ase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κB p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers.The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patients with UC were significantly higher than in normal controls at both mRNA and protein levels.These data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of UC and underscore the potential value of anti-UC strategies in the clinical management of this disease.展开更多
The development of novel and efficient antiplatelet agents that have few adverse effects and methods that improve antiplatelet resistance has long been the focus of international research on the prevention and treatme...The development of novel and efficient antiplatelet agents that have few adverse effects and methods that improve antiplatelet resistance has long been the focus of international research on the prevention and treatment of cardiovascular and cerebrovascular diseases.Recent advances in platelet proteomics have provided a technology platform for high-quality research of platelet pathophysiology and the development of new antiplatelet drugs.The study of blood stasis syndrome(BSS)and activated blood circulation of traditional Chinese medicine(TCM)is one of the most active fields where the integration of TCM and western medicine in China has been successful.Activated blood circulation herbs(ABC herbs)of Chinese medicine are often used in the treatment of BSS.Most ABC herbs have antiplatelet and anti-atherosclerosis activity,but knowledge about their targets is lacking.Coronary heart disease(CHD),BSS,and platelet activation are closely related.By screening and identifying activated platelet proteins that are differentially expressed in BSS of CHD,platelet proteomics has helped researchers interpret the antiplatelet mechanism of action of ABC herbs and provided many potential biomarkers for BSS that could be used to evaluate the clinical curative effect of new antiplatelet drugs.In this article the progress of platelet proteomics and its advanced application for research of BSS and ABC herbs of Chinese medicine are reviewed.展开更多
In order to search for sources of the raw material of the Qin’s terracotta warriors and horses, we selected 20 samples of pottery warriors and pottery horses of the Qin’s Mausoleum from pit No. 1,19 samples of potte...In order to search for sources of the raw material of the Qin’s terracotta warriors and horses, we selected 20 samples of pottery warriors and pottery horses of the Qin’s Mausoleum from pit No. 1,19 samples of pottery warriors and brick from pit No. 2, 20 samples of clays near the Qin’s Mausoleum and 2 samples of Yaozhou porcelain bodies. The 32 kinds of element content of each sample were measured by neutron activation analysis (NAA). These data were analyzed by fuzzy cluster analysis, the trend cluster analysis diagram was obtained. The results showed that samples of terracotta warriors and horses from pits No.1 and No. 2 were closely related to the loam layer near Qin’s Mausoleum, but their relations with the loess layers were not so close, and they were out of all relation to Yaozhou porcelain bodies. Thus, it could be deduced that the Li Mountain clay may be considered as the original place of the raw materials of the terracotta warriors and horses, the kiln sites might be located nearby the Qin’s展开更多
This paper proposes an optimal dynamic reserve activation plan after the occurrence of an emergency situation （generator/transmission line outage, load increase or both）. An optimal plan is developed to handle the e...This paper proposes an optimal dynamic reserve activation plan after the occurrence of an emergency situation （generator/transmission line outage, load increase or both）. An optimal plan is developed to handle the emergency, using the coordinated action of fast and slow reserves, for secure operation with minimum overall cost. It considers the reserves supplied by the conventional thermal generators （spinning reserves）, hydro power units and load demands （demand-side reserves）. The optimal backing down of costly/fast reserves and bringing up of slow reserves in each sub-interval in an integrated manner is proposed. The proposed reserve activation approaches are solved using the genetic algorithm, and some of the simulation results are also compared using the Matlab optimization toolbox and the general algebraic modeling system （GAMS） software. The simulation studies are performed on the IEEE 30, 57 and 300 bus test systems. These results demonstrate the advantage of the proposed integrated/dynamic reserve activation plan over the conventional/sequential approach.展开更多
文摘尿激酶型纤溶酶原激活物(urokinase type plasminogen activator,uPA)是纤溶酶原的重要激活物之一,其特异性受体为纤溶酶原激活物受体(urokinase type plasminogen activator receptor,uPAR).大量研究表明,uPA/uPAR系统对纤溶酶原活性起调控作用,参与多种与基细胞外基质降解、重塑相关的病理生理过程.肿瘤组织中,在uPA/uPAR系统的作用下将纤溶酶原激活为纤溶酶,促进基底膜和细胞外基质内相关成分的降解,为肿瘤的侵袭、转移提供有利微环境.此外,uPA/uPAR系统对于肿瘤的增殖及肿瘤血管形成也具有调控作用.本文就uPA/uPAR系统在肿瘤中的作用及其临床意义做一综述.
文摘The expression of signal transducer and activator of transcription 6(STAT6)and nuclear factor-κB(NF-κB)in the colonic mucosa of patients with ulcerative colitis(UC)was examined.Real-time polymer-ase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κB p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers.The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patients with UC were significantly higher than in normal controls at both mRNA and protein levels.These data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of UC and underscore the potential value of anti-UC strategies in the clinical management of this disease.
基金supported by the National Natural Science Foundation of China(30901949,81073086,81030063,81102845)
文摘The development of novel and efficient antiplatelet agents that have few adverse effects and methods that improve antiplatelet resistance has long been the focus of international research on the prevention and treatment of cardiovascular and cerebrovascular diseases.Recent advances in platelet proteomics have provided a technology platform for high-quality research of platelet pathophysiology and the development of new antiplatelet drugs.The study of blood stasis syndrome(BSS)and activated blood circulation of traditional Chinese medicine(TCM)is one of the most active fields where the integration of TCM and western medicine in China has been successful.Activated blood circulation herbs(ABC herbs)of Chinese medicine are often used in the treatment of BSS.Most ABC herbs have antiplatelet and anti-atherosclerosis activity,but knowledge about their targets is lacking.Coronary heart disease(CHD),BSS,and platelet activation are closely related.By screening and identifying activated platelet proteins that are differentially expressed in BSS of CHD,platelet proteomics has helped researchers interpret the antiplatelet mechanism of action of ABC herbs and provided many potential biomarkers for BSS that could be used to evaluate the clinical curative effect of new antiplatelet drugs.In this article the progress of platelet proteomics and its advanced application for research of BSS and ABC herbs of Chinese medicine are reviewed.
基金This work was supported by the National Natural Science Foundation of China (Grant Nos. 59872032 and 10175053) the Natural Science Foundation of Henan Province (Grant No. 004051500) the Youth Foundation of Zhengzhou University and Open Lab of Nuclear
文摘In order to search for sources of the raw material of the Qin’s terracotta warriors and horses, we selected 20 samples of pottery warriors and pottery horses of the Qin’s Mausoleum from pit No. 1,19 samples of pottery warriors and brick from pit No. 2, 20 samples of clays near the Qin’s Mausoleum and 2 samples of Yaozhou porcelain bodies. The 32 kinds of element content of each sample were measured by neutron activation analysis (NAA). These data were analyzed by fuzzy cluster analysis, the trend cluster analysis diagram was obtained. The results showed that samples of terracotta warriors and horses from pits No.1 and No. 2 were closely related to the loam layer near Qin’s Mausoleum, but their relations with the loess layers were not so close, and they were out of all relation to Yaozhou porcelain bodies. Thus, it could be deduced that the Li Mountain clay may be considered as the original place of the raw materials of the terracotta warriors and horses, the kiln sites might be located nearby the Qin’s
文摘This paper proposes an optimal dynamic reserve activation plan after the occurrence of an emergency situation （generator/transmission line outage, load increase or both）. An optimal plan is developed to handle the emergency, using the coordinated action of fast and slow reserves, for secure operation with minimum overall cost. It considers the reserves supplied by the conventional thermal generators （spinning reserves）, hydro power units and load demands （demand-side reserves）. The optimal backing down of costly/fast reserves and bringing up of slow reserves in each sub-interval in an integrated manner is proposed. The proposed reserve activation approaches are solved using the genetic algorithm, and some of the simulation results are also compared using the Matlab optimization toolbox and the general algebraic modeling system （GAMS） software. The simulation studies are performed on the IEEE 30, 57 and 300 bus test systems. These results demonstrate the advantage of the proposed integrated/dynamic reserve activation plan over the conventional/sequential approach.
