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OBSERVING THE ENTIRE GLOBE FOR THE GOOD OF THE MANKIND——China takes an Active Part in Activities of the“International Space Year”
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作者 Chen Shupeng 《遥感信息》 CSCD 1990年第A02期2-2,共1页
The experience of the mankind in studying the planet of our own, is long and the progress is accelerated. From the numerous geographic adventures organized in the past thousand years came only the brief knowledge of t... The experience of the mankind in studying the planet of our own, is long and the progress is accelerated. From the numerous geographic adventures organized in the past thousand years came only the brief knowledge of the outline of the land and ocean; with the scientific explorations and topographic mapping activities done in the 300-plus years that followed, only about 30% of the land got mapped. But things have been changed greatly since the beginning of the century, when the air planes were put into use for mapping: up to 1950’s, the mapped areas had gone up to 70%; From 1957, a series of resource and environment satellites have been launched one after another,observing the globe, giving coverage of it and providing endlessly varieties of information about the seas and the lands day and night. 展开更多
关键词 China takes an active Part in activities of the International Space Year OBSERVING THE ENTIRE GLOBE FOR THE GOOD OF THE MANKIND
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CAS Delegation Attended the Activities of IFAN Actively
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《China Standardization》 2005年第1期38-39,共2页
On November 10-12,the 11^(th) IFAN International Conference of StandardsUsers and the 31^(st) IFAN Members' Assembly of the International Federation of Standards Users wereheld in the Renaissance Hotel of Amsterda... On November 10-12,the 11^(th) IFAN International Conference of StandardsUsers and the 31^(st) IFAN Members' Assembly of the International Federation of Standards Users wereheld in the Renaissance Hotel of Amsterdam, the capital of Holland, and Mr. Neel Reeve, Presidentof IFAN, hosted the Conference and the Assembly. CAS (China Association for Standardization)delegation, consisting of Ms. Li Rui, President of CAS and the leader of the delegation, and twomembers, Zhang Wen and Xu Dajun attended the Conference and the Assembly. 展开更多
关键词 CAS Delegation Attended the activities of IFAN actively St
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Anti-ulcer Activity of Curcumin on Experimental Gastric Ulcer in Rats and Its Effect on Oxidative Stress/Antioxidant,IL-6 and Enzyme Activities 被引量:6
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作者 M.TUORKEY K.KAROLIN 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2009年第6期488-495,共8页
Objective To investigate the possible mechanism by which curcumio protects stomach during the acute chronic phase of gastric ulcer disease. Methods The rats were divided into four groups and fasted for 2 days with fle... Objective To investigate the possible mechanism by which curcumio protects stomach during the acute chronic phase of gastric ulcer disease. Methods The rats were divided into four groups and fasted for 2 days with flee access to water. On the third day, the animals were fasted for a further 24 h with no access to water followed by surgery. Rats received different doses of curcumin (20, 40, and 80 mg/kg) or vehicle by oral gavage. Nineteen hours after ulcer induction, the rats were killed by decapitation. Stomach was opened along the greater curvature and ulcerative lesions were counted. Total juice acidity, neutrophils activity, mitochondrial activity, total antioxidants, paraoxonase (PON 1)/arylesterase and total peroxides were evaluated. DNA fragmentation (%) and pro-inflammatory cytokine IL-6 level were measured. The level of different gastro-cytoprotective effectors including total antioxidants and paraoxonase (PON 1)/arylesterase activities was measured. Results The anti-ulcer activity of curcumin was displayed by attenuating the different ulcerative effectors including gastric acid hyper-secretion, total peroxides, myeloperoxiase (MPO) activity, IL-6 and apoptotic incidence. Conclusion Cureumin appears to have a propitious protective effect against gastric ulcer development. 展开更多
关键词 CURCUMIN Paraoxonase/Arylesterase activity Mitochondrial activity and Myeloperoxiase activity
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Fight fire with fire?Promoting physical activity and health through active video games 被引量:4
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作者 Zan Gao 《Journal of Sport and Health Science》 SCIE 2017年第1期1-3,127,共4页
Physical inactivity has been identified as one of the leading causes of many chronic diseases such as cardiovascular disease,type 2 diabetes,and obesity.Technology such as video games plays a complicated role in physi... Physical inactivity has been identified as one of the leading causes of many chronic diseases such as cardiovascular disease,type 2 diabetes,and obesity.Technology such as video games plays a complicated role in physical inactivity—much like a double-edged sword.Traditionally,video games have contributed to the epidemic of physical inactivity and have 展开更多
关键词 AVG PA Promoting physical activity and health through active video games Fight fire with fire
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Flux emergence in the solar active region NOAA 11158: the evolution of net current 被引量:1
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作者 Panditi Vemareddy Parameswaran Venkatakrishnan Solipuram Karthikreddy 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2015年第9期1547-1558,共12页
We present a detailed investigation of the evolution of observed net vertical current using a time series of vector magnetograms of the active region (AR) NOAA 11158 obtained from the Helioseismic and Magnetic Image... We present a detailed investigation of the evolution of observed net vertical current using a time series of vector magnetograms of the active region (AR) NOAA 11158 obtained from the Helioseismic and Magnetic Imager. We also discuss the relation of net current to the observed eruptive events. The AR evolved from the βγ to βγδ3 configuration over a period of six days. The AR had two sub-regions of activity with opposite chirality: one dominated by sunspot rotation producing a strong CME, and the other showing large shear motions producing a strong flare. The net current in each polarity over the CME producing sub-region increased to a maximum and then decreased when the sunspots were separated. The time profile of net current in this sub-region followed the time profile of the rotation rate of the south-polarity sunspot in the same sub-region. The net current in the flaring sub-region showed a sudden increase at the time of the strong flare and remained unchanged until the end of the observation, while the sunspots maintained their close proximity. The systematic evo- lution of the observed net current is seen to follow the time evolution of total length of strongly sheared polarity inversion lines in both of the sub-regions. The observed photospheric net current could be explained as an inevitable product of the emergence of a twisted flux rope, from a higher pressure confinement below the photosphere into the lower pressure environment of the photosphere. 展开更多
关键词 Sun:active regions -- magnetic fields -- activity -- coronal mass ejec-tions -- non-potentiality -- electric current
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LINEAR ACTIVE STRUCTURES AND MODES (Ⅱ) —DISCRETE SYSTEMS AND BEAMS
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作者 王永刚 龚靖School of Civil Engineering and Mechanics +10 位作者 Xi'an Jiaotong University Xi'an 710049 P.R.China Department of Civil Engineering Northeast China Institute of Electric Power Jilin 132012 P.R.China 张景绘School of Civil Engineering and Mechanics Xi'an Jiaotong University Xi'an 710049 P.R.China 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2004年第8期854-862,共9页
The basic concepts about the active structures and some attributes of the modes were presented in paper “Liner Active Structures and Modes]( I) ". The characteristics of the active discrete systems and active be... The basic concepts about the active structures and some attributes of the modes were presented in paper “Liner Active Structures and Modes]( I) ". The characteristics of the active discrete systems and active beams were discussed, especially, the stability of the active structures and the orthogonality of the eigenvectors. The notes about modes were portrayed by a model of a seven-storeyed building with sensors and actuators. The concept of the adjoint active structure was extended from the discrete systems to the beams that were the representations of the continuous structures. Two types of beams with different placements of the measuring and actuating systems were discussed in detail. One is the beam with the discrete sensors and actuators, and the other is the beam with distributed sensor and actuator function. The orthogonality conditions were derived with the modal shapes of the active beam and its adjoint active beam. An example shows that the variation of eigenvalues with feedback amplitude for the homo-configuration and non-homo-configuration active structures. 展开更多
关键词 I) ". The characteristics of the active discrete systems and active beams were discussed especially the stability of the active structures and the orthogonality of the eigenvectors. The notes about modes were portrayed by a model of a seven-s
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The Urgency of Interest-developed Communicative Activities
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作者 Yaqin He 《Sino-US English Teaching》 2004年第2期51-55,共5页
The article holds that there is an urgent need to implement interest-activated communicative activities in English classes in accordance with the present situation of Shanxi. These activities, as illustrated in the ex... The article holds that there is an urgent need to implement interest-activated communicative activities in English classes in accordance with the present situation of Shanxi. These activities, as illustrated in the examples, are a means to activate the students' interest in English. Moreover, the significance of such activities is mentioned. 展开更多
关键词 Communicative activities motivation communicative competence interest activation
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Biological process of soil improvement in civil engineering:A review 被引量:16
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作者 Murtala Umar Khairul Anuar Kassim Kenny Tiong Ping Chiet 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2016年第5期767-774,共8页
The concept of using biological process in soil improvement which is known as bio-mediated soil improvement technique has shown greater potential in geotechnical engineering applications in terms of performance and en... The concept of using biological process in soil improvement which is known as bio-mediated soil improvement technique has shown greater potential in geotechnical engineering applications in terms of performance and environmental sustainability. This paper presents a review on the soil microorganisms responsible for this process, and factors that affect their metabolic activities and geometric compatibility with the soil particle sizes. Two mechanisms of biomineralization, i.e. biologically controlled and biologically induced mineralization, were also discussed. Environmental and other factors that may be encountered in situ during microbially induced calcite precipitation (MICP) and their influences on the process were identified and presented. Improvements in the engineering properties of soil such as strength/stiffness and permeability as evaluated in some studies were explored. Potential applications of the process in geotechnical engineering and the challenges of field application of the process were identified. 展开更多
关键词 Bio-mediated soil improvement Microorganisms Metabolic activities BiomineralizationUrease activity
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Preparation and modification of activated carbon for benzene adsorption by steam activation in the presence of KOH 被引量:12
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作者 Yao Xin Liu Jinchang +2 位作者 Gong Guozhuo Jiang Yu Xie Qiang 《International Journal of Mining Science and Technology》 SCIE EI 2013年第3期395-401,共7页
A series of activated carbons from Taixi anthracite were prepared by steam activation in the presence of KOH and then they were modified by different methods. The regulation of porosity and the modification of surface... A series of activated carbons from Taixi anthracite were prepared by steam activation in the presence of KOH and then they were modified by different methods. The regulation of porosity and the modification of surface chemistry were carried out with the aim to improve the benzene adsorption capacity of activated carbon. The influences of KOH and activation process parameters including activation temperature, activation time and steam flow rate on porosity of activated carbon were evaluated, and the effect of modification methods on surface chemistry was investigated. Also, the relationship between benzene adsorption capacity and porosity and surface chemistry was analyzed. Results show that activation temperature is the dominant factor in the activation process; the introduction of KOH into the raw material can enhance the reactivity of char in activation process, meanwhile it shows a negative effect on the porosity development, especially on the mesopore development. Results of FTIR analysis indicate that anthracite-based activated carbon with condensed aromatics and chemically inert oxygen does not present the nature to be surface modified. Besides, benzene adsorption capacity has an approximate linear relationship with surface area and in our preparation, benzene adsorption capacity and surface area of activated carbon are up to 1210 m 2 /g and 423 mg/g, respectively. 展开更多
关键词 Activated carbon Steam activation Surface modification Benzene Potassium hydroxide
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Seed Priming with Beta-Amino Butyric Acid Improves Abiotic Stress Tolerance in Rice Seedlings 被引量:3
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作者 Kolothodi Chandran JISHA Jos Thomas PUTHUR 《Rice science》 SCIE CSCD 2016年第5期242-254,共13页
We studied the influence of seed priming with beta-amino butyric acid(BABA) on the growth, physiological and biochemical parameters of seedlings with varied abiotic stress tolerance, which were raised and grown unde... We studied the influence of seed priming with beta-amino butyric acid(BABA) on the growth, physiological and biochemical parameters of seedlings with varied abiotic stress tolerance, which were raised and grown under unstressed and stressed(NaCl/PEG-6000) conditions. Under stressed conditions, the growth of rice seedlings was less when compared to control plants. After BABA priming, the seedling growth increased both under unstressed and stressed conditions as compared to the respective controls. BABA priming of rice seeds caused increase in the photosynthetic pigment content of the leaves, modified the chlorophyll a fluorescence related parameters and also enhanced the photosystem activities of seedlings when compared to their respective non-primed controls. BABA priming also caused increased mitochondrial activities of the rice seedlings. Moreover, BABA priming significantly reduced malondialdehyde content in the seedlings and also resulted in accumulation of proline especially in the NaCl tolerant variety Vyttila 6. BABA seed priming also enhanced the activity of nitrate reductase enzyme and activities of antioxidant enzymes like guaiacol peroxidase and superoxide dismutase. The presence of BABA was detected by high performance thin layer chromatography analysis in the rice seeds whereas in the seedlings it was not detected. Thus, it can be inferred that the seed priming effect of BABA mainly occurred within the seeds, which was further carried to the seedlings. It is concluded that BABA priming of seeds improved the drought and salinity stress tolerance of all the three rice varieties and it was significantly evident in the drought tolerant variety Vaisakh and NaCl tolerant variety Vyttila 6, when compared to the stress sensitive variety Neeraja. 展开更多
关键词 abiotic stress drought mitochondrial activity photochemical activity seed priming rice beta-amino butyric acid
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New Activated Carbon with High Thermal Conductivity and Its Microwave Regeneration Performance 被引量:4
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作者 谷雪贤 SU Zhanjun 奚红霞 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2016年第2期328-333,共6页
Using a walnut shellas a carbon source and ZnCl_2 as an activating agent,we resolved the temperature gradient problems of activated carbon in the microwave desorption process.An appropriate amount of silicon carbide w... Using a walnut shellas a carbon source and ZnCl_2 as an activating agent,we resolved the temperature gradient problems of activated carbon in the microwave desorption process.An appropriate amount of silicon carbide was added to prepare the composite activated carbon with high thermalconductivity while developing VOC adsorption-microwave regeneration technology.The experimentalresults show that the coefficient of thermalconductivity of SiC-AC is three times as much as those of AC and SY-6.When microwave power was 480 W in its microwave desorption,the temperature of the bed thermaldesorption was 10 ℃ to 30 ℃ below that of normalactivated carbon prepared in our laboratory.The toluene desorption activation energy was 16.05 k J·mol^(-1),which was 15% less than the desorption activation energy of commercialactivated carbon.This study testified that the process could maintain its high adsorption and regeneration desorption performances. 展开更多
关键词 activated carbon with high thermal conductivity activation energy for desorption VOCs microwave radiation
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Simvastatin Prevents Lipopolysaccharide-induced Septic Shock in Rats 被引量:1
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作者 喻莉 达兴文 +2 位作者 武晓灵 何奥迪 龙鼎 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2017年第2期226-230,共5页
Simvastatin is a hypolipidemic drug that inhibits hydroxymethylglutaryl coenzyme A(HMGCoA) reductase to control elevated cholesterol,or hypercholesterolemia.Previous studies have shown that simvastatin may attenuate... Simvastatin is a hypolipidemic drug that inhibits hydroxymethylglutaryl coenzyme A(HMGCoA) reductase to control elevated cholesterol,or hypercholesterolemia.Previous studies have shown that simvastatin may attenuate inflammation in ischemia-reperfusion injury and sepsis.Herein,we hypothesized that simvastatin may prevent rats from lipopolysaccharide(LPS)-induced septic shock.In our study,rats were divided into a saline group,an LPS group and an LPS plus simvastatin group.Male Sprague-Dawley(SD) rats were pretreated with simvastatin(1 mg/kg) for 30 min before the addition of LPS(8 mg/kg),with variations in left ventricular pressure recorded throughout.Ninety min after LPS injection,whole blood was collected from the inferior vena cava,and neutrophils were separated from the whole blood using separating medium.The neutrophils were then lysed for Western blotting to detect the levels of urokinase-type plasminogen activator(u PA) and plasminogen activator inhibitor-1(PAI-1).In addition,mesentery microcirculations of inlet diameter,outlet diameter and blood flow rate were measured in all three groups.The results indicated that simvastatin significantly promoted heart systolic function and increased the level of u PA while simultaneously inhibited the expression of PAI-1 as compared with LPS group.Moreover,simvastatin reversed the LPS-induced inhibition of mesentery microcirculation.Taken together,it was suggested that simvastatin can effectively protect the rats from LPS-induced septic shock. 展开更多
关键词 septic shock lipopolysaccharide urokinase-type plasminogen activator plasminogen activator inhibitor-1 simvastatin
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Can Asymmetry of Solar Activity be Extended into Extended Cycle? 被引量:1
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作者 Ke-JunLi Jing-XiuWang 《Chinese Journal of Astronomy and Astrophysics》 CSCD 北大核心 2002年第1期66-70,共5页
With the use of the Royal Greenwich Observatory data set of sunspot groups, an attempt is made to examine the north-south asymmetry of solar activity in the 'extended' solar cycles. It is inferred that the asy... With the use of the Royal Greenwich Observatory data set of sunspot groups, an attempt is made to examine the north-south asymmetry of solar activity in the 'extended' solar cycles. It is inferred that the asymmetry established for individual solar cycles does not extend to the 'extended' cycles. 展开更多
关键词 Sun: sunspot - Sun: active cycle - Sun: activity
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Method of forecasting seismic energy induced by longwall exploitation based on changes in ground subsidence 被引量:2
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作者 Violetta Sokoa Szewioa 《Mining Science and Technology》 EI CAS 2011年第3期375-379,共5页
A method of forecasting total seismic energy induced by longwall exploitation, based on changes in ground subsidence, is presented in the form of a linear regression model with one with one independent variable. In th... A method of forecasting total seismic energy induced by longwall exploitation, based on changes in ground subsidence, is presented in the form of a linear regression model with one with one independent variable. In the method, ground subsidence is described with a cross-section area of a subsidence trough Pw along a line of observations in the direction of an advancing longwall front, approximately along the axis of the longwall area. Total seismic energy is determined on the basis of seismic energy data of tremors induced by exploitation. The presentation consists of a detailed method and evaluation of its predictive ability for the area of longwall exploitation within the region of one of the coal mines in the Upper Silesian Coal Basin. This method can be used for forecasting the total seismic energy released by tremors within the area directly connected with the exploitation, in which the seismic activity induced by this exploitation occurs. The estimation of the parameters of the determined model should each time be carried out with investigations of the correctness of the model. The method cannot be applied when the number of recorded phenomena is small and when there is insufficient data to make it possible to calculate the index Pw. 展开更多
关键词 Seismic activity Mining ground deformation Seismic hazard Prediction of seismic activity
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Kinetics of continuous biodegradation of pesticide organic wastewater by activated carbon-activated sludge
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作者 Zhou Xiao yun, Chen Ming College of Biological & Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 1999年第1期122-127,共6页
Organic triazophos wastewater was continuously treated with Rhodopseudomonas capsulatus and activated carbon and activated sludge system(PACT AS) in a plug bioreactor. A kinetic model of PACT AS wastewater trea... Organic triazophos wastewater was continuously treated with Rhodopseudomonas capsulatus and activated carbon and activated sludge system(PACT AS) in a plug bioreactor. A kinetic model of PACT AS wastewater treatment system was established to provide an useful basis for further simulate scale up treatment of toxic organic wastewater. 展开更多
关键词 wastewater treatment Rhodopseudomonas capsulatus activated carbon activated sludge kinetics.
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The relationships of solar flares with both sunspot and geomagnetic activity 被引量:1
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作者 Zhan-Le Du Hua-Ning Wang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第4期400-410,共11页
The relationships between solar flare parameters (total importance, time duration, flare index, and flux) and sunspot activity (R z ) as well as those between geomagnetic activity (aa index) and the flare parame... The relationships between solar flare parameters (total importance, time duration, flare index, and flux) and sunspot activity (R z ) as well as those between geomagnetic activity (aa index) and the flare parameters can be well described by an integral response model with the response time scales of about 8 and 13 months, respectively. Compared with linear relationships, the correlation coefficients of the flare parameters with R z , of aa with the flare parameters, and of aa with R z based on this model have increased about 6%, 17%, and 47% on average, respectively. The time delays between the flare parameters with respect to R z , aa to the flare parameters, and aa to R z at their peaks in a solar cycle can be predicted in part by this model (82%, 47%, and 78%, respectively). These results may be further improved when using a cosine filter with a wider window. It implies that solar flares are related to the accumulation of solar magnetic energy in the past through a time decay factor. The above results may help us to understand the mechanism of solar flares and to improve the prediction of the solar flares. 展开更多
关键词 Sun: activity -- Sun: sunspots -- Sun: flares -- geomagnetic activity
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Geographically Distinct Expression Profile of Host Defense Peptides in the Skin of the Chinese Odorous Frog, Odorrana margaretae
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作者 Guiying LING Li LI +3 位作者 Jiuxiang GAO Haining YU Yipeng WANG Jiang ZHOU 《Asian Herpetological Research》 SCIE 2013年第4期288-297,共10页
Odorrana margaretae (Anura: Ranidae) is widely distributed in the southern provinces of China. Previously, 72 antimicrobial peptides (AMPs) belonging to 21 families were identified from the skin of O. margaretae,... Odorrana margaretae (Anura: Ranidae) is widely distributed in the southern provinces of China. Previously, 72 antimicrobial peptides (AMPs) belonging to 21 families were identified from the skin of O. margaretae, which were captured in the Hunan province. In the present study, five O. margaretae frogs were captured from the Guizhou province and a total of 28 cDNAs encoding 17 host defense peptides (HDPs) belonging to 14 families were cloned from the skin cDNA library of O. margaretae. Among the 17 HDPs, only one (brevinin-1-Omar5) had been characterized. The distinct HDP expression profiles for O. margaretae in the previous and present study may be attributed to the environmental differences between the sampling locations and the genetic divergence among O. margaretae populations. Besides, 11 of the 17 HDPs identified in the present study were novel for ranids. In order to understand their roles in host defense reactions, three HDPs (odorranain-H-OM1, odorranain-M-OM and ranatuerin-2-OM), which possess low sequence similarity with the known amphibian HDPs, were selected for further chemical synthesis and functional analysis. Odorranain-H-OM1 showed direct antimicrobial activity against bacteria and fungi. Odorranain-M-OM exhibited concentration-dependent anti-oxidant activity. Ranatuerin-2-OM showed lectin-like activity and could strongly hemagglu -tinate human intact erythrocytes with or without the presence of Ca2+. The diverse activities of HDPs implied that they may play different roles in host defense reactions of O. margaretae. 展开更多
关键词 AMPHIBIAN host defense peptides (HDPs) Odorrana margaretae antimicrobial activity anti-oxidant activity erythrocytes hemagglutinating activity
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Competition between C-C and C-H Activation in Reactions of Neutral Nickel Atom with Cycloalkanes (n = 3-7)
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作者 杨静 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2014年第1期122-134,共13页
A theoretical investigation of the reaction mechanisms for C-H and C-C bond activation processes in the reaction of Ni with cycloalkanes C,,H2. (n = 3-7) is carried out. For the Ni + CnH2, (n = 3, 4) reactions, t... A theoretical investigation of the reaction mechanisms for C-H and C-C bond activation processes in the reaction of Ni with cycloalkanes C,,H2. (n = 3-7) is carried out. For the Ni + CnH2, (n = 3, 4) reactions, the major and minor reaction channels involve C-C and C-H bond activations, respectively, whereas Ni atom prefers the attacking of C-H bond over the C-C bond in CnH2n (n = 5=7). The results are in good agreement with the experimental study. In all cases, intermediates and transition states along the reaction paths of interest are characterized, It is found that both the C-H and C-C bond activation processes are proposed to proceed in a one-step manner via one transition state. The overall C-H and C-C bond activation processes are exothermic and involve low energy barriers, thus transition metal atom Ni is a good mediator for the activity of cycloalkanes CnH2n (n = 3 -7). 展开更多
关键词 reaction mechanism C-H bond activation C-C bond activation cycioalkanes nickel atom
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Effects of Buyang Huanwu decoction and Astragalus mongholicus on platelet activating factor receptor activity in rabbits in vitro
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作者 Hui Yao1, Jiping Zhang2, Zhixi Chen3, Yongjie Wu4, Zhiqiang Li3 1Department of Pharmacy, 2Department of Science Education, Foshan Second People’s Hospital, Foshan 528000, Guangdong Province, China 3Laboratory of Nuclear Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong Province, China 4Department of Pharmacology, College of Pharmaceutical Science, Lanzhou University, Lanzhou 730000, Gansu Province, China 《Neural Regeneration Research》 SCIE CAS CSCD 2006年第7期634-637,共4页
BACKGROUND: The pharmacological action of traditional Chinese medicine compound is the comprehensive effect of the various ingredients, and the interactions of various ingredients are closely correlated with the final... BACKGROUND: The pharmacological action of traditional Chinese medicine compound is the comprehensive effect of the various ingredients, and the interactions of various ingredients are closely correlated with the final effect. In order to reveal the compatibility mechanism of BHD's prescription in treating and preventing ischemic cerebrovascular disease, we needed explore the effect and relation of ingredients in the prescription. OBJECTIVE: To observe the effect of Buyang Huanwu decoction (BHD) and Astragalus mongholicus on the activity of platelet activating factor receptor (PAFR) in the platelet of rabbits in vitro, and investigate the mechanism of Astragalus mongholicus. DESIGN: A decomposed recipes study. SETTING: Guangzhou University of Traditional Chinese Medicine. MATERIALS: Five New Zealand rabbits, weighing 2-3 kg, both sexes, were used. BHD was composed of Sheng Huang Qi 120 g, Dang Gui Wei 6 g, Chi Shao 4.5 g, Chuan Xiong 3 g, Di Long 3 g, Tao Ren 3 g, Hong Hua 3 g. The prescription for activating blood circulation consisted of Dang Gui Wei 6 g, Chi Shao 4.5 g, Chuan Xiong 3 g, Di Long 3 g, Tao Ren 3 g and Hong Hua 3 g. The prescription for invigorating qi consisted of 120 g Sheng Huang Qi. The prepared herbal pieces were purchased from the traditional Chinese medicine Dispensary of Foshan Second People's Hospital, and appraised by Professor Xu from Science of Chinese Materia Medica College, Guangzhou University of Traditional Chinese Medicine. 3H-PAF was supplied by Amersham Co., Ltd. (specific activity: 6. 475 TBq/mmol; batch number: 200402); PAF standard by Biomol Co., Ltd. (batch number: P1318V). METHODS: The experiments were carried out in the Laboratory of Nuclear Medicine, Guangzhou University of Traditional Chinese Medicine from September to December 2004. ① Injections of BHD, prescriptions for activating blood circulation and invigorating qi were prepared by the decoction and alcohol sedimentation technique. Rabbit common carotid artery blood (40 mL) was drawn via intubation to prepare platelet suspension of (0.8-1.0)×1010 L-1. ② Determination of 3H-PAF and washed PAFR binding: The general combination tube (T) contained washed platelet-rich plasma (WPRP) 380 μL + 3H-PAF (0.35 nmol/L)10 μL+distilled water 5 μL; The nonspecific binding tube (P) contained WPRP 380 μL+3H-PAF(0.35 nmol/L)10 μL+cold PAF (1 μmol/L) 5 μL; The sample tube (Y) contained WPRP 380 μL+3H-PAF(0.35 nmol/L)10 μL+experimental medicine (injection of BHD, prescriptions for activating blood circulation or invigorating qi) 5 μL. The test was conducted for three times for each sample in the same way as mentioned above. The samples were shaken on the oscillator for 30 s, then bathed at 25 ℃ for 40 minutes, and the reaction was terminated with cold Tris buffer containing 0.1% BSA, multichannel cell detachment separator was used for vacuum suction to filter the separated free 3H-PAF, and the filter paper was washed with cold Tris buffer for four times, then dried in the baking oven (80 ℃) for 1 hour, and placed in xylol liquid scintillator, and the radioactivity was determined automatically by the liquid scintillation detector. The mean of the three parallel tubes was calculated. The specific binging inhibition rate was calculated: SBIR=[(T-Y)/(T-P)]×100%]. ③ Univariate analysis of variance was conducted. And for comparison of each paired groups, the q test was adopted. MAIN OUTCOME MEASURES: Effect of BHD whole prescription, prescriptions for activating blood circulation and invigorating qi on the specific binding inhibition rate of 3H-PAF and PAFR. RESULTS: BHD, prescriptions for activating blood circulation and invigorating qi were all able to inhibit the specific binding of 3H-PAF to PAFR, the specific blinding inhibition rates were (45.90±7.50)%, (97.90±1.84)% and (26.75±2.48)%, respectively, and there were significant differences between every two groups (P < 0.01). CONCLUSION: Single Astragalus mongholicus (120 g) can inhibit the specific blinding of PAFR in the platelet of the rabbit with 3H-PAF, but the combination of Astragalus mongholicus with the drugs for activating blood circulation in BHD can significantly decrease the inhibiting action of the latter on PAFR activity of the platelet, reflecting the combined mechanism of 'removing blood stasis without injuring the vital qi' in BHD. 展开更多
关键词 PAFR Effects of Buyang Huanwu decoction and Astragalus mongholicus on platelet activating factor receptor activity in rabbits in vitro
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Study on the Synthesis and Antitumor Activity of Indolecarbazole Compounds Modified by Amino Acid and Piperidine
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作者 赵玲玲 祁刚 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2017年第6期918-924,共7页
A series of antitumor compounds with indolecarbazole structure modified by amino acid and piperidine were designed and synthesized. The indolecarbazole parent nucleus was firstly synthesized, condensed with bromine su... A series of antitumor compounds with indolecarbazole structure modified by amino acid and piperidine were designed and synthesized. The indolecarbazole parent nucleus was firstly synthesized, condensed with bromine substituted amino acid methyl ester, then hydrolyzed and condensed with piperidine to produce the target compounds. In vitro cytotoxin activity test was performed against 7 target compounds with methylthiazolyldiphenyl-tetrazolium bromide(MTT), and the results showed that compounds CZ-2, CZ-3 and CZ-5 have higher activity against human colon cancers(HT-29) and(HCT-8), hepatocellular carcinoma(Bel-7402), NSCLC(A549) and breast cancer(MCF-7) cells as compared with the positive control JDC-108. 展开更多
关键词 indolecarbazole antitumor activity cytotoxin activity
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