Pavement snow and icing are worldwide problems, but effective countermeasures are just beginning to be developed in China. The two most common snow and ice removal methods are mechanical clearance and chemical melting...Pavement snow and icing are worldwide problems, but effective countermeasures are just beginning to be developed in China. The two most common snow and ice removal methods are mechanical clearance and chemical melting, and the advantages and disadvantages of each approach are discussed here, including environmental and structural damage caused by corrosive snow melting agents. New developments in chemical melting agents and mechanical equipment are discussed, and an overview of alternative thermal melting systems is presented, including the use of geothermy and non-geothermal heating systems utilizing solar energy, electricity, conductive pavement materials, and infrared/microwave applications. Strategic recommendations are made for continued enhancement of public safety in snow and ice conditions.展开更多
AIM： To study the relationship between anti-β2- glycoprotein Ⅰ （aβ2GPⅠ） antibodies and platelet activation state in patients with ulcerative colitis （UC） and its significance. METHODS： Peripheral blood sampl...AIM： To study the relationship between anti-β2- glycoprotein Ⅰ （aβ2GPⅠ） antibodies and platelet activation state in patients with ulcerative colitis （UC） and its significance. METHODS： Peripheral blood samples were collected from 56 UC patients （34 males and 22 females, aged 43.5 years, range 21-66 years）, including 36 at active stage and 20 at remission stage, and 25 sex-and age-matched controls. The level of aβ2GP Ⅰ was measured by ELISA. The platelet activation markers, platelet activation complex- Ⅰ （PAC- Ⅰ ） and P-selectin （CD62P） were detected by flow cytometry. RESULTS： The A value for IgG aβ2GP Ⅰ in the active UC group was 0.61 ± 0.13, significantly higher than that in the remittent UC and control groups （0.50 ± 0.13 and 0.22 ± 0.14, P 〈 0.01）. There was a significant difference between the two groups （P 〈 0.01）. The A value for IgM aβ2GP Ⅰ in the active and remittent UC groups was 0.43 ± 0.13 and 0.38 ± 0.12, significantly higher than that in the control group （0.20 ± 0.12, P 〈 0.01）. However, there was no significant difference between the two groups （P 〉 0.05）. The PAC- Ⅰ positive rate for the active and remittent UC groups was 30.6% ± 7.6% and 19.6% ± 7.8% respectively, significantly higher than that for the control group （6.3% ± 1.7%,P 〈 0.01）. There was a significant difference between the two groups （P 〈 0.01）. The CD62P positive rate for the active and remittent UC groups was 45.0% ± 8.8% and 31.9% ± 7.8% respectively, significantly higher than that for the control group （9.2% ± 2.7%, P 〈 0.01）. There was a significant difference between the two groups （P 〈 0.01）. In the active UC group, the more severe the state of illness was, the higher the A value for IgG aβ2GP Ⅰ was, and the positive rate for PAC-Ⅰ and CD62P was positively correlated with the state of illness （Faβ2GP Ⅰ = 3.679, P 〈 0.05; FPAC-Ⅰ （%） = 5.346, P 〈 0.01; and FCD62P （%） = 5. 418, P 〈 0.01）. Meanwhile, in the same state of illness, the A value for IgG aβ2GP Ⅰ was positively correlated to the positive rates for PAC-Ⅰ and CD62P. CONCLUSION： aβ2GP Ⅰ level, platelet activation state and their relationship of them are closely correlated with the pathogenesis and development of UC.展开更多
自动驾驶智能汽车逐渐普及,其在通过城市路面的沟渠、井盖和减速带等特殊路面时,制动与减速时的稳定性与乘坐舒适性较差,为改善这一状况,对悬架的设计提出了更高的要求。为了提高自动驾驶智能汽车制动与减速时的稳定性,通过融合比例积...自动驾驶智能汽车逐渐普及,其在通过城市路面的沟渠、井盖和减速带等特殊路面时,制动与减速时的稳定性与乘坐舒适性较差,为改善这一状况,对悬架的设计提出了更高的要求。为了提高自动驾驶智能汽车制动与减速时的稳定性,通过融合比例积分微分(Proportional Integral Derivative,PID)与模糊算法,设计了针对这些特殊路面的主动悬架模糊PID控制器,在Matlab/Simulink软件中搭建了半车主动悬架仿真模型,通过惯性测量单元(Inertial Measurement Unit,IMU)实车测量了沟渠路面的路面激励信息,并完成仿真试验。结果表明,当自动驾驶智能汽车在C级路面和沟渠路面行驶时,设计的主动悬架模糊PID控制器较单一算法的控制器更有效地降低了车身垂向加速度、车身俯仰角加速度、车轮动载荷和悬架动行程,改善了悬架性能。展开更多
基金supported by the National Natural Science Fund of China(No.41121061)the National Key Basic Research and Development Program(No.2012CB026102)the Fund of the "Hundred People Plan" of CAS(to WenBing Yu)
文摘Pavement snow and icing are worldwide problems, but effective countermeasures are just beginning to be developed in China. The two most common snow and ice removal methods are mechanical clearance and chemical melting, and the advantages and disadvantages of each approach are discussed here, including environmental and structural damage caused by corrosive snow melting agents. New developments in chemical melting agents and mechanical equipment are discussed, and an overview of alternative thermal melting systems is presented, including the use of geothermy and non-geothermal heating systems utilizing solar energy, electricity, conductive pavement materials, and infrared/microwave applications. Strategic recommendations are made for continued enhancement of public safety in snow and ice conditions.
基金The National Natural Science Foundation of China, No. 30572106
文摘AIM： To study the relationship between anti-β2- glycoprotein Ⅰ （aβ2GPⅠ） antibodies and platelet activation state in patients with ulcerative colitis （UC） and its significance. METHODS： Peripheral blood samples were collected from 56 UC patients （34 males and 22 females, aged 43.5 years, range 21-66 years）, including 36 at active stage and 20 at remission stage, and 25 sex-and age-matched controls. The level of aβ2GP Ⅰ was measured by ELISA. The platelet activation markers, platelet activation complex- Ⅰ （PAC- Ⅰ ） and P-selectin （CD62P） were detected by flow cytometry. RESULTS： The A value for IgG aβ2GP Ⅰ in the active UC group was 0.61 ± 0.13, significantly higher than that in the remittent UC and control groups （0.50 ± 0.13 and 0.22 ± 0.14, P 〈 0.01）. There was a significant difference between the two groups （P 〈 0.01）. The A value for IgM aβ2GP Ⅰ in the active and remittent UC groups was 0.43 ± 0.13 and 0.38 ± 0.12, significantly higher than that in the control group （0.20 ± 0.12, P 〈 0.01）. However, there was no significant difference between the two groups （P 〉 0.05）. The PAC- Ⅰ positive rate for the active and remittent UC groups was 30.6% ± 7.6% and 19.6% ± 7.8% respectively, significantly higher than that for the control group （6.3% ± 1.7%,P 〈 0.01）. There was a significant difference between the two groups （P 〈 0.01）. The CD62P positive rate for the active and remittent UC groups was 45.0% ± 8.8% and 31.9% ± 7.8% respectively, significantly higher than that for the control group （9.2% ± 2.7%, P 〈 0.01）. There was a significant difference between the two groups （P 〈 0.01）. In the active UC group, the more severe the state of illness was, the higher the A value for IgG aβ2GP Ⅰ was, and the positive rate for PAC-Ⅰ and CD62P was positively correlated with the state of illness （Faβ2GP Ⅰ = 3.679, P 〈 0.05; FPAC-Ⅰ （%） = 5.346, P 〈 0.01; and FCD62P （%） = 5. 418, P 〈 0.01）. Meanwhile, in the same state of illness, the A value for IgG aβ2GP Ⅰ was positively correlated to the positive rates for PAC-Ⅰ and CD62P. CONCLUSION： aβ2GP Ⅰ level, platelet activation state and their relationship of them are closely correlated with the pathogenesis and development of UC.
文摘自动驾驶智能汽车逐渐普及,其在通过城市路面的沟渠、井盖和减速带等特殊路面时,制动与减速时的稳定性与乘坐舒适性较差,为改善这一状况,对悬架的设计提出了更高的要求。为了提高自动驾驶智能汽车制动与减速时的稳定性,通过融合比例积分微分(Proportional Integral Derivative,PID)与模糊算法,设计了针对这些特殊路面的主动悬架模糊PID控制器,在Matlab/Simulink软件中搭建了半车主动悬架仿真模型,通过惯性测量单元(Inertial Measurement Unit,IMU)实车测量了沟渠路面的路面激励信息,并完成仿真试验。结果表明,当自动驾驶智能汽车在C级路面和沟渠路面行驶时,设计的主动悬架模糊PID控制器较单一算法的控制器更有效地降低了车身垂向加速度、车身俯仰角加速度、车轮动载荷和悬架动行程,改善了悬架性能。
