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Strategies to achieve effective nitrogen activation
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作者 Bin Chang Huabin Zhang +1 位作者 Shuhui Sun Gaixia Zhang 《Carbon Energy》 SCIE EI CAS CSCD 2024年第5期137-163,共27页
Ammonia serves as a crucial chemical raw material and hydrogen energy carrier.Aqueous electrocatalytic nitrogen reduction reaction(NRR),powered by renewable energy,has attracted tremendous interest during the past few... Ammonia serves as a crucial chemical raw material and hydrogen energy carrier.Aqueous electrocatalytic nitrogen reduction reaction(NRR),powered by renewable energy,has attracted tremendous interest during the past few years.Although some achievements have been revealed in aqueous NRR,significant challenges have also been identified.The activity and selectivity are fundamentally limited by nitrogen activation and competitive hydrogen evolution.This review focuses on the hurdles of nitrogen activation and delves into complementary strategies,including materials design and system optimization(reactor,electrolyte,and mediator).Then,it introduces advanced interdisciplinary technologies that have recently emerged for nitrogen activation using high-energy physics such as plasma and triboelectrification.With a better understanding of the corresponding reaction mechanisms in the coming years,these technologies have the potential to be extended in further applications.This review provides further insight into the reaction mechanisms of selectivity and stability of different reaction systems.We then recommend a rigorous and detailed protocol for investigating NRR performance and also highlight several potential research directions in this exciting field,coupling with advanced interdisciplinary applications,in situ/operando characterizations,and theoretical calculations. 展开更多
关键词 activation via mediators catalyst optimization electrochemical nitrogen fixation high-energy activation of nitrogen NITROGEN
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LncRNA LUCAT1 Activation Mediated by theDown-regulation of DNMT1 Is Involved inCell Apoptosis Induced by PM2.5 被引量:2
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作者 LING Xiao Xuan ZHANG Hai Qiao +6 位作者 LIU Jia Xian LIU Zhi Dong PENG Jian Ming ZHANG Xiao Qing SHAO Jun Li CHEN Zhen Fa LIU Lin Hua 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2018年第8期608-612,共5页
Particulate matter (PM), which is a great environmental concern, has been classified as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC);.Epidemiological and experimental studie... Particulate matter (PM), which is a great environmental concern, has been classified as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC);.Epidemiological and experimental studies have indicated that chronic exposure to PM, especially PM;(particles with an aerodynamic diameter less than 展开更多
关键词 PBS RNA LncRNA LUCAT1 Activation Mediated by the Down-regulation of DNMT1 Is Involved in Cell Apoptosis Induced by PM Figure
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Activation of epidermal growth factor receptor mediates myocardial ischemia/reperfusion arrhythmias in anaesthetized rats
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作者 MEI Feng~2,JI Zhou-xiang~1,QIN Fu~1,LEI Yang~1,HUI Liu~1 (1.Department of Pharmacology,Tongji Medical College, Huazhong University of Science and Technology,Wuhan 4300074 2.Department of Anesthesiology,Union Hospital, Tongji Medical College,Huazhong University of Science and Technology,Wuhan 4300074) 《岭南心血管病杂志》 2011年第S1期222-222,共1页
Objectives Epidermal growth factor receptor (EGFR)is a receptor protein tyrosine kinase and plays a critical role in the development and function of the heart.Previous studies have demonstrated that EGFR is involved... Objectives Epidermal growth factor receptor (EGFR)is a receptor protein tyrosine kinase and plays a critical role in the development and function of the heart.Previous studies have demonstrated that EGFR is involved in regulating electrical excitability of the heart.The present study was designed to investigate whether EGFR activation would mediate myocardial arrhythmias induced by ischemia/reperfu- sion in anaesthetized rats.Methods and results Myocardial ischemia/reperfusion arrhythmias were induced by 10 min ligation of the left anterior descending coronary artery,followed by a 30 min reperfusion in anaesthetized rats.Incidence and severity of cardiac arrhythmias were significantly reduced by pretreatment with the EGFR kinase inhibitor AG556.Phosphorylation level of myocardial EGFR was increased during ischemia and at early reperfusion.Intramyocardial transfection of EGFR siRNA reduced EGFR mRNA and protein,and decreased the incidence of ventricular fibrillation induced by reperfusion.Interestingly,tyrosine phosphorylation levels of cardiac Na<sup>+</sup> channel(I<sub>Na</sub>) and L-type Ca<sup>2+</sup> channel(I<sub>Ca.l</sub>) were significantly increased at corresponding time points to the alteration of phosphorylated EGFR level during reperfusion.AG556 pretreatment countered the increased tyrosine phosphorylation level of Na<sup>+</sup> and L-type Ca<sup>2+</sup> channels induced by reperfusion.No significant alteration was observed in tyrosine phosphorylation levels of cardiac Kv4.2 and Kir2.1 channels during the cardiac ischemia/reperfusion. Conclusions These results demonstrate for the first time that EGFR plays an important role in the genesis of myocardial ischemia/reperfusion arrhythmias,which is likely mediated at least in part by enhancing tyrosine phosphorylation of cardiac Na<sup>+</sup> and L-type Ca<sup>2+</sup> channels. 展开更多
关键词 EGFR Activation of epidermal growth factor receptor mediates myocardial ischemia/reperfusion arrhythmias in anaesthetized rats
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Biophotonic Activity and Transmission Mediated by Mutual Actions of Neurotransmitters are Involved in the Origin and Altered States of Consciousness 被引量:3
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作者 Weitai Chai Zhengrong Han +6 位作者 Zhuo Wang Zehua Li Fangyan Xiao Yan Sun Yanfeng Dai Rendong Tang Jiapei Dai 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第3期534-538,共5页
Dear Editor Despite remarkable advances in our understanding of brain functions,the neural substrates and correlates of consciousness remain unclear[1].It has been argued that classical physics is intrinsically incapa... Dear Editor Despite remarkable advances in our understanding of brain functions,the neural substrates and correlates of consciousness remain unclear[1].It has been argued that classical physics is intrinsically incapable of explaining the holistic aspects of consciousness. 展开更多
关键词 Biophotonic Activity and Transmission Mediated by Mutual Actions of Neurotransmitters are Involved in the Origin and Altered States of Consciousness NMDAR
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Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation 被引量:15
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作者 Wang Chenji (王陈继) Huang Haojie (黄浩杰) Sun Yinhao (孙颖浩) 《Science Foundation in China》 CAS 2017年第3期39-39,共1页
Subject Code:H16With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Wang Chenji(王陈继)from Fudan University,Prof.Huang Haojie(黄浩杰)from Mayo... Subject Code:H16With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Wang Chenji(王陈继)from Fudan University,Prof.Huang Haojie(黄浩杰)from Mayo Clinic and Sun Yinhao(孙颖浩)from the Second Military Medical University have 展开更多
关键词 Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation
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