Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction

Objective:To investigate the effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction. Methods:A total of 74 patients with acute cerebral infarction treated in our hospital from March 2014 to December 2015 were retrospectively analyzed, and they were divided into ginkgo-damole group and conventional treatment group according to a therapeutic schedule that whether ginkgo-diyidamolum were included. At Week 2 and Week 4 after treatment, contents of apoptosis molecule, nerve injury molecule and index of platelet aggregation in serum were detected. Results:At Week 2 after treatment, contents of soluble Fas, soluble Fas ligand, soluble tumor necrosis factor related apoptosis inducing ligand, S100β, neuron specific enolase, glial fibrillary acidic protein, myelin basic protein, malonaldehyde, endothelin-1, fibrinogen and D-dimer in patients' sera of ginkgo-damole group were significantly lower than those of conventional treatment group. Contents of nitric oxide in sera were obviously higher than that of conventional treatment group. At Week 4 after treatment, contents of soluble Fas, soluble Fas ligand, soluble tumor necrosis factor related apoptosis inducing ligand, S100β, neuron specific enolase, glial fibrillary acidic protein, myelin basic protein, malonaldehyde, endothelin-1, fibrinogen and D-dimer in patients' sera of ginkgo-damole group were significantly lower than those of conventional treatment group. Contents of nitric oxide in sera were obviously higher than that of conventional treatment group. Conclusions:Adjuvant therapy with ginkgo-damole can inhibit the apoptosis of neuron cells and neurogliocyte and reduce the neural function injury and the situation of platelet aggregation.

Identification of microRNAs and messenger RNAs involved in human umbilical cord mesenchymal stem cell treatment of ischemic cerebral infarction using integrated bioinformatics analysis

In recent years,a large number of differentially expressed genes have been identified in human umbilical cord mesenchymal stem cell(hUMSC)transplants for the treatment of ischemic cerebral infarction.These genes are involved in various biochemical processes,but the role of microRNAs(miRNAs)in this process is still unclear.From the Gene Expression Omnibus(GEO)database,we downloaded two microarray datasets for GSE78731(messenger RNA(mRNA)profile)and GSE97532(miRNA profile).The differentially expressed genes screened were compared between the hUMSC group and the middle cerebral artery occlusion group.Gene ontology enrichment and pathway enrichment analyses were subsequently conducted using the online Database for Annotation,Visualization,and Integrated Discovery.Identified genes were applied to perform weighted gene co-suppression analyses,to establish a weighted co-expression network model.Furthermore,the protein-protein interaction network for differentially expressed genes from turquoise modules was built using Cytoscape(version 3.40)and the most highly correlated subnetwork was extracted from the protein-protein interaction network using the MCODE plugin.The predicted target genes for differentially expressed miRNAs were also identified using the online database starBase v3.0.A total of 3698 differentially expressed genes were identified.Gene ontology analysis demonstrated that differentially expressed genes that are related to hUMSC treatment of ischemic cerebral infarction are involved in endocytosis and inflammatory responses.We identified 12 differentially expressed miRNAs in middle cerebral artery occlusion rats after hUMSC treatment,and these differentially expressed miRNAs were mainly involved in signaling in inflammatory pathways,such as in the regulation of neutrophil migration.In conclusion,we have identified a number of differentially expressed genes and differentially expressed mRNAs,miRNA-mRNAs,and signaling pathways involved in the hUMSC treatment of ischemic cerebral infarction.Bioinformatics and interaction analyses can provide novel clues for further research into hUMSC treatment of ischemic cerebral infarction.

Three-dimensional arterial spin labeling and diffusion kurtosis imaging in evaluating perfusion and infarct area size in acute cerebral ischemia

BACKGROUND Early thrombolytic therapy is crucial to treat acute cerebral infarction,especially since the onset of thrombolytic therapy takes 1-6 h.Therefore,early diagnosis and evaluation of cerebral infarction is important.AIM To investigate the diagnostic value of magnetic resonance multi-delay threedimensional arterial spin labeling(3DASL)and diffusion kurtosis imaging(DKI)in evaluating the perfusion and infarct area size in patients with acute cerebral ischemia.METHODS Eighty-four patients who experienced acute cerebral ischemia from March 2019 to February 2021 were included.All patients in the acute stage underwent magnetic resonance-based examination,and the data were processed by the system’s own software.The apparent diffusion coefficient(ADC),average diffusion coefficient(MD),axial diffusion(AD),radial diffusion(RD),average kurtosis(MK),radial kurtosis(fairly RK),axial kurtosis(AK),and perfusion parameters post-labeling delays(PLD)in the focal area and its corresponding area were compared.The correlation between the lesion area of cerebral infarction under MK and MD and T2-weighted imaging(T2WI)was analyzed.RESULTS The DKI parameters of focal and control areas in the study subjects were compared.The ADC,MD,AD,and RD values in the lesion area were significantly lower than those in the control area.The MK,RK,and AK values in the lesion area were significantly higher than those in the control area.The MK/MD value in the infarct lesions was used to determine the matching situation.MK/MD<5 mm was considered matching and MK/MD≥5 mm was considered mismatching.PLD1.5s and PLD2.5s perfusion parameters in the central,peripheral,and control areas of the infarct lesions in MK/MD-matched and-unmatched patients were not significantly different.PLD1.5s and PLD2.5s perfusion parameter values in the central area of the infarct lesions in MK/MD-matched and-unmatched patients were significantly lower than those in peripheral and control areas.The MK and MD maps showed a lesion area of 20.08±5.74 cm^(2) and 22.09±5.58 cm^(2),respectively.T2WI showed a lesion area of 19.76±5.02 cm^(2).There were no significant differences in the cerebral infarction lesion areas measured using the three methods.MK,MD,and T2WI showed a good correlation.CONCLUSION DKI parameters showed significant difference between the focal and control areas in patients with acute ischemic cerebral infarction.3DASL can effectively determine the changes in perfusion levels in the lesion area.There was a high correlation between the area of the infarct lesions diagnosed by DKI and T2WI.

EFFECT OF ACUPUNCTURE ON PLASMA STRESS HORMONE LEVELS OF HYPOTHALAMUS-PITUITARY-ADRENAL AXIS IN TYPE II DIABETES WITH CONCURRENT ACUTE CEREBRAL INFARCTION PATIENTS

Objective: To observe the effect of acupuncture on the contents of stress hormones of the hypothalamus pituitary adrenal axis (HPA) in treatment of type II diabetes with concurrent acute cerebral infarction patients. Methods: 60 cases of inpatients were randomly and evenly divided into treatment group (conventional medication plus acupuncture) and control (conventional mediation) group. Plasma corticotropin releasing hormone (CRH), adrenocorticotropin hormone (ACTH) and corticosteroid (CS) contents before and after treatment were measured using radioimmunoassay (RIA) and compared with those of healthy subject group (n=30). Results: Plasma CRH, ACTH and CS levels in patients of both treatment group and control group at admission were significant higher than those of normal subject group (P<0.05). After treatment for 15～30 days, results showed that plasma CRH, ACTH and CS levels in both treatment and control groups lowered significantly in comparison with those of pre treatment (P<0.05 or 0.01); while those of treatment group were even more lower (being closer to the normal values) than those of control group (P<0.05 or 0.01). Conclusion: Acupuncture therapy can reduce the stress state of HPA in type II diabetes with concurrent acute cerebral infarction patients, i.e. regulate the neuroendocrine immunological net, which may be one of the mechanisms for acupuncture treatment of cerebral stroke.

CLINICAL OBSERVATION ON THE TREATMENT OF ACUTE CEREBRAL INFARCTION WITH SCALP-ACUPUNCTURE

Abstract: In the present paper, the authors report the findings of scalp-acupuncture treatment of 50 cases of acute cerebral Infarction. A total of 100 patients were randomly divided into scalp acupuncture group (n = 50) and medication control group (n= 50). In the former group, penetration needling from Baihui (GV 20) to Qianding (GV 21) and from Shuaigu(GB 8) to Xuanli (GB 6) was performed, followed by conducting electroacupuncture (EA) stimulation; while in control group, intravenous drip of Ligustrazine injectio 120 mg plus 5% glucose solution 250 mL (once daily, with 14 days being a therapeutic course) was given in the first therapeutic course and then intravenous drip of Piracetum injectio (2 g plus 5% glucose or normal saline 250 mL, once daily, continuously for 14 days) conducted in the second therapeutic course. Results: After treatment, of the 50 cases in scalp acupuncture group, 26 (52%) were recovered basically, 15 (30%) had significant improvement, 7 (14%) had improvement and 2 (4%) failed in the treatment; while of the 50 cases in control group, 15 (30%) recovered basically, 17 (34%) had marked improvement, 16 (32%) had improvement and 2 (4%) failed in the treatment. The integral values of hemiplegia and aphasia of scalp acupuncture group were less than those of control group (P <0.01). It Indicates that the therapeutic effect of scalp acupuncture is superior to that of control group.

Study on the Treatment of Acute Cerebral Infarction by Xuanzhong(GB 39)Toward Sanyinjiao(SP 6)Acupuncture as Main Therapy

目的:观察针刺疗法治疗急性脑梗死的疗效。方法:将80例急性脑梗死患者随机分为治疗组40例,对照组40例,采用悬钟透三阴交为主的针刺法,经治疗1个疗程后.比效2组的疗效及治疗前后脑梗死灶大小变化。结果:经1个疗程后.治疗组总痊愈率88.5%.对照组57.5%.二者差异有显著性意义(P<0.05);梗死病灶变化好转率治疗组明显高于对照组,亦有显著性意义(P<0.05)。结论:该疗法是降低中风致残率,提高治愈率的有效方法。

急性脑梗死介入治疗联合静脉溶栓治疗的效果观察

目的 探究介入治疗联合静脉溶栓对急性脑梗死患者的治疗效果。方法 80例急性脑梗死患者,合理且随机划分为对照组和观察组,每组40例。对照组采取静脉溶栓治疗,观察组在对照组基础上采用介入治疗。比较两组患者神经功能缺损评分、血清学相关指标(神经生长因子、神经元特异性烯醇化酶、脑钠肽)、活化部分凝血活酶时间、凝血酶原时间、凝血酶时间、纤维蛋白原、并发症发生情况。结果 观察组患者治疗后1 d、7 d、2周神经功能缺损评分均低于对照组(P<0.05)。治疗后,两组患者神经生长因子、神经元特异性烯醇化酶、脑钠肽水平均下降,且观察组患者神经生长因子(95.31±9.65)ng/ml、神经元特异性烯醇化酶(10.26±1.37)μg/L、脑钠肽(157.43±13.25)ng/L均低于对照组的(116.38±10.46)ng/ml、(15.86±1.86)μg/L、(189.46±17.78)ng/L(P<0.05)。治疗后,观察组患者活化部分凝血活酶时间(35.43±2.21)s、凝血酶原时间(13.26±1.53)s、凝血酶时间(17.46±2.24)s比对照组的(30.48±2.15)、(10.93±1.29)、(15.55±1.87)s更长,纤维蛋白原(2.44±0.43)g/L比对照组的(4.21±0.64)g/L更低(P<0.05)。观察组并发症发生率5.00%比对照组的25.00%更低(P<0.05)。结论 针对急性脑梗死患者,采取静脉溶栓联合介入治疗可有效改善患者神经功能及血清学状况,且可以有效改善活化部分凝血活酶时间等相关临床指标,减少相关并发症的发生,该治疗方案临床应用效果理想,预后效果良好,值得在临床广泛推广。

脑血容量指数预测急性缺血性卒中患者血管内治疗远期预后的价值分析

目的探讨CT灌注指数与急性缺血性卒中(AIS)患者血管内治疗(EVT)远期预后的相关性。方法纳入64例诊断AIS且经EVT的患者并进行1年随访。主要结局指标包括术后1年改良Rankin量表(mRS)评分0~2分(良好预后)。所有患者根据低灌注强度比(HIR)(<0.3 vs≥0.3)和脑血容量(CBV)指数(>0.7 vs≤0.7)进行分组,将组间临床资料及术后1年mRS评分进行比较;通过Logistic回归分析术后1年良好预后的影响因素。结果61例患者完成随访,其中术后1年达到良好预后的有34例(55.7%)。高CBV组良好预后率明显高于低CBV组(76.9%vs 40%),低HIR组良好预后率明显高于高HIR组(73.9%vs 44.7%)(P<0.05)。CBV指数是术后1年良好预后的保护因素(P=0.046)。结论CBV指数可预测AIS患者EVT远期预后情况,有望为患者EVT提供临床依据。

磁共振弥散加权成像联合CRP对急性缺血性脑梗死时间窗的鉴别价值

目的磁共振弥散加权成像(DWI)联合血清C反应蛋白(CRP)对急性缺血性脑梗死时间窗的鉴别价值。方法回顾性分析2021年6月至2023年6月宝鸡市中心医院收治的195例急性缺血性脑梗死患者床资料,其中男111例,女84例,年龄范围57~75岁。按发病至接受磁共振检查前时间分为超急性期组(病程≤6 h)67例、急性期组(病程6~72 h)79例、亚急性期组(≥72~168 h)49例;比较3组患者的DWI检查结果[表观弥散系数(ADC)]及CRP水平,受试者操作特征曲线(ROC)分析DWI联合CRP对急性缺血性脑梗死时间窗的鉴别价值,采用t检验、F检验进行统计分析。结果超急性期组患侧ADC为(0.33±0.08)×10^(-3) mm^(2)/s,低于急性期组的(0.40±0.09)×10^(-3) mm^(2)/s、亚急性期组的(1.56±0.25)×10^(-3) mm^(2)/s,3组比较差异有统计学意义(F=34.455,P<0.05);且超急性期组、急性期组患者患侧ADC值低于健侧,但亚急性期组患者ADC值高于健侧,差异有统计学意义(均P<0.05)。超急性期组CRP为(9.39±3.03)mg/L,高于急性期组(6.01±1.27)mg/L、亚急性期(5.48±1.33)mg/L(q=16.09、712.295,均P<0.05);但急性期组、亚急性期CRP比较差异无统计学意义(q=1.933、P>0.05)。ROC显示ADC鉴别急性缺血性脑梗死超急性期的曲线下面积(AUC)为0.587,灵敏度为100.00%、特异度为38.38%;CRP鉴别急性缺血性脑梗死超急性期的AUC为0.888,灵敏度为73.13%、特异度为96.87%;ADC联合CRP的AUC为0.918,灵敏度、特异度分别为85.07%、86.72%。结论急性缺血性脑梗死患者的ADC与血清CRP水平均可有效鉴别时间窗,ADC鉴别超急性缺血性脑梗死存在高灵敏度优势,CRP则具有高特异度优势,两者联合可进一步优化鉴别效能。

介入溶栓治疗颅内大血管狭窄急性闭塞致脑梗死的疗效及对患者血清BDNF GAP-43和NGF的影响

目的 探讨介入溶栓治疗颅内大血管狭窄急性闭塞致脑梗死的临床疗效及对患者血清脑源性神经营养因子(BDNF)、神经生长相关蛋白43(GAP-43)和神经生长因子(NGF)水平的影响。方法 将56例颅内大血管狭窄急性闭塞致脑梗死患者按治疗方法分为对照组(28例)和研究组(28例)。对照组患者给予常规治疗,研究组患者在对照组基础上给予介入溶栓治疗。比较两组临床疗效以及不良事件发生率,比较治疗前后两组患者美国国立卫生研究院卒中量表(NHISS)评分、脑血流灌注指标、生存质量综合评定问卷简表(WHOQOL-BREF)评分及血清BDNF、GAP-43和NGF水平。结果 治疗后两组患者NHISS评分均较治疗前降低,且研究组低于对照组(P<0.01);治疗后两组患者脑血流量(CBF)、脑血容量(CBV)、脑血流平均通过时间(MTT)均较治疗前升高,且研究组高于对照组(P<0.01)。治疗后,研究组患者WHOQDL-BREF各维度评分均高于对照组(P<0.01)。治疗后,两组患者血清BDNF、GAP-43和NGF水平均较治疗前升高,且研究组高于对照组(P<0.01)。研究组患者临床总有效率高于对照组(P<0.05),两组患者不良事件发生率比较差异无统计学意义(P>0.05)。结论 介入溶栓治疗颅内大血管狭窄急性闭塞致脑梗死能够显著改善患者神经缺损程度,改善脑部供血,提高其生活质量,疗效显著。

银丹心脑通软胶囊联合静脉溶栓治疗急性缺血性脑卒中的临床疗效

目的:探讨银丹心脑通软胶囊联合静脉溶栓治疗急性缺血性脑卒中(AIS)患者的临床疗效。方法:选取2022年1月-2023年1月徐州市第一人民医院收治的AIS患者80例为研究对象,根据随机数字表法分为对照组和研究组,各40例。对照组给予静脉溶栓治疗,观察组给予银丹心脑通软胶囊联合静脉溶栓治疗。比较两组患者临床效果。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P=0.004);治疗后,两组甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均降低,研究组低于对照组,两组高密度脂蛋白胆固醇水平均升高,研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组活化部分凝血酶时间、凝血酶原时间水平均降低,研究组低于对照组,两组纤维蛋白原、D-二聚体水平均升高,研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组卒中量表、Rankin修订总评分均降低,研究组低于对照组,差异有统计学意义(P<0.05)。结论:AIS患者采用银丹心脑通软胶囊联合静脉溶栓治疗效果显著,可改善患者神经功能缺损、病残程度、血脂水平及凝血功能。

三酰甘油与APOE基因多态性在短暂性脑缺血发作患者发生急性脑梗死中的交互作用研究

目的探讨三酰甘油(TG)与载脂蛋白E(APOE)基因多态性在短暂性脑缺血发作(TIA)患者发生急性脑梗死中的交互作用。方法对2019年1月—2021年6月349例TIA进行6个月随访,根据是否发生急性脑梗死分为发生组、未发生组,比较2组一般资料、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、TG、APOE基因多态性,并比较不同TG水平患者APOE基因多态性,使用多因素Logistic回归分析TIA发生急性脑梗死的影响因素,使用交互作用系数γ分析TG与APOE基因多态性的交互作用。结果随访6个月,共45例(12.89%)TIA患者发生急性脑梗死。发生组TG高于未发生组(P<0.01)。发生组及TG升高患者E3/3基因型、ε3等位基因频率分别低于未发生组及TG正常患者,E3/4基因型、ε4等位基因频率分别高于未发生组及TG正常患者(P<0.05)。校正TIA持续时间、TIA发作频率后,TG、APOE基因型E3/3、E3/4及等位基因ε4仍是TIA发生急性脑梗死的独立影响因素(P<0.01)。TG升高与APOE基因型E3/4在TIA发生急性脑梗死中呈正向交互作用,且交互作用符合次相乘模型。结论TG升高与APOE基因型E3/4在TIA发生急性脑梗死中呈正向交互作用,且交互作用符合次相乘模型,TG升高可增强APOE基因型E3/4对TIA发生急性脑梗死的易感性。

益气通脉汤联合针刺治疗气虚血瘀型急性脑梗死临床观察

目的探讨益气通脉汤联合针刺疗法对气虚血瘀型急性脑梗死患者血液流变学及血清相关指标的影响。方法将2021年6月—2022年6月泉州市中医院内科收治的气虚血瘀型急性脑梗死患者80例作为观察对象,按随机数字表法分成对照组(40例)、研究组(40例)。两组均行常规西医治疗,研究组同时采用益气通脉汤联合针刺治疗,对比两组治疗前后血液流变学、血清相关指标水平和不良反应发生率。结果与治疗前相比,治疗2周后,两组纤维蛋白原、高切血黏度、D-二聚体、血浆黏度及血清低氧诱导因子-1α(HIF-1α)水平均下降,且研究组较对照组更低,两组血清血管内皮生长因子(VEGF)水平均升高,且研究组较对照组更高,差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论气虚血瘀型急性脑梗死患者接受益气通脉汤联合针刺治疗能更好地调控血液流变学指标和血清相关指标,改善脑血液循环,加快病情恢复,且安全性高。

脑肠同调论针刺治疗急性脑梗死血清代谢组学研究

目的 分析脑肠同调论针刺治疗急性脑梗死的血清代谢组学的影响。方法 纳入2018年3月—2022年12月医院收治的急性脑梗死患者126例作为研究对象,随机数字表法分为两组,对照组63例采用常规疗法,观察组63例在此基础上采用脑肠同调论针刺治疗,对比两组治疗效果、神经功能,炎症因子水平以及对血清代谢组学的影响。结果 观察组总有效率为96.83%(61/63),远高于对照组的80.96%(57/63),神经功能缺损评分(NIHSS)评分低于对照组(P<0.05);治疗后观察组白介素-17(Interleukin-17,IL-17)、超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)、血浆氧化三甲胺(trimethylamine oxide, TMAO)水平均低于对照组(P<0.05);治疗后观察组苯丙氨酸、溶血卵磷脂、焦谷氨酸水平低于对照组(P<0.05)。结论 脑肠同调论针刺治疗急性脑梗死效果明确,可减轻患者炎症反应,调节其肠道菌群代谢产物水平及氨基酸、磷脂代谢障碍等,使紊乱的代谢趋于正常,以达促进神经功能恢复,改善患者预后的目的,有较高应用价值。

急性心脑梗死临床特征及治疗转归的研究

目的急性心脑梗死(cardio-cerebral infarction,CCI)是急性心肌梗死(acute myocardial infarction,AMI)合并急性缺血性脑卒中(acute ischemic stroke,AIS)的严重临床综合征,包括同步性CCI(synchronous CCI,SCCI)和异时性CCI(metachronous CCI,MCCI)。本研究拟探讨其临床特征、治疗现状及预后。方法采用单中心回顾性研究,纳入2014年1月~2021年12月首都医科大学宣武医院收治的CCI患者。采集分析人口统计学信息、临床特征、治疗和结局(全因死亡、MACE事件、mRS评分、出血事件)。结果研究纳入137例CCI患者,包括同步性CCI 28例和异时性CCI 109例。高血压、吸烟、糖尿病是最常见危险因素。患者心功能显著降低,42.9%KillipⅢ~Ⅳ级,40.0%左心室射血分数减低。AIS最主要病因为大动脉粥样硬化,入院NHISS评分为11.24±10.50。患者急诊再灌注治疗率低(29.2%),相比未接受急诊再灌注组患者,接受急诊再灌注组院内病死率较低(P=0.042)。院内全因死亡率高达27.0%,心力衰竭(43.8%)是最常见的MACE事件。出院时神经功能良好(mRS 0~2分)占34.3%。严重出血事件27例(19.7%),其中脑梗死出血转化19例(13.9%)。结论CCI的治疗仍面临挑战,患者急诊再灌注率低,抗栓方案个体差异大,临床预后差。未来亟需更多临床研究推动CCI治疗管理的优化。

脑血容量指数预测超时间窗前循环大血管闭塞病人血管内治疗预后的价值

目的探讨脑血容量指数(CBV Index)在预测超时间窗(>6 h)前循环大血管闭塞急性缺血性卒中(AIS)病人血管内治疗(EVT)后90 d神经功能结局中的价值。方法回顾性纳入EVT后超时间窗前循环大血管闭塞AIS病人137例,分析病人的一般临床资料和头颅CT灌注(CTP)影像。根据术后90 d改良Rankin量表(mRS)评分,将病人分为预后良好组(mRS≤2分)60例和预后不良组(mRS>2分)77例。采用Mann-Whitney U检验、卡方检验或Fisher确切概率检验比较2组间梗死核心体积、CBV Index、低灌注强度比(HIR)和一般临床资料。采用多因素Logistic回归分析并构建超时间窗前循环大血管闭塞AIS病人EVT后预后预测模型。采用受试者操作特征(ROC)曲线下面积(AUC)分析预测效能。结果与预后不良组比较,预后良好组病人的年龄小、男性占比高、入院时NIHSS评分低,且梗死核心体积小、血管再开通良好比例高、CBV Index高、HIR低(均P<0.05)。Logistic回归分析显示年龄、入院时NIHSS评分、血管再开通情况和CBV Index是预测超时间窗前循环大血管闭塞AIS病人EVT后预后的独立预测因子(均P<0.05)。ROC曲线分析显示整合了年龄、入院时NIHSS评分、血管再开通情况和CBV Index的联合模型对病人预后具有较高的预测效能,AUC为0.878,敏感度为81.67%,特异度为87.01%。结论CBV Index与超时间窗前循环大血管闭塞AIS病人EVT后90 d神经功能结局相关,整合了年龄、入院时NIHSS评分、血管再开通情况和CBV Index的模型可有效预测预后。

ADC值、FA值与TIA患者血管狭窄程度的相关性及其联合检测对TIA患者发生ACI的预测价值

目的 探究弥散加权成像(DWI)参数表现扩散系统(ADC)值、弥散张量成像(DTI)参数向异性分数(FA)值与短暂性脑缺血发作(TIA)血管狭窄程度的相关性,及联合检测对TIA患者发生急性脑梗死(ACI)的预测价值。方法 选取河南省第二人民医院2022年1月至2023年1月收治的110例TIA患者,均进行DWI、DTI检查。比较不同血管狭窄程度TIA患者ADC值、FA值,分析ADC值、FA值与TIA血管狭窄程度的相关性。根据TIA患者入院治疗后3个月内是否发生ACI,分为ACI组和非ACI组,分析ADC值、FA值联合检测对TIA患者发生ACI的预测价值。结果 血管狭窄程度轻度、中度、重度TIA患者ADC值、FA值比较:重度<中度<轻度(P<0.05);TIA患者ADC值、FA值与血管狭窄程度呈负相关(r=-0.786、-0.679,P<0.05);非ACI组ADC值、FA值高于ACI组(P<0.05);ADC值与FA值联合检测预测TIA患者发生ACI的AUC、敏感度均高于DC值、FA值单独检测(P<0.05)。结论 ADC值、FA值可用于评估TIA患者血管狭窄程度,且联合检测对TIA患者发生ACI具有较高的预测价值,临床常可通过DWI检查和DTI检查获取ADC值、FA值,用于评估TIA患者血管狭窄的严重程度,并预测ACI发生的可能性,为临床早期制定干预措施提供依据,进而减少ACI的发生,改善TIA患者的预后。

以假性周围神经麻痹为首发症状的急性缺血性脑卒中临床分析

目的分析以假性周围神经麻痹为首发症状的急性缺血性脑卒中患者的临床特点及早期诊断。方法回顾性分析15例首发症状为假性周围神经麻痹的急性缺血性脑卒中患者的临床资料。结果15例患者中,男性多见,均为急性起病,首发症状为假性周围神经麻痹,部分患者病情进展,均由头颅MRI确诊为急性脑梗死,>50%的患者存在颅内动脉狭窄或闭塞,脑血管病高危因素多为高同型半胱氨酸血症和高血压,治疗上主要采取抗栓、降脂,预后良好。结论临床上以假性周围神经麻痹为首发症状的急性缺血性脑卒中患者较为罕见,极易误诊,对急性起病的有脑血管病高危因素的男性周围神经麻痹患者,仍需尽早行头颅MRI检查以明确诊断。

从脾论治缺血性中风恢复期及验案举隅

目前随着中国人民生活水平逐渐提高,缺血性中风的发病率也在不断上升。缺血性中风恢复期为缺血性中风急性发病后的2周至6个月内,是由急性期向后遗症期过渡的中间时期,也是言语、认知、运动等功能恢复的关键时期,其中医病机以虚中夹实为主,与脾的关系尤为密切。文章论述从脾诊治缺血性中风恢复期的理论依据及临床应用,为脑梗死恢复期的临床治疗提供新的思路。

急性缺血性卒中急性期药物治疗进展

卒中是我国成人致死、致残的第一位病因。急性缺血性卒中(acute ischemic stroke,AIS)是卒中最常见的类型,严重影响患者生活质量,造成沉重的疾病负担,其防治是医学领域亟待解决的重大问题。AIS的发病机制复杂,治疗上应基于对患者的整体评估进行综合决策,并遵循规范的诊治流程。目前针对AIS急性期的治疗策略主要有两方面,一是尽早开通阻塞血管恢复脑组织灌注,挽救缺血半暗带;二是多靶点抑制缺血性病理生理级联反应,保护脑细胞。近年来,AIS在溶栓、抗血小板以及细胞保护各领域的药物治疗发展迅速,本文结合目前国内外的相关研究成果,对AIS急性期药物治疗进展做一综述,为更多有效治疗药物的研发提供科学依据和思路。