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Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease 被引量:2
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作者 Nileshkumar J Patel Aashay Patel +16 位作者 Kanishk Agnihotri Dhaval Pau Samir Patel Badal Thakkar Nikhil Nalluri Deepak Asti Ritesh Kanotra Sabeeda Kadavath Shilpkumar Arora Nilay Patel Achint Patel Azfar Sheikh Neil Patel Apurva O Badheka Abhishek Deshmukh Hakan Paydak Juan Viles-Gonzalez 《World Journal of Cardiology》 CAS 2015年第7期397-403,共7页
Atrial fibrillation(AF) is the most common type of sustained arrhythmia,which is now on course to reach epidemic proportions in the elderly population. AF is a commonly encountered comorbidity in patients with cardiac... Atrial fibrillation(AF) is the most common type of sustained arrhythmia,which is now on course to reach epidemic proportions in the elderly population. AF is a commonly encountered comorbidity in patients with cardiac and major non-cardiac diseases. Morbidity and mortality associated with AF makes it a major healthcare burden. The objective of our article is to determine the prognostic impact of AF on acute coronary syndromes,heart failure and chronic kidney disease. Multiple studies have been conducted to determine if AF has an independent role in the overall mortality of such patients. Our review suggests that AF has an independent adverse prognostic impact on the clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease. 展开更多
关键词 ATRIAL FIBRILLATION heart failure chronic kidney disease acute coronary SYNDROMES PROGNOSTIC IMPACT
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Development of Nursing Protocol for Preventing Interruptions during Clinical Examinations and Treatments in the Early Days of Hospitalization for Acute Exacerbation of Chronic Heart Failure in Patients with Impaired Cognitive Function 被引量:2
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作者 Haruka Otsu Hiroko Yokotani +4 位作者 Natsuko Jukei Yoshiko Sakai Shigehito Narita Tamao Susukida Miho Tsujino 《Health》 2018年第6期773-788,共16页
The purpose of this study is to prepare a nursing protocol for preventing interruptions during clinical examinations and treatments performed in the early days of hospitalization for acute exacerbation of chronic hear... The purpose of this study is to prepare a nursing protocol for preventing interruptions during clinical examinations and treatments performed in the early days of hospitalization for acute exacerbation of chronic heart failure in patients with impaired cognitive function. For the first stage of the research, we prepared a draft of the nursing protocol based on a basic survey. For the second stage, semi-structured interviews were conducted with 5 nurses specialized in chronic heart failure and 11 nurses in dementia care to ensure content validity of the draft protocol. For the third stage, we examined the possibility of clinical application of the revised version of the protocol draft prepared in the second stage of the study. For assessment items, significant points of nursing care, and specific nursing care practice in this revised version, 73 subjects (84.9%) considered effective for patients, in terms of prevention of interruptions during clinical examinations and treatments in the early days of hospitalization. All items and contents were considered useful by more than 60% of the nurses. Considering that the nurses working in the clinical setting reported 84.9% of usefulness, we concluded that this nursing protocol remained valid at a certain level. We consider that this nursing protocol will be useful especially for newly graduated/employed nurses as a procedure manual which can reduce their anxiety or stress caused by lack of knowledge or experiences. 展开更多
关键词 Dementia Cognitive Impairment acute EXACERBATION of chronic heart failure EARLY DAYS of HOSPITALIZATION NURSING PROTOCOL
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Development of Nursing Protocol for Preventing Discontinuation of Treatments by Methods Other than Physical Restraint during Acute Exacerbation of Chronic Heart Failure in Patients with Impaired Cognitive Function 被引量:2
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作者 Haruka Otsu Shiori Fujimoto +5 位作者 Nozomi Murakami Tatsuki Ohhara Yoko Takeya Tatsuya Ohno Chieko Suzuki Sanae Takahashi 《Health》 2018年第6期789-815,共27页
The purpose of this study is to prepare a nursing protocol for preventing discontinuation of treatments using a method other than physical restraint during acute exacerbation of chronic heart failure in patients with ... The purpose of this study is to prepare a nursing protocol for preventing discontinuation of treatments using a method other than physical restraint during acute exacerbation of chronic heart failure in patients with impaired cognitive function. For the first stage of the study, we prepared a draft of the nursing protocol based on a basic survey. For the second stage, semi-structured interviews were conducted with 5 nurses specialized in chronic heart failure and 10 nurses in dementia case to ensure content validity of the draft protocol. For the third stage, we examined the possibility of clinical application of the revised version of the protocol draft prepared in the second stage of the study. For assessment items, significant points of nursing care, and specific nursing care practice in this revised version, 154 subjects (93.9%) considered effective for patients, in terms of prevention of treatment discontinuation using a method other than physical restraint. All items and contents were considered useful by more than 60% of the nurses. Considering that the nurses working in the clinical setting reported 93.9% of usefulness, we concluded that this nursing protocol remained valid at a certain level. We also received a comment from the certified nurses that we should include the basic contents for newly graduated nurses. We consider that this nursing protocol will be also useful for newly graduated nurses to acquire knowledge. It helped to standardize nursing care in order to predict potential risks for patients with impaired cognitive function. 展开更多
关键词 DEMENTIA IMPAIRED Cognitive Function acute EXACERBATION of chronic heart failure Physical Restraint NURSING PROTOCOL
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Effect of ivabradine in the treatment of acute exacerbation of chronic obstructive pulmonary disease with heart failure 被引量:1
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作者 Jing Z Qing G +4 位作者 Li-hong Z Liang S Dong-xia LI Cui-cui G Guo-hong Y 《Journal of Hainan Medical University》 2019年第19期31-36,共6页
Objective: To observe the effectiveness and safety of ivabradine in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and heart failure. Methods:Patients who were admitted to hospital ... Objective: To observe the effectiveness and safety of ivabradine in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and heart failure. Methods:Patients who were admitted to hospital with AECOPD during the period from August 2017 to July 2018. Then those both had heart failure with reduced ejection fraction(HFrEF) and a resting heart rate>70 beats/min were enrolled. A total of 86 cases were screened and completed, which were randomly divided into two groups for treatment. The control group(41 cases) received standard treatments, such as oxygen, anti-infection, anti-spasmodic, hormone, diuretic, ACEI/ARB, recombinant human brain natriuretic peptide (rhBNP), etc. The bisoprolol was given 2.5~5 mg orally once a day to control heart rate, and the test group(45 cases) was further treated with ivabradine 2.5~5 mg orally twice a day on the basis of the control group. The average heart rate, cardiac function, lung function, and 6-minute walking test were compared between the two groups. Results: After treatment, the average heart rate of the test group was lower than the control group, and the heart rate control rate(<70 beats/min%) of the test group was superior to the control group. The level of N-terminal B-type natriuretic peptide(NT-proBNP) in test group was significantly lower than that in control group. The distance of the 6-minute walking test in e test group was significantly longer than that in control group. Conclusion: Ivabradine combined with bisoprolol could help patients with AECOPD and heart failure to further reduce the heart rates, improve heart function and exercise tolerance. Moreover, the therapeutic safety was acceptable during the short term. 展开更多
关键词 IVABRADINE acute exacerbation of chronic obstructive pulmonary disease heart failure heart rate
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Development of a Nursing Protocol for Hospitalized Patients with Reduced Cognitive Function in the Process of Recovery from Acute Exacerbation of Chronic Heart Failure
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作者 Haruka Otsu Tsukiko Narasaki +5 位作者 Ayumi Kamura Kyoko Maeda Tomoko Sumiwaka Tomie Uno Misato Takamori Toshimichi Wada 《Health》 2018年第7期879-901,共23页
The purpose of this study is to develop a nursing protocol aiming at early recovery of hospitalized patients with reduced cognitive functions in the process of recovery from acute exacerbation of chronic heart failure... The purpose of this study is to develop a nursing protocol aiming at early recovery of hospitalized patients with reduced cognitive functions in the process of recovery from acute exacerbation of chronic heart failure. At the first stage of the research, a draft nursing protocol was prepared based on a basic survey. At the second stage of research, a semi-structured interview was conducted for 4 nurses certified for chronic heart failure nursing and 11 nurses certified for dementia nursing so as to ensure content validity of the draft nursing protocol. At the third stage of the study, the possibility of clinical application of the nursing protocol revision plan proposed at the second stage of the study was examined. The nursing protocol revision plan was effective for 118 nurses (90.1%) who carried out the protocol for the target patient on assessment items, essential points of nursing care and specific nursing care. There were no items or contents for which confirmation of usefulness was less than 60%. Since 90.1% of the usefulness was confirmed by nurses working in the actual clinical setting, the authors believe that this nursing protocol was secured to a certain level. The nursing protocol developed in this study has been requested by nurses at clinical sites in the past. It is very meaningful in improving nursing for the early recovery of hospitalized patients with reduced cognitive function in the process of recovery from acute exacerbation of chronic heart failure. 展开更多
关键词 DEMENTIA Cognitive IMPAIRMENT acute EXACERBATION of chronic heart failure RECOVERY NURSING PROTOCOL
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The Lebanese Society of Cardiology Consensus Statement on the Use of Natriuretic Peptides for the Management of Heart Failure
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作者 Tony Abdel Massih Hadi Skouri +4 位作者 Antoine Sarkis Malek Mohammad Abbas Alaaeddine Jean Paul Sahakian James Januzzi 《World Journal of Cardiovascular Diseases》 2023年第6期297-308,共12页
Plasma concentration of Natriuretic Peptide (NP) is a valuable diagnostic tool for heart failure (HF). It can help rule out or confirm a diagnosis of HF based on symptoms, but its use is not clearly defined. NPs shoul... Plasma concentration of Natriuretic Peptide (NP) is a valuable diagnostic tool for heart failure (HF). It can help rule out or confirm a diagnosis of HF based on symptoms, but its use is not clearly defined. NPs should be used in conjunction with physical examination and other diagnostic tests. However, it is important to note that several conditions besides the diagnosis of HF may cause NPs levels to be elevated. Additionally, there are situations when NP concentrations may be below diagnostic thresholds in [1]. This consensus statement aims to provide a straightforward diagnostic flowchart for clinicians in both the emergency department and outpatient settings to aid in diagnosing both acute and chronic HF. The diagnosis of acute HF can be ruled out with a BNP level of 100 pg/mL or NTproBNP level of 300 pg/mL, regardless of the patient’s age. To identify HF, a 3-level cut-off point based on the patient’s age is recommended. Chronic heart failure can be ruled out with a BNP level of 35 pg/mL or NTproBNP level of 125 pg/mL, regardless of thepatient’s age [1]. 展开更多
关键词 acute heart failure chronic heart failure Natriuretic Peptides NT-PROBNP BNP Algorithm
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脂蛋白(a)与高龄慢性心力衰竭急性失代偿患者的预后相关性研究 被引量:1
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作者 冯超 杨雪圆 冯津萍 《中华老年心脑血管病杂志》 CAS 北大核心 2024年第3期254-257,共4页
目的 分析脂蛋白(a)[Lp(a)]与年龄≥80岁慢性心力衰竭(CHF)患者不良预后之间的关系,以及高龄CHF患者不良预后的影响因素。方法 收集2018年6月至2021年8月天津大学胸科医院心脏重症病房收治的高龄CHF急性失代偿患者135例,根据血清Lp(a)水... 目的 分析脂蛋白(a)[Lp(a)]与年龄≥80岁慢性心力衰竭(CHF)患者不良预后之间的关系,以及高龄CHF患者不良预后的影响因素。方法 收集2018年6月至2021年8月天津大学胸科医院心脏重症病房收治的高龄CHF急性失代偿患者135例,根据血清Lp(a)水平,分为高Lp(a)组[Lp(a)≥300 mg/L]73例和低Lp(a)组[Lp(a)<300 mg/L]62例,收集所有入组患者基线临床资料、12个月内随访结果,主要终点事件为因心力衰竭再住院和(或)全因死亡的复合终点。采用Kaplan-Meier生存曲线比较2组生存情况,采用logistic回归分析高龄CHF患者1年内发生终点事件的危险因素。结果 高Lp(a)组慢性肾脏病比例,同型半胱氨酸、TC及LDL-C水平高于低Lp(a)组,差异有统计学意义(P<0.05)。Kaplan-Meier生存分析显示,低Lp(a)组1年内无主要终点事件平均生存时间长于高Lp(a)组[9.8个月(95%CI:8.884~10.665)vs 8.2个月(95%CI:7.057~9.272),P<0.05]。多因素logistic回归分析显示,Lp(a)≥300 mg/L(OR=2.841,95%CI:1.133~7.092,P=0.026)、女性(OR=2.809,95%CI:1.111~7.092,P=0.029)、使用利尿剂(OR=4.631,95%CI:1.103~19.443,P=0.036)是患者1年内发生主要终点事件的独立危险因素。结论 Lp(a)≥300 mg/L是高龄CHF患者1年内发生因心力衰竭再住院和(或)全因死亡的独立危险因素。 展开更多
关键词 心力衰竭 脂蛋白(a) 预后 慢性心力衰竭急性失代偿
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参附注射液治疗心肾阳虚型慢性心力衰竭急性加重的临床研究
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作者 杨帆 冉永玲 +5 位作者 彭聪 桂青 卢飚 袁良 黄平 戴小华 《中西医结合心脑血管病杂志》 2024年第11期1936-1940,共5页
目的:观察参附注射液治疗心肾阳虚型慢性心力衰竭急性加重的临床疗效。方法:选取2023年10月—2024年1月在安徽中医药大学第一附属医院住院的慢性心力衰竭急性加重病人60例,按照随机数字表法分为观察组与对照组,各30例。观察组给予参附... 目的:观察参附注射液治疗心肾阳虚型慢性心力衰竭急性加重的临床疗效。方法:选取2023年10月—2024年1月在安徽中医药大学第一附属医院住院的慢性心力衰竭急性加重病人60例,按照随机数字表法分为观察组与对照组,各30例。观察组给予参附注射液加西医常规治疗,对照组仅给予西医常规治疗,比较两组治疗前后血浆氨基末端B型钠尿肽前体(NT-proBNP)、超敏肌钙蛋白I(hs-cTnI)、6 min步行试验(6MWT)、明尼苏达州心力衰竭生活质量问卷评分(MLHFQ)、中医证候积分及纽约心脏病协会(NYHA)心功能分级。结果:与治疗前比较,两组治疗后NT-proBNP、hs-cTnI水平降低(P<0.05),两组治疗后NT-proBNP、hs-cTnI水平比较差异均无统计学意义(P>0.05);与治疗前比较,两组治疗后6MWT、MLHFQ评分均明显改善(P<0.05),观察组改善程度优于对照组(P<0.05);两组治疗后各单项中医证候积分低于治疗前(P<0.05),观察组治疗后喘促气短、倦怠乏力、畏寒肢冷及言语声低评分低于对照组(P<0.05)。观察组总有效率为96.7%,对照组为80.0%,两组比较差异有统计学意义(P<0.05)。结论:参附注射液联合西药常规治疗可改善心肾阳虚型慢性心力衰竭急性加重病人心功能,提高病人运动耐量和生活质量。 展开更多
关键词 慢性心力衰竭 心肾阳虚 急性加重 参附注射液 心功能 中医证候
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Performance measures for management of chronic heart failure patients with acute coronary syndrome in China: results from the Bridging the Gap on Coronary Heart Disease Secondary Prevention in China (BRIG) Project 被引量:7
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作者 WANG Na ZHAO Dong +6 位作者 LIU Jing LIU Jun Cheuk-Man Yu WANG Wei SUN Jia-yi LIYan CHEN Bu-xing 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第14期2625-2631,共7页
Background Chronic heart failure (CHF) is a severe clinical syndrome associated with high morbidity and mortality, and with high health care expenditures. No nationwide data are currently available regarding the qua... Background Chronic heart failure (CHF) is a severe clinical syndrome associated with high morbidity and mortality, and with high health care expenditures. No nationwide data are currently available regarding the quality of clinical management of CHF patients in China. The aim of this study was to assess the quality of care of CHF inpatients in China. Methods The American College of Cardiology/American Heart Association Clinical Performance Measures for Adults with Chronic Heart Failure (Inpatient Measurement Set) with slight modifications was used to measure the performance status in 612 CHF patients with acute coronary syndrome (ACS) from 65 hospitals across all regions of China. Results The implementation rates of guideline recommended strategies for CHF management were low. Only 57.5% of the CHF patients received complete discharge instructions, 53.6% of the patients received evaluation of left ventricular systolic function, 62.8% received an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker at discharge, and 52.7% received a p-blocker at discharge, 56.3% of the smokers received smoking cessation counseling. The rate of warfarin utilization was only 9.7% in CHF patients with atrial fibrillation. Most patients (81.4%) did not receive all the first four treatments. There were marked differences in the quality of CHF management among patients with different characteristics. Conclusions Performance measures provide a standardized method of assessing quality of care, and can thus highlight problems in disease management in clinical practice. The quality of care for CHF patients with ACS in China needs to be improved. 展开更多
关键词 chronic heart failure quality of care acute coronary syndrome
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精细化容量管理对慢性心力衰竭急性加重患者的影响 被引量:1
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作者 王芳芳 文杰 +2 位作者 张慧颖 郭敏 李小红 《中国护理管理》 CSCD 北大核心 2024年第4期588-592,共5页
目的:分析精细化容量管理在慢性心力衰竭急性加重患者出院前后护理中的应用效果,以期进一步提高慢性心力衰竭急性加重患者的临床护理水平。方法:采用便利抽样法选择2022年9月至2023年3月在北京市某三级甲等医院心内科住院的60例慢性心... 目的:分析精细化容量管理在慢性心力衰竭急性加重患者出院前后护理中的应用效果,以期进一步提高慢性心力衰竭急性加重患者的临床护理水平。方法:采用便利抽样法选择2022年9月至2023年3月在北京市某三级甲等医院心内科住院的60例慢性心力衰竭急性加重患者,随机分为对照组和实验组。对照组采用药物常规治疗加常规心内科护理,实验组在对照组的基础上进行精细化容量管理干预,评价精细化容量管理对住院天数、氨基末端脑钠肽前体、明尼苏达心力衰竭生活质量问卷、出院3个月心力衰竭再住院情况的影响。结果:实验组的住院天数明显短于对照组(P=0.024),且住院期间实验组的氨基末端脑钠肽前体下降水平优于对照组(P=0.025),干预2周后,实验组的明尼苏达心力衰竭生活质量问卷评分明显低于对照组(P=0.048),但实验组与对照组的出院3个月再住院情况比较,差异无统计学意义(P=0.731)。结论:精细化容量管理方法可行、有效,在不增加治疗成本的基础上,可以明显缩短慢性心力衰竭急性加重患者的住院时间,提高生活质量。 展开更多
关键词 慢性心力衰竭急性加重 精细化容量管理 护理
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误诊为多种心外系统疾病的老年冠心病心力衰竭临床分析
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作者 赵兴娟 杨帆 +3 位作者 于淑华 孙冰岩 赵丽 康翠霞 《临床误诊误治》 CAS 2024年第7期1-5,共5页
目的探讨老年人冠心病心力衰竭多系统表现和早期误诊原因。方法分析2021年1月—2023年6月老年冠心病心力衰竭误诊8例临床资料。结果8例中2例咳嗽、咳痰,胸闷气促,两肺底湿啰音,肺纹理增粗紊乱,心电图示ST-T段压低,有慢性支气管炎病史,... 目的探讨老年人冠心病心力衰竭多系统表现和早期误诊原因。方法分析2021年1月—2023年6月老年冠心病心力衰竭误诊8例临床资料。结果8例中2例咳嗽、咳痰,胸闷气促,两肺底湿啰音,肺纹理增粗紊乱,心电图示ST-T段压低,有慢性支气管炎病史,误诊“慢性支气管炎急性发作”;3例中2例恶心、呕吐,剑突下轻压痛,1例腹痛、腹泻、脐周轻度压痛,心电图示ST-T段压低3例、室性早搏2例,有慢性胃炎病史,误诊“急性胃肠炎”;1例腹胀、食欲不振、乏力,双下肢轻度水肿,丙氨酸转氨酶轻度升高,误诊为“慢性肝炎”;2例头晕、失眠、烦躁不安,心电图示窦性心动过速,有高血压、高脂血症史,误诊“脑动脉硬化症”。经详细询问病史、相关治疗史及认真查体,会诊后完善相关检查,确诊冠心病心力衰竭。误诊时间2~5 d。后予抗心力衰竭治疗,预后良好。随访半年,病情稳定。结论当老年患者以心外系统症状为首诊症状就诊时,应详细询问心脏病史,充分了解伴随症状,认真查体,避免遗漏相关阳性体征,及时行超声心动图、心电图等辅助检查,可有效避免误诊。 展开更多
关键词 冠心病 心力衰竭 老年人 误诊 慢性支气管炎急性发作 急性胃肠炎 慢性肝炎 脑动脉硬化症
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心肾综合征的诊治最新进展
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作者 翟秋月 刘文花 《中国当代医药》 CAS 2024年第14期186-192,共7页
心肾综合征(CRS)是指心脏和肾脏同时出现急性或慢性功能障碍,导致一系列连锁反应,并对心脏和肾脏造成互损,具有较高的发病率和死亡率。当前临床上CRS主要包括5种类型,不同的CRS致病机制不同,且表型之间存在很大差异。尽管近年来心力衰竭... 心肾综合征(CRS)是指心脏和肾脏同时出现急性或慢性功能障碍,导致一系列连锁反应,并对心脏和肾脏造成互损,具有较高的发病率和死亡率。当前临床上CRS主要包括5种类型,不同的CRS致病机制不同,且表型之间存在很大差异。尽管近年来心力衰竭(HF)和慢性肾脏病(CKD)的基础研究和综合管理手段取得了较大进展,但在CRS中具有里程碑意义的代表性随机对照研究不足,而且这些患者的治疗主要是从相应的HF或CKD试验中推断出来的,因此,目前仍无非常有效的针对CRS的治疗措施。随着医疗卫生技术和人口老龄化的进展,CRS越来越受到人们的重视,根据最新研究结果对CRS患者进行最佳评估管理愈显重要。本文复习总结当前国内外最新研究成果,就CRS的诊断、发病机制、临床治疗等最新进展进行综述。 展开更多
关键词 心肾综合征 心力衰竭 急性肾损伤 慢性肾脏病
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BiPAP无创机械通气对COPD合并急性左心衰竭患者心肺功能及血流动力学的影响
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作者 石开勤 杨学知 +3 位作者 江美芳 杨蕾 梁妮 杨霞 《中国急救复苏与灾害医学杂志》 2024年第10期1312-1315,共4页
目的探究双水平气道正压无创机械通气(BiPAP)对慢性阻塞性肺疾病(COPD)合并急性左心衰竭患者的影响。方法前瞻性选取于我院就诊的114例COPD合并急性左心衰竭患者为研究对象,并经抽签法随机分为观察组(常规药物联合BiPAP无创机械通气,57... 目的探究双水平气道正压无创机械通气(BiPAP)对慢性阻塞性肺疾病(COPD)合并急性左心衰竭患者的影响。方法前瞻性选取于我院就诊的114例COPD合并急性左心衰竭患者为研究对象,并经抽签法随机分为观察组(常规药物联合BiPAP无创机械通气,57例)及对照组(常规药物治疗,57例)。于治疗1个月后评估两组患者临床疗效,比较治疗前、治疗1个月后其心功能、肺通气[呼吸道总阻力(R_(5))、中心呼吸道阻力(R_(20))、周边呼吸道阻力(R_(5)-R_(20))]、血气水平、血流动力学[血流量(BF)、血流速度(BV)]的变化。结果治疗1个月后,观察组[CO(58.38±5.34)mL、SpO_(2)(95.69±0.41)%、PaO_(2)(66.27±3.41)mmHg、BF(44.65±7.11)mL/min、BV(24.47±4.41)cm/s]均显著高于对照组的[CO(54.87±4.59)mL、SpO_(2)(92.76±0.35)%、PaO_(2)(62.42±3.07)mmHg、BF(40.76±6.78)mL/min、BV(22.62±4.07)cm/s](P<0.05);观察组治疗1个月后[LVESD(39.53±2.06)mm、LVEDD(50.22±2.13)mm、R_(5)(0.77±0.14)[kpa/(L·s)]、R_(20)(0.48±0.09)[kpa/(L·s)]、R_(5)-R_(20)(0.28±0.06)[kpa/(L·s)]、PaCO_(2)(47.32±3.28)mmHg]显著低于对照组的[LVESD(43.48±2.23)mm、LVEDD(53.60±2.36)mm、R_(5)(0.92±0.18)[kpa/(L·s)]、R_(20)(0.52±0.11)[kpa/(L·s)]、R_(5)-R_(20)(0.34±0.09)[kpa/(L·s)]、PaCO_(2)(50.22±3.38)mmHg],差异有统计学意义(P<0.05)。观察组治疗1个月后,其临床疗效显著高于对照组(47.37%vs.28.08%,P<0.05)。结论采用BiPAP无创机械通气治疗对于COPD合并急性左心衰竭患者的临床应用效果较好,可明显提高患者心、肺通气功能,缓解其缺氧状态。 展开更多
关键词 无创呼吸机 螺内酯 慢性阻塞性肺疾病 急性左心衰竭 心功能 肺通气 血流动力学
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左西孟旦联合新活素对慢性心力衰竭急性失代偿期患者的疗效
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作者 宋丽娟 赵双凤 赵德全 《西北药学杂志》 CAS 2024年第3期119-122,共4页
目的探究左西孟旦联合新活素对慢性心力衰竭急性失代偿期(acute decompensated heart failure,ADHF)患者心功能、血清脑钠肽(brain natriuretic peptide,BNP)和肌钙蛋白Ⅰ(troponinⅠ,cTnⅠ)的影响。方法选取就诊的ADHF患者100例作为研... 目的探究左西孟旦联合新活素对慢性心力衰竭急性失代偿期(acute decompensated heart failure,ADHF)患者心功能、血清脑钠肽(brain natriuretic peptide,BNP)和肌钙蛋白Ⅰ(troponinⅠ,cTnⅠ)的影响。方法选取就诊的ADHF患者100例作为研究对象,随机分为观察组和对照组,每组50例。对照组给予左西孟旦治疗,观察组给予左西孟旦联合新活素治疗,比较2组治疗后的临床疗效、纠正心力衰竭时间、住院时间和不良反应,比较2组治疗前后左心室射血分数(left ventricular ejection fraction,LVEF)、左室舒张末期内径(left ventricular end diastopc diameter,LVEDD)、左心室收缩末期内径(left ventricular end systolic diameter,LVESD)、24 h尿量、BNP、cTnⅠ和超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)。结果观察组的总有效率(96.00%)高于对照组(78.00%),P<0.05;观察组的心力衰竭纠正时间和住院时间均短于对照组(P<0.05);观察组LVEF水平高于对照组,LVEDD和LVESD水平低于对照组(P<0.05);观察组BNP、cTnⅠ和hs-CRP水平均低于对照组(P<0.05);观察组的不良反应发生率(6.00%)与对照组的不良反应发生率(8.00%)比较,差异无统计学意义(P>0.05)。结论左西孟旦联合新活素可提高ADHF患者的心功能,降低血清BNP、cTnⅠ的水平。 展开更多
关键词 左西孟旦 新活素 慢性心力衰竭 急性失代偿期 心功能
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基于补肾活血法探讨中药自拟方在急性心肌梗死后慢性心力衰竭治疗中对心功能改善的效果
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作者 李洁 董显峰 +2 位作者 解晓青 朱栋栋 李焱 《西部医学》 2024年第8期1196-1201,共6页
目的分析补肾活血自拟方在急性心肌梗死(AMI)后慢性心力衰竭(CHF)治疗中对心功能的改善效果。方法选定青岛市中医医院2022年2月—2023年2月就诊的90例AMI后CHF患者进行回顾性研究,根据治疗方案的不同将其分为对照组和观察组,每组45例。... 目的分析补肾活血自拟方在急性心肌梗死(AMI)后慢性心力衰竭(CHF)治疗中对心功能的改善效果。方法选定青岛市中医医院2022年2月—2023年2月就诊的90例AMI后CHF患者进行回顾性研究,根据治疗方案的不同将其分为对照组和观察组,每组45例。对照组给予常规西药治疗,观察组在对照组基础上给予补肾活血自拟方治疗。比较两组临床疗效、中医证候积分、Lee氏心衰积分、6 min步行距离(6WMD)、心功能超声指标[每搏输出量(SV)、心输出量(CO)、左室射血分数(LVEF)]、心功能生化指标[心肌肌钙蛋白I(cTnI)、可溶性人基质裂解素2(sST2)、N末端B型利钠肽原(NT-proBNP)]、不良反应总发生率。结果观察组临床总有效率高于对照组(P<0.05)。观察组治疗后胸闷胸痛、心悸气短、腰膝酸软、面浮肢肿积分均低于对照组(P<0.05)。观察组治疗后Lee氏心衰积分低于对照组(P<0.05),观察组治疗后6WMD高于对照组(P<0.05)。观察组治疗后SV、CO、LVEF均高于对照组(P<0.05)。观察组治疗后血清cTnI、sST2、NT-proBNP水平均低于对照组(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论补肾活血自拟方可有效缓解AMI后CHF患者胸闷、呼吸困难等症状,提高运动耐力及临床疗效,改善心功能,且治疗期间患者未出现严重不良反应,安全有效。 展开更多
关键词 补肾活血方 急性心肌梗死 慢性心力衰竭 临床疗效 心功能
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个体化预测老年慢性肾衰竭患者并发急性左心衰风险的列线图模型构建
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作者 沈玉娟 《中国医院统计》 2024年第1期19-24,共6页
目的构建个体化预测老年慢性肾衰竭患者并发急性左心衰风险的列线图模型。方法选取2019年1月至12月某医院收治的294例老年慢性肾衰竭患者作为研究对象,根据有无发生急性左心衰分为左心衰组(n=61)和对照组(n=233),收集患者临床资料,采用... 目的构建个体化预测老年慢性肾衰竭患者并发急性左心衰风险的列线图模型。方法选取2019年1月至12月某医院收治的294例老年慢性肾衰竭患者作为研究对象,根据有无发生急性左心衰分为左心衰组(n=61)和对照组(n=233),收集患者临床资料,采用单因素和多因素logistic回归分析老年慢性肾衰竭患者并发急性左心衰的危险因素,并建立列线图模型。结果年龄≥70岁、糖尿病、血压控制不佳、血磷浓度≥1.61 mmol/L、血红蛋白<60 g/L和肺部感染是老年慢性肾衰竭患者并发急性左心衰的危险因素(P<0.05)。模型验证结果显示C-index为0.745,校准曲线趋近于理想曲线,ROC曲线的AUC为0.751(95%CI:0.711~0.791),决策曲线显示阈值概率为10%~84%时列线图预测风险净获益。结论年龄≥70岁、糖尿病、血压控制不佳、血磷浓度≥1.61 mmol/L、血红蛋白<60 g/L和肺部感染会增加老年慢性肾衰竭患者并发急性左心衰的风险,本研究建立的列线图模型对老年慢性肾衰竭患者并发急性左心衰具有良好的预测效能。 展开更多
关键词 老年慢性肾衰竭 急性左心衰 危险因素 列线图
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加味来复汤对慢性心力衰竭急性加重期血清H-FABP、cTnI及NT-proBNP表达的影响
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作者 李想 李妍 岳宝霞 《中国中医急症》 2024年第6期1034-1038,共5页
目的观察加味来复汤联合常规疗法治疗慢性心力衰竭(CHF)急性加重期的临床疗效。方法将100例患者随机分为两组各50例。对照组采用西医综合治疗措施,观察组在对照组的基础上采用加味来复汤辨证内服,每天1剂,连续治疗4周。比较治疗前后超... 目的观察加味来复汤联合常规疗法治疗慢性心力衰竭(CHF)急性加重期的临床疗效。方法将100例患者随机分为两组各50例。对照组采用西医综合治疗措施,观察组在对照组的基础上采用加味来复汤辨证内服,每天1剂,连续治疗4周。比较治疗前后超声心动图参数;检测治疗前后心肌损伤生物标志物水平;进行治疗前后6分钟步行距离(6MWT)、阳虚血瘀证积分、NYHA心功能分级和静息心率评估;进行治疗前后Memorial心力衰竭症状评估量表(MSAS-HF)和明尼苏达心衰生活质量量表(MLHFQ)评估;比较治疗后疾病总有效率。结果治疗后,两组患者超声心动图参数[左室射血分数(LVEF)、每搏心搏量(SV)、每分钟心排血量(CO)和心脏指数(CI)]均升高(P<0.05),且观察组高于对照组(P<0.05);治疗后,两组患者N末端B型利钠肽原(NT-proBNP),采用酶联免疫吸附剂测定心脏肌钙蛋白I(c TnI)、心型脂肪酸结合蛋白(H-FABP)和半乳糖凝集素-3(GAL-3)水平下降(P<0.05),且观察组低于对照组(P<0.05)。治疗后,两组患者MSAS-HF量表各个维度评分和总分降低(P<0.05),两组患者MLHFQ量表各个维度评分和总分降低(P<0.05),两组患者阳虚血瘀证各主要症状和总积分降低,且观察组以上各指标均低于对照组(P<0.05)。治疗后两组6MWT增加(P<0.05),静息心率减少(P<0.05),且均以观察组为显著(P<0.05)。观察组总有效率明显高于对照组(P<0.05)。结论加味来复汤联合常规疗法治疗CHF急性加重期患者,可保护心肌损伤,减轻心衰相关临床症状、体征及中医证候,改善心功能,提高患者的生活质量和运动耐力,临床疗效优于西医常规治疗效果。 展开更多
关键词 慢性心力衰竭 急性加重期 加味来复汤 阳虚血瘀证 生活质量 心肌损伤生物标志物
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老年COPD急性加重期并发急性左心衰竭的风险预测列线图模型构建及预防建议
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作者 陈勇 季曼曼 《全科护理》 2024年第3期416-420,共5页
目的:构建老年慢性阻塞性肺疾病(COPD)急性加重期并发急性左心衰竭的风险预测列线图模型,提出预防建议。方法:回顾性分析2020年6月—2022年7月医院收治的259例老年COPD急性加重期病人的临床资料,根据病人有无并发急性左心衰竭将其分为... 目的:构建老年慢性阻塞性肺疾病(COPD)急性加重期并发急性左心衰竭的风险预测列线图模型,提出预防建议。方法:回顾性分析2020年6月—2022年7月医院收治的259例老年COPD急性加重期病人的临床资料,根据病人有无并发急性左心衰竭将其分为并发组和未并发组,采用多因素Logistic回归分析法分析老年COPD急性加重期并发急性左心衰竭的危险因素,并构建风险预测列线图模型。结果:合并高血压、合并糖尿病、二氧化碳分压增高、右心室舒张末期内径均是老年COPD急性加重期病人并发急性左心衰竭的危险因素(P<0.05),白蛋白、氧分压、左心室内径缩短率是其保护因素(P<0.05);基于以上7项影响因素构建风险预测列线图模型,受试者工作特征曲线显示该模型预测的曲线下面积为0.849[95%CI(0.781,0.916)],校准曲线与理想曲线贴合良好,Hosmer-Lemeshow检验(P=0.440)。结论:整合老年COPD急性加重期并发急性左心衰竭的影响因素构建风险预测列线图模型具有良好的区分度和准确度,对临床评估、干预具有一定的指导价值。 展开更多
关键词 慢性阻塞性肺疾病 急性左心衰竭 老年 列线图
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探讨重组人脑利钠肽治疗慢性心衰急性加重期患者的临床效果
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作者 周纪星 《中外医疗》 2024年第1期102-105,共4页
目的分析慢性心衰急性加重期患者采用重组人脑利钠肽治疗的临床效果。方法随机选取2020年6月—2021年6月临沂市中心医院心内科收治的60例慢性心衰急性加重期患者为研究对象。按照区组随机法分为对照组和研究组,各30例,对照组患者开展常... 目的分析慢性心衰急性加重期患者采用重组人脑利钠肽治疗的临床效果。方法随机选取2020年6月—2021年6月临沂市中心医院心内科收治的60例慢性心衰急性加重期患者为研究对象。按照区组随机法分为对照组和研究组,各30例,对照组患者开展常规治疗,研究组患者开展常规治疗+重组人脑利钠肽治疗,分析重组人脑利钠肽的治疗价值。结果治疗后,研究组患者红细胞沉降率、红细胞压积、血浆动力黏度、全血动力黏度、血液血浆动力黏度、QT间期离散度水平、冠状动脉左前降支内径、左室舒张末期内径、左室收缩末期内径水平更低,左室射血分数水平更高,差异有统计学意义(P均<0.05);治疗后,研究组患者血肌酐(77.31±6.43)μmol/L、脑钠肽前体(1328.43±150.96)pg/mL水平更低,表皮生长因子受体(55.31±5.29)mL/(min·1.73 m^(2))水平更高,差异有统计学意义(t=6.243、5.228、6.351,P均<0.05)。结论重组人脑利钠肽治疗在改善患者的心衰相关指标、心功能和血流流变学指标方面表现更为优越,患者治疗后临床效果更好。 展开更多
关键词 慢性心衰急性加重期 重组人脑利钠肽 心功能
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血清BNP、CRP、PCT水平对慢阻肺急性加重期患者并发心力衰竭的预测价值
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作者 刘媛 王澎 聂静 《航空航天医学杂志》 2024年第3期270-273,共4页
目的探讨血清B型钠尿肽(BNP)、C反应蛋白(CRP)、降钙素原(PCT)水平对慢阻肺急性加重期(AECOPD)患者并发心力衰竭的预测价值。方法回顾性收集2021年06月-2023年06月收治的48例住院治疗期间并发心力衰竭的AECOPD患者病历资料为发生组,另... 目的探讨血清B型钠尿肽(BNP)、C反应蛋白(CRP)、降钙素原(PCT)水平对慢阻肺急性加重期(AECOPD)患者并发心力衰竭的预测价值。方法回顾性收集2021年06月-2023年06月收治的48例住院治疗期间并发心力衰竭的AECOPD患者病历资料为发生组,另收集医院同期收治的住院治疗期间未并发心力衰竭的48例AECOPD患者病历资料为未发生组。对比两组患者基线资料及血清BNP、CRP、PCT等实验室指标,通过受试者工作曲线(ROC)检验血清BNP、CRP、PCT预测AECOPD患者并发心力衰竭的价值。结果发生组年龄、血清BNP、CRP、PCT水平均显著高于未发生组,差异有统计学意义(P<0.05)。经点二列相关性分析显示,血清BNP、CRP、PCT与AECOPD患者并发心力衰竭间呈正相关(r>0,P<0.05)。绘制ROC曲线,结果显示,血清BNP、CRP、PCT水平单独及联合预测AECOPD患者并发心力衰竭的曲线下面积(AUC)值分别为为0.802、0.740、0.764、0.898,联合预测价值最高。结论血清BNP、CRP、PCT能较好预测AECOPD患者并发心力衰竭,三者值越高,AECOPD患者并发心力衰竭的可能性越大。 展开更多
关键词 慢阻肺急性加重期 心力衰竭 B型钠尿肽 C反应蛋白 降钙素原
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