Objective: To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D 2 dimer (D-dimer) before...Objective: To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D 2 dimer (D-dimer) before and after treatment. Methods: Eighty-eight patients with blood stasis syndrome (BSS) of acute cerebral infarction (ACI) were randomly divided into two groups, both of which were treated with conventional treatment, i.e. with western medicine (WM), with Salvia injection added through intravenously dripping.One of the two groups was used as the control and the other group as the treated group who had ABCBS herbs orally taken in addition. The duration of treatment course for both groups was 3 weeks. Results: There were changes in both groups over clinical symptoms, nerve function deficit scoring and GMP-140, D-dimer, but the treated group showed significantly better than that of the control group, ( P <0.05). Conclusion: ABCBS principle could serve as an important auxiliary treating method for BSS of ACI, as it can effectively alter the blood of ACI patients which was viscous, condense, coagulant and aggregating.展开更多
Objective:To study the correlation of serum Lp-PLA2 and NSE levels with nerve injury degree and lipid metabolism change in patients with acute cerebral infarction.Methods: Patients diagnosed with acute cerebral infarc...Objective:To study the correlation of serum Lp-PLA2 and NSE levels with nerve injury degree and lipid metabolism change in patients with acute cerebral infarction.Methods: Patients diagnosed with acute cerebral infarction in our hospital between March 2014 and October 2016 were selected as the cerebral infarction group of the study, and healthy subjects receiving physical examination during the same period were selected as control group. Serum was collected to determine the levels of Lp-PLA2 and NSE as well as the content of nerve injury molecules and lipid metabolism molecules.Results:Serum Lp-PLA2, NSE, NO, MDA, LPO, 8-OHdG, ox-LDL, LDL-C and ApoB levels of cerebral infarction group were significantly higher than those of control group while HDL-C and ApoA1 content were significantly lower than those of control group;serum NO, MDA, LPO and 8-OHdG content of patients with NSE>Q3 were significantly higher than those of patients with<Q1, Q1-Q2 and Q2-Q3, serum NO, MDA, LPO and 8-OHdG content of patients with Q2-Q3 were significantly higher than those of patients with<Q1 and Q1-Q2, and serum NO, MDA, LPO and 8-OHdG content of patients with Q1-Q2 were significantly higher than those of patients with<Q1;serum ox-LDL, LDL-C and ApoB content of patients with Lp-PLA2>Q3 were significantly higher than those of patients with<Q1, Q1-Q2 and Q2-Q3 while HDL-C and ApoA1 content were significantly lower than those of patients with<Q1, Q1-Q2 and Q2-Q3;serum ox-LDL, LDL-C and ApoB content of patients with Q2-Q3 were significantly higher than those of patients with <Q1 and Q1-Q2 while HDL-C and ApoA1 content were significantly lower than those of patients with<Q1 and Q1-Q2;serum ox-LDL, LDL-C and ApoB content of patients with Q1-Q2 were significantly higher than those of patients with<Q1 while HDL-C and ApoA1 content were significantly lower than those of patients with<Q1.Conclusion: Serum Lp-PLA2 and NSE levels increase significantly in patients with acute cerebral infarction, the increase of Lp-PLA2 is associated with abnormal lipid metabolism, and the increase of NSE is associated with neural oxidative damage.展开更多
Objective:To study the effect of salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection on serum BNP, Hcy, MMP-2, S100B protein and hemorheology in patients with acute...Objective:To study the effect of salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection on serum BNP, Hcy, MMP-2, S100B protein and hemorheology in patients with acute cerebral watershed infarction.Methods:A total of 90 patientswith acute cerebral watershed infarction in our hospital from August 2014 to December 2016 were enrolled in this study. The subjects were divided into the control group (n=45) and the treatment group (n=45) randomly. The control group was treated with hydroxyethyl starch injection, the treatment group was treated withsalvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection, and both the two groups were treated for 2 weeks. The serum BNP, Hcy, MMP-2, S100B protein and hemorheology of the two groups before and after treatments were compared.Results:There were no significantly differences of the serum BNP, Hcy, MMP-2, S100B protein and hemorheology of the two groups before treatment. The serum BNP, Hcy, MMP-2, S100B proteinlevels of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group. The PV, Lr, Mr, Hr and RE of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group.Conclusion:Salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injectioncan significantlyimprovetheneurological function and hemorheology, reduce inflammation of the patients with acute cerebral watershed infarction, and it was worthy clinical application.展开更多
文摘Objective: To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D 2 dimer (D-dimer) before and after treatment. Methods: Eighty-eight patients with blood stasis syndrome (BSS) of acute cerebral infarction (ACI) were randomly divided into two groups, both of which were treated with conventional treatment, i.e. with western medicine (WM), with Salvia injection added through intravenously dripping.One of the two groups was used as the control and the other group as the treated group who had ABCBS herbs orally taken in addition. The duration of treatment course for both groups was 3 weeks. Results: There were changes in both groups over clinical symptoms, nerve function deficit scoring and GMP-140, D-dimer, but the treated group showed significantly better than that of the control group, ( P <0.05). Conclusion: ABCBS principle could serve as an important auxiliary treating method for BSS of ACI, as it can effectively alter the blood of ACI patients which was viscous, condense, coagulant and aggregating.
文摘Objective:To study the correlation of serum Lp-PLA2 and NSE levels with nerve injury degree and lipid metabolism change in patients with acute cerebral infarction.Methods: Patients diagnosed with acute cerebral infarction in our hospital between March 2014 and October 2016 were selected as the cerebral infarction group of the study, and healthy subjects receiving physical examination during the same period were selected as control group. Serum was collected to determine the levels of Lp-PLA2 and NSE as well as the content of nerve injury molecules and lipid metabolism molecules.Results:Serum Lp-PLA2, NSE, NO, MDA, LPO, 8-OHdG, ox-LDL, LDL-C and ApoB levels of cerebral infarction group were significantly higher than those of control group while HDL-C and ApoA1 content were significantly lower than those of control group;serum NO, MDA, LPO and 8-OHdG content of patients with NSE>Q3 were significantly higher than those of patients with<Q1, Q1-Q2 and Q2-Q3, serum NO, MDA, LPO and 8-OHdG content of patients with Q2-Q3 were significantly higher than those of patients with<Q1 and Q1-Q2, and serum NO, MDA, LPO and 8-OHdG content of patients with Q1-Q2 were significantly higher than those of patients with<Q1;serum ox-LDL, LDL-C and ApoB content of patients with Lp-PLA2>Q3 were significantly higher than those of patients with<Q1, Q1-Q2 and Q2-Q3 while HDL-C and ApoA1 content were significantly lower than those of patients with<Q1, Q1-Q2 and Q2-Q3;serum ox-LDL, LDL-C and ApoB content of patients with Q2-Q3 were significantly higher than those of patients with <Q1 and Q1-Q2 while HDL-C and ApoA1 content were significantly lower than those of patients with<Q1 and Q1-Q2;serum ox-LDL, LDL-C and ApoB content of patients with Q1-Q2 were significantly higher than those of patients with<Q1 while HDL-C and ApoA1 content were significantly lower than those of patients with<Q1.Conclusion: Serum Lp-PLA2 and NSE levels increase significantly in patients with acute cerebral infarction, the increase of Lp-PLA2 is associated with abnormal lipid metabolism, and the increase of NSE is associated with neural oxidative damage.
基金Hubei Natural Science Foundation Project Plan 2015(2015-cEV129).
文摘Objective:To study the effect of salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection on serum BNP, Hcy, MMP-2, S100B protein and hemorheology in patients with acute cerebral watershed infarction.Methods:A total of 90 patientswith acute cerebral watershed infarction in our hospital from August 2014 to December 2016 were enrolled in this study. The subjects were divided into the control group (n=45) and the treatment group (n=45) randomly. The control group was treated with hydroxyethyl starch injection, the treatment group was treated withsalvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection, and both the two groups were treated for 2 weeks. The serum BNP, Hcy, MMP-2, S100B protein and hemorheology of the two groups before and after treatments were compared.Results:There were no significantly differences of the serum BNP, Hcy, MMP-2, S100B protein and hemorheology of the two groups before treatment. The serum BNP, Hcy, MMP-2, S100B proteinlevels of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group. The PV, Lr, Mr, Hr and RE of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group.Conclusion:Salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injectioncan significantlyimprovetheneurological function and hemorheology, reduce inflammation of the patients with acute cerebral watershed infarction, and it was worthy clinical application.
