BACKGROUND The study focuses on the use of multi-parametric ultrasound[gray scale,color Doppler and shear wave elastography(SWE)]to differentiate stable renal allografts from acute graft dysfunction and to assess time...BACKGROUND The study focuses on the use of multi-parametric ultrasound[gray scale,color Doppler and shear wave elastography(SWE)]to differentiate stable renal allografts from acute graft dysfunction and to assess time-dependent changes in parenchymal stiffness,thereby assessing its use as an efficient monitoring tool for ongoing graft dysfunction.To date,biopsy is the gold standard for evaluation of acute graft dysfunction.However,because it is invasive,it carries certain risks and cannot be used for follow-up monitoring.SWE is a non-invasive imaging modality that identifies higher parenchymal stiffness values in cases of acute graft dysfunction compared to stable grafts.AIM To assess renal allograft parenchymal stiffness by SWE and to correlate its findings with functional status of the graft kidney.METHODS This prospective observational study included 71 renal allograft recipients.Multi-parametric ultrasound was performed on all patients,and biopsies were performed in cases of acute graft dysfunction.The study was performed for a period of 2 years at Sanjay Gandhi Postgraduate Institute of Medical Sciences,Lucknow,a tertiary care center in north India.Independent samples t-test was used to compare the means between two independent groups.Paired-samples t-test was used to test the change in mean value between baseline and follow-up obser-vations.RESULTS Thirty-one patients had experienced acute graft dysfunction at least once,followed by recovery,but none of them had a history of chronic renal allograft injury.Mean baseline parenchymal stiffness in stable grafts and acute graft dysfunction were 30.21+2.03 kPa(3.17+0.11 m/s)and 31.07+2.88 kPa(3.22+0.15 m/s),respectively;however,these differences were not statistically significant(P=0.305 and 0.252,respectively).There was a gradual decrease in SWE values during the first 3 postoperative months,followed by an increase in SWE values up to one-year post-transplantation.Patients with biopsy-confirmed graft dysfunction showed higher SWE values compared to those with a negative biopsy.However,receiver operating characteristic analysis failed to show statistically significant cut-off values to differentiate between the stable graft and acute graft dysfunction.CONCLUSION Acute graft dysfunction displays higher parenchymal stiffness values compared to stable grafts.Therefore,SWE may be useful in monitoring the functional status of allografts to predict any ongoing dysfunction.展开更多
文摘BACKGROUND The study focuses on the use of multi-parametric ultrasound[gray scale,color Doppler and shear wave elastography(SWE)]to differentiate stable renal allografts from acute graft dysfunction and to assess time-dependent changes in parenchymal stiffness,thereby assessing its use as an efficient monitoring tool for ongoing graft dysfunction.To date,biopsy is the gold standard for evaluation of acute graft dysfunction.However,because it is invasive,it carries certain risks and cannot be used for follow-up monitoring.SWE is a non-invasive imaging modality that identifies higher parenchymal stiffness values in cases of acute graft dysfunction compared to stable grafts.AIM To assess renal allograft parenchymal stiffness by SWE and to correlate its findings with functional status of the graft kidney.METHODS This prospective observational study included 71 renal allograft recipients.Multi-parametric ultrasound was performed on all patients,and biopsies were performed in cases of acute graft dysfunction.The study was performed for a period of 2 years at Sanjay Gandhi Postgraduate Institute of Medical Sciences,Lucknow,a tertiary care center in north India.Independent samples t-test was used to compare the means between two independent groups.Paired-samples t-test was used to test the change in mean value between baseline and follow-up obser-vations.RESULTS Thirty-one patients had experienced acute graft dysfunction at least once,followed by recovery,but none of them had a history of chronic renal allograft injury.Mean baseline parenchymal stiffness in stable grafts and acute graft dysfunction were 30.21+2.03 kPa(3.17+0.11 m/s)and 31.07+2.88 kPa(3.22+0.15 m/s),respectively;however,these differences were not statistically significant(P=0.305 and 0.252,respectively).There was a gradual decrease in SWE values during the first 3 postoperative months,followed by an increase in SWE values up to one-year post-transplantation.Patients with biopsy-confirmed graft dysfunction showed higher SWE values compared to those with a negative biopsy.However,receiver operating characteristic analysis failed to show statistically significant cut-off values to differentiate between the stable graft and acute graft dysfunction.CONCLUSION Acute graft dysfunction displays higher parenchymal stiffness values compared to stable grafts.Therefore,SWE may be useful in monitoring the functional status of allografts to predict any ongoing dysfunction.
