To determine the effect of humoral factors and their interaction on the developement of acute hypoxic pulmonary pressor response (HPPR), we performed studies in 16 mongrel dogs. We measured plasma levels of noradreali...To determine the effect of humoral factors and their interaction on the developement of acute hypoxic pulmonary pressor response (HPPR), we performed studies in 16 mongrel dogs. We measured plasma levels of noradrealin (NE), angiotensin Ⅱ (AII), prostaglandin F2α (PGF2α), 6-keto-prostaglandin F1α (6KPGF1α), thromboxane B2 (TXB2), leukotriene B4 (LTB4) and 5-hydroxytryptamine (5-HT) before, during and after HPPR. Multiple regression analysis showed that the changes of pulmonary arterial systolic pressure (PASP) and pulmonary arterial diastolic pressure (PADP) correlated well with those of plasma concentration of NE, PGF2α and 6KPGF1α, respectively (r were equal to 0.633 and 0.668, respectively, P<0.01). The results of orthogonal experiment analysis with an injection of exogenous NE, PGF2α and PGIα into main pulmonary artery of dogs showed that NE and the interaction of PGF2α and PGI2α increased PASP (P<0.05) and PGI2 attenuated PASP (P<0.01). The interaction of PGF2α and PGI2 and of PGF2α and NE increased PADP(P<0.01) and PGI2 attenuated PADP (P<0.01).展开更多
The effect of inhalation of nitric oxide（NO）gas on acute hypoxic pulmonary hypertension was studied.Eighteen mongrel dogs were divided into two groups; hypoxic control group（FIO=11％， n=10）and NO inhalation gloup...The effect of inhalation of nitric oxide（NO）gas on acute hypoxic pulmonary hypertension was studied.Eighteen mongrel dogs were divided into two groups; hypoxic control group（FIO=11％， n=10）and NO inhalation gloup（FIO=11％，NO inspiratory concentration=44ppm，n=8）.展开更多
文摘To determine the effect of humoral factors and their interaction on the developement of acute hypoxic pulmonary pressor response (HPPR), we performed studies in 16 mongrel dogs. We measured plasma levels of noradrealin (NE), angiotensin Ⅱ (AII), prostaglandin F2α (PGF2α), 6-keto-prostaglandin F1α (6KPGF1α), thromboxane B2 (TXB2), leukotriene B4 (LTB4) and 5-hydroxytryptamine (5-HT) before, during and after HPPR. Multiple regression analysis showed that the changes of pulmonary arterial systolic pressure (PASP) and pulmonary arterial diastolic pressure (PADP) correlated well with those of plasma concentration of NE, PGF2α and 6KPGF1α, respectively (r were equal to 0.633 and 0.668, respectively, P<0.01). The results of orthogonal experiment analysis with an injection of exogenous NE, PGF2α and PGIα into main pulmonary artery of dogs showed that NE and the interaction of PGF2α and PGI2α increased PASP (P<0.05) and PGI2 attenuated PASP (P<0.01). The interaction of PGF2α and PGI2 and of PGF2α and NE increased PADP(P<0.01) and PGI2 attenuated PADP (P<0.01).
文摘The effect of inhalation of nitric oxide（NO）gas on acute hypoxic pulmonary hypertension was studied.Eighteen mongrel dogs were divided into two groups; hypoxic control group（FIO=11％， n=10）and NO inhalation gloup（FIO=11％，NO inspiratory concentration=44ppm，n=8）.
