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Pathological Changes of Acute Immune Hepatitis in Mini Pigs
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作者 殷国庆 林厚基 +1 位作者 李解权 杜开和 《The Journal of Biomedical Research》 CAS 1996年第1期48-53,共6页
Thepurposeofthisstudywastoestablishanexperimentalmodelofa-cuteimmunehepatitiswithpathologicalfeaturessimilartothoseseninhumanacutevi-ralhepatitisfortheuseofexploringitspathogenesisandevaluatingitstherapy.Thehepatocyte... Thepurposeofthisstudywastoestablishanexperimentalmodelofa-cuteimmunehepatitiswithpathologicalfeaturessimilartothoseseninhumanacutevi-ralhepatitisfortheuseofexploringitspathogenesisandevaluatingitstherapy.Thehepatocytewaspreparedfromaminipigandusedasantigenandantiserumwasob-tainedfromthegoatbyinjectionofthepreparedantigen.Theacuteimmunehepatitismodelwasestablishedbyinjectingantiserum(2.5ml/kg)intominipigsviathemesen-tericvein.Specimensoftheminipigliversweretakenatdifferentintervalsafteranti-seruminjectionandpathologicfeatureswereobservedbygros,lightandelectronmi-croscopicexaminations.Thecontrolgroupandcarbontetrachloridegroupwerealsoin-cluded.Theresultsshowed:①incontrolgroupthemorphologywasnormal;②incarbontetrachloridegroup,lesionsweremainlylocatedinthecenteroflobule;③thepatholog-icalfeaturesofthisacuteimmunehepatitiscoincidedwiththoseofhumanacuteviralhepatitis.Itissuggestedthatthisexperimentalmodelwouldbeadoptedforotherrele-vantstudies. 展开更多
关键词 acuteimmunehepatitis pathologicalchanges experimentalmodel minipigs
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