A novel series of cb-nitenpyram analogues （2a--2p） were designed and prepared by introducing the 1,4-dihydropyridine, with their eis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that mo...A novel series of cb-nitenpyram analogues （2a--2p） were designed and prepared by introducing the 1,4-dihydropyridine, with their eis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most compounds exhibited good insecticidal activities at 20 mg/L against Aphis medicagini, and analogues 2a and 2d aflbrded the best activity, and both of them had 100% mortality at 4 mg/L. In addition, molecular docking studies were also performed to model the ligand-receptor complexes, and the results explained the structure-activity relationships observed in vitro, which may provide some useful information for future design of new insecticides.展开更多
基金Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc.201200165.Acknowledgement This work was supported by the National Natural Science Foundation of China （21042010, 21102092 and 30870560）, the Key Scientific ＂Twelfth Five-Year＂ National Technology Support Program （2011BAE06B0117）, the Innovation Project of Shanghai Education Commission （12YZ078）, the Leading Academic Discipline Project of Shanghai Normal University （DZL808）, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University （07dz22303）. We are also grateful for the support from Branch of National Pesticide R＆D South Center.
文摘A novel series of cb-nitenpyram analogues （2a--2p） were designed and prepared by introducing the 1,4-dihydropyridine, with their eis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most compounds exhibited good insecticidal activities at 20 mg/L against Aphis medicagini, and analogues 2a and 2d aflbrded the best activity, and both of them had 100% mortality at 4 mg/L. In addition, molecular docking studies were also performed to model the ligand-receptor complexes, and the results explained the structure-activity relationships observed in vitro, which may provide some useful information for future design of new insecticides.
