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Solid Phase Synthesis of 3,4,5-Trisubstituted-1,2,4-Triazoles Derivatives from the Resin-Bound Acylhydrazines
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作者 Rongjian Xie Xingang Liu +1 位作者 Chao Mai Zhanxiang Liu 《International Journal of Organic Chemistry》 2013年第1期35-40,共6页
An extension of our methodology on solid-phase synthesis of 3,4,5-trisubstituted-1,2,4-triazoles under mild conditions has been developed. Firstly, the resin-bound acylhydrazine is reacted with orthoesters to provide ... An extension of our methodology on solid-phase synthesis of 3,4,5-trisubstituted-1,2,4-triazoles under mild conditions has been developed. Firstly, the resin-bound acylhydrazine is reacted with orthoesters to provide resin-bound 1,3,4-oxadiazoles. Secondly, condensation of 1,3,4-oxadiazoles resin with the corresponding arylamines hydrochloride to form the the resin-bound triazoles. 3,4,5-Trisubstituted-1,2,4-triazoles derivatives were obtained from resin-bound acylhydrazines in several steps providing 78% - 87% overall yields and excellent purity. The advantages of this method include straightforward operation and high yield and purity of the products. 展开更多
关键词 Resin-Bound acylhydrazine Solid-Phase Synthesis 1 2 4-Triazoles
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One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water
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作者 闫旭 葛泽梅 +1 位作者 程铁明 李润涛 《Journal of Chinese Pharmaceutical Sciences》 CAS 2008年第4期277-280,共4页
An efficient and environmental-friendly one-pot procedure has been developed for the synthesis of 1,3,4-oxadiazole-5- thioethers by the reaction of acylhydrazine with carbon disulfide and organic halides or α, β-uns... An efficient and environmental-friendly one-pot procedure has been developed for the synthesis of 1,3,4-oxadiazole-5- thioethers by the reaction of acylhydrazine with carbon disulfide and organic halides or α, β-unsaturated carbonyl compounds. The reactions were carried out in water in the presence of potassium phosphate within 2-4 h to afford the expected products in excellent yields. 展开更多
关键词 1 3 4-Oxadiazole-5-thioether One-pot synthesis Environmental-friendly Aqueous medium acylhydrazine Potassium phosphate
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An Efficient Method for the Synthesis of Acyl-diazenes Using NaNO_2/NaHSO_4·H_2O 被引量:7
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作者 Jian Ping LI Ping LIU Yu Lu WANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第7期677-680,共4页
An efficient and convenient method for the synthesis of acyl-diazenes is reported. Ten acyl-diazenes have been synthesized from acylhydrazines in excellent yields under mild conditions. There are eight new substances... An efficient and convenient method for the synthesis of acyl-diazenes is reported. Ten acyl-diazenes have been synthesized from acylhydrazines in excellent yields under mild conditions. There are eight new substances among these compounds. 展开更多
关键词 Acyl-diazenes acylhydrazines NaNO2/NaHSO4H2O.
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Synthesis and Bioactivities Evaluation of Novel Anthranilic Diamides Containing N-(tert-Butyl)benzohydrazide Moiety as Potent Ryanodine Receptor Activator 被引量:1
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作者 Yunyun Zhou Wei Wei +1 位作者 Liangliang Zhu Yuxin Li 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2019年第6期605-610,共6页
Anthranilic diamides have been proven to be a class of efficacious and safe insecticides targeting ryanodine receptors (RyRs) during the last decade. In order to develop innovative scaffolds with high insecticidal act... Anthranilic diamides have been proven to be a class of efficacious and safe insecticides targeting ryanodine receptors (RyRs) during the last decade. In order to develop innovative scaffolds with high insecticidal activity, two series of N-pyridylpyrazole derivatives containing N-(tert-butyl)benzohydrazide substructures were designed and synthesized. Their insecticidal activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) were evaluated. Preliminary bioassay results revealed that some of the new compounds exhibited good insecticidal activity against the oriental armyworm and diamondback moth. The mode of action of these compounds were verified using calcium-imaging technique and the results showed that some new compounds could effectively modulate the insect cytosolic Ca^2+ level, and break the cellular calcium homeostasis, indicating some of these compounds were potent activators of the RyRs. 展开更多
关键词 anthranilic diamides acylhydrazine HETEROCYCLES calcium channel STRUCTURE-ACTIVITY relationships INSECTICIDAL activities
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