制备橙皮素胶束溶液,并以Zeta电位和经皮渗透速率为指标,考察透明质酸对胶束溶液稳定性和经皮渗透活性的影响。结果表明,透明质酸可显著提高橙皮素胶束溶液的稳定性和经皮渗透活性,当其质量分数为0.5%时,胶束溶液透明稳定、无不良气味,...制备橙皮素胶束溶液,并以Zeta电位和经皮渗透速率为指标,考察透明质酸对胶束溶液稳定性和经皮渗透活性的影响。结果表明,透明质酸可显著提高橙皮素胶束溶液的稳定性和经皮渗透活性,当其质量分数为0.5%时,胶束溶液透明稳定、无不良气味,室温下pH平均值为5.4±0.1,Zeta电位平均值为-32.62 m V,橙皮素经豚鼠皮肤的稳态渗透速率常数Js达7.475 8μg/(cm^2·h),为对照组的1.5倍。橙皮素胶束溶液耐寒和耐热实验均表现出良好的稳定性。展开更多
[Objectives] The research aimed to optimize extraction process of fucoidan from Sargassum fusiforme( FSF) and study its moisturizing performance. [Methods]Extracting condition of FSF by cellulase hydrolysis-ultrasonic...[Objectives] The research aimed to optimize extraction process of fucoidan from Sargassum fusiforme( FSF) and study its moisturizing performance. [Methods]Extracting condition of FSF by cellulase hydrolysis-ultrasonic assisted extraction method was optimized. The influences of solvent p H,enzyme dosage,extraction temperature,cellulose hydrolysis time,ultrasonication time,and the ratio of material to liquid on FSF were investigated by single factor and orthogonal experiments. [Results] The optimum extraction conditions were as followings:p H,4. 5; enzyme dosage,1%; extraction temperature,40℃; cellulose hydrolysis time,2 h; ultrasonic time,15 min; and the ratio of material to liquid,1∶ 10( g∶ m L). Under the optimal condition,the extraction yield of FSF was 8. 50%,RSD = 2. 74%. The short-time hygroscopicity( within 8 h) of crude extract of fucoidan from S. fusiforme( CEFSF) was better than glycerin,butanediol,and sodium alginate,and the moisture retention capacity of 1% CEFSF aqueous solution was better than 1% butanediol or 1% sodium alginate,and was equal to 5% glycerin under relative humidity of 43% and 81%. The determination results of skin moisture content and transepidermal water loss rate( TEWL)showed that: 5% CEFSF solution had good moisturizing effect. [Conclusions]The research could provide certain reference for deep development of S. fusiforme.展开更多
文摘制备橙皮素胶束溶液,并以Zeta电位和经皮渗透速率为指标,考察透明质酸对胶束溶液稳定性和经皮渗透活性的影响。结果表明,透明质酸可显著提高橙皮素胶束溶液的稳定性和经皮渗透活性,当其质量分数为0.5%时,胶束溶液透明稳定、无不良气味,室温下pH平均值为5.4±0.1,Zeta电位平均值为-32.62 m V,橙皮素经豚鼠皮肤的稳态渗透速率常数Js达7.475 8μg/(cm^2·h),为对照组的1.5倍。橙皮素胶束溶液耐寒和耐热实验均表现出良好的稳定性。
文摘[Objectives] The research aimed to optimize extraction process of fucoidan from Sargassum fusiforme( FSF) and study its moisturizing performance. [Methods]Extracting condition of FSF by cellulase hydrolysis-ultrasonic assisted extraction method was optimized. The influences of solvent p H,enzyme dosage,extraction temperature,cellulose hydrolysis time,ultrasonication time,and the ratio of material to liquid on FSF were investigated by single factor and orthogonal experiments. [Results] The optimum extraction conditions were as followings:p H,4. 5; enzyme dosage,1%; extraction temperature,40℃; cellulose hydrolysis time,2 h; ultrasonic time,15 min; and the ratio of material to liquid,1∶ 10( g∶ m L). Under the optimal condition,the extraction yield of FSF was 8. 50%,RSD = 2. 74%. The short-time hygroscopicity( within 8 h) of crude extract of fucoidan from S. fusiforme( CEFSF) was better than glycerin,butanediol,and sodium alginate,and the moisture retention capacity of 1% CEFSF aqueous solution was better than 1% butanediol or 1% sodium alginate,and was equal to 5% glycerin under relative humidity of 43% and 81%. The determination results of skin moisture content and transepidermal water loss rate( TEWL)showed that: 5% CEFSF solution had good moisturizing effect. [Conclusions]The research could provide certain reference for deep development of S. fusiforme.
