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血清CagA抗体、G-17、PINP在结直肠癌和腺瘤性息肉中的诊断价值
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作者 王晓倩 于宁 +4 位作者 李华 朱淑娜 刘琼 翟颖 杜洁 《中国实验诊断学》 2024年第11期1334-1339,共6页
目的探究血清细胞毒素相关基因A(CagA)抗体、胃泌素-17(G-17)、Ⅰ型前胶原氨基端前肽(PINP)在结直肠癌和腺瘤性息肉中的诊断价值。方法选取保定市第一中医院2022年1月至2023年6月期间收治的77例结直肠癌患者及105例腺瘤性息肉患者作为... 目的探究血清细胞毒素相关基因A(CagA)抗体、胃泌素-17(G-17)、Ⅰ型前胶原氨基端前肽(PINP)在结直肠癌和腺瘤性息肉中的诊断价值。方法选取保定市第一中医院2022年1月至2023年6月期间收治的77例结直肠癌患者及105例腺瘤性息肉患者作为研究对象,另选取同期在医院体检的83名健康者作为对照组。采用受试者工作特征(ROC)曲线分析血清CagA抗体、G-17和PINP对腺瘤性息肉和结肠癌的诊断价值。结果腺瘤性息肉组和结直肠癌组血清CagA抗体阳性率及G-17表达水平均高于对照组,且结直肠癌组高于腺瘤性息肉组(P<0.05),血清PINP表达水平则与之相反;血清CagA抗体、G-17和PINP表达与息肉直径、结直肠癌分化程度及Dukes分期有关(P<0.05);血清CagA抗体、G-17和PINP单独检测腺瘤性息肉的曲线下面积(AUC)分别为0.547、0.704和0.656,而三者联合检测的AUC为0.829,三者联合检测优于血清CagA抗体、G-17和PINP各自单独检测(Z_(三者联合-CagA抗体)=4.099、Z_(三者联合-G-17)=4.317,Z_(三者联合-PINP)=4.942,P均<0.001);血清CagA抗体、G-17和PINP单独检测结肠癌的AUC分别为0.665、0.659和0.826,而三者联合检测的AUC为0.900,三者联合检测优于血清CagA抗体、G-17和PINP各自单独检测(Z_(三者联合-CagA抗体)=6.196、Z_(三者联合-G-17)=5.988,Z_(三者联合-PINP)=3.992,P均<0.001)。结论血清CagA抗体、G-17和PINP与腺瘤性息肉和结直肠癌的发生及发展密切相关,三者联合检测能够辅助临床诊断腺瘤性息肉和结直肠癌。 展开更多
关键词 细胞毒素相关基因A 胃泌素-17 Ⅰ型前胶原氨基端前肽 结直肠癌 腺瘤性息肉
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Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction 被引量:1
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作者 Ki-Jae Park Hong-Jo Choi +4 位作者 Sung-Heun Kim Sang-Young Han Sook-Hee Hong Jin-Han Cho Hyung-Ho Kim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第1期146-149,共4页
We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited ... We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge. Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution. An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum. Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge. CT scan showed the typical finding of intussusception. We performed laparoscopic anterior resection and anastomosis after the sponge-on-the-stickassisted manual reduction. The permanent pathologic finding showed villotubular adenoma of the sigmoid colon. 展开更多
关键词 Sigmoidorectal intussusception adenomatouspolyp Laparoscopic resection
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