To better understand the community patterns mediated by connectivity in artificial reefs of coastal areas, it is necessary to understand the distribution and coexistence of organisms with artificial reefs area and adj...To better understand the community patterns mediated by connectivity in artificial reefs of coastal areas, it is necessary to understand the distribution and coexistence of organisms with artificial reefs area and adjacent waters. This study was conducted to examine main catches assemblages collected by trawls in Haizhou Bay,which included five habitats: the artificial reef area(AR), aquaculture area(AA), natural area(NA), estuary area(EA) and comprehensive effect area(CEA). The result shows that the total abundances of species in the five habitats were highly different(univariate PERMANOVA: P = 0.001, n = 24), but some species were also unique in their habitat(e.g. Scapharca subcrenata and Glossaulax didyma in AA). The body size distribution of specific species between habitats are different. For Collichthys lucidus, their body size in AR(14.63 cm ± 1.64 cm) and EA(14.3 cm ± 0.85 cm) is higher than that in NA(10.65 cm ± 1.64 cm), CEA(11.28 cm ± 1.85 cm) and AA(12.1 cm ±0.43 cm), which indicates the potential connection from AR to EA mediated by their adult population. We concluded that artificial reefs in AR can be considered key components that have the ability to support species assemblages in adjacent habitats. This study has implications for the conservation and monitoring of species assemblages in coastal areas in terms of that artificial reefs can be applied in different stages of habitat protection implementation and in different combinations of scenarios.展开更多
The distribution of oil and gas resources is intricately connected to the underlying structure of the lithosphere.Therefore,investigating the characteristics of lithospheric thickness and its correlation with oil and ...The distribution of oil and gas resources is intricately connected to the underlying structure of the lithosphere.Therefore,investigating the characteristics of lithospheric thickness and its correlation with oil and gas basins is highly important.This research utilizes recently enhanced geological–geophysical data,including topographic,geoid,rock layer thickness,variable rock layer density,and interface depth data.Employing the principles of lithospheric isostasy and heat conduction,we compute the laterally varying lithospheric thickness in the China seas and adjacent areas.From these results,two pivotal parameters for different types of oil and gas basins were statistically analyzed:the minimum lithospheric thickness and the relative fluctuation in lithospheric thickness.A semiquantitative analysis was used to explore the connection between these parameters and the hydrocarbon abundance within the oil and gas basins.This study unveils distinct variations in lithospheric thickness among basins,with oil and gas rich basins exhibiting a thicker lithosphere in the superimposed basins of central China and a thinner lithosphere in the rift basins of eastern China.Notably,the relative fluctuations in lithospheric thickness in basins demonstrate significant disparities:basins rich in oil and gas often exhibit greater thickness fluctuations.Additionally,in the offshore basins of China,a conspicuous negative linear correlation is observed between the minimum lithospheric thickness and the relative fluctuation in lithospheric thickness.This study posits that deep-seated thermal upwelling results in lithospheric undulations and extensional thinning in oil and gas basins.Concurrently,sustained deep-seated heat influences sedimentary materials in basins,creating favorable conditions for oil and gas generation.The insights derived from this study contribute to a quantitative understanding of the intricate relationships between deep lithospheric structures and oil and gas basins.These findings provide valuable guidance for future oil and gas exploration in the studied areas.展开更多
In order to improve the seismic performance of adjacent buildings,two types of tuned inerter damper(TID)damping systems for adjacent buildings are proposed,which are composed of springs,inerter devices and dampers in ...In order to improve the seismic performance of adjacent buildings,two types of tuned inerter damper(TID)damping systems for adjacent buildings are proposed,which are composed of springs,inerter devices and dampers in serial or in parallel.The dynamic equations of TID adjacent building damping systems were derived,and the H2 norm criterion was used to optimize and adjust them,so that the system had the optimum damping performance under white noise random excitation.Taking TID frequency ratio and damping ratio as optimization parameters,the optimum analytical solutions of the displacement frequency response of the undamped structure under white noise excitation were obtained.The results showed that compared with the classic TMD,TID could obtain a better damping effect in the adjacent buildings.Comparing the TIDs composed of serial or parallel,it was found that the parallel TIDs had more significant advantages in controlling the peak displacement frequency response,while the H2 norm of the displacement frequency response of the damping system under the coupling of serial TID was smaller.Taking the adjacent building composed of two ten-story frame structures as an example,the displacement and energy collection time history analysis of the adjacent building coupled with the optimum design parameter TIDs were carried out.It was found that TID had a better damping effect in the full-time range compared with the classic TMD.This paper also studied the potential power of TID in adjacent buildings,which can be converted into available power resources during earthquakes.展开更多
BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair space.The combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant ...BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair space.The combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant therapeutic effect.AIM To explore clinical efficacy,bone density,and follow-up of implant and orthodontic treatment for patients with inclined adjacent teeth.METHODS In total,98 patients with oblique adjacent teeth were randomly assigned to implant restoration combined with orthodontic treatment(group A,n=49)or to receive implant restoration alone(group B,n=49).Changes in alveolar ridge bone density and apical bone density were observed before and after treatment in the two groups.Changes in chewing function and language function were compared between the two groups of patients.Follow-up lasted for 12 mo after repair to observe any adverse reactions in the oral cavity.RESULTS The clinical effective rates of group A and group B were 97.96%and 85.71%,respectively,with group A having a higher clinical effective rate than group B.After treatment,the bone density of the alveolar ridge and apical bone in both groups decreased compared to before treatment,while the chewing and language functions improved.The changes in various indicators in group A were more significant.After treatment,the satisfaction rate of group A(97.96%)was higher than that of group B(79.59%).The incidence of adverse reactions in group A(2.04%)was lower than that in group B(24.49%).CONCLUSION The amalgamation of implant restoration and orthodontic treatment for adjacent tilted teeth demonstrates notable clinical efficacy,diminishes alveolar bone resorption,and fosters patient functional rehabilitation while exhibiting negligible adverse reactions.展开更多
Taking Heidaigou Open-cast Mine and Haerwusu Open-cast Mine in Zhungeer mining area as the research objects,this paper deeply analyzes the current mining status of the two mines.Based on the existing working line leng...Taking Heidaigou Open-cast Mine and Haerwusu Open-cast Mine in Zhungeer mining area as the research objects,this paper deeply analyzes the current mining status of the two mines.Based on the existing working line length,mining technology,transportation system,equipment configuration,transportation access and many other factors,it systematically discusses the feasibility of straightening the working line of adjacent open-cast mines.Through in-depth theoretical analysis,it establishes the mathematical model of impact indicators and cost calculation,and it is concluded that the work line straightening can be technically achieved.However,from the perspective of economic benefits,straightening the working line does not show obvious advantages.展开更多
BACKGROUND Although percutaneous vertebral augmentation(PVA)is a commonly used procedure for treating vertebral compression fracture(VCF),the risk of vertebral refracture should be considered.Chronic kidney disease-mi...BACKGROUND Although percutaneous vertebral augmentation(PVA)is a commonly used procedure for treating vertebral compression fracture(VCF),the risk of vertebral refracture should be considered.Chronic kidney disease-mineral and bone disorder(CKD-MBD)is a systemic disease of mineral and bone metabolism.It is associated with an increased risk of fracture.Few studies have reported the use of PVA in patients with CKD-MBD.We herein report a rare case wherein the cemented vertebra and the adjacent vertebra refractured simultaneously in a CKD-MBD patient after PVA.CASE SUMMARY A 74-year-old man suffered from low back pain after taking a fall about 3 wk ago.According to physical examination,imaging and laboratory findings,diagnoses of T12 VCF,CKD-MBD,and chronic kidney disease stage 5 were established.He then received percutaneous vertebroplasty at T12 vertebra.Fourteen weeks later,he presented with T12 and L1 vertebral refractures caused by lumbar sprain.Once again,he was given PVA which was optimized for the refractured vertebrae.Although the short-term postoperative effect was satisfactory,he reported chronic low back pain again at the 3-month follow-up.CONCLUSION It is necessary that patients with CKD-MBD who have received PVA are aware of the adverse effects of CKD-MBD.It may increase the risk of vertebral refracture.Furthermore,the PVA surgical technique needs to be optimized according to the condition of the patient.The medium-and long-term effects of PVA remain uncertain in patients with CKD-MBD.展开更多
Currently, land resources are becoming more and more constrained and structures are getting closer to each other. To investigate the seismic response of inter-story isolated structure to adjacent structure, models con...Currently, land resources are becoming more and more constrained and structures are getting closer to each other. To investigate the seismic response of inter-story isolated structure to adjacent structure, models considering no soil-structure interaction (SSI), considering soil-structure interaction (SSI), and considering structure-soil-structure interaction (SSSI) were established. Nonlinear seismic response comparative analysis was conducted by varying the spacing between adjacent structure and inter-story isolated structure, as well as the weight of adjacent structure, under different earthquake inputs, in order to obtain the structural response characteristics. The results indicate that the inter-story drift and inter-story shear of the inter-story isolated structure without considering SSI are smaller than those considering SSI and SSSI. The inter-story drift and inter-story shear of the inter-story isolated structure considering SSSI are further affected compared to that of the inter-story isolated structure considering only SSI. As the spacing between adjacent structure and inter-story isolated structure increases, the influence of adjacent structure on inter-story isolated structure decreases. The variation in the spacing between the two structures has a negligible effect on the isolation layer of the inter-story isolated structure. With the increase in the weight of adjacent structure, the influence of adjacent structure on inter-story isolated structure becomes more significant. The increasing weight of adjacent structure has an increasing effect on the Isolation layer of the inter-story isolated structure.展开更多
The cell density, species composition and distribution of phytoplankton, and their relations to environmental factors in Prydz Bay and its adjacent sea area, Antarctica (69degrees-77degrees E, 62degrees-70degrees S) d...The cell density, species composition and distribution of phytoplankton, and their relations to environmental factors in Prydz Bay and its adjacent sea area, Antarctica (69degrees-77degrees E, 62degrees-70degrees S) during the austral summer of 1998/1999 were investigated. A total of 48 taxa belonging to 21 genera of phytoplankton in the sea area were identified. The average cell density of phytoplankton was 22.46 x 10(3) cells/dm(3), of which diatoms were predominant (84.51%). The highest cell density of phytoplankton occurred in Prydz Bay and the adjacent continental shelf where the average cell density was 46.03 x 10(3) cells/dm(3). The lowest cell density (3.34 x 10(3) cells/dm(3)) occurred in deep sea area. The dominant species of phytoplankton was Fragilariopsis curta. The vertical distribution of phytoplankton density was highest in the upper part of 0-50 in depth, lower in 100 in and lowest in 150 in. The species composition and cell density of phytoplankton were influenced by water circulation. The cell density was positively correlated with water temperature and salinity, and negatively correlated with the concentration of nutrients.展开更多
Diurnal and semi-diurnal tides in the Taiwan Strait and its adjacent areas are calculated by using a two-dimensional finite-difference model. Compared with data of more than 20 observation stations around the Taiwan S...Diurnal and semi-diurnal tides in the Taiwan Strait and its adjacent areas are calculated by using a two-dimensional finite-difference model. Compared with data of more than 20 observation stations around the Taiwan Strait, the model-produced results agree quite well with those of previous researches using observational data from coastal tidal gauge stations. According to the results, the co-tidal and co-range charts are given. Furthermore, the characteristics of 8 major tidal constituents have been uminated respectively. The result shows that: (1) The tide motion can be attributed to the interaction between the degenerative rotary tidal system in the north and the progressive tidal system in the south. (2) The southward and northward tidal waves of semi-diurnal tide converge in the middle of the Taiwan Strait while the diurnal tidal waves propagate southwestward through the Taiwan Strait and the Luzon Strait. (3) The maximum amplitude of semi-diurnal tides exists at the area between the Meizhou Bay and Xinghua Bay, and that of diurnal tides appears in the region to the east of the Leizhou Peninsula, (4) The patterns of co-tidal and co-range charts of N2, K2 and P1, Q1 tidal constituents are similar to those of M2, S2 and K1 O1 tidat constituents, respectively展开更多
Pn velocity lateral variation and anisotropy images were reconstructed by adding about 50 000 travel times from the regional seismic networks to the datum set of near 40 000 travel times from National Seismic Network ...Pn velocity lateral variation and anisotropy images were reconstructed by adding about 50 000 travel times from the regional seismic networks to the datum set of near 40 000 travel times from National Seismic Network of China used by WANG, et al. We discussed the relation of Pn velocity variation to Moho depth, Earths heat flow, distribution of Cenozoic volcanic rock and the result of rock experiment under high pressure and high temperature. The result of quantitative analysis indicates that Pn velocity is positively correlated with the crust thickness and negatively correlated with the Earths heat flow. Two linear regression equations, one between Pn velocity and crust thickness, and the other between Pn velocity and heat flow, were obtained. The rate of variation of Pn veloc-ity vP with pressure P, Pv/p, estimated from the velocity variation with crust thickness Hv/p, is close to the result obtained from the rock experiment under high pressure and high temperature. If the effect of crust thick-ness on Pn velocity is deducted from the velocity variation, then the low Pn velocity beneath Qinghai-Xizang pla-teau is more notable. The low Pn velocity regions well agree with the Cenozoic volcanic rock. In the several re-gions with significant anisotropy, the direction of fast Pn velocity is consistent with the orientation of maximum principal crustal compressive stress, and also with the direction of present-day crustal movement. It indicates that the fast Pn velocity direction may be related to the deformation or flow of top mantle material along the direction of maximum pressure.展开更多
We assembled approximately 328 seismic records. The data set was from 4 digitally recording long-period and broadband stations of CDSN. We carried out the inversion based on the partitioned waveform inversion (PWI). I...We assembled approximately 328 seismic records. The data set was from 4 digitally recording long-period and broadband stations of CDSN. We carried out the inversion based on the partitioned waveform inversion (PWI). It partitions the large-scale optimization problem into a number of independent small-scale problems. We adopted surface waveform inversion with an equal block (2((2() discretization in order to acquire the images of shear velocity structure at different depths (from surface to 430 km) in the crust and upper-mantle. The resolution of all these anomalies has been established with (check-board( resolution tests. These results show significant difference in velocity, lithosphere and asthenosphere structure between South China Sea and its adjacent regions.展开更多
A formulation of the multi degree of freedom equations of motion for damper connected adjacent multi story buildings under earthquake excitation is presented.The ground acceleration due to e...A formulation of the multi degree of freedom equations of motion for damper connected adjacent multi story buildings under earthquake excitation is presented.The ground acceleration due to earthquake is regarded as a stochastic process,and a pseudo excitation algorithm in frequency domain is implemented in a computer program to handle the non orthogonal damping properties of the system.The effectiveness of joint dampers is then investigated in terms of the reduction of displacement,acceleration and shear force responses of adjacent buildings.展开更多
A regional ocean reanalysis system for the coastal waters of China and adjacent seas has been developed by the National Marine Data and Information Service(NMDIS).It produces a dataset package called CORA (China oc...A regional ocean reanalysis system for the coastal waters of China and adjacent seas has been developed by the National Marine Data and Information Service(NMDIS).It produces a dataset package called CORA (China ocean reanalysis).The regional ocean model used is based on the Princeton Ocean Model with a generalized coordinate system(POMgcs).The model is parallelized by NMDIS with the addition of the wave breaking and tidal mixing processes into model parameterizations.Data assimilation is a sequential three-dimensional variational(3D-Var) scheme implemented within a multigrid framework.Observations include satellite remote sensing sea surface temperature(SST),altimetry sea level anomaly(SLA),and temperature/salinity profiles.The reanalysis fields of sea surface height,temperature,salinity,and currents begin with January 1986 and are currently updated every year. Error statistics and error distributions of temperature,salinity and currents are presented as a primary evaluation of the reanalysis fields using sea level data from tidal gauges,temperature profiles,as well as the trajectories of Argo floats.Some case studies offer the opportunity to verify the evolution of certain local circulations.These evaluations show that the reanalysis data produced provide a good representation of the ocean processes and phenomena in the coastal waters of China and adjacent seas.展开更多
A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of ...A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of edges incident with v, where uv∈ E(G). The adjacent vertex distinguishing acyclic edge chromatic number of G, denoted by X'Aa(G), is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G. If a graph G has an adjacent vertex distinguishing acyclic edge coloring, then G is called adjacent vertex distinguishing acyclic. In this paper, we obtain adjacent vertex-distinguishing acyclic edge coloring of some graphs and put forward some conjectures.展开更多
The formation process of the Dianqiangui basin, a special basin, occurred after the Caledonian orogeny, in the south of Guizhou, the west of Guangxi and the southeast of Yunnan, experienced three periods: it began ...The formation process of the Dianqiangui basin, a special basin, occurred after the Caledonian orogeny, in the south of Guizhou, the west of Guangxi and the southeast of Yunnan, experienced three periods: it began in the Devonian, persisted in the Carboniferous, and became fiercer in the Permian. Controlled by syndepositional fault-zones, varieties of isolated carbonate platforms, large and small, were developed in the background of a deep-water basin, namely, an inter-platform ditch. And a special paleogeographical Late Paleozoic pattern marked by “platform-basin-hill-trough” was produced in both the Dianqiangui basin and its adjacent areas. Affected by regional tectonic activities and the global changes in the sea level, the platform carbonates and coal measures superimposed each other cyclically on the attached platform. The reef-building on the isolated platform and the margin of the attached platform corresponds to the development of the shale succession in the deep-water basin. All of these elementary characteristics reflect a regular and sophisticated filling succession of the Dianqiangui basin, a result of the dual controls of the regionally tectonic activities and the eustacy. Based on the two elementary features of the third-order sequences, i.e. the regularity of sedimentary-facies succession in space and the simultaneity of environmental changes in time, 25 third-order sequences could be discerned in the Upper Paleozoic strata in the Dianqiangui basin and its adjacent areas. On the basis of the two kinds of facies-changing surfaces and the two kinds of diachronisms in stratigraphic records, the regional Late Paleozoic sequence-stratigraphic framework in the Dianqiangui basin and its adjacent areas can be established. There are two types of facies-changing surfaces and two types of diachronisms in stratigraphic records: the static type, a result of the change in sedimentary facies in space, and the dynamic type, a result of the change in time. These two types of facies-changing surfaces led to the generation of the two types of diachronisms: the diachronism of facies-changing surfaces that was formed by the static facies-changing surfaces, and the diachronism of punctuated surfaces that was formed by the dynamic facies-changing surfaces. The two types of facies-changing surfaces and the two types of diachronisms in stratigraphic records are the key to the establishment of the sequence-stratigraphic framework. The sequence boundaries could be divided geologically into four types: tectonic unconformity, sedimentary unconformity, drowned unconformity and their correlative surfaces. All of these four types can be further grouped into exposed punctuated surfaces and deepened punctuated surfaces. The tectonic unconformity is similar to Type Ⅰ sequence boundary, and the sedimentary unconformity is similar to Type Ⅱ sequence boundary defined by Vail et al.. In terms of sequence stratigraphy, the tectonic unconformities of the Ziyun movement, the Qiangui epeirogeny and the Dongwu revolution as well as the drowned unconformity in the transitional period from the Permian to the Triassic can be systematically defined and their geological characteristics are briefly presented.展开更多
This paper investigates the adjacent interactions of three novel solitons for the quintic complex Ginzburg-Landau equation, which are plain pulsating, erupting and creeping solitons. It is found that different perform...This paper investigates the adjacent interactions of three novel solitons for the quintic complex Ginzburg-Landau equation, which are plain pulsating, erupting and creeping solitons. It is found that different performances are presented for different solitons due to isolated regions of the parameter space where they exist. For example, plain pulsating and erupting solitons exhibit mutual annihilation during collisions with the decrease of total energy, but for creeping soliton, the two adjacent pulses present soliton fusion without any loss of energy. Otherwise, the method for restraining the interactions is also found and it can suppress interactions between these two adjacent pulses effectively.展开更多
The spatial distribution patterns of total organic carbon and total nitrogen show significant correlations with currents of the East China Sea Shelf. Corresponding to distributions of these currents, the study area co...The spatial distribution patterns of total organic carbon and total nitrogen show significant correlations with currents of the East China Sea Shelf. Corresponding to distributions of these currents, the study area could be divided into four different parts. Total organic carbon, total nitrogen, and organic carbon and nitrogen stable isotopes in sediments show linear correlations with mean grain size, respectively, thus "grain size effect" is an important factor that influences their distributions. C/N ratios can reflect source information of organic matter to a certain degree. In contrast, nitrogen stable isotope shows different spatial distribution patterns with C/N and organic carbon stable isotope, according to their relationships and regional distributions. The highest contribution (up to 50%) of terrestrial organic carbon appears near the Changjiang Estuary with isolines projecting towards northeast, indicating the influence of the Changjiang dilution water. Terrestrial particulate organic matter suffers from effects of diagenesis, benthos and incessant inputting of dead organic matter of plankton, after depositing in seabed. Therefore, the contribution of terrestrial organic carbon to particulate organic matter is obviously greater than that to organic matter in sediments in the same place.展开更多
Let G(V, E) be a simple connected graph and k be positive integers. A mapping f from V∪E to {1, 2, ··· , k} is called an adjacent vertex-distinguishing E-total coloring of G(abbreviated to k-AVDETC), i...Let G(V, E) be a simple connected graph and k be positive integers. A mapping f from V∪E to {1, 2, ··· , k} is called an adjacent vertex-distinguishing E-total coloring of G(abbreviated to k-AVDETC), if for uv ∈ E(G), we have f(u) ≠ f(v), f(u) ≠ f(uv), f(v) ≠ f(uv), C(u) ≠C(v), where C(u) = {f(u)}∪{f(uv)|uv ∈ E(G)}. The least number of k colors required for which G admits a k-coloring is called the adjacent vertex-distinguishing E-total chromatic number of G is denoted by x^e_(at) (G). In this paper, the adjacent vertexdistinguishing E-total colorings of some join graphs C_m∨G_n are obtained, where G_n is one of a star S_n , a fan F_n , a wheel W_n and a complete graph K_n . As a consequence, the adjacent vertex-distinguishing E-total chromatic numbers of C_m∨G_n are confirmed.展开更多
The Wenchuan earthquake has altered the crustal motion characteristics in the eastern margin of the Tibetan Plateau and adjacent regions.Using discontinuous GPS survey data for 2008–2012, the velocity field for the E...The Wenchuan earthquake has altered the crustal motion characteristics in the eastern margin of the Tibetan Plateau and adjacent regions.Using discontinuous GPS survey data for 2008–2012, the velocity field for the Eurasia reference framework has been obtained, and the general trend of contemporary crustal motion after the occurrence of the Wenchuan earthquake has been studied.In addition, using the velocity field, the block movement velocity has been estimated by least-squares fitting.Furthermore, the properties and displacement rates of main faults have been obtained from the differences in velocity vectors of the blocks on both sides of the faults.The results reveal that there are no obvious changes in the general characteristics of crustal motion in this area after the Wenchuan earthquake.The earthquake mainly changed the rate of the movement of the Chuan-Qing block and caused variation in the movement direction of the South China block.The effect of the earthquake on faults is mainly reflected in variations in fault displacement velocity; there is no fundamental change in the properties of fault activity.The displacement rates of the Xianshuihe fault decreased by 3–4 mm/a, the Longmenshan fault increased by 9–10 mm/a, and the northern segment of the Anninghe fault increased by approximately 9 mm/a.Furthermore, the displacement rates of the Minjiang, Xueshan, Huya, Longquanshan, and Xinjin faults increased by 2–3 mm/a.This implies that the effects of the Wenchuan earthquake on crustal movement can mainly be observed in the Chuan-Qing, South China, and N-Chuan-Dian blocks and their internal faults, as well as the Xianshuihe and Longmenshan faults and the northern section of the Anninghe fault.The reason for this is that the Wenchuan earthquake disturbed the kinematic and dynamic balance in the region.展开更多
BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis.Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer(CRC...BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis.Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer(CRC).AIM To estimate whether a methylation gene panel in different clinical stages can reflect a different prognosis.METHODS We enrolled 120 CRC patients from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select six genes involved in carcinogenesis pathways.Patients were divided into two groups based on the methylation status of the six evaluated genes,namely,the<3 aberrancy group and≥3 aberrancy group.Various tumor stages were divided into two subgroups(local and advanced stages)on the basis of the pathological type of the following tissues:Tumor and adjacent normal tissues(matched normal).We assessed DNA methylation in tumors and adjacent normal tissues from CRC patients and analyzed the association between DNA methylation with different cancer stages and the prognostic outcome including time to progression(TTP)and overall survival.RESULTS We observed a significantly increasing trend of hazard ratio as the number of hypermethylated genes increased both in normal tissue and tumor tissue.The 5-year TTP survival curves showed a significant difference between the≥3 aberrancy group and the<3 aberrancy group.Compared with the<3 aberrancy group,a significantly shorter TTP was observed in the≥3 aberrancy group.We further analyzed the interaction between CRC prognosis and different cancer stages(local and advanced)according to the methylation status of the selected genes in both types of tissues.There was a significantly shorter 5-year TTP for tumors at advanced stages with the promoter methylation status of selected genes than for those with local stages.We found an interaction between cancer stages and the promoter methylation status of selected genes in both types of tissues.CONCLUSION Our data provide a significant association between the methylation markers in normal tissues with advanced stage and prognosis of CRC.We recommend using these novel markers to assist in clinical decision-making.展开更多
基金The China Scholarship Council under contract No.202308310175the China Postdoctoral Science Foundation under contract No.E-6005-00-0042-39+6 种基金Postdoctoral Fellowship Program of CPSF under contract No. GZC20231539the Jiangsu Haizhou Bay National Sea Ranching Demonstration Project under contract No. D–8005–18–0188Shanghai Municipal Science and Technology Commission Local Capacity Construction Project under contract No. 21010502200the Science Foundation for Youths of Jiangsu ProvinceChina under contract No. BK20170438the Science and Technology Projects in Nantong under contract No. JC2018014the Social Livelihood Key Projects of Nantong under contract No. MS22021015。
文摘To better understand the community patterns mediated by connectivity in artificial reefs of coastal areas, it is necessary to understand the distribution and coexistence of organisms with artificial reefs area and adjacent waters. This study was conducted to examine main catches assemblages collected by trawls in Haizhou Bay,which included five habitats: the artificial reef area(AR), aquaculture area(AA), natural area(NA), estuary area(EA) and comprehensive effect area(CEA). The result shows that the total abundances of species in the five habitats were highly different(univariate PERMANOVA: P = 0.001, n = 24), but some species were also unique in their habitat(e.g. Scapharca subcrenata and Glossaulax didyma in AA). The body size distribution of specific species between habitats are different. For Collichthys lucidus, their body size in AR(14.63 cm ± 1.64 cm) and EA(14.3 cm ± 0.85 cm) is higher than that in NA(10.65 cm ± 1.64 cm), CEA(11.28 cm ± 1.85 cm) and AA(12.1 cm ±0.43 cm), which indicates the potential connection from AR to EA mediated by their adult population. We concluded that artificial reefs in AR can be considered key components that have the ability to support species assemblages in adjacent habitats. This study has implications for the conservation and monitoring of species assemblages in coastal areas in terms of that artificial reefs can be applied in different stages of habitat protection implementation and in different combinations of scenarios.
基金supported by the National Key Research and Development Plan project“Research on Comprehensive Processing and Interpretation Methods of Aeronautical Geophysical Data and Soft ware Development”under contract No.2017YFC0602202。
文摘The distribution of oil and gas resources is intricately connected to the underlying structure of the lithosphere.Therefore,investigating the characteristics of lithospheric thickness and its correlation with oil and gas basins is highly important.This research utilizes recently enhanced geological–geophysical data,including topographic,geoid,rock layer thickness,variable rock layer density,and interface depth data.Employing the principles of lithospheric isostasy and heat conduction,we compute the laterally varying lithospheric thickness in the China seas and adjacent areas.From these results,two pivotal parameters for different types of oil and gas basins were statistically analyzed:the minimum lithospheric thickness and the relative fluctuation in lithospheric thickness.A semiquantitative analysis was used to explore the connection between these parameters and the hydrocarbon abundance within the oil and gas basins.This study unveils distinct variations in lithospheric thickness among basins,with oil and gas rich basins exhibiting a thicker lithosphere in the superimposed basins of central China and a thinner lithosphere in the rift basins of eastern China.Notably,the relative fluctuations in lithospheric thickness in basins demonstrate significant disparities:basins rich in oil and gas often exhibit greater thickness fluctuations.Additionally,in the offshore basins of China,a conspicuous negative linear correlation is observed between the minimum lithospheric thickness and the relative fluctuation in lithospheric thickness.This study posits that deep-seated thermal upwelling results in lithospheric undulations and extensional thinning in oil and gas basins.Concurrently,sustained deep-seated heat influences sedimentary materials in basins,creating favorable conditions for oil and gas generation.The insights derived from this study contribute to a quantitative understanding of the intricate relationships between deep lithospheric structures and oil and gas basins.These findings provide valuable guidance for future oil and gas exploration in the studied areas.
基金This research was funded by the Natural Science Research Project of Higher Education Institutions in Anhui Province(Grant No.2022AH040045)the Anhui Provincial Natural Science Foundation(Grant No.2008085QE245)the Project of Science and Technology Plan of Department of Housing and Urban-Rural Development of Anhui Province(Grant No.2021-YF22).
文摘In order to improve the seismic performance of adjacent buildings,two types of tuned inerter damper(TID)damping systems for adjacent buildings are proposed,which are composed of springs,inerter devices and dampers in serial or in parallel.The dynamic equations of TID adjacent building damping systems were derived,and the H2 norm criterion was used to optimize and adjust them,so that the system had the optimum damping performance under white noise random excitation.Taking TID frequency ratio and damping ratio as optimization parameters,the optimum analytical solutions of the displacement frequency response of the undamped structure under white noise excitation were obtained.The results showed that compared with the classic TMD,TID could obtain a better damping effect in the adjacent buildings.Comparing the TIDs composed of serial or parallel,it was found that the parallel TIDs had more significant advantages in controlling the peak displacement frequency response,while the H2 norm of the displacement frequency response of the damping system under the coupling of serial TID was smaller.Taking the adjacent building composed of two ten-story frame structures as an example,the displacement and energy collection time history analysis of the adjacent building coupled with the optimum design parameter TIDs were carried out.It was found that TID had a better damping effect in the full-time range compared with the classic TMD.This paper also studied the potential power of TID in adjacent buildings,which can be converted into available power resources during earthquakes.
基金the Review Committee of General Hospital of Central Theater Command(Approval No.05901).
文摘BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair space.The combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant therapeutic effect.AIM To explore clinical efficacy,bone density,and follow-up of implant and orthodontic treatment for patients with inclined adjacent teeth.METHODS In total,98 patients with oblique adjacent teeth were randomly assigned to implant restoration combined with orthodontic treatment(group A,n=49)or to receive implant restoration alone(group B,n=49).Changes in alveolar ridge bone density and apical bone density were observed before and after treatment in the two groups.Changes in chewing function and language function were compared between the two groups of patients.Follow-up lasted for 12 mo after repair to observe any adverse reactions in the oral cavity.RESULTS The clinical effective rates of group A and group B were 97.96%and 85.71%,respectively,with group A having a higher clinical effective rate than group B.After treatment,the bone density of the alveolar ridge and apical bone in both groups decreased compared to before treatment,while the chewing and language functions improved.The changes in various indicators in group A were more significant.After treatment,the satisfaction rate of group A(97.96%)was higher than that of group B(79.59%).The incidence of adverse reactions in group A(2.04%)was lower than that in group B(24.49%).CONCLUSION The amalgamation of implant restoration and orthodontic treatment for adjacent tilted teeth demonstrates notable clinical efficacy,diminishes alveolar bone resorption,and fosters patient functional rehabilitation while exhibiting negligible adverse reactions.
文摘Taking Heidaigou Open-cast Mine and Haerwusu Open-cast Mine in Zhungeer mining area as the research objects,this paper deeply analyzes the current mining status of the two mines.Based on the existing working line length,mining technology,transportation system,equipment configuration,transportation access and many other factors,it systematically discusses the feasibility of straightening the working line of adjacent open-cast mines.Through in-depth theoretical analysis,it establishes the mathematical model of impact indicators and cost calculation,and it is concluded that the work line straightening can be technically achieved.However,from the perspective of economic benefits,straightening the working line does not show obvious advantages.
文摘BACKGROUND Although percutaneous vertebral augmentation(PVA)is a commonly used procedure for treating vertebral compression fracture(VCF),the risk of vertebral refracture should be considered.Chronic kidney disease-mineral and bone disorder(CKD-MBD)is a systemic disease of mineral and bone metabolism.It is associated with an increased risk of fracture.Few studies have reported the use of PVA in patients with CKD-MBD.We herein report a rare case wherein the cemented vertebra and the adjacent vertebra refractured simultaneously in a CKD-MBD patient after PVA.CASE SUMMARY A 74-year-old man suffered from low back pain after taking a fall about 3 wk ago.According to physical examination,imaging and laboratory findings,diagnoses of T12 VCF,CKD-MBD,and chronic kidney disease stage 5 were established.He then received percutaneous vertebroplasty at T12 vertebra.Fourteen weeks later,he presented with T12 and L1 vertebral refractures caused by lumbar sprain.Once again,he was given PVA which was optimized for the refractured vertebrae.Although the short-term postoperative effect was satisfactory,he reported chronic low back pain again at the 3-month follow-up.CONCLUSION It is necessary that patients with CKD-MBD who have received PVA are aware of the adverse effects of CKD-MBD.It may increase the risk of vertebral refracture.Furthermore,the PVA surgical technique needs to be optimized according to the condition of the patient.The medium-and long-term effects of PVA remain uncertain in patients with CKD-MBD.
文摘Currently, land resources are becoming more and more constrained and structures are getting closer to each other. To investigate the seismic response of inter-story isolated structure to adjacent structure, models considering no soil-structure interaction (SSI), considering soil-structure interaction (SSI), and considering structure-soil-structure interaction (SSSI) were established. Nonlinear seismic response comparative analysis was conducted by varying the spacing between adjacent structure and inter-story isolated structure, as well as the weight of adjacent structure, under different earthquake inputs, in order to obtain the structural response characteristics. The results indicate that the inter-story drift and inter-story shear of the inter-story isolated structure without considering SSI are smaller than those considering SSI and SSSI. The inter-story drift and inter-story shear of the inter-story isolated structure considering SSSI are further affected compared to that of the inter-story isolated structure considering only SSI. As the spacing between adjacent structure and inter-story isolated structure increases, the influence of adjacent structure on inter-story isolated structure decreases. The variation in the spacing between the two structures has a negligible effect on the isolation layer of the inter-story isolated structure. With the increase in the weight of adjacent structure, the influence of adjacent structure on inter-story isolated structure becomes more significant. The increasing weight of adjacent structure has an increasing effect on the Isolation layer of the inter-story isolated structure.
文摘The cell density, species composition and distribution of phytoplankton, and their relations to environmental factors in Prydz Bay and its adjacent sea area, Antarctica (69degrees-77degrees E, 62degrees-70degrees S) during the austral summer of 1998/1999 were investigated. A total of 48 taxa belonging to 21 genera of phytoplankton in the sea area were identified. The average cell density of phytoplankton was 22.46 x 10(3) cells/dm(3), of which diatoms were predominant (84.51%). The highest cell density of phytoplankton occurred in Prydz Bay and the adjacent continental shelf where the average cell density was 46.03 x 10(3) cells/dm(3). The lowest cell density (3.34 x 10(3) cells/dm(3)) occurred in deep sea area. The dominant species of phytoplankton was Fragilariopsis curta. The vertical distribution of phytoplankton density was highest in the upper part of 0-50 in depth, lower in 100 in and lowest in 150 in. The species composition and cell density of phytoplankton were influenced by water circulation. The cell density was positively correlated with water temperature and salinity, and negatively correlated with the concentration of nutrients.
基金supported by the National Natural Science Foundation of China under contract Nos. 40576015, 40810069004 and 40821063by the key research project of Fujian Province under contract No. 2004N203by the Fujian demonstrating region of the "863" Project of the Ministry of Science and Technology of China
文摘Diurnal and semi-diurnal tides in the Taiwan Strait and its adjacent areas are calculated by using a two-dimensional finite-difference model. Compared with data of more than 20 observation stations around the Taiwan Strait, the model-produced results agree quite well with those of previous researches using observational data from coastal tidal gauge stations. According to the results, the co-tidal and co-range charts are given. Furthermore, the characteristics of 8 major tidal constituents have been uminated respectively. The result shows that: (1) The tide motion can be attributed to the interaction between the degenerative rotary tidal system in the north and the progressive tidal system in the south. (2) The southward and northward tidal waves of semi-diurnal tide converge in the middle of the Taiwan Strait while the diurnal tidal waves propagate southwestward through the Taiwan Strait and the Luzon Strait. (3) The maximum amplitude of semi-diurnal tides exists at the area between the Meizhou Bay and Xinghua Bay, and that of diurnal tides appears in the region to the east of the Leizhou Peninsula, (4) The patterns of co-tidal and co-range charts of N2, K2 and P1, Q1 tidal constituents are similar to those of M2, S2 and K1 O1 tidat constituents, respectively
基金State Key Basic Research Project of Development and Programming Mechanism and Prediction of Continental Strong Earthquakes (G1998040700).
文摘Pn velocity lateral variation and anisotropy images were reconstructed by adding about 50 000 travel times from the regional seismic networks to the datum set of near 40 000 travel times from National Seismic Network of China used by WANG, et al. We discussed the relation of Pn velocity variation to Moho depth, Earths heat flow, distribution of Cenozoic volcanic rock and the result of rock experiment under high pressure and high temperature. The result of quantitative analysis indicates that Pn velocity is positively correlated with the crust thickness and negatively correlated with the Earths heat flow. Two linear regression equations, one between Pn velocity and crust thickness, and the other between Pn velocity and heat flow, were obtained. The rate of variation of Pn veloc-ity vP with pressure P, Pv/p, estimated from the velocity variation with crust thickness Hv/p, is close to the result obtained from the rock experiment under high pressure and high temperature. If the effect of crust thick-ness on Pn velocity is deducted from the velocity variation, then the low Pn velocity beneath Qinghai-Xizang pla-teau is more notable. The low Pn velocity regions well agree with the Cenozoic volcanic rock. In the several re-gions with significant anisotropy, the direction of fast Pn velocity is consistent with the orientation of maximum principal crustal compressive stress, and also with the direction of present-day crustal movement. It indicates that the fast Pn velocity direction may be related to the deformation or flow of top mantle material along the direction of maximum pressure.
基金State Natural Scientific Foundation (49734150) and National High Performance Computation Foundation.
文摘We assembled approximately 328 seismic records. The data set was from 4 digitally recording long-period and broadband stations of CDSN. We carried out the inversion based on the partitioned waveform inversion (PWI). It partitions the large-scale optimization problem into a number of independent small-scale problems. We adopted surface waveform inversion with an equal block (2((2() discretization in order to acquire the images of shear velocity structure at different depths (from surface to 430 km) in the crust and upper-mantle. The resolution of all these anomalies has been established with (check-board( resolution tests. These results show significant difference in velocity, lithosphere and asthenosphere structure between South China Sea and its adjacent regions.
文摘A formulation of the multi degree of freedom equations of motion for damper connected adjacent multi story buildings under earthquake excitation is presented.The ground acceleration due to earthquake is regarded as a stochastic process,and a pseudo excitation algorithm in frequency domain is implemented in a computer program to handle the non orthogonal damping properties of the system.The effectiveness of joint dampers is then investigated in terms of the reduction of displacement,acceleration and shear force responses of adjacent buildings.
文摘A regional ocean reanalysis system for the coastal waters of China and adjacent seas has been developed by the National Marine Data and Information Service(NMDIS).It produces a dataset package called CORA (China ocean reanalysis).The regional ocean model used is based on the Princeton Ocean Model with a generalized coordinate system(POMgcs).The model is parallelized by NMDIS with the addition of the wave breaking and tidal mixing processes into model parameterizations.Data assimilation is a sequential three-dimensional variational(3D-Var) scheme implemented within a multigrid framework.Observations include satellite remote sensing sea surface temperature(SST),altimetry sea level anomaly(SLA),and temperature/salinity profiles.The reanalysis fields of sea surface height,temperature,salinity,and currents begin with January 1986 and are currently updated every year. Error statistics and error distributions of temperature,salinity and currents are presented as a primary evaluation of the reanalysis fields using sea level data from tidal gauges,temperature profiles,as well as the trajectories of Argo floats.Some case studies offer the opportunity to verify the evolution of certain local circulations.These evaluations show that the reanalysis data produced provide a good representation of the ocean processes and phenomena in the coastal waters of China and adjacent seas.
基金supported by NSFC of China (No. 19871036 and No. 40301037)Faculty Research Grant,Hong Kong Baptist University
文摘A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of edges incident with v, where uv∈ E(G). The adjacent vertex distinguishing acyclic edge chromatic number of G, denoted by X'Aa(G), is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G. If a graph G has an adjacent vertex distinguishing acyclic edge coloring, then G is called adjacent vertex distinguishing acyclic. In this paper, we obtain adjacent vertex-distinguishing acyclic edge coloring of some graphs and put forward some conjectures.
文摘The formation process of the Dianqiangui basin, a special basin, occurred after the Caledonian orogeny, in the south of Guizhou, the west of Guangxi and the southeast of Yunnan, experienced three periods: it began in the Devonian, persisted in the Carboniferous, and became fiercer in the Permian. Controlled by syndepositional fault-zones, varieties of isolated carbonate platforms, large and small, were developed in the background of a deep-water basin, namely, an inter-platform ditch. And a special paleogeographical Late Paleozoic pattern marked by “platform-basin-hill-trough” was produced in both the Dianqiangui basin and its adjacent areas. Affected by regional tectonic activities and the global changes in the sea level, the platform carbonates and coal measures superimposed each other cyclically on the attached platform. The reef-building on the isolated platform and the margin of the attached platform corresponds to the development of the shale succession in the deep-water basin. All of these elementary characteristics reflect a regular and sophisticated filling succession of the Dianqiangui basin, a result of the dual controls of the regionally tectonic activities and the eustacy. Based on the two elementary features of the third-order sequences, i.e. the regularity of sedimentary-facies succession in space and the simultaneity of environmental changes in time, 25 third-order sequences could be discerned in the Upper Paleozoic strata in the Dianqiangui basin and its adjacent areas. On the basis of the two kinds of facies-changing surfaces and the two kinds of diachronisms in stratigraphic records, the regional Late Paleozoic sequence-stratigraphic framework in the Dianqiangui basin and its adjacent areas can be established. There are two types of facies-changing surfaces and two types of diachronisms in stratigraphic records: the static type, a result of the change in sedimentary facies in space, and the dynamic type, a result of the change in time. These two types of facies-changing surfaces led to the generation of the two types of diachronisms: the diachronism of facies-changing surfaces that was formed by the static facies-changing surfaces, and the diachronism of punctuated surfaces that was formed by the dynamic facies-changing surfaces. The two types of facies-changing surfaces and the two types of diachronisms in stratigraphic records are the key to the establishment of the sequence-stratigraphic framework. The sequence boundaries could be divided geologically into four types: tectonic unconformity, sedimentary unconformity, drowned unconformity and their correlative surfaces. All of these four types can be further grouped into exposed punctuated surfaces and deepened punctuated surfaces. The tectonic unconformity is similar to Type Ⅰ sequence boundary, and the sedimentary unconformity is similar to Type Ⅱ sequence boundary defined by Vail et al.. In terms of sequence stratigraphy, the tectonic unconformities of the Ziyun movement, the Qiangui epeirogeny and the Dongwu revolution as well as the drowned unconformity in the transitional period from the Permian to the Triassic can be systematically defined and their geological characteristics are briefly presented.
基金Project supported by the National Natural Science Foundation of China (Grant No 60477026).
文摘This paper investigates the adjacent interactions of three novel solitons for the quintic complex Ginzburg-Landau equation, which are plain pulsating, erupting and creeping solitons. It is found that different performances are presented for different solitons due to isolated regions of the parameter space where they exist. For example, plain pulsating and erupting solitons exhibit mutual annihilation during collisions with the decrease of total energy, but for creeping soliton, the two adjacent pulses present soliton fusion without any loss of energy. Otherwise, the method for restraining the interactions is also found and it can suppress interactions between these two adjacent pulses effectively.
基金National Basic Research Program of China, No.2002CB412401 National Natural Science Foundation of China, No.40506022+1 种基金 No.40506013 Natural Science Foundation of Jiangsu Province, No.BK2006131
文摘The spatial distribution patterns of total organic carbon and total nitrogen show significant correlations with currents of the East China Sea Shelf. Corresponding to distributions of these currents, the study area could be divided into four different parts. Total organic carbon, total nitrogen, and organic carbon and nitrogen stable isotopes in sediments show linear correlations with mean grain size, respectively, thus "grain size effect" is an important factor that influences their distributions. C/N ratios can reflect source information of organic matter to a certain degree. In contrast, nitrogen stable isotope shows different spatial distribution patterns with C/N and organic carbon stable isotope, according to their relationships and regional distributions. The highest contribution (up to 50%) of terrestrial organic carbon appears near the Changjiang Estuary with isolines projecting towards northeast, indicating the influence of the Changjiang dilution water. Terrestrial particulate organic matter suffers from effects of diagenesis, benthos and incessant inputting of dead organic matter of plankton, after depositing in seabed. Therefore, the contribution of terrestrial organic carbon to particulate organic matter is obviously greater than that to organic matter in sediments in the same place.
基金Supported by the NNSF of China(10771091)Supported by the Qinglan Project of Lianyungang Teacher’s College(2009QLD3)
文摘Let G(V, E) be a simple connected graph and k be positive integers. A mapping f from V∪E to {1, 2, ··· , k} is called an adjacent vertex-distinguishing E-total coloring of G(abbreviated to k-AVDETC), if for uv ∈ E(G), we have f(u) ≠ f(v), f(u) ≠ f(uv), f(v) ≠ f(uv), C(u) ≠C(v), where C(u) = {f(u)}∪{f(uv)|uv ∈ E(G)}. The least number of k colors required for which G admits a k-coloring is called the adjacent vertex-distinguishing E-total chromatic number of G is denoted by x^e_(at) (G). In this paper, the adjacent vertexdistinguishing E-total colorings of some join graphs C_m∨G_n are obtained, where G_n is one of a star S_n , a fan F_n , a wheel W_n and a complete graph K_n . As a consequence, the adjacent vertex-distinguishing E-total chromatic numbers of C_m∨G_n are confirmed.
基金supported by a geological survey project of the China Geological Survey (No.1212011140013, No.12120113009800)
文摘The Wenchuan earthquake has altered the crustal motion characteristics in the eastern margin of the Tibetan Plateau and adjacent regions.Using discontinuous GPS survey data for 2008–2012, the velocity field for the Eurasia reference framework has been obtained, and the general trend of contemporary crustal motion after the occurrence of the Wenchuan earthquake has been studied.In addition, using the velocity field, the block movement velocity has been estimated by least-squares fitting.Furthermore, the properties and displacement rates of main faults have been obtained from the differences in velocity vectors of the blocks on both sides of the faults.The results reveal that there are no obvious changes in the general characteristics of crustal motion in this area after the Wenchuan earthquake.The earthquake mainly changed the rate of the movement of the Chuan-Qing block and caused variation in the movement direction of the South China block.The effect of the earthquake on faults is mainly reflected in variations in fault displacement velocity; there is no fundamental change in the properties of fault activity.The displacement rates of the Xianshuihe fault decreased by 3–4 mm/a, the Longmenshan fault increased by 9–10 mm/a, and the northern segment of the Anninghe fault increased by approximately 9 mm/a.Furthermore, the displacement rates of the Minjiang, Xueshan, Huya, Longquanshan, and Xinjin faults increased by 2–3 mm/a.This implies that the effects of the Wenchuan earthquake on crustal movement can mainly be observed in the Chuan-Qing, South China, and N-Chuan-Dian blocks and their internal faults, as well as the Xianshuihe and Longmenshan faults and the northern section of the Anninghe fault.The reason for this is that the Wenchuan earthquake disturbed the kinematic and dynamic balance in the region.
基金Supported by the Ministry of Science and Technology,Taiwan,No.MOST 104-2314-B-016-010-MY2 and No.MOST 106-2320-B-016-018the Ministry of National Defense,Taiwan,No.MAB-107-075,No.MAB-108-057and No.MAB-109-061
文摘BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis.Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer(CRC).AIM To estimate whether a methylation gene panel in different clinical stages can reflect a different prognosis.METHODS We enrolled 120 CRC patients from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select six genes involved in carcinogenesis pathways.Patients were divided into two groups based on the methylation status of the six evaluated genes,namely,the<3 aberrancy group and≥3 aberrancy group.Various tumor stages were divided into two subgroups(local and advanced stages)on the basis of the pathological type of the following tissues:Tumor and adjacent normal tissues(matched normal).We assessed DNA methylation in tumors and adjacent normal tissues from CRC patients and analyzed the association between DNA methylation with different cancer stages and the prognostic outcome including time to progression(TTP)and overall survival.RESULTS We observed a significantly increasing trend of hazard ratio as the number of hypermethylated genes increased both in normal tissue and tumor tissue.The 5-year TTP survival curves showed a significant difference between the≥3 aberrancy group and the<3 aberrancy group.Compared with the<3 aberrancy group,a significantly shorter TTP was observed in the≥3 aberrancy group.We further analyzed the interaction between CRC prognosis and different cancer stages(local and advanced)according to the methylation status of the selected genes in both types of tissues.There was a significantly shorter 5-year TTP for tumors at advanced stages with the promoter methylation status of selected genes than for those with local stages.We found an interaction between cancer stages and the promoter methylation status of selected genes in both types of tissues.CONCLUSION Our data provide a significant association between the methylation markers in normal tissues with advanced stage and prognosis of CRC.We recommend using these novel markers to assist in clinical decision-making.