While influenza remains a major threat to public health, researchers continue to search for a universal solution to improving the efficacy of the influenza vaccine. Even though influenza affects people of all differen...While influenza remains a major threat to public health, researchers continue to search for a universal solution to improving the efficacy of the influenza vaccine. Even though influenza affects people of all different ages, it can be extremely hazardous to people of 65 years of age or older since that is the population that makes up the high majority of the death toll caused by influenza-related diseases. Elderly individuals suffer the effects of immunosenescence as they age, which is the diminishing of the overall immune response. Immunosenescence occurs by specifically affecting the adaptive immune response which controls the establishment of immunity after vaccination or infection. There are many studies under way that are trying to find a resolution to the problem of the influenza vaccine not providing enough protection in the elderly population. One of the possible strategies is to seek the use of an optimal adjuvant, an immunological agent that can enhance immune responses, with the current vaccine formulation. Here, we used the murine model to review the effects of adjuvants on the antibody response to influenza vaccines in aged mice. Since adjuvants can enhance the production of important inflammatory cytokines and activation of dendritic cells, the stimulation of these cells are boosted to increase the effectiveness of the influenza vaccine in aged mice which would hopefully translate to the elderly.展开更多
Oligodeoxynucleotides(ODN)containing unmethylated CpG dinucleotides in contexts of unique sequence (CpG motifs)is active as adjuvant in induction of cellular and humoral immune responses in young mice.To date,there ar...Oligodeoxynucleotides(ODN)containing unmethylated CpG dinucleotides in contexts of unique sequence (CpG motifs)is active as adjuvant in induction of cellular and humoral immune responses in young mice.To date,there are only limited reports about effect of CpG ODN on immune responses against hepatitis B(HB) infection in aged mice.Our studies demonstrated there were significant increases in secreting of total anti-HB IgG,IgG1 and IgG2a,as well as of IL-12 and IFN-γ,when CpG ODNs were injected together with hepatitis B antigen in aged mice.Moreover,CpG ODN could stimulate proliferation of spleen lymphocytes in a dose-dependent manner.Taken together,the results we obtained indicate that the adding of CpG ODN into the vaccine antigen might be useful in development of more effective vaccination for inducing anti-HB virus responses in the elderly.Cellular & Molecular Immunology.2004;1(2):148-152.展开更多
文摘While influenza remains a major threat to public health, researchers continue to search for a universal solution to improving the efficacy of the influenza vaccine. Even though influenza affects people of all different ages, it can be extremely hazardous to people of 65 years of age or older since that is the population that makes up the high majority of the death toll caused by influenza-related diseases. Elderly individuals suffer the effects of immunosenescence as they age, which is the diminishing of the overall immune response. Immunosenescence occurs by specifically affecting the adaptive immune response which controls the establishment of immunity after vaccination or infection. There are many studies under way that are trying to find a resolution to the problem of the influenza vaccine not providing enough protection in the elderly population. One of the possible strategies is to seek the use of an optimal adjuvant, an immunological agent that can enhance immune responses, with the current vaccine formulation. Here, we used the murine model to review the effects of adjuvants on the antibody response to influenza vaccines in aged mice. Since adjuvants can enhance the production of important inflammatory cytokines and activation of dendritic cells, the stimulation of these cells are boosted to increase the effectiveness of the influenza vaccine in aged mice which would hopefully translate to the elderly.
基金supported by the natural science foundation of Guangdong (NO.000754).
文摘Oligodeoxynucleotides(ODN)containing unmethylated CpG dinucleotides in contexts of unique sequence (CpG motifs)is active as adjuvant in induction of cellular and humoral immune responses in young mice.To date,there are only limited reports about effect of CpG ODN on immune responses against hepatitis B(HB) infection in aged mice.Our studies demonstrated there were significant increases in secreting of total anti-HB IgG,IgG1 and IgG2a,as well as of IL-12 and IFN-γ,when CpG ODNs were injected together with hepatitis B antigen in aged mice.Moreover,CpG ODN could stimulate proliferation of spleen lymphocytes in a dose-dependent manner.Taken together,the results we obtained indicate that the adding of CpG ODN into the vaccine antigen might be useful in development of more effective vaccination for inducing anti-HB virus responses in the elderly.Cellular & Molecular Immunology.2004;1(2):148-152.