Adjustment of Administrative Divisions and Upgrading of Industrial Structure in Hefei Metropolitan Area:Taking"Partitions of Chaohu"as a Quasi-natural Experiment

Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.

Intranasal administration of stem cell-derived exosomes for central nervous system diseases

Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular communication.These nanosized vesicles transport internalized proteins,mRNA,miRNA,and other bioactive molecules.Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders.These exosomes exhibit multifaceted properties including antiapoptotic,anti-inflammatory,neurogenic,and vasculogenic effects.Furthermore,exosomes offer several advantages over stem cell therapy,such as high preservation capacity,low immunogenicity,the ability to traverse the blood-brain barrier,and the potential for drug encapsulation.Consequently,researchers have turned their attention to exosomes as a novel therapeutic avenue.Nonetheless,akin to the limitations of stem cell treatment,the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application.To overcome this hurdle,intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system.By exploiting the olfactory and trigeminal nerve axons,this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier.Notably,exosomes,owing to their small size,can readily access the nerve pathways using this method.As a result,intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments.In this comprehensive review,we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases.Furthermore,we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

Exploring Paths for Substantive Settlement of Administrative Disputes:An Empirical Analysis Based on Practice in Weiyuan County,Sichuan Province

As an effective means of addressing social contradictions,the substantive settlement of administrative disputes refers to the timely,impartial,and effective handling of such disputes.It embodies the essence of the modern governance system enabled by the principles and methodologies of the rule of law.Administrative reconsideration,the main channel for settling administrative disputes,is an inevitable consequence of its effective role in settling such disputes.The efficient adjudication of administrative litigation is an indispensable prerequisite for achieving the substantive settlement of administrative disputes,while the diverse approaches employed in settling these disputes contribute to achieving source governance of such disputes.Along with the efficient adjudication of administrative litigation and the multiple approaches to settling administrative disputes,the effectiveness of administrative reconsideration decisions constitutes a comprehensive system that ensures the substantive settlement of administrative disputes.

Oral administration microrobots for drug delivery

Oral administration is the most simple, noninvasive, convenient treatment. With the increasing demands on thetargeted drug delivery, the traditional oral treatment now is facing some challenges: 1) biologics how toimplement the oral treatment and ensure the bioavailability is not lower than the subcutaneous injections;2)How to achieve targeted therapy of some drugs in the gastrointestinal tract? Based on these two issues, drugdelivery microrobots have shown great application prospect in oral drug delivery due to their characteristics offlexible locomotion or driven ability. Therefore, this paper summarizes various drug delivery microrobotsdeveloped in recent years and divides them into four categories according to different driving modes: magneticcontrolleddrug delivery microrobots, anchored drug delivery microrobots, self-propelled drug delivery microrobotsand biohybrid drug delivery microrobots. As oral drug delivery microrobots involve disciplines such asmaterials science, mechanical engineering, medicine, and control systems, this paper begins by introducing thegastrointestinal barriers that oral drug delivery must overcome. Subsequently, it provides an overview of typicalmaterials involved in the design process of oral drug delivery microrobots. To enhance readers’ understanding ofthe working principles and design process of oral drug delivery microrobots, we present a guideline for designingsuch microrobots. Furthermore, the current development status of various types of oral drug delivery microrobotsis reviewed, summarizing their respective advantages and limitations. Finally, considering the significantconcerns regarding safety and clinical translation, we discuss the challenges and prospections of clinical translationfor various oral drug delivery microrobots presented in this paper, providing corresponding suggestions foraddressing some existing challenges.

Succession Plan for Nursing Academic Program Administrators

Leadership succession in nursing academic programs poses a significant challenge, primarily due to the limited availability of professionals with the competencies required for effective leadership [1]. This study aims to address this gap by investigating the critical factors in succession planning for nursing program administrators. The research objectives include identifying the competencies necessary for academic administrators, assessing the experience of current administrators, and developing a comprehensive succession plan framework. The research uses qualitative methods, including literature review, interviews with nursing administrators, and analysis of existing succession models. Results highlight the importance of integrating strategic planning into succession processes to ensure smooth transitions and organizational stability. Conclusions suggest that a formalized succession plan, incorporating mentorship and leadership development, can mitigate leadership gaps in nursing academia [2].

Analysis of the Standardization of Administrative Management in Colleges and Universities Under the Background of Information Technology

In the development of the information age,universities should recognize the significant impact of information technology on their own development.In practice,it is possible to effectively improve the efficiency and quality of work by dealing with and constructing information-based methods,innovating administrative management models,and adopting more efficient and scientific methods to address various problems and shortcomings encountered in work.As an important part of university management,administrative management is a complex task.Establishing a standardized management model through information technology can further improve the comprehensive efficiency of administrative management.In this regard,the administrative standardization in universities under the background of information technology is analyzed and studied in this paper.

Comparison of administrative and regulatory green technologies development between China and the U.S.based on patent analysis

With the increasing importance of computer intelligence in the new round of the industrial revolution,administrative,regulatory,or design(ARD)green technology contributes to improving national technological competitiveness and promoting the transformation of green technology,which is becoming an important field under sustainable development goals.The U.S.and China ranked top two in terms of paper influence and patent applications in the field of ARD green technology.However,few comparative studies have been conducted in these two countries.This study presents the evolution and landscapes of ARD green technology between China and the U.S.,focusing on comparing development priorities and technical layouts in each five-year plan period.According to the“International Patent Classification(IPC)Green Inventory”launched by the World Intellectual Property Organization(WIPO),we retrieved 69,412 patents published between 2001 and 2020 from the PatSnap database.Descriptive,content,and thematic network analyses were conducted using latent dirichlet allocation(LDA)and community detection algorithms.The results show that both China and the U.S.strategically focus on ARD green technology development.The technical topics in this field can be divided into three themes:data processing systems,traffic control systems,and building designs.The emphasis on technology research and development(R&D)differs between China and the U.S.There is also evidence that the U.S.has advantages in terms of technological innovation and capabilities.However,China has an advantage in terms of data volume,and the gap between China and the U.S.is gradually narrowing.We also highlight the contributions and limitations of this study.

The Development Trend of Enterprise Business Administration and the Innovation of Management Mode

In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting substantial challenges.The intensification of market competition exerts development pressure on many enterprises,and coupled with the unstable strength of some businesses,numerous problems in business management arise.These issues hinder the smooth execution of various business activities.Therefore,it is crucial to ensure effective business administration to conduct different business activities in an orderly manner,promptly avoid adverse risks,and strengthen control over multiple factors.The innovation and improvement of business administration are of great significance for enhancing the management level and market competitiveness of modern enterprises,accelerating their healthy development,and creating numerous opportunities.Consequently,this paper analyzes and explores the development trends of enterprise business administration and the innovation of management models for reference.

Exploring Corporate Tax Compliance in the Era of Digital Tax Collection and Administration:Insights from the“Golden Tax Phase Four”Project

This article primarily examines the current state of tax collection and management,alongside other associated issues.It integrates insights from China’s“14th Five-Year Plan”and anticipates the imminent implementation of the“Golden Tax Phase Four.”With this backdrop,the article offers recommendations for advancing the reform of the tax collection and management system,fostering the development of intelligent taxation,and accelerating the modernization of tax collection and management in China.

Administrative Urbanization and City-making in Post-reform China: A Case Study of Ordos City, Inner Mongolia

In post-reform China, local governments, instead of the central state, have become major promoters of urbanization. Differing from the existing literature based on Western theories, this article argues that a localized perspective, ‘administrative urbanization', can provide a contextual explanation for the mechanism of urbanization in the reform era. The case study of Ordos indicates that new town construction, especially in the inland area, has become the main strategy for investment attraction and economic development. The local government has played a dominant role in this construction through a series of administrative measures, including avoidance of central state regulations, land leasing, high standard infrastructure construction, relocation policies and industrial attraction. This article also explores the issue of unsustainability in the new town, and identifies that underdeveloped industrialization, slow population agglomeration and real estate bubbles are primary threats to the sustainability of administrative urbanization.

Evolutionary Pattern and Effect of Administrative Division Adjustment During Urbanization of China:Empirical Analysis on Multiple Scales

The adjustment of administrative divisions is one of the important factors guiding China's urbanization, which has profound economic and social effects for regional development. In this paper, we comprehensively describe the process of the adjustment of administrative divisions at provincial and municipal levels in China and summarize the effects on the basic structure and patterns of the spatial development. We quantitatively assess the effects on fields such as urbanization and social economy through the use of multidimensional scaling. The results show that: 1) Upgrading county to municipality(or city-governed district) is the main way of adjusting the administrative divisions. It is also an important factor in the spatial differentiation of interprovincial urbanization. China's population urbanization can be divided into four patterns including interprovincial migration, provincial migration, natural growth, and growth caused by the adjustment of administrative divisions, which is also the main reason for the increased Chinese urbanization rate at the provincial level. 2) Taking the city of Beijing as an example, we generalize five adjustment patterns made to administrative divisions: the set-up of sub-districts, the set-up of regional offices, the upgrading of townships to sub-districts, the upgrading of townships to towns, and the set-up of towns and the addition of new regional offices. We summarize the municipal urban spatial structure, including the sub-district office area in the central urban area, the regional office area in the new urban area, the mixed area of villages, towns, and sub-district offices in the suburb area, and the township area in the outer suburb area. 3) The adjustment of administrative divisions triggers a significant circulative accumulation effect, resulting in the spatial locking of population and industrial agglomeration. It affects the evolution of the urban spatial form and plays an important role in shaping the urban spatial structure to move to the characteristic of multicenter. In general, the adjustment of administrative divisions was an important factor affecting the inflated statistical level of urbanization and also an important driving force for the evolution of Chinese urban spatial organization structure.

Circumstance of endoscopic and laparoscopic treatments for gastric cancer in Japan: A review of epidemiological studies using a national administrative database

Currently, endoscopic submucosal dissection(ESD) and laparoscopic gastrectomy(LG) have become widely accepted and increasingly play important roles in the treatment of gastric cancer. Data from an administrative database associated with the diagnosis procedure combination(DPC) system have revealed some circumstances of ESD and LG in Japan. Some studiesdemonstrated that medical costs or length of stay of patients receiving ESD for gastric cancer had become significantly reduced while length of hospitalization and costs were significantly increased in older patients. With respect to LG, some recent reports have shown that this has been a cost-beneficial treatment for patients compared with open gastrectomy while simultaneous LG and cholecystectomy is a safe procedure for patients with both gastric cancer and gallbladder stones. These epidemiological studies using the administrative database in the DPC system closely reflect clinical circumstances of endoscopic and surgical treatment for gastric cancer in Japan. However, DPC database does not contain detailed clinical data such as histological types and lesion size of gastric cancer. The link between the DPC database and another detailed clinical database may be vital for future research into endoscopic and laparoscopic treatments for gastric cancer.

Administrative Patent Enforcement in China

China is one of the major markets for patent filing and patent exploitation.A powerful enforcement environment may boost both of patent filing and exploitation.A two-track system for the patent enforcement is available in China:the administrative system via local intellectual property offices,and the judicial system via courts.

Spheres of Urban Influence and Factors in Beijing-Tianjin-Hebei Metropolitan Region Based on Viewpoint of Administrative Division Adjustment

The coordinated development of Beijing, Tianjin and Hebei has been elevated as China's important strategy. And, the priority in considering how to bring the maximum effect of their coordinated development into play is to delineate the spheres of urban influence with regard to the cities in the Beijing-Tianjin-Hebei Metropolitan Region. By building an evaluation index system of urban comprehensive strength, this paper applies the principal component analysis method to determine centrality strength of the cities, and the breakpoint theory and weighted Voronoi diagram to identify the spheres of urban influence in all central cities of the region. Results show that 13 central cities within the region greatly differ in strength, which can be classified into four tiers and that the spheres of urban influence do not have a high goodness of fit with administrative jurisdiction scope. Cities like Beijing, Tianjin, Shijiazhuang and Handan have larger spheres of urban, spheres of urban influence in Tangshan and Qinhuangdao are basically consistent with their administrative jurisdiction scopes, and seven cities including Langfang and Baoding have smaller spheres of urban influence. So according to these cities' comprehensive strength and spheres of influence, the region can be divided into five plates: Beijing, Tianjin, Shijiazhuang, Tangshan and Handan. The major influence factors for inconsistency between spheres of urban influence and spheres of jurisdiction include difference in urban administrative ranking, small number of central cities with weak strength, discrepancy in the number of counties under jurisdiction, unreasonable spheres of jurisdiction and diversity in topographical conditions. In order to solve the imbalance in the spheres of urban influence and those of jurisdiction and better facilitate the coordinated development of the region, it is advised to adjust administrative areas so as to obtain more optimized urban spatial layout and more reasonable urban scale hierarchy system.

Survival and comorbidities in lung cancer patients:Evidence from administrative claims data in Germany

Lung cancer is the most common cancer type worldwide and has the highest and second highest mortality rate for men and women respectively in Germany.Yet,the role of comorbid illnesses in lung cancer patient prognosis is still debated.We analyzed administrative claims data from one of the largest statutory health insurance(SHI)funds in Germany,covering close to 9 million people(11%of the national population);observation period was from 2005 to 2019.Lung cancer patients and their concomitant diseases were identified by ICD-10-GM codes.Comorbidities were classified according to the Charlson Comorbidity Index(CCI).Incidence,comorbidity prevalence and survival are estimated considering sex,age at diagnosis,and place of residence.Kaplan Meier curves with 95%confidence intervals were built in relation to common comorbidities.We identified 70,698 lung cancer incident cases in the sample.Incidence and survival figures are comparable to official statistics in Germany.Most prevalent comorbidities are chronic obstructive pulmonary disease(COPD)(36.7%),followed by peripheral vascular disease(PVD)(18.7%),diabetes without chronic complications(17.4%),congestive heart failure(CHF)(16.5%)and renal disease(14.7%).Relative to overall survival,lung cancer patients with CHF,cerebrovascular disease(CEVD)and renal disease are associated with largest drops in survival probabilities(9%or higher),while those with PVD and diabetes without chronic complications with moderate drops(7%or lower).The study showed a negative association between survival and most common comorbidities among lung cancer patients,based on a large sample for Germany.Further research needs to explore the individual effect of comorbidities disentangled from that of other patient characteristics such as cancer stage and histology.

Effects of China's Administrative Approval Reforms on Transaction Cost and Economic Growth

China＇s economic growth miracle despite complicated administrative approval formalities prompted us to raise the following question： ls it true that reforming administrative approval will promote economic growth？ Based on our analysis on market entry, we discovered that reforming administrative approval will spur economic growth by reducing transaction cost for firms. Administrative approval may suppress social cost and propel China＇s economic growth; China＇s gradualist approval reforms may indeed propel economic growth by reducing transaction cost for firms. With the data of prefecture-level cities during 2000-2013 and data of companies listed on the SME board during 2010-2014, we tested the effects of approval reforms on economic growth and on transaction cost, and employed instrumental variable and PSM for the treatment of the endogeneity problem - all these tests led to robust and consistent results. Moreover, we discovered that difference in government policy implementation in the approval process is the root cause of corruption and rent seeking.

Evaluation of Daylighting and Thermo-EnergeticPerformance in Administrative Building in the South ofBrazil

Daylight is a fundamental element to obtain built environments that promote environmental comfort and energy efficiency. However, strategies that enhance the building daylight performance can affect its thermal energetic performance. In this sense, research that addresses these aspects at the same time is considered essential. The objective of this paper was to evaluate the daylighting and thermal-energetic performance of administrative environments in a public institution, and to propose strategies that will enhance the use of daylight and lower energy consumption. Therefore, for future projects, and considering new buildings, and retrofit, this research will be an important reference. The research was developed through a case study of an administrative building model, in which the characteristics of solar orientation, light shelf use, glass type, and light and dark colors in walls were modified and combined, deriving it into models proposed. The daylighting performance evaluations were performed through dynamic simulation with the Rhinoceros for Diva software, and the thermal-energetic performance evaluations with the EnergyPlus software. The results of the work showed that a suitable solar orientation has a great impact on the automation of daylight and the energy consumption of the evaluated models, followed by the type of glass and the use of the light colors in internal walls, and that the use of artificial lighting with dimerization is fundamental as a complement to the daylight autonomy. For the boundary conditions of the study, the use of light shelves modified neither the daylight performance nor the thermal-energetic performance of the evaluated models.

Wildlife Export Quota and Its Administrative System

The authors discussed the administrative system of export quota and its method of calculation in the international wildlife trade. Three methods for determining wildlife export quota in China was put forvvard, based on the trend and status, domestic use, and historical export of wildlife resources. They include the single factor method, the double factor method, and the multiple faCtor method. In addition, the approaches and measures to establish and carry out the administrative system of wildlife export quota in China were discussed in this paper.

Emergency medicine residencies structure of trainees'administrative experience:A cross-sectional survey

BACKGROUND:While the Accreditation Council for Graduate Medical Education(ACGME)mandates that emergency medicine residencies provide an educational curriculum that includes administrative seminars and morbidity and mortality conference,there is significant variation as to how administrative topics are implemented into training programs.We seek to determine the prevalence of dedicated administrative rotations and details about the components of the curriculum.METHODS:In this descriptive study,a 12-question survey was distributed via the CORD listserv;each member program was asked questions concerning the presence of an administrative rotation and details about its components.These responses were then analyzed with simple descriptive statistics.RESULTS:A total of 114 of the 168 programs responded,leading to a 68%response rate.Of responders,73%have a dedicated administrative rotation(95%CI 64.0 to 80.4).The content areas covered by the majority of programs with a dedicated program include performance improvement(n=68),patient safety(n=64),ED operations(n=58),patient satisfaction(n=54),billing and coding(n=47),and inter-professional collaboration(n=43).Experiential learning activities include review of patient safety reports(n=66)and addressing patient complaints(n=45).Most of the teaching on the rotation is either in-person(n=65)and/or self-directed reading assignments(n=48).The most commonly attended meetings during the rotation include performance improvement(n=60),ED operations(n=59),and ED faculty(n=44).CONCLUSION:This paper provides an overview of the most commonly covered resident administrative experiences that can be a guide as we work to develop an ideal administrative curriculum for EM residents.

Administrative division system changes and urbanization in China

s—This paper ana1yses the relationship between the administrative division system changes (ADSC) and the urbanization process in China, especially in Guangdong Province since the 1980s. It points out that there are three high tides in ADSC since the 1980s relevant to the changes of economic development. The guiding principle for ADSC is to give local government incentives by transferring more administrative powers to them and bringing along regional development by central city. This paper also discusses problems existed and future prospectives.