Wildlife Export Quota and Its Administrative System

The authors discussed the administrative system of export quota and its method of calculation in the international wildlife trade. Three methods for determining wildlife export quota in China was put forvvard, based on the trend and status, domestic use, and historical export of wildlife resources. They include the single factor method, the double factor method, and the multiple faCtor method. In addition, the approaches and measures to establish and carry out the administrative system of wildlife export quota in China were discussed in this paper.

Integration of GIS in the Development of an Environmental Cadastre Administrative System for the Environment Protection Agency Sierra Leone

The Environment Protection Agency Sierra Leone (EPA) is mandated by law to issue Environmental Impact Assessment license. Currently the agency achieves this mandate by issuing environmental licenses manually which always encountered lot of problems of accountability and transparency of the management of environmental licenses and assessment documentation. Client’s information and documentation is usually mixed up while carrying files from one point to the other or from one staff to another. Data on client are stored in a way which makes it difficult for the management to retrieve useful information on time. This paper explores these challenges faced by the manual system of issuing environmental licenses and infer solutions to the current challenges by integrating a Geographic Information Systems (GIS) to develop an Environmental Cadastre administrative System (ECAS) which establishes a web-based information repository database developed with open sources software (Java, PHP, MySQL, QGIS) that published revenues online and made the data available to stakeholders and/or the public to complete the cycle of accountability and transparency. The information is presented and downloadable in a comprehensible and user-friendly manner, which in turn improves monitoring and reporting, and increases effectiveness and accountability of the management of environmental licenses and assessment documentation. The findings show these challenges facing the manual system, the back and forth between EPA and the client in the EIA process, the difficulty in the searching a client record, the mixing up of Client’s information and documentation by carrying files from one point to the other, and the storage of data on client in a way which makes it difficult for the management to retrieve useful information on time, and lack of back up when data or information is lost. Problems encountered in the time-consuming nature of the manual retrieval of files and preparation of prompt and accurate reports make it become a difficult task to accomplish as data and information are difficult to retrieve or collect from various files. Based on these findings, this paper provides the possible solution to the above problems. An online Environmental Cadastre administrative System (ECAS) which establishes a web-based information repository database was designed to capture the full lifecycle of environmental licenses including all stages of monitoring, licenses and payments and seamlessly manage the environmental impact assessment (EIA) licenses.

China's Reform on Administrative System

Five Features of China’s Reform on Administrative System China started with the great historic process of Reform and Open-up more than 30 years ago.Since them,reform on China’s administrative system has been under way.To sum up the course of 30 odd years,the features of China’s reform on administrative system are as follows.First,as China’s reform made its first breakthrough in rural areas,

Establishing Government Administrative System On Auto-Products To Harmonize With Commonly-Used Systems Over The World

The first Industrial Policy of China in 90’s——The Industrial Policy of Motor Industry was isaued on July 4, 1994. It was the first time for Chinese Central Government to launch in this policy the supervision and management system over auto products (include motorcycle) relating to safety, emission control and energy-saving

Intranasal administration of stem cell-derived exosomes for central nervous system diseases

Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular communication.These nanosized vesicles transport internalized proteins,mRNA,miRNA,and other bioactive molecules.Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders.These exosomes exhibit multifaceted properties including antiapoptotic,anti-inflammatory,neurogenic,and vasculogenic effects.Furthermore,exosomes offer several advantages over stem cell therapy,such as high preservation capacity,low immunogenicity,the ability to traverse the blood-brain barrier,and the potential for drug encapsulation.Consequently,researchers have turned their attention to exosomes as a novel therapeutic avenue.Nonetheless,akin to the limitations of stem cell treatment,the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application.To overcome this hurdle,intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system.By exploiting the olfactory and trigeminal nerve axons,this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier.Notably,exosomes,owing to their small size,can readily access the nerve pathways using this method.As a result,intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments.In this comprehensive review,we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases.Furthermore,we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

Information Network Systems and Information Sharing on Administrative Websites

In Japanese 'e-government' policy, called 'e-Japan', the 'administrative document management system' is functioning as information searching systems. On the other hand, this system has also generated the problem that it is not fully functioning as a means for the information sharing in a governmental agency. So, the purpose of this research is to find how the administrative document management system can function as information sharing in administrative organization. For this purpose, this paper considers the current status and some problems firstly. And secondary, this paper proposes the idea and constructs some information systems using administrative official Website. This is the method and approach of this research. As a conclusion, this proposal information system junctions as information sharing support systems.

Administrative division system changes and urbanization in China

s—This paper ana1yses the relationship between the administrative division system changes (ADSC) and the urbanization process in China, especially in Guangdong Province since the 1980s. It points out that there are three high tides in ADSC since the 1980s relevant to the changes of economic development. The guiding principle for ADSC is to give local government incentives by transferring more administrative powers to them and bringing along regional development by central city. This paper also discusses problems existed and future prospectives.

On the Administrative Litigation and Reconciliation System in China

With the development of our society, the object and scope of government＇ s administrative function are expanding day by day.Facing the complicated new situation, new problem and the enhancement of the rule of law, the difficulty of hearing the administrative case isincreasing. This article mainly analyzes the present situation of the reconciliation of administrative litigation, discusses how to construct ourcountry＇ s administrative litigation reconciliation system, promote the administrative trial work smoothly, and better protect the legitimate rightsand interests of the parties.

Studies on Administrative Service Standards System Construction and Application in Tai’An

This paper studies the administrative service standards system construction and application in Tai＇An, China＇s first administrative service standardization demonstration city, proposes a new way for local government to strengthen self-improvement and elevate the public satisfacton level, and provides important technical support for service-oriented governmental administration mode explorations.

Local Administrative System of the Third Dynasty of Ur and its Characteristics of the Partition of Military and Civilian Affairs

Owing to the rather peaceful unifi cation policy of the Third Dynasty of Ur,the old aristocracy enjoyed a variety of political and social rights,playing signifi cant infl uence on the local administrative system at the beginning.In order to strengthen centralization and control,the kings gradually selected and appointed several foreign military officials to balance these old aristocratic networks.As a result,a separate management of military and civilian affairs in the local administrative system of the Third Dynasty of Ur appeared.By counterbalancing military offi cers and civilian offi cials,the political situation of the Third Dynasty of Ur became relatively stable.Nevertheless,the old aristocracy was not exterminated,and the military offi cials slowly became powerful,too.This resulted in a gradual weakening of the king’s rule and eventually led to a collapse of whole dynasty.

The Differences between County,County-level City and Municipal District in the System of Administrative Divisions in China

Administrative division is an important means of political power reorganization and management,resource integration and optimal allocation,which profoundly shapes the spatial layout of urban development in China.To clarify and compare differences between counties,county-level cities and municipal districts is the primary premise for the study of administrative division and urban development.This paper analyzes the institutional differences between counties and county-level cities,as well as counties,county-level cities and municipal districts,from the aspects of organizational structure,urban construction planning,land management,finance,taxation and public services.The research shows that the establishment of counties,county-level cities and municipal districts adapt to different levels and stages of economic and social development,and the conversion from county to county-level city and the conversion from county(or county-level city)to municipal district are both important transformation ways to change their administrative systems,which has different management system and operation pattern.At the same time,the transformation of county-level administrative region is also a“double-edged sword”,we should think about the administrative system as a whole to decide whether it should be adjusted,and effectively respond to the actual needs of local economic and social development.

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance.Polysaccharidebased microneedles(PSMNs)have emerged as a transformative solution for ophthalmic drug delivery.However,a comprehensive review of PSMNs in ophthalmology has not been published to date.In this review,we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery.We provide a thorough analysis of PSMNs,summarizing the design principles,fabrication processes,and challenges addressed during fabrication,including improving patient comfort and compliance.We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios.Finally,we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

Adjustment of Administrative Divisions and Upgrading of Industrial Structure in Hefei Metropolitan Area:Taking"Partitions of Chaohu"as a Quasi-natural Experiment

Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.

Effects of estradiol-17β and bisphenol A administered chronically to mice throughout pregnancy and lactation on the male pups＇ reproductive system

Aim： To assess the effect of estradiol-17β （E2） and bisphenol A （BPA） administered chronically by implanting a silicone tube throughout pregnancy and lactation on male pups＇ reproductive system in ICR mice. Methods： Female mice were implanted with a tube filled with 10 ng, 500 ng, 1 μg, or 10 μg of E2, or 100 μg or 5 mg of BPA, before mating. The tube was kept in the mice throughout pregnancy and lactation, until the pups had weaned at 4 weeks of age. During the period, E2 was released from the tube at 120 pg or 6, 12 or 120 ng/day, and BPA at 1.2 or 60 μg/day. Results： Most of the mice given 1 μg and 10 lag of E2 did not maintain their pregnancy. However, the other groups showed high rates of birth, more than 70%. At age of 4 weeks, the male pups were killed. Body weight and reproductive organ weights （testes, epididymides and accessory reproductive glands） in the treated groups did not differ from the control values, whereas the percentage of seminiferous tubules in the testis with mature spermatids was significantly lower in the groups given 10 ng and 500 ng of E2 and 5 mg of BPA than that in the control. Conclusion： Chronic exposure to E2 and BPA might disrupt spermatogenesis in male pups. （Asian JAndrol 2008 Mar; 10： 271-276）

Administrative Urbanization and City-making in Post-reform China: A Case Study of Ordos City, Inner Mongolia

In post-reform China, local governments, instead of the central state, have become major promoters of urbanization. Differing from the existing literature based on Western theories, this article argues that a localized perspective, ‘administrative urbanization', can provide a contextual explanation for the mechanism of urbanization in the reform era. The case study of Ordos indicates that new town construction, especially in the inland area, has become the main strategy for investment attraction and economic development. The local government has played a dominant role in this construction through a series of administrative measures, including avoidance of central state regulations, land leasing, high standard infrastructure construction, relocation policies and industrial attraction. This article also explores the issue of unsustainability in the new town, and identifies that underdeveloped industrialization, slow population agglomeration and real estate bubbles are primary threats to the sustainability of administrative urbanization.

Evolutionary Pattern and Effect of Administrative Division Adjustment During Urbanization of China:Empirical Analysis on Multiple Scales

The adjustment of administrative divisions is one of the important factors guiding China's urbanization, which has profound economic and social effects for regional development. In this paper, we comprehensively describe the process of the adjustment of administrative divisions at provincial and municipal levels in China and summarize the effects on the basic structure and patterns of the spatial development. We quantitatively assess the effects on fields such as urbanization and social economy through the use of multidimensional scaling. The results show that: 1) Upgrading county to municipality(or city-governed district) is the main way of adjusting the administrative divisions. It is also an important factor in the spatial differentiation of interprovincial urbanization. China's population urbanization can be divided into four patterns including interprovincial migration, provincial migration, natural growth, and growth caused by the adjustment of administrative divisions, which is also the main reason for the increased Chinese urbanization rate at the provincial level. 2) Taking the city of Beijing as an example, we generalize five adjustment patterns made to administrative divisions: the set-up of sub-districts, the set-up of regional offices, the upgrading of townships to sub-districts, the upgrading of townships to towns, and the set-up of towns and the addition of new regional offices. We summarize the municipal urban spatial structure, including the sub-district office area in the central urban area, the regional office area in the new urban area, the mixed area of villages, towns, and sub-district offices in the suburb area, and the township area in the outer suburb area. 3) The adjustment of administrative divisions triggers a significant circulative accumulation effect, resulting in the spatial locking of population and industrial agglomeration. It affects the evolution of the urban spatial form and plays an important role in shaping the urban spatial structure to move to the characteristic of multicenter. In general, the adjustment of administrative divisions was an important factor affecting the inflated statistical level of urbanization and also an important driving force for the evolution of Chinese urban spatial organization structure.

Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 （FNDC5） protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue （WAT） and uncoupling protein I （UCP1） expression, leading to an increase in total body energy expenditure by augmented UCPl-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones, including growth plate, trabecular bone, cortical bone, articular cartilage, and bone-tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal （IP） administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-kB ligand （RANKL）- induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice.

Comparison of international mine reclamation bonding systems with recommendations for China

Mine reclamation bonds are used in countries with mineral mining to ensure that reclamation of the mined area is completed. The United States, Canada, and Australia are countries with established mine reclamation bond programs, with the United States coal system having been in place since 1977. China implemented a bonding system in 1998 and by 2013 all 31 provinces had established a system. An effective bonding system must be conditioned on fair and enforceable nationwide reclamation standard, stimulate companies to conduct reclamation by forming economic incentives rather than penalties that become a liability, and allow for full public participation. Based on these principles, this paper compares seven important factors for a successful reclamation bonding system： laws and regulations, administrative authority, bond types, bond size, calculation method, bond release, and public participation. The results show variation in policies and procedures for bonding among countries. Using principles and policies primarily from the United States, China should establish a national reclamation bonding system with legislation that forms a national authority to oversee and enforce reclamation standards and bond requirements. In addition, China can expand bond financial types and strategies, set the size of reclamation bonds at the level of a third-party reclamation cost, and set unified standards for calculation. Phased bond release should be established with specific reclamation criteria for each phase of release. Finally, bonding regulations should clearly identify opportunities for full public participation in the process.

Spheres of Urban Influence and Factors in Beijing-Tianjin-Hebei Metropolitan Region Based on Viewpoint of Administrative Division Adjustment

The coordinated development of Beijing, Tianjin and Hebei has been elevated as China's important strategy. And, the priority in considering how to bring the maximum effect of their coordinated development into play is to delineate the spheres of urban influence with regard to the cities in the Beijing-Tianjin-Hebei Metropolitan Region. By building an evaluation index system of urban comprehensive strength, this paper applies the principal component analysis method to determine centrality strength of the cities, and the breakpoint theory and weighted Voronoi diagram to identify the spheres of urban influence in all central cities of the region. Results show that 13 central cities within the region greatly differ in strength, which can be classified into four tiers and that the spheres of urban influence do not have a high goodness of fit with administrative jurisdiction scope. Cities like Beijing, Tianjin, Shijiazhuang and Handan have larger spheres of urban, spheres of urban influence in Tangshan and Qinhuangdao are basically consistent with their administrative jurisdiction scopes, and seven cities including Langfang and Baoding have smaller spheres of urban influence. So according to these cities' comprehensive strength and spheres of influence, the region can be divided into five plates: Beijing, Tianjin, Shijiazhuang, Tangshan and Handan. The major influence factors for inconsistency between spheres of urban influence and spheres of jurisdiction include difference in urban administrative ranking, small number of central cities with weak strength, discrepancy in the number of counties under jurisdiction, unreasonable spheres of jurisdiction and diversity in topographical conditions. In order to solve the imbalance in the spheres of urban influence and those of jurisdiction and better facilitate the coordinated development of the region, it is advised to adjust administrative areas so as to obtain more optimized urban spatial layout and more reasonable urban scale hierarchy system.