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Identification of adrafinil and its main metabolite modafinil in human hair.Self-administration study and interpretation of an authentic case 被引量:1
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作者 Alice Ameline Laurie Gheddar +1 位作者 Jean-Sébastien Raul Pascal Kintz 《Forensic Sciences Research》 CSCD 2020年第4期322-326,共5页
For several years,the misuse of stimulant substances is increasingly observed both in the field of sport,to improve the functions of the body and therefore to be more performant,and also by non-athletes to make life m... For several years,the misuse of stimulant substances is increasingly observed both in the field of sport,to improve the functions of the body and therefore to be more performant,and also by non-athletes to make life more tolerable on a daily basis.Adrafinil,2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide,is a drug designed for the treatment of narcolepsy by promoting an awakened state,and to treat alertness and neurological symptoms in the elderly.It is primarily metabolized in vivo to an active form,i.e.modafinil,2-((diphenylmethyl)sulfinyl)acetamide.The World Anti-Doping Agency(WADA)banned these two drugs in sports in 2004.The authors report an authentic case involving adrafinil and modafinil.The laboratory was requested to test for adrafinil in a hair strand collected from a woman found in posses-sion of vials of adrafinil and suspected of trafficking.A specific method was developed by liquid chromatography tandem mass spectrometry(LC-MS/MS).Unlike modafinil(varying from 6.8 to 13.9ng/mg),adrafinil was not identified in the strand.The interpretation of the results was difficult because this is the first case describing human hair analysis.In order to be able to interpret the results,a self-administration study was conducted after an oral administration to a volunteer(200 mg)whose beard hair was collected 10days after adminis-tration.The analysis of this specimen highlighted the presence of adrafinil at 0.8ng/mg and modafinil at 0.5 ng/mg.These results demonstrate the dual identification of both compounds after a single consumption,even after administration of a low dose.According to these results,the analysis of the hair strand from the authentic case does not match with a con-sumption of adrafinil,in accordance with abuse of modafinil alone.Intelligence considered that this was a trafficking case of adrafinil,with no self-consumption. 展开更多
关键词 Forensic sciences forensic toxicology adrafinil MODAFINIL human hair UPLC-MS/MS STIMULANTS
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阿屈非尼的合成和NMR研究 被引量:1
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作者 陆江海 王杉 +3 位作者 邓静 张亦农 吴侔天 张长久 《中国新药杂志》 CAS CSCD 北大核心 2005年第5期583-584,共2页
目的:合成阿屈非尼的2种异构体。方法:以二苯基甲醇和巯基乙酸为原料经4步反应合成目标产物,并对其进行~1H、^(13)C-NMR、~1H-~1HCOSY(氢-氢相关二维谱)、HMQC(氢核检测的异核多量子碳氢相关谱)和HMBC(氢核检测的异核多量子远程碳氢相关... 目的:合成阿屈非尼的2种异构体。方法:以二苯基甲醇和巯基乙酸为原料经4步反应合成目标产物,并对其进行~1H、^(13)C-NMR、~1H-~1HCOSY(氢-氢相关二维谱)、HMQC(氢核检测的异核多量子碳氢相关谱)和HMBC(氢核检测的异核多量子远程碳氢相关谱)等2D-NMR实验。结果:合成了阿屈非尼,4步反应总收率为49.2%。结论:首次报道了阿屈非尼的2种异构体氢谱和碳谱数据。新的合成方法为为阿屈非尼及其代谢物的研究提供了物质基础和理论依据。 展开更多
关键词 阿屈非尼 合成 核磁共振
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阿屈非尼的合成
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作者 徐杰 彭学东 +1 位作者 张梅 唐汝培 《中国医药工业杂志》 CAS CSCD 北大核心 2014年第10期910-912,共3页
二苯甲酮经还原得二苯甲醇,与巯基乙酸缩合得2-(二苯甲硫基)乙酸,再经双氧水氧化、甲醇酯化和盐酸羟胺酰胺化反应得到阿屈非尼,总收率约76%。
关键词 阿屈非尼 抗抑郁药 合成
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