During the whole life cycle of mammals, new neurons are constantly regenerated in the subgranular zone of the dentate gyms and in the subventricular zone of the lateral ventricles. Thanks to emerging methodologies, gr...During the whole life cycle of mammals, new neurons are constantly regenerated in the subgranular zone of the dentate gyms and in the subventricular zone of the lateral ventricles. Thanks to emerging methodologies, great progress has been made in the characterization of spinal cord endogenous neural stem cells （ependymal cells） and identification of their role in adult spinal cord development. As recently evidenced, both the intrinsic and extrinsic molecular mechanisms of ependymal cells control the sequential steps of the adult spinal cord neurogenesis. This review introduces the concept of adult endogenous neurogenesis, the reaction of ependymal cells after adult spinal cord injury （SCI）, the heterogeneity and markers of ependymal cells, the factors that regulate ependymal cells, and the niches that impact the activation or differentiation of ependymal ceils.展开更多
基金supported by the State Key Program of National Natural Science Foundation of China(31130022,31320103903,31271037)the National Science and Technology Pillar Program of China(2012BAI17B04)+2 种基金the International Cooperation in Science and Technology Projects of the Ministry of Science Technology of China(2014DFA30640)the National Ministry of Education Special Fund for Excellent Doctoral Dissertation(201356)the Special Funds for Excellent Doctoral Dissertation of Beijing,China(20111000601)
文摘During the whole life cycle of mammals, new neurons are constantly regenerated in the subgranular zone of the dentate gyms and in the subventricular zone of the lateral ventricles. Thanks to emerging methodologies, great progress has been made in the characterization of spinal cord endogenous neural stem cells （ependymal cells） and identification of their role in adult spinal cord development. As recently evidenced, both the intrinsic and extrinsic molecular mechanisms of ependymal cells control the sequential steps of the adult spinal cord neurogenesis. This review introduces the concept of adult endogenous neurogenesis, the reaction of ependymal cells after adult spinal cord injury （SCI）, the heterogeneity and markers of ependymal cells, the factors that regulate ependymal cells, and the niches that impact the activation or differentiation of ependymal ceils.
