Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode...Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.展开更多
Due to the increasing broadband Internet access, VOIP adoption as well as the Web 2.0 concepts, online language learning communities have gained great popularity among adult language learners. Based upon Malcolm Knowl...Due to the increasing broadband Internet access, VOIP adoption as well as the Web 2.0 concepts, online language learning communities have gained great popularity among adult language learners. Based upon Malcolm Knowles' adult learning theory, this paper analyzes the innovation that online language learning communities have brought to adult language learning programs. At the same time, the limitations of such programs have been pointed out.展开更多
Online English learning as an outcome of the rapid development of the Internet has got a wider and wider market in China. However, problems of varieties have also occurred along its way. People never stop thinking of ...Online English learning as an outcome of the rapid development of the Internet has got a wider and wider market in China. However, problems of varieties have also occurred along its way. People never stop thinking of better strategies either in designing online course wares or tutorials to help smooth the learning process. My experience as a tutor is that interaction of affective domain and higher levels of cognitive domain of Bloom＇s Taxonomy plays an important role in face-to-face tutorials of online English learning.展开更多
Aim:To gain knowledge of how adult students experienced the first year of a blended learning master programme to better understand their learning process.Methods:A qualitative,exploratory,descriptive study based on da...Aim:To gain knowledge of how adult students experienced the first year of a blended learning master programme to better understand their learning process.Methods:A qualitative,exploratory,descriptive study based on data from two focus group interviews with students attending a blended learning Master programme.Qualitative content analysis based on Graneheim and Lundman’s procedures was applied.Findings:Our analyses revealed one main theme:aspiring for competence in a multifaceted everyday life and four main categories:acquiring professional competence,struggling to manage diverse forms of communication,demanding task juggling and confused student role.Conclusions:The participants experienced that the programme enabled them to acquire professional competence relevant to practice.Despite the challenges,the programme is recommended for prospective students who live in both urban and rural areas,who are working and also responsible for children and other family tasks.展开更多
This paper considers online classification learning algorithms for regularized classification schemes with generalized gradient. A novel capacity independent approach is presented. It verifies the strong convergence o...This paper considers online classification learning algorithms for regularized classification schemes with generalized gradient. A novel capacity independent approach is presented. It verifies the strong convergence of sizes and yields satisfactory convergence rates for polynomially decaying step sizes. Compared with the gradient schemes, this al- gorithm needs only less additional assumptions on the loss function and derives a stronger result with respect to the choice of step sizes and the regularization parameters.展开更多
This paper analyzes advantages and disadvantages of the current several popular computer-aided English learning software. combined with modem English teaching philosophy, proposed learning system with synchronization,...This paper analyzes advantages and disadvantages of the current several popular computer-aided English learning software. combined with modem English teaching philosophy, proposed learning system with synchronization, interactivity, intelligence, and incentives in one of the English to students. System uses JavaEE framework to build, each module uses a low coupling between the way facilitate future extensions. The system can help students build confidence and motivate its progress.展开更多
Use the Internet for online learning has become one of the directions of the development of education, the traditional classroom learning, the breakthrough time and geographical constraints, more convenient interactio...Use the Internet for online learning has become one of the directions of the development of education, the traditional classroom learning, the breakthrough time and geographical constraints, more convenient interaction between teachers and students, learning resources are more abundant, more diverse learning styles, has broad application prospects. System uses B / S mode, the application of Java language, together with the MySQL database, high security and good performance.展开更多
There is an apparent contrast between children’s first language acquisition and adults’second language acquisition,which are mainly manifested in the following three aspects:age difference,difference in learning pro...There is an apparent contrast between children’s first language acquisition and adults’second language acquisition,which are mainly manifested in the following three aspects:age difference,difference in learning process and motivation difference.This paper will analyze these three differences in detail,and combine the analysis results to guide second language pedagogical implications according to the current situation.展开更多
E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a mo...E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a modern structured MOODLE interactive course, designed for the needs of the laboratory course “Automotive Systems”. The study concerns Greek secondary vocational education pupils aged 18 and vocational training adult students aged 20 to 50 years. The multistage, equal size simple random cluster sample was used as a sampling method. Pupils and adult students of each cluster completed structured 10-question questionnaires both before and after attending the course. A total of 120 questionnaires were collected. In general, our findings disclosed that the majority of pupils and adult students had significantly improved their knowledge and skills from using MOODLE. They reported strengthening conventional teaching, using the new MOODLE technology. The satisfaction indices improved quite, with the differences in their mean values being statistically significant.展开更多
基金supported by the National Institutes of Health,Nos.AA025919,AA025919-03S1,and AA025919-05S1(all to RAF).
文摘Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.
文摘Due to the increasing broadband Internet access, VOIP adoption as well as the Web 2.0 concepts, online language learning communities have gained great popularity among adult language learners. Based upon Malcolm Knowles' adult learning theory, this paper analyzes the innovation that online language learning communities have brought to adult language learning programs. At the same time, the limitations of such programs have been pointed out.
文摘Online English learning as an outcome of the rapid development of the Internet has got a wider and wider market in China. However, problems of varieties have also occurred along its way. People never stop thinking of better strategies either in designing online course wares or tutorials to help smooth the learning process. My experience as a tutor is that interaction of affective domain and higher levels of cognitive domain of Bloom＇s Taxonomy plays an important role in face-to-face tutorials of online English learning.
基金supported in part by Inland Norway University of Applied Sciences,Faculty of Health and Social Sciences,NO-2418 Elverum,Norway.No external funding.
文摘Aim:To gain knowledge of how adult students experienced the first year of a blended learning master programme to better understand their learning process.Methods:A qualitative,exploratory,descriptive study based on data from two focus group interviews with students attending a blended learning Master programme.Qualitative content analysis based on Graneheim and Lundman’s procedures was applied.Findings:Our analyses revealed one main theme:aspiring for competence in a multifaceted everyday life and four main categories:acquiring professional competence,struggling to manage diverse forms of communication,demanding task juggling and confused student role.Conclusions:The participants experienced that the programme enabled them to acquire professional competence relevant to practice.Despite the challenges,the programme is recommended for prospective students who live in both urban and rural areas,who are working and also responsible for children and other family tasks.
文摘This paper considers online classification learning algorithms for regularized classification schemes with generalized gradient. A novel capacity independent approach is presented. It verifies the strong convergence of sizes and yields satisfactory convergence rates for polynomially decaying step sizes. Compared with the gradient schemes, this al- gorithm needs only less additional assumptions on the loss function and derives a stronger result with respect to the choice of step sizes and the regularization parameters.
文摘This paper analyzes advantages and disadvantages of the current several popular computer-aided English learning software. combined with modem English teaching philosophy, proposed learning system with synchronization, interactivity, intelligence, and incentives in one of the English to students. System uses JavaEE framework to build, each module uses a low coupling between the way facilitate future extensions. The system can help students build confidence and motivate its progress.
文摘Use the Internet for online learning has become one of the directions of the development of education, the traditional classroom learning, the breakthrough time and geographical constraints, more convenient interaction between teachers and students, learning resources are more abundant, more diverse learning styles, has broad application prospects. System uses B / S mode, the application of Java language, together with the MySQL database, high security and good performance.
文摘There is an apparent contrast between children’s first language acquisition and adults’second language acquisition,which are mainly manifested in the following three aspects:age difference,difference in learning process and motivation difference.This paper will analyze these three differences in detail,and combine the analysis results to guide second language pedagogical implications according to the current situation.
文摘E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a modern structured MOODLE interactive course, designed for the needs of the laboratory course “Automotive Systems”. The study concerns Greek secondary vocational education pupils aged 18 and vocational training adult students aged 20 to 50 years. The multistage, equal size simple random cluster sample was used as a sampling method. Pupils and adult students of each cluster completed structured 10-question questionnaires both before and after attending the course. A total of 120 questionnaires were collected. In general, our findings disclosed that the majority of pupils and adult students had significantly improved their knowledge and skills from using MOODLE. They reported strengthening conventional teaching, using the new MOODLE technology. The satisfaction indices improved quite, with the differences in their mean values being statistically significant.
