Analysis of Adverse Reactions in the Treatment of COVID-19 with Three Chinese Patent Medicines and Three Herbal Formulas

Objective To explore the rules and characteristics of the adverse drug reactions(ADRs)of three Chinese patent medicines and three herbal formulas for the treatment of COVID-19,and to provide a reference for clinical safe medication.Methods The cases and ADR reports of the three Chinese patent medicines and three herbal formulas in PubMed,Web of Science,Springer Link,CNKI,Wanfang and VIP database were retrieved from December 2019 to May 2021.Then we extracted and analyzed the effective information included in the literature.Results and Conclusion According to the pre-developed retrieval plan,a total of 136 documents were obtained,and a total of 6 documents met the inclusion criteria finally.553 patients used three Chinese patent medicines and three herbal formulas,and there were 133 cases of adverse reactions.The adverse reactions of patients taking the three Chinese patent medicines and three herbal formulas can all be explained under the theory of traditional Chinese medicine,and the adverse reactions can be eliminated by adding or subtracting the flavor of the medicine or stopping the medicine.

Enhancing ulcerative colitis treatment with traditional Chinese medicine

Inflammatory bowel disease,particularly ulcerative colitis(UC),poses significant treatment challenges due to its chronic nature and potential for severe complications.This editorial reviews a recent network meta-analysis that evaluated the efficacy of and highlighted the superior outcomes achieved by combining each of five traditional Chinese medicine(TCM)formulations with mesalazine for the adjuvant treatment of UC.Clinical outcomes included enhanced mucosal healing,improved quality of life,and reduced recurrence rates.Additionally,the combination therapy resulted in a lower incidence of adverse reactions compared with mesalazine monotherapy.Despite these promising results,limitations such as variability in study quality and TCM dosage highlight the need for further highquality,large-sample,multicenter randomized controlled trials.This editorial underscores the potential of TCM in enhancing UC management and calls for more rigorous research to substantiate these findings and refine clinical guidelines.

Use of traditional Chinese medicine in the treatment of immune-related adverse events of cancer immunotherapy

Immune checkpoint inhibitors(ICPI)have shown considerable promise in the treatment of tumors.However,immune-related adverse events(irAEs)caused by ICPI have been reported in nearly every organ system.Whilst this represents a new challenge in the field of cancer treatment,traditional Chinese medicine(TCM)provides benefits in the treatment of irAEs.This article reviews the studies of the treatment of immune-related gastrointestinal diseases and dermatosis with TCM and introduces the collaborative efforts between China and France in the implementation of TCM for the treatment of irAEs.

An ultra-robust fingerprinting method for quality assessment of traditional Chinese medicine using multiple reaction monitoring mass spectrometry

Chromatographic fingerprinting has been perceived as an essential tool for assessing quality and chemical equivalence of traditional Chinese medicine.However,this pattern-oriented approach still has some weak points in terms of chemical coverage and robustness.In this work,we proposed a multiple reaction monitoring(MRM)-based fingerprinting method in which approximately 100 constituents were simultaneously detected for quality assessment.The derivative MRM approach was employed to rapidly design MRM transitions independent of chemical standards,based on which the large-scale fingerprinting method was efficiently established.This approach was exemplified on QiShenYiQi Pill(QSYQ),a traditional Chinese medicine-derived drug product,and its robustness was systematically evaluated by four indices:clustering analysis by principal component analysis,similarity analysis by the congruence coefficient,the number of separated peaks,and the peak area proportion of separated peaks.Compared with conventional ultraviolet-based fingerprints,the MRM fingerprints provided not only better discriminatory capacity for the tested normal/abnormal QSYQ samples,but also higher robustness under different chromatographic conditions(i.e.,flow rate,apparent pH,column temperature,and column).The result also showed for such large-scale fingerprints including a large number of peaks,the angle cosine measure after min-max normalization was more suitable for setting a decision criterion than the unnormalized algorithm.This proof-of-concept application gives evidence that combining MRM technique with proper similarity analysis metrices can provide a highly sensitive,robust and comprehensive analytical approach for quality assessment of traditional Chinese medicine.

Studies on the Degranulation of RBL-2H3 Cells Induced by Traditional Chinese Medicine Injections

Aims: To study RBL-2H3 cell degranulation phenomena induced by some TCMIs through cell morphological and ultra-structural observation, released enzyme activity and establish RBL-2H3 cell degranulation test indicated by β- hexosaminidase activity as a method to evaluate TCMIs at nonclinical stage. Methods: RBL-2H3 cells were used to study the degranulation by co-culture with positive control C48/80 and some TCMIs through morphological and ultra-structure observation, β-hexosaminidase activity detection. RBL-2H3 cell degranulation test was established to detect β-hexosaminidase activity caused by 17 kinds of TCMIs and their ingredients. The cytotoxicity effect of some TCMIs on both RBL 2H3 and BRL cells was measured by CCK-8 assay. Results: Toluidine blue staining and ultra-structure of electronic microscope observation of treated RBL-2H3 cells showed degranulation morphologically. Detection of β-hexosaminidase activity in the supernatant of treated cells showed some TCMIs had elevated enzyme release rates. Further analysis of the ingredients and compound in Tanreqing Injection and Shengmai Injection showed Scutellaria baicalensis Georgi in Tanreqing Injection, Red ginseng and Fructus Schisandrae Chinensis in Shengmai Injection were responsible to the degranulation of RBL-2H3 cells. Osmotic pressures and pH influenced RBL-2H3 degranulation. High Osmotic pressure of Tanreqing Injection and low pH of chlorogenic acid at 2.5 and 5.0 mmol/L congcentration might be responsible to high β-hexosaminidase activity. Most of the TCMIs inducing degranulation had cytotoxicity effect for both RBL-2H3 and BRL cells, but some TCMIs inducing degranulation had no cytotoxicity effect. Conclusion: Some TCMIs can induce degranulation of RBL-2H3 cells;RBL-2H3 cell degranulation test can be used in non-clinical stage to detect the risk causing anaphylactoid reactions. Osmotic pressures and pH influenced RBL-2H3 degranulation, and they should be measured before testing. The mechanism of degranulation caused by some TCMIs is cytotoxic, and some are non-cytotoxic and may be through exicytosis.

Analysis of the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction caused by lung cancer chemotherapy

Objective:To explore the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Methods:The literatures on prevention and treatment of gastrointestinal reaction after chemotherapy with Chinese medicine were searched from CNKI,Wanfang and VIP databases from the establishment of the database to September 2020.After screening,the database was established,and data mining was conducted by using IBM SPSS statistics 20.0 and IBM SPSS modeler 18.0 to summarize the medication rules of traditional Chinese medicine in the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Results:(1)A total of 131 literatures involving 245 traditional Chinese medicines were included for data mining;(2)High frequency drugs include Astragalus membranaceus,liquorice,Poria cocos,Atractylodes macrocephala,Pinellia ternata,Codonopsis pilosula,Ophiopogon japonicus,coix seed,Pericarpium Citri Reticulatae,Radix Glehniae and so on;(3)The traditional Chinese medicine used is mainly tonifying deficiency medicine,resolving phlegm and relieving cough and asthma medicine,diuresis and dampness medicine,heat clearing medicine and antiphlogistic medicine.The medicine tastes bitter and sweet,and has cold and warm properties.The meridian tropism involves liver,lung,stomach,spleen and kidney;(4)Seven core TCM combinations were obtained by cluster analysis,and 24 drug pairs(groups)were obtained by association rule analysis.Conclusion:Through the data mining of traditional Chinese medicine for the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer,we can find out the potential rules of traditional Chinese medicine prescription,and clarify the core Chinese medicine,which is helpful to provide certain reference for the development and research of drugs for the treatment of gastrointestinal reaction and modern clinical practice.

The prognosis and survival of integrated traditional Chinese and western medicine on glioma: a meta-analysis

Objective:To systematically access the effects of integrated traditional Chinese and western medicine treatment versus western medicine treatment alone in glioma.Methods:Published randomized controlled trials were included from electronic databases(Cochrane Library,Pubmed,Embase,Chinese National Knowledge Infrastructure,Wanfang database,Chinese Scientific Journal Database,Chinese Biomedical Literature Database.Deadline on January 30,2020).The Cochrane handbook was referred to evaluate the methodological quality.Curative efficacy,gastrointestinal side effects,bone marrow suppression,survival time and quality of life(Karnofsky)were compared between the two groups.Meta-analysis was conducted using Reveman 5.3 and Stata 14.0 software.Results:Twelve randomized controlled trials involved 886 cases were selected,including 446 cases in the trial group and 440 cases in the control group.The meta-analysis indicated that the overall efficacy of integrated traditional Chinese and western medicine showed significant improvement compared with western medicine alone.The effects included reduced tumor size(RR=1.32,95%CI(1.18,1.49),P<0.05),gastrointestinal adverse reactions(RR=0.42,95%CI(0.30,0.60),P<0.05),bone marrow suppression(RR=0.437,95%CI(0.282,0.677),P<0.05),and improved KPS score(SMD=0.632,95%CI(0.312,0.952),P<0.05).Conclusion:For patients with glioma,integrated traditional Chinese and western medicine treatment can be one of the options for a better treatment.

The effects of Chinese herbal medicines on Madopar dose and adverse reaction during the maintenance phase of Parkinson's disease:a systematic review with meta-analysis

Background:Parkinson’s disease is a progressive neurodegenerative disease,and is usually treated with levodopa combined with dopa decarboxylase inhibitor like Madopar.In order to improve the efficacy and reduce adverse reactions,Chinese herbal medicines are usually applied with Madopar to treat Parkinson’s disease in clinic.According to the results of certain randomized controlled trials,levodopa drugs combined with Chinese herbal medicines could achieve better effects like the improvement of clinical symptoms,the reduced incidence of adverse reactions,and the reduced dose of levodopa drugs(especially in the maintenance phase).However,not all the randomized controlled trials showed favorable effect on Parkinson’s disease.Therefore,it is necessary to find out how to effectively combine Chinese herbal medicines with Madopar.In order to evaluate the effects of Chinese herbal medicines on Madopar dose and adverse reaction during the maintenance phase of Parkinson’s disease,a meta-analysis was conducted.Methods:A systematic research was carried out for randomized controlled trials of combined Chinese herbal medicines and Madopar treatment for Parkinson’s disease during the maintenance phase published till August 2019.The primary outcome was the Madopar dose and secondary outcome was the incidence of adverse reaction.Data were pooled and analyzed with RevMan 5.3.Results:A total of 18 studies were included with 1,169 cases.However,study quality evaluation showed low methodological quality.Meta-analyses showed that the dose of Madopar in the treatment group was significantly lower than that in the control group,and the incidence of adverse reactions in the treatment group was also significantly lower than that in the control group.However,the correlation analysis showed that the reduction of Madopar dose was not related to the reduction of incidence of adverse reactions(P>0.05).There existed publication bias on the primary outcome and secondary outcome.Conclusions:Chinese herbal medicines could reduce the Madopar dose and adverse reaction during the maintenance phase of Parkinson’s disease treatment.This conclusion must be considered cautiously,for lack of studies of high quality.

A meta-analysis of Chinese herbal medicines for vascular dementia

OBJECTIVE： To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL： We retrieved publications from Cochrane Library （2004 to July 2011）, PubMed （1966 to July 2011）, the Chinese Science and Technique Journals Database （1977 to July 2011）, the China National Knowledge Infrastructure （1979 to July 2011）, Google Scholar （July 2011）, and the Chinese Biomedical Database （1977 to July 2011） using the key words ＂Chinese medicine OR Chinese herbal medicine＂ and ＂vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia＂. SELECTION CRITERIA： Randomized controlled trials comparing Chinese herbal medicines with placebo/western medicine in the treatment of patients with vascular dementia were included. Diagnostic standards included Diagnostic and Statistical Manual of Mental Disorders-IV, and National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et I＇Enseignement en Neurosciences. Two participants independently conducted literature screening, quality evaluation and data extraction. The quality of each trial was assessed according to the Cochrane Reviewers＇ Handbook 5.0. MAIN OUTCOME MEASURES： Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions. RESULTS： We identified 1 143 articles discussing the effects of Chinese medicine on vascular dementia. Thirty-one of these were included in the analysis. These studies involved a total of 2 868 participants （1 605 patients took Chinese medicine decoctions （treatment group）; 1 263 patients took western medicine or placebo）. The results of our meta-analysis revealed that Chinese herbal remedies in the treatment group were more efficacious than the control intervention （relative risk （RR） = 1.27; 95% confidence interval （C/）： 1.18-1.38, P 〈 0.01）. Mini-Mental State Examination scores were higher in patients taking Chinese herbal medicines than in those in the control group （weighted mean difference （WMD） = 2.83; 95%CI： 2.55-3.12, P 〈 0.01）. Patients in the treatment group showed better disease amelioration than those in the control group （Hasegawa Dementia Scale scores; WMD = 2.41, 95%CI： 1.48-3.34, P 〈 0.01）. There were also considerably fewer adverse reactions among those in the treatment group compared with those in the control group （RR = 0.20, 95%CI： 0.08-0.47, P 〈 0.01）. CONCLUSION： Chinese herbal medicine appears to be safer and more effective than control measures in the treatment of vascular dementia. However, the included trials were generally low in quality. More well-designed, high-quality trials are needed to provide better evidence for the assessment of the efficacy and safety of Chinese medicines for vascular dementia.

不同中药炮制措施对中药饮片治疗效果的影响探讨

目的 分析不同中药炮制措施对中药饮片治疗效果的影响。方法 80例接受中药饮片治疗的患者,随机分为对照组与观察组,各40例。对照组在水处理前分档,观察组在水处理前分档联合炮制前分档。对比两组治疗效果及不良反应发生情况。结果 观察组治疗总有效率97.50%高于对照组的82.50%,差异有统计学意义(P<0.05)。观察组不良反应发生率5.00%显著低于对照组的20.00%,差异有统计学意义(P<0.05)。结论 不同的中药炮制措施会对中药饮片的治疗效果产生影响,水处理前分档联合炮制前分档的方式,可以使整体的治疗效果得到提升,并降低不良反应的发生率。

中西医结合干预对急性白血病化疗患者不良反应的防治效果

目的观察中西医结合措施对急性白血病(AL)患者化疗期间不良反应的干预效果。方法选择2020年1月至2022年12月收治的AL化疗患者80例为研究对象,按照随机数字表法分为2组,对照组40例予西医常规干预措施,治疗组40例在对照组的基础上联合中医综合疗法。比较2组治疗前后便秘症状(包括大便性质评分及排便困难程度)评分、睡眠障碍[采用睡眠状况自评量表(SRSS)进行评价]、癌因性疲乏(采用Piper疲乏量表评分进行评价)、简明生活质量量表(SF-36)(包括生理功能、生理职能、躯体疼痛、社会功能、活力、情感职能、精神健康及总体健康)评分及心理状况[采用焦虑自评量表(SAS)及抑郁自评量表(SDS)评价]变化情况,比较2组治疗期间治疗满意度评分。结果与本组治疗前比较,2组治疗后大便性质评分及排便困难程度评分均降低(P<0.05),且治疗组治疗后大便性质评分及排便困难程度评分均低于对照组(P<0.05)。与本组治疗前比较,2组治疗后SRSS评分及Piper疲乏量表评分均降低(P<0.05),且治疗组治疗后SRSS评分及Piper疲乏量表评分均低于对照组(P<0.05)。与本组治疗前比较,2组治疗后SF-36生理功能、生理职能、躯体疼痛、社会功能、活力、情感职能、精神健康及总体健康评分均升高(P<0.05),且治疗组治疗后SF-36各项评分均高于对照组(P<0.05)。与本组治疗前比较,2组治疗后SAS评分及SDS评分均降低(P<0.05),且治疗组治疗后SAS评分及SDS评分均低于对照组(P<0.05)。治疗组治疗期间满意度评分(8.19±0.64)分,对照组治疗期间满意度评分(7.36±0.57)分,治疗组满意度评分高于对照组(P<0.05)。结论中西医结合措施可有效改善AL患者化疗期间便秘、睡眠障碍及癌因性疲乏症状,提高其生活质量,缓解焦虑与抑郁状态,提高患者满意度。

T细胞亚群与应用免疫检查点抑制剂的肿瘤患者产生不良反应的相关性分析

目的观察临床不同癌种患者在接受肿瘤细胞免疫检查点抑制剂治疗前后外周血中T淋巴细胞亚群的变化,探索其与不良反应发生相关性。方法回顾性收集2021年8月~2022年12月于辽宁中医药大学附属医院住院接受ICIs治疗的60例肿瘤患者的临床资料,对比接受ICI治疗前后的CD3^(+)、CD4^(+)、CD8^(+)计数及CD4^(+)/CD8^(+)的变化,分析T细胞亚群变化的影响因素。结果接受ICI治疗后CD3^(+)、CD4^(+)计数较前升高、CD4^(+)/CD8^(+)较前升高,差异具有统计学意义(P<0.05);虽CD8^(+)较前降低,但差异无统计学意义(P>0.05)。结果显示使用中药时间越长,CD4^(+)/CD8^(+)更趋近于正常范围0.7~2.78,同时不良反应出现的几率越低,irAEs分级越低。结论细胞病理免疫分析的T淋巴细胞结果或可作为临床指导预防免疫相关不良反应的指标之一,治疗过程中联合应用中药可显著降低临床不良反应。

免疫检查点抑制剂导致甲状腺功能异常的中西医诊疗思路

随着免疫检查点抑制剂(immune checkpoint inhibitor,ICPi)治疗人群的不断扩大,以及临床上的应用,接受这些药物治疗的患者生存时间明显提高,免疫相关不良反应的发生也逐渐受到重视。免疫系统的过度反应会导致不良反应的发生,这些不良反应称为免疫相关不良事件(Immune related adverse events,irAEs)。irAEs可以影响多个器官系统,其中内分泌系统是最常受累的系统之一,而甲状腺功能减退和甲状腺功能亢进的发生率最高,现代医学经常通过适当的激素替代,硫代酰胺,皮质类固醇来治疗,但仍有部分患者未能完全缓解,中医药可展现出其独特的优势和价值,很好的改善这部分患者症状,提高生存质量。本文就中西医诊疗ICPi所致甲状腺irAEs进行综述。

益气活血中药对化疗患者心脏功能的影响

目的探讨肿瘤治疗相关心血管毒性(CTR-CVT)的早期监测指标及益气活血类中药对CTR-CVT的预防作用。方法选取2019年1月至2022年1月该院行抗肿瘤治疗且经病理学诊断确诊的恶性肿瘤患者40例,将其按照1∶1比例随机分为对照组及治疗组,对照组接受化疗,治疗组在化疗基础上联合益气活血中药。比较2组心肌酶谱[α-羟丁酸脱氢酶(α-HBDH)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、谷草转氨酶(AST)]、B型脑钠肽(BNP)、肌钙蛋白Ⅰ(CTNⅠ)、左心室射血分数(LVEF)水平,并对心电图异常及心血管不良事件发生情况进行分析。结果对照组化疗后CK、CK-MB、α-HBDH、LDH、BNP水平高于化疗前,AST、CTNⅠ低于化疗前,差异无统计学意义(P>0.05)。治疗组化疗后α-HBDH、LDH、BNP、AST、CK、CK-MB、CTNⅠ水平与化疗前比较,差异无统计学意义(P>0.05)。2组化疗后BNP、α-HBDH、LDH水平比较,差异有统计学意义(P<0.05),但AST、CK-MB、CK、CTNⅠ水平比较,差异无统计学意义(P>0.05)。2组化疗后LVEF水平及心血管不良事件发生情况比较,差异有统计学意义(P<0.05)。2组化疗后心肌酶谱指标、BNP水平、CTNⅠ水平及心电图异常情况比较,差异无统计学意义(P>0.05)。结论心肌酶谱、BNP、CTNⅠ可以作为CTR-CVT的早期监测指标。益气活血类中药在一定程度上具有预防CTR-CVT的作用,其可以改善患者心脏功能及BNP、LVEF水平,降低心血管不良事件发生率。

活血化瘀类中成药治疗糖尿病视网膜病变的网状Meta分析

目的:应用网状Meta分析方法,比较不同活血化瘀类中成药治疗糖尿病视网膜病变(DR)的临床有效率、实验室指标改善情况及治疗的安全性。方法:通过检索中国知网(CNKI)、万方数据知识服务平台、维普期刊资源整合服务平台(VIP)、Web of Science及Pubmed等数据库获得关于活血化瘀类中成药治疗DR的临床随机对照研究,检索时限为建库至2023年4月10日,并对所检索到的文献进行筛选提取资料,通过Stata 16.0软件实施网状Meta分析。结果:最终纳入63项研究,分析结果显示:复方丹参滴丸+羟苯磺酸钙胶囊总体疗效最为显著;芪明颗粒+羟苯磺酸钙胶囊在改善DR患者视力方面疗效最为显著;复方血栓通胶囊+羟苯磺酸钙胶囊在改善DR患者黄斑厚度及视野灰度值方面疗效最好;和血明目片+羟苯磺酸钙胶囊在减小患者血管瘤体积方面疗效较好;治疗组与对照组均有不良反应报道,治疗组不良反应总体较少。结论:与单用羟苯磺酸钙胶囊比较,活血化瘀类中成药联合羟苯磺酸钙胶囊治疗DR患者,可提高临床有效率,改善患者实验室检查指标,减少不良反应。

中药沐足联合穴位贴敷治疗小儿百日咳的临床观察

目的探讨中药沐足联合穴位贴敷治疗小儿百日咳的临床效果。方法选取2021年3月至2023年10月九江市妇幼保健院收治的66例百日咳患儿作为研究对象,按照随机数字表法分为对照组(33例)和观察组(33例)。对照组采用注射用乳糖酸红霉素治疗,观察组加用中药沐足联合穴位贴敷治疗。比较两组临床疗效、肺功能、血清学指标、症状评分及不良反应。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组吸呼比(TI/TE)、潮气量(VT)、达峰容积比(VPEF/VE)和达峰时间比(TPEF/TE)均高于本组治疗前,且观察组上述指标高于对照组,差异有统计学意义(P<0.05);治疗后,两组C反应蛋白(CRP)、白细胞计数(WBC)水平及症状评分均低于本组治疗前,且观察组上述指标低于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论小儿百日咳应用中药沐足联合穴位贴敷治疗效果较好,可改善肺功能,减轻炎症反应,安全可靠,值得推广。

蝮蛇咬伤中医治疗优化方案的疗效评价

目的评价中医优化方案治疗蝮蛇咬伤的临床疗效。方法回顾研究蝮蛇咬伤住院患者资料,根据中医治疗方案的不同,将符合纳入标准的病例分为对照组87例、试验组82例,对照组采用未优化中医方案,试验组采用优化中医方案,2组均配合以西医常规治疗,比较2组治疗前后伤肢肿胀疼痛程度、症状与体征积分、炎症指标、脏器功能指标、治愈率、治愈时间。结果在伤肢肿胀疼痛程度及症状消失时间、症状与体征积分方面,试验组治疗效果较对照组更为显著(P<0.05);2组治疗后6 d,WBC、N%、CRP、ALT、AST、Cr、NGAL、CK-MB指标均降低(P<0.05),试验组CRP、ALT、AST、Cr、NGAL指标较对照组降低更明显(P<0.05),但在降低CK-MB方面,2组效果相当,无明显差异(P>0.05);治愈率方面:试验组(97.56%,80/82)显著高于对照组(88.51%,77/87)(P<0.05),治愈时间方面:试验组较对照组用时更短(P<0.05)。结论中医优化方案能快速缓解蝮蛇咬伤肢体肿痛及全身症状、减轻机体炎症反应、改善重要脏器功能,临床效果好,值得推广应用。

子午流注开穴法预防生长激素激发试验不良反应临床观察

目的观察子午流注开穴法预防生长激素(GH)激发试验不良反应的临床疗效。方法选取2021年11月—2022年10月于广州中医药大学顺德医院进行GH激发试验的矮小症儿童80例,随机分为对照组、观察组,各40例。对照组给予常规护理及治疗,观察组在对照组的基础上加子午流注开穴法贴敷神阙穴。比较两组患儿不良反应情况。结果观察组不良反应发生率为7.5%(3/40),低于对照组的27.5%(11/40),差异有统计学意义(P<0.05);且观察组不良反应出现时间晚于对照组,持续时间短于对照组,差异均有统计学意义(P<0.05)。结论子午流注开穴法贴敷神阙穴,可降低GH激发试验不良反应发生率,减少患儿痛苦,提高家属满意度,保证激发试验顺利进行,值得临床推广。

中医特色健康管理模式联合中药热敷对腰突症患者疼痛及功能康复的影响

目的研究探讨中医特色健康管理模式联合中药热敷对腰突症患者疼痛及功能康复的影响。方法选取2021年6月—2023年6月本院收治的100例腰突症患者为对象,随机数字表法分为观察组、对照组,每组50例。对照组以常规护理干预结合中药热敷干预,观察组在此基础上增加中医特色健康管理模式干预。评估对比两组中医症状评分、疼痛程度、康复效果、不良事件发生率。结果观察组在干预2、4、8、12周时中医症状评分低于对照组(P<0.05)。观察组在干预2、4、8、12周时视觉模拟评分低于对照组(P<0.05)。观察组在干预2、4、8、12周时日本骨科协会评估治疗评分低于对照组(P<0.05)。观察组不良事件发生率6.00%,低于对照组的22.00%(P<0.05)。结论中医特色健康管理模式联合中药热敷对腰突症效果良好,缓解中医症状和疼痛程度,恢复腰椎功能,降低各种不良事件发生。

细胞焦亡在动脉粥样硬化中的作用及中医药调控研究进展

动脉粥样硬化(atherosclerosis, AS)是脂质沉积于血管壁导致的慢性炎症性疾病,是冠心病、高血压病、心力衰竭等心脑血管疾病的病理基础,动脉粥样硬化斑块的稳定或破裂是心血管事件发生与否的重要影响因素。细胞焦亡是一种促炎性质的程序性细胞死亡,过度的细胞焦亡可引起细胞裂解死亡并发级联炎症反应。越来越多的研究表明细胞焦亡在AS的病理进程中扮演重要角色,NOD样受体蛋白3 (nod-like receptor protein 3,NLRP3)、半胱氨酸天冬氨酸蛋白酶-1(cysteinyl aspartate specific proteinase-1,Caspase-1)、细胞焦亡执行蛋白(gasdermin D,GSDMD)等细胞焦亡的关键蛋白参与AS血管内皮细胞损伤、内皮功能障碍、平滑肌细胞表型转换、巨噬细胞死亡、泡沫细胞形成等过程,已成为AS新的治疗靶点。中医药是历史悠久的医药学体系,随着研究的深入,中药复方及中药单体活性成分通过调控细胞焦亡干预AS的作用逐步被阐明,且具有多途径,多靶点,不良反应小等独特优势。基于上述研究,阐述细胞焦亡的概念及发生机制,归纳细胞焦亡在AS病程中的作用,并总结中药复方和单味中药有效成分基于细胞焦亡干预AS的研究进展,以期为AS的防治及中药新药的开发提供新的思路。