In order to make equipment run safely, economically and continuously, some new maintenance models were put forward to improve the equipment after-sale maintenance service, such as E-maintenance, third-party maintenanc...In order to make equipment run safely, economically and continuously, some new maintenance models were put forward to improve the equipment after-sale maintenance service, such as E-maintenance, third-party maintenance, etc. To certain extent, the models solved the problem of the distance between the manufacturer and customer and the dispersion of the maintenance technologies, however, those resources are still widely distributed and do not collaborate efficiently. In this paper, a network-based collaborative maintenance service model was proposed for after-sales equipment to solve the problem of maintenance resources integration. Concretely, equipment designers, maintainers, spare parts suppliers and maintenance experts were grouped together to establish dynamic alliance. The leader of the alliance is the manufacturer under guaranty period or equipment user exceeding the guaranty period. The process of maintenance service was divided into three stages which are fault diagnosis, maintenance decision and maintenance implementation. The sub-alliances were established to carry out maintenance work at each stage. In addition, the business process of network-based collaborative maintenance was analyzed and collaborative business system for equipment＇s after-sales collaborative maintenance service was designed. In the end, an informational economics model of network-based collaborative maintenance was established to demonstrate the effectiveness of this maintenance model.展开更多
Epigenetic changes in the spinal cord play a key role in the initiation and maintenance of nerve injury-induced neuro pathic pain.N6-methyladenosine(m6A)is one of the most abundant internal RNA modifications and plays...Epigenetic changes in the spinal cord play a key role in the initiation and maintenance of nerve injury-induced neuro pathic pain.N6-methyladenosine(m6A)is one of the most abundant internal RNA modifications and plays an essential function in gene regulation in many diseases.However,the global m6A modification status of mRNA in the spinal cord at different stages after neuropathic pain is unknown.In this study,we established a neuropathic pain model in mice by preserving the complete sural nerve and only damaging the common peroneal nerve.High-throughput methylated RNA immunoprecipitation sequencing res ults showed that after spared nerve injury,there were 55 m6A methylated and diffe rentially expressed genes in the spinal cord.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway results showed that m6A modification triggered inflammatory responses and apoptotic processes in the early stages after spared nerve injury.Over time,the diffe rential gene function at postoperative day 7 was enriched in "positive regulation of neurogenesis" and "positive regulation of neural precursor cell prolife ration." These functions suggested that altered synaptic morphological plasticity was a turning point in neuropathic pain formation and maintenance.Results at postoperative day 14 suggested that the persistence of neuropathic pain might be from lipid metabolic processes,such as "very-low-density lipoprotein particle clearance," "negative regulation of choleste rol transport" and "membrane lipid catabolic process." We detected the expression of m6A enzymes and found elevated mRNA expression of Ythdf2 and Ythdf3 after spared nerve injury modeling.We speculate that m6A reader enzymes also have an important role in neuropathic pain.These results provide a global landscape of mRNA m6A modifications in the spinal cord in the spared nerve injury model at diffe rent stages after injury.展开更多
The rapid rise and development of the computer industry in China has promoted the production of and demand for computer diskettes. China, with over 30 diskette production lines and an annual production of 2 billion di...The rapid rise and development of the computer industry in China has promoted the production of and demand for computer diskettes. China, with over 30 diskette production lines and an annual production of 2 billion diskettes, including some for export, has become the biggest diskette producing country in the world. However, imported diskettes, especially high grade brands, enjoy a good market here. That’s why many world renowned diskette展开更多
As a part of the product development process, the after-sales services are not only a source of innovation, but also they benefit from value creation through new managerial methodologies for the achievement of competi...As a part of the product development process, the after-sales services are not only a source of innovation, but also they benefit from value creation through new managerial methodologies for the achievement of competitive advantage and customer satisfaction. The objective of the paper is to further understand value creation for the after-sales services. We present the case of the creation of a new business for the after-sales services for the entrance into a new market. The new business is created by two gurus in the aerospace industry. A typology of guidelines is derived, based on organizational and strategic perspectives, for the after-sales services value creation and the guidelines for the creation of a new business as well as for the entrance of into a new market are presented.展开更多
Missile is an important weapon system of the army.The spare parts of missile equipment are significant effect on military operations.In order to improve the mission completion rate of missile equipment in wartime,this...Missile is an important weapon system of the army.The spare parts of missile equipment are significant effect on military operations.In order to improve the mission completion rate of missile equipment in wartime,this paper introduces data sensing method to forecast the demand of valuable spare parts of missile equipment dynamically.Firstly,the information related to valuable spare parts of missile equipment was obtained by data sensing,and the sample size was determined by Bernoulli uniform sampling probability.Secondly,according to the data quality of multi-source and multi-modal,the data requirement for dynamic demand prediction of valuable spare parts of missile equipment was obtained.Finally,according to the characteristics of the spare parts,the life of the spare parts was predicted,realizing the dynamic prediction of the demand for valuable spare parts of missile equipment.The results show that the demand of valuable spare parts of missile equipment can be predicted dynamically by using this method,the accuracy is higher than 95%,and the real-time performance is more excellent.展开更多
基金supported by National Natural Science Foundation of China (Grant No. 70301012)National Hi-tech Research and Development Program of China (863 Program, Grant No. 2006AA04Z369-1)Innovative Talent Project of the Third Stage of "211" Project, Chongqing University, China (Grant No. S-09107)
文摘In order to make equipment run safely, economically and continuously, some new maintenance models were put forward to improve the equipment after-sale maintenance service, such as E-maintenance, third-party maintenance, etc. To certain extent, the models solved the problem of the distance between the manufacturer and customer and the dispersion of the maintenance technologies, however, those resources are still widely distributed and do not collaborate efficiently. In this paper, a network-based collaborative maintenance service model was proposed for after-sales equipment to solve the problem of maintenance resources integration. Concretely, equipment designers, maintainers, spare parts suppliers and maintenance experts were grouped together to establish dynamic alliance. The leader of the alliance is the manufacturer under guaranty period or equipment user exceeding the guaranty period. The process of maintenance service was divided into three stages which are fault diagnosis, maintenance decision and maintenance implementation. The sub-alliances were established to carry out maintenance work at each stage. In addition, the business process of network-based collaborative maintenance was analyzed and collaborative business system for equipment＇s after-sales collaborative maintenance service was designed. In the end, an informational economics model of network-based collaborative maintenance was established to demonstrate the effectiveness of this maintenance model.
基金National Natural Science Foundation of China,No.819 73305 (to ZQ)Science and Technology Planning Project of Guangzhou of China,No.20190401 0487 (to ZQ)+1 种基金Natural Science Foundation of Guangdong Province,China,No.2021A1515010897 (to TT)Discipline Construction Fund of Cen tral Peoples Hospital of Zhanjiang,Nos.2020A01 (to TT) and 2020A02 (to TT)。
文摘Epigenetic changes in the spinal cord play a key role in the initiation and maintenance of nerve injury-induced neuro pathic pain.N6-methyladenosine(m6A)is one of the most abundant internal RNA modifications and plays an essential function in gene regulation in many diseases.However,the global m6A modification status of mRNA in the spinal cord at different stages after neuropathic pain is unknown.In this study,we established a neuropathic pain model in mice by preserving the complete sural nerve and only damaging the common peroneal nerve.High-throughput methylated RNA immunoprecipitation sequencing res ults showed that after spared nerve injury,there were 55 m6A methylated and diffe rentially expressed genes in the spinal cord.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway results showed that m6A modification triggered inflammatory responses and apoptotic processes in the early stages after spared nerve injury.Over time,the diffe rential gene function at postoperative day 7 was enriched in "positive regulation of neurogenesis" and "positive regulation of neural precursor cell prolife ration." These functions suggested that altered synaptic morphological plasticity was a turning point in neuropathic pain formation and maintenance.Results at postoperative day 14 suggested that the persistence of neuropathic pain might be from lipid metabolic processes,such as "very-low-density lipoprotein particle clearance," "negative regulation of choleste rol transport" and "membrane lipid catabolic process." We detected the expression of m6A enzymes and found elevated mRNA expression of Ythdf2 and Ythdf3 after spared nerve injury modeling.We speculate that m6A reader enzymes also have an important role in neuropathic pain.These results provide a global landscape of mRNA m6A modifications in the spinal cord in the spared nerve injury model at diffe rent stages after injury.
文摘The rapid rise and development of the computer industry in China has promoted the production of and demand for computer diskettes. China, with over 30 diskette production lines and an annual production of 2 billion diskettes, including some for export, has become the biggest diskette producing country in the world. However, imported diskettes, especially high grade brands, enjoy a good market here. That’s why many world renowned diskette
文摘As a part of the product development process, the after-sales services are not only a source of innovation, but also they benefit from value creation through new managerial methodologies for the achievement of competitive advantage and customer satisfaction. The objective of the paper is to further understand value creation for the after-sales services. We present the case of the creation of a new business for the after-sales services for the entrance into a new market. The new business is created by two gurus in the aerospace industry. A typology of guidelines is derived, based on organizational and strategic perspectives, for the after-sales services value creation and the guidelines for the creation of a new business as well as for the entrance of into a new market are presented.
文摘Missile is an important weapon system of the army.The spare parts of missile equipment are significant effect on military operations.In order to improve the mission completion rate of missile equipment in wartime,this paper introduces data sensing method to forecast the demand of valuable spare parts of missile equipment dynamically.Firstly,the information related to valuable spare parts of missile equipment was obtained by data sensing,and the sample size was determined by Bernoulli uniform sampling probability.Secondly,according to the data quality of multi-source and multi-modal,the data requirement for dynamic demand prediction of valuable spare parts of missile equipment was obtained.Finally,according to the characteristics of the spare parts,the life of the spare parts was predicted,realizing the dynamic prediction of the demand for valuable spare parts of missile equipment.The results show that the demand of valuable spare parts of missile equipment can be predicted dynamically by using this method,the accuracy is higher than 95%,and the real-time performance is more excellent.
