Bowel preparation protocol for hospitalized patients ages 50 years or older:A randomized controlled trial

BACKGROUND The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 years.Therefore,the population that is≥50 years in age requires long-term and regular colonoscopies.Uncomfortable bowel preparation is the main reason preventing patients from undergoing regular colonoscopies.The standard bowel preparation regimen of 4-L polyethylene glycol(PEG)is effective but poorly tolerated.AIM To investigate an effective and comfortable bowel preparation regimen for hospitalized patients≥50 years in age.METHODS Patients were randomly assigned to group 1(2-L PEG+30-mL lactulose+a lowresidue diet)or group 2(4-L PEG).Adequate bowel preparation was defined as a Boston bowel preparation scale(BBPS)score of≥6,with a score of≥2 for each segment.Non-inferiority was prespecified with a margin of 10%.Additionally,the degree of comfort was assessed based on the comfort questionnaire.RESULTS The proportion of patients with a BBPS score of≥6 in group 1 was not significantly different from that in group 2,as demonstrated by intention-to-treat(91.2%vs 91.0%,P=0.953)and per-protocol(91.8%vs 91.0%,P=0.802)analyses.Furthermore,in patients≥75 years in age,the proportion of BBPS scores of≥6 in group 1 was not significantly different from that in group 2(90.9%vs 97.0%,P=0.716).Group 1 had higher comfort scores(8.85±1.162 vs 7.59±1.735,P<0.001),longer sleep duration(6.86±1.204 h vs 5.80±1.730 h,P<0.001),and fewer awakenings(1.42±1.183 vs 2.04±1.835,P=0.026)than group 2.CONCLUSION For hospitalized patients≥50 years in age,the bowel preparation regimen comprising 2-L PEG+30-mL lactulose+a low-residue diet produced a cleanse that was as effective as the 4-L PEG regimen and even provided better comfort.

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to 2021.It also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly patients.Methods Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the CRIMS.Trend tests and spatial analyses were also conducted.Results Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in China.The main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in women.The proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for CHC.The spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern provinces.Conclusion In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual transmission.The primary modes of infection were CHC and NMNCHC.There were variations in the sex ratio among different age groups,infected through various sexual behaviors.HIV/AIDS cases exhibited spatial clustering.Based on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

Factors Associated with Mortality in Children Aged 1 Month to 15 Years Hospitalized in the Pediatric Ward of the Kalaban-Coro Reference Health Center: Cross-Sectional Study

Introduction: Infant and child mortality is a worldwide concern, but developing countries such as Mali are more affected. The aim of this study was to investigate morbidity and factors associated with mortality in children aged 1 month to 15 years. Methodology: This was a cross-sectional study which took place from January 1 to December 31, 2020 covering children aged 1 month to 15 years hospitalized at the Kalaban-Coro CSRéf. Data were entered into Excel and analyzed using SPSS version 20 software. Results: Five hundred children aged 1 months to 15 years were included. The age range 1 to 5 years (53.6%) and male sex (58.2%) were the most represented. Malaria (72.2%), acute respiratory infections (6.2%) and diarrhea/dehydration (3%) were the main morbidities. Mortality was estimated at 10.6%, and the two main causes of death were malaria (56.6%) and acute respiratory infections (7.54%). Univariate analysis revealed a statistically significant association between the dependent variable (death) and age (p Conclusion: This study confirms the high rate of infant and child morbidity and mortality in our health facilities. Strengthening human resources and intensifying behavior-change communication can help reverse the trend.

Age,blood tests and comorbidities and AIMS65 risk scores outperform Glasgow-Blatchford and pre-endoscopic Rockall score in patients with upper gastrointestinal bleeding

BACKGROUND Upper gastrointestinal(GI)bleeding is a life-threatening condition with high mortality rates.AIM To compare the performance of pre-endoscopic risk scores in predicting the following primary outcomes:In-hospital mortality,intervention(endoscopic or surgical)and length of admission(≥7 d).METHODS We performed a retrospective analysis of 363 patients presenting with upper GI bleeding from December 2020 to January 2021.We calculated and compared the area under the receiver operating characteristics curves(AUROCs)of Glasgow-Blatchford score(GBS),pre-endoscopic Rockall score(PERS),albumin,international normalized ratio,altered mental status,systolic blood pressure,age older than 65(AIMS65)and age,blood tests and comorbidities(ABC),including their optimal cut-off in variceal and non-variceal upper GI bleeding cohorts.We subsequently analyzed through a logistic binary regression model,if addition of lactate increased the score performance.RESULTS All scores had discriminative ability in predicting in-hospital mortality irrespective of study group.AIMS65 score had the best performance in the variceal bleeding group(AUROC=0.772;P<0.001),and ABC score(AUROC=0.775;P<0.001)in the non-variceal bleeding group.However,ABC score,at a cut-off value of 5.5,was the best predictor(AUROC=0.770,P=0.001)of inhospital mortality in both populations.PERS score was a good predictor for endoscopic treatment(AUC=0.604;P=0.046)in the variceal population,while GBS score,(AUROC=0.722;P=0.024),outperformed the other scores in predicting surgical intervention.Addition of lactate to AIMS65 score,increases by 5-fold the probability of in-hospital mortality(P<0.05)and by 12-fold if added to GBS score(P<0.003).No score proved to be a good predictor for length of admission.CONCLUSION ABC score is the most accurate in predicting in-hospital mortality in both mixed and non-variceal bleeding population.PERS and GBS should be used to determine need for endoscopic and surgical intervention,respectively.Lactate can be used as an additional tool to risk scores for predicting inhospital mortality.

齐齐哈尔社区65岁以上老年人超重和肥胖与慢性病的相关性调查

目的:分析齐齐哈尔地区65岁以上老年人超重和肥胖的流行特点及其对高血压、高血糖及高血脂等慢性病的影响,为高血压、高血糖及高血脂等慢性病的有效防治提供参考。方法:选取2021年9月齐齐哈尔社区703例65岁以上老年人作为研究对象,对其身高、体重、收缩压、舒张压、空腹血糖、胆固醇进行调查测定,并计算体质量指数(BMI)。结果:该社区65岁以上老年人超重率为22.90%,肥胖率为23.47%,其中,女性超重率为23.42%,男性超重率达为22.29%,两者比较差异无统计学意义(χ^(2)=3.364,P>0.05);女性肥胖率为25.53%,男性肥胖率为21.05%,两者比较,差异无统计学意义(χ^(2)=1.450,P>0.05)。超重组和肥胖组的高血压检出率比较,差异有统计学意义(χ^(2)=71.746、11.537,P<0.01)。超重组和肥胖组的高血糖检出率比较,差异有统计学意义(χ^(2)=8.780、14.286,P<0.01)。超重组和肥胖组的高胆固醇检出率比较,差异有统计学意义(χ^(2)=17.798、18.705,P<0.01)。结论:减少超重、肥胖情况的发生能够对高血压、糖尿病及其他心血管病起到良好的预防和控制作用,65岁以上老年人可通过开展健康教育活动的方式,加强对超重和肥胖产生危害的认识,逐渐形成规律的生活方式、合理的饮食结构,保持运动和良好的心态,定期进行身体健康检查,对超重或肥胖及早干预,减少相关慢性疾病的发生。

National Nutrition and Health Systematic Survey for Children 0–17 Years of Age in China

The main purpose of the National Nutrition and Health Systematic Survey for children 0-17 years of age in China(CNHSC)was to collect basic data on the nutrition,development,and health status for children in different regions across China using evidence-based,reliable,and cost-effective approaches.Children and their parents or guardians from seven regions(south,southwest,north,northwest,eastern,central,and northeast China)in China were recruited.A multi-stage stratified randomized sampling method was used.Two provinces were randomly sampled from each of the seven regions,from which one urban district and one rural country were also randomly sampled,resulting in a total of 28 survey counties/districts.Dietary surveys,health examinations,laboratory testing,and questionnaires were used to collect dietary intake,nutritional status,child development,and health status information.Nutrition,health,and lifestyle assessment of children and their parents was determined using the Knowledge Attitude Practice(KAP)survey.Greater than 100,000 children(38,000 children<6 years of age and 66,000 children6-17 years of age)completed the survey.The survey provided comprehensive data on child nutrition and health status for future studies and will serve as the basis for an integrated nutrition and health improvement strategies proposal for children in China.

Prevalence and Years Lived with Disability for Dental Caries among Children Aged 0-14 Years in China, 1990-2016

The estimate of dental caries among Chinese children at the microscale level using standard methodology remains unclear. In this study, we assessed and analyzed the disease burden of childhood dental caries in China by extracting data from the Global Burden of Disease, Injuries, and Risk Factors Study 2016 （GBD 2016）. In 2016, the number of cases, prevalence, years lived with disability （YLD）, and age-standardized YLD rate of dental caries was 93.0 million, 43.0%, 32,200 person years, and 14.8 per 100,000, respectively. Across 33 provincial units, the disease burden was highest in Hubei （YLD rate 28.6 per 100,000）, lowest in Macao （9.1 per 100,000）, while geographical clustering was not observed. Compared with 1990, the prevalence in 2016 decreased from 46.8% to 43.0%, and the YLD rate decreased from 16.5 per 100,000 to 14.8 per 100,000. Given the slight decrease in dental caries burden, the prevalence and disease burden remained high among Chinese children. Strategies for addressing the spatial inequity of childhood dental caries require geographical targeting.

Dietary Behaviors and Influencing Factors among Rural Left-behind Children Aged below 7 Years in China

Left-behind children comprise a special population inChinese rural areas. According to the 2007 China Census,the number ofleft-behind children aged≤14 years was estimated at 58 million which suggested that these childrencon stituted a

Factors Influencing Preventive Behaviors of Mothers for Diarrhea in Children Aged 1-5 Years in Buol District, Indonesia

This study aims to determine the factors related with mothers＇ behaviors in preventing diarrhea in children aged 1-5 years inBuol District. This was a cross-sectional survey design with health belief model as the conceptual framework. A total of 300mothers were selected by using purposive sampling method based on criteria. Mothers were interviewed by using astructured questionnaire during October to November 2015. A chi-square （X^2） test was used to determine a significantassociation between independent variables and dependent variable. The finding showed that 68.3% of mothers hadgood behaviors in preventing diarrhea. The factors significantly related to mothers＇ behaviors included perceivedsusceptibility to diarrhea, perceived severity of diarrhea, perceived benefits of diarrhea prevention behaviors, and perceivedbarriers of diarrhea prevention behaviors CP 〈 .01, p 〈 .01, p 〈 .01, and p 〈 .01 respectively）. Further, mothers had highperception to comply with diarrhea prevention behaviors. Those who perceived that diarrhea prevention behaviors werehighly beneficial to their children had good behaviors in preventing diarrhea. However, taking certain actions must considernegative aspects.

Risk Factors for Geo-Helminthiasis in Children Aged 6 - 36 Months in a Rural Health District in Cameroon

Introduction and Objectives: Soil-Transmitted-Helminthiasis (STH) is a public health problem in Cameroon. The control strategies currently in place, particularly chemoprevention, has shortcomings linked to the target population, which are school-age children. The objective was to determine the prevalence and the risk factors associated with geo-helminthiasis in children aged 0 to 3 years in a rural health district. Method: From December 2020 to May 2021, a descriptive and analytical cross-sectional study of 376 children between 6 and 36 months was carried out in the Akonolinga health district. This was a cluster sampling in 4 health areas. Stool samples were collected and analysed using the mini-FLOTAC method. The results expressed as the number of eggs per gram of stool. A questionnaire on socio-demographic and lifestyle data was administered to the parents. The Chi-squared test was used to measure the association between geo-helminth infection and the data collected. A multivariate analysis using logistic regression was performed (p 0.05). Results: The prevalence of STH was 19.4% (Ascaris lumbricoides: 16% and Trichuris trichiura: 8%). Risk factors were: consumption of contaminated water (AOR = 1.93 [1.03 - 3.6];p = 0.040), early contact of the child with the ground (before age of 4 months) (AOR = 4.9 [2.1 - 11.37];p .001), habit of walking barefoot (AOR = 2.91 [1.1 - 7.97];p = 0.038), and living in a habitat with unpaved ground (AOR = 7.4 [1.55 - 35.7];p = 0.012). Conclusion: The prevalence of STHs in infants was high. Preventive chemotherapy should be extended to this age-group, and other measures intensified.

上海芷江西路社区859例65岁以上老人腹部超声检查结果回顾性分析

目的:分析社区65岁以上老人体检者腹部超声结果,了解社区老人腹部超声异常情况。方法:回顾性分析2022年9月至12月859例65岁以上老人体检者的腹部超声检查结果,其中男性359例,女性500例,平均年龄(70.98±4.80)岁。结果:859例体检者中检出腹部超声异常680人,异常检出率79.16%。检出异常排前五位依次为脂肪肝45.75%、肝囊肿26.31%、胆囊结石13.15%、胆囊壁胆固醇结晶5.01%、胆囊息肉样病变3.84%。肝囊肿检出率男性为33.15%、女性为21.4%,男性和女性的差异有统计学意义(P<0.05)。胆囊壁胆固醇结晶检出率男性7.24%、女性3.4%,男性和女性的差异有统计学意义(P<0.05),75岁以下老人胆囊结石检出率为11.29%、75岁及以上老人为23.31%,差异有统计学意义(P<0.05)。结论:上海芷江西路社区老人腹部超声检出肝胆疾病较多,定期检查可监测此类慢性疾病的变化情况,为疾病的管理及进一步诊治提供依据,具有及早发现肿瘤等疾病的价值。

The overview of the language acquisition for Chinese city children aged 0-3 years

This paper examines the language development of Chinese children aged 0-3years in city family. About baby＇s language development by the time stages accordingly. Paying special attention to the efforts for the parents or caregivers. Infants receive more talking education and speak earlier. Most parents can hardly wait for their baby to say its first word and communicate with their baby. From about 2 years old, the child should be able to use simple phrases, retell simple story and even to sing song. Parents play an important role in this stage. By the 3 years children begin to use most of function words rather than omit them. And acquisition for the second language will help children＇s language development. The children have a gift for learning language.

Epidemiologic surve of blood lipid level among 1401 residents aged≥60 years in rong-gui community

Objectives To investigate prevalence of blood lipid level among 1401 residents aged≥60 years in rong-gui community.Methods 1401 ones(579 males,822 females, (68.12±6.64)years Of total 1503 residents aged≥60 years in the 2 villages which were randomly exampled in rong-gui community were investigated.867 ones aged among 60-69 years(61.9%),430 ones aged among 70-79 years (30.7%),104 ones aged≥60 years(7.4%).Investigative items included age,sex,total cholesterol(TC),triglyceride (TG),body height,body weight,waist circumference(WC), hip circumference(HC),fasting plasma glucose(FG),blood pressure,history of past illness,body mass index(BMI), waist hip ratio(WHR),waist height ratio(WHtR).Results (l)Of total 1401 residents,Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male(P【0.01), The difference among three age groups were not significant, the combined prevalence of hyperlipemia and borderline hyperlipemia was 80.1%.(2)The FG、BMI、SBP、DBP、WC、WHR、WHtR of residents with hyperlipemia were higher than ones with normal blood lipid level(P【0.01).(3)By Pearson correlation analysis,we found that hyperlipemia was obviously correlated with FG,BMI,WC,WHR,WHtR, SBP,DBP.Conclusions(1)Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male.(2) hyperlipemia were obviously correlated with higher FG、BMI、WC、WHR、WHtR、SBP、DBP.

Introducing a 2nd Universal Space-Time Constant Can Explain the Observed Age of the Universe and Dark Energy

The purpose of this paper is to introduce new theoretical concepts as opposed to accepting the existence of dark entities, such as dark energy. This research sought to introduce a 2nd universal space-time constant, besides having a finite speed constant (speed of light in vacuum c). A finite universal age constant b is introduced. Namely, this paper shows that the changes in the Earth’s anomalistic year duration over time support the hypothesis of the age of the universe correlating with a maximum number of orbital revolutions constant. Neglecting the gravitational influence of other cosmological entities in the proximity of the Earth, the constant maximum number of revolutions is herewith determined solely by the Earth’s orbital revolutions around the Sun. The value of the universal age constant b is calculated to be around 13.8 billion orbital revolutions, derived out of an equation related to the changes in the Earth’s anomalistic year duration over time and the so-called Hubble tension. The above-mentioned calculated value b correlates well with the best fit to measured data of the cosmic microwave background radiation (CMBR) by the Planck spacecraft, the age of the observed universe is measured to be approximately 13.787 ± 0.020 billion years (2018 final data release). Developing a theory with this 2nd universal space-time constant b, being covariant with respect to the Lorentz transformations when time spans are large, gives results such as: A confirmation of the measured CMBR value of 13.787 ± 0.020 billion years. Correlating well with the observed expansion rate of the universe (dark energy). The universe’s expansion accelerating over the last four to five billion years.

Epidemiologic surve of Overweight and obesity among residents aged≥60 years in ronggui community

Objectives To investigate prevalence of overweight and obesity among residents aged 3≥60 years in ronggui community.Methods 1372 ones(570 males,802 females,68.03±6.62 years) Of total 1503 residents aged≥60 years in the 2 villages which were randomly exampled in rong-gui community were investigated.857 ones aged among 60-69 years(62.5%),416 ones aged among 70-79 years (30.3%),99 ones aged≥60 years(7.2%).Investigative items included age,sex,body height,body weight,waist circumference(WC),hip circumference(HC)、fasting plasma glucose(FG),total cholesterol(TC),triglyceride(TG),blood pressure,history of past illness,body mass index(BMI),waist hip ratio(WHR) and waist height ratio(WHtR).Results (1)Of total 1372 residents,the combined prevalence of overweight and obesity was 39.4%.Prevalence of overweight, obesity were 29.4%,10.0%respectively.Prevalence of overweight, obesity of male were 30.8%,6.0%,and female, 28.5%,12.8%respectively.Prevalence of overweight,obesity of residents aged 60-69 years were 31.2%,11.3%,70-79 years were 27.0%,9.1%and≥80 years were 25.2%,2.0% respectively.The difference between male and female、among three age groups were not significant.(2)Of total 1372 residents, prevalence of central adiposity were 34.6%,male was 15.9%and female was 52.4%,female signifleanfly higher than male(P【0.01).(3)The FG^TG.SBP^DBP of residents with overweight、obesity or central adiposity were higher than residents with normal weight or WC(P【0.01).(4)By Pearson correlation analysis,we found that overweight、obesity and central adiposity were obviously correlated with FG、TG、SBP、DBP(P【0.01),were not correlated with TC(P】0.05). Conclusions(1)Of total 1372 residents,the combined preva- lence of overweight and obesity was 39.4%,prevalence of overweight,obesity were 29.4%,10.0%respectively,prevalence of central adiposity were 34.6%,female was 52.4%, female signifleanfly higher than male.(2)overweight.obesity and central adiposity were obviously correlated with FG,TG, SBP,DBP.

Surgical results and prognosis of patients with primary bronchogenic carcinoma aged less than 30 years

Objective To investigate and analyze the clinical and pathological features of surgical treatment for primary bronchogenic carcinoma in adolescent patients. Methods A retrospective review is presented of patients less than 30 years with surgical treatment of bronchogenic

Ailogeneic hematopoietic cell transplantation for malignant hematological diseases in patients older than 50 years of age

Objective To investigate the efficiency and safety of allogeneic hematopoietic cell transplantation for malignant hematological diseases in patients older than 50 years of age. Methods From May 2002 to January 2010,35 patients P 】 50 years with malignant hematological diseases received allogeneic hematopoietic

2022年厦门市≥65岁老年人健康体检结果分析

目的:分析2022年厦门市≥65岁老年人的健康体检结果,为开展社区老年人健康管理提供依据。方法:对2022年厦门市265140名≥65岁老年人的健康体检结果进行汇总分析。结果:厦门市≥65岁老年人主要体检异常结果为中心性肥胖(65.47%)、心电图异常(54.74%)、确诊高血压(46.97%)、肝功能异常(39.70%)、超重(39.20%)。女性中心性肥胖发生率高于男性,差异有统计学意义(χ^(2)=6.311,P=0.012),BMI正常的老年人中心性肥胖发生率为28.96%。高血压患者血压控制率为64.92%,普通人群高血压发生率为24.29%。糖尿病患者血糖控制率为41.50%,普通人群高血糖发生率为20.43%。患有≥1种慢性病的老年人占比为85.59%,患有≥2种慢性病的占62.85%。结论:2022年厦门市≥65岁老年人慢性病患病率高且共病问题突出,应采取综合干预措施,实现老年人多病共管、共防、共治、共减。

Age Structure and Change Trend of Tobacco Farmers:A Case Study of Shashi Town,Liuyang City,Hunan Province

Taking the tobacco-growing area of Shashi Town,Liuyang City as the object,the number of registered,newly added and resigned tobacco farmers in each year,average age,number and proportion of tobacco farmers of different ages,number and proportion of tobacco farmers born in different eras,as well as planting scale and planting history of flue-cured tobacco in the last 10 years were analyzed statistically.The results showed that the number of tobacco farmers in Shashi Town showed a rapid decline trend from 2012 to 2018,while the average age continuously increased,and the average planting scale rose in a wave like way.From 2019 to 2021,the decline rate of the number of tobacco farmers slowed down,and the average planting scale continuously increased,while the aging of tobacco farmers accelerated.Meantime,the birth years of tobacco farmers were further concentrated in the 1960s,and they were mainly at the age of 50-59.The tobacco industry in Shashi Town of Liuyang City is facing the crisis of aging tobacco farmers and no successor of flue-cured tobacco planting,and it is predicted that the next 5-10 years will continue the change trend from 2019 to 2021.

Mohnarin 2009年度报告:青壮年(14-65岁)来源菌株耐药监测

目的了解我国青壮年(14-65岁)感染患者病原菌构成及其耐药情况。方法收集114家成员单位2009年度抗菌药物敏感试验数据,根据Mohnarin的监测方案和CLSI2009年标准,用WHONET软件(5.5版本)对青壮年(14-65岁)患者的耐药监测数据进行分析总结。结果 2009年度全国114家Mohnarin成员单位,临床分离菌青壮年人群来源的菌株共82115株。其中,革兰阴性菌占70.04%,主要菌株依次为大肠埃希菌14696株(17.90%)、肺炎克雷伯菌8517株(10.37%)、铜绿假单胞菌7903株(9.62%)及鲍曼不动杆菌7309株(8.90%);革兰阳性菌占29.96%,主要菌株依次为金黄色葡萄球菌7550株(9.19%)、表皮葡萄球菌4068株(4.95%)、粪肠球菌3099株(3.77%)和屎肠球菌2590株(3.15%)。对葡萄球菌属保持100%敏感的有利奈唑胺、万古霉素;出现替考拉宁耐药的葡萄球菌约0.8%和万古霉素耐药的屎肠球菌为2.6%;肠杆菌科细菌中,大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌的ESBL检出率分别为62.1%,42.4%和27.5%;所有上报的肠杆菌科细菌,均开始出现碳青霉烯类耐药菌株;非发酵菌对各类抗菌药物的敏感性均很低,保持70%敏感率的药物主要有多粘菌素B和碳青霉烯类;但不动杆菌对碳青霉烯类的敏感性已下降到50%左右;苛氧菌在青壮年人群感染标本中的分离率仍很低,但对各类抗菌药物保持很高的敏感性。结论我国青壮年人群感染病原菌以革兰阴性菌为主,所有细菌对常用抗菌药物的耐药性严重。