Aims: This study compares the WHO (2007) and the National Health Examination Survey (NHANES III) reference intervals and investigates the differences when applied on a Canadian cohort of older children and adolescents...Aims: This study compares the WHO (2007) and the National Health Examination Survey (NHANES III) reference intervals and investigates the differences when applied on a Canadian cohort of older children and adolescents. Methods: We calculated height, weight and BMI z-scores of 4375 consecutive patients (1993 female, 45.6%) aged 5 - 20 years attending outpatient clinics at a single tertiary care centre using reference data of the latest NHANES (III) survey and the WHO (2007) growth charts. To address age dependency, data was stratified into age groups. Results: Using the NHANES III reference intervals, medians of weight (+0.46), height (+0.29) and BMI z-scores (+0.46) were significantly non-zero. The WHO (2007) growth charts yielded medians of +2.05, +0.32, +0.53 for weight, height and BMI z-scores respectively, all significantly non-zero. When comparing both growth charts, Canadian children had significantly different weight and BMI z-scores (p 95th percentile) doubled from 8.6% to 16.0%. A significant age dependency was observed with higher WHO (2007) weight z-scores (>7 years) and higher BMI z-scores (7 to 13 years) and no significant difference was observed for height z-scores across all age groups. Gender differences were observed for weight z-scores (>9 years) and BMI (males: 9 - 11 years, p = 0.0118;11 - 13 years, p = 0.0069) whereas no significant difference was found in height z-scores across all age groups. Conclusion: Our results reveal substantial differences between both reference populations and thus interpretation needs be done with caution, especially when labelling results as abnormal.展开更多
目的:通过比较肥胖青少年基础代谢率实测值与公式推测值的一致性,探讨以性别、年龄、身高和体重为主要参数的基础代谢率推测公式能否适用于中国肥胖青少年。方法:以66名中国肥胖青少年(男32人,女34人)为对象,晨起空腹进行相关人体测量,...目的:通过比较肥胖青少年基础代谢率实测值与公式推测值的一致性,探讨以性别、年龄、身高和体重为主要参数的基础代谢率推测公式能否适用于中国肥胖青少年。方法:以66名中国肥胖青少年(男32人,女34人)为对象,晨起空腹进行相关人体测量,并采用便携式气体代谢分析仪测定受试者的基础代谢率,区分性别后分别比较采用Harris and Benedict公式、Schofield公式和Mifflin公式计算的基础代谢率与实测值的差异。结果:中国肥胖青少年基础代谢率采用Mifflin公式和Harris and Benedict公式的推测值与实测值相比,偏倚较小,Mifflin公式为-5.79 kcal/d(男)和-57.45 kcal/d(女),Harris and Benedict公式为-109.86 kcal/d(男)和-63.76 kcal/d(女),均在临床可接受的范围(-250 kcal/d,250 kcal/d)内。Harris and Benedict公式推测男女肥胖青少年基础代谢率的一致性界限分别为(男:-732.16 kcal/d,512.45 kcal/d)和(女:-595.01 kcal/d,467.49 kcal/d),Mifflin公式推测男女肥胖青少年基础代谢率的一致性界限分别为(男:-597.91 kcal/d,586.33 kcal/d)和(女:-603.01,531.84),均超出临床可接受范围。Schofield公式计算女性肥胖青少年基础代谢率的推测值与实测值相比,偏倚为-123.69 kcal/d,计算男性肥胖青少年基础代谢率的推测值与实测值的偏倚为-260.35 kcal/d,其一致性界限超出临床可接受范围。结论:Harris and Benedict公式、Schofield公式和Mifflin公式用于评估中国肥胖青少年基础代谢率时,其推测值与实测值的一致性界限均超出临床可接受范围,以上三个公式所得基础代谢率推测值与间接测热法实测值一致性较差,评估中国肥胖青少年基础代谢率的准确性不够。展开更多
文摘Aims: This study compares the WHO (2007) and the National Health Examination Survey (NHANES III) reference intervals and investigates the differences when applied on a Canadian cohort of older children and adolescents. Methods: We calculated height, weight and BMI z-scores of 4375 consecutive patients (1993 female, 45.6%) aged 5 - 20 years attending outpatient clinics at a single tertiary care centre using reference data of the latest NHANES (III) survey and the WHO (2007) growth charts. To address age dependency, data was stratified into age groups. Results: Using the NHANES III reference intervals, medians of weight (+0.46), height (+0.29) and BMI z-scores (+0.46) were significantly non-zero. The WHO (2007) growth charts yielded medians of +2.05, +0.32, +0.53 for weight, height and BMI z-scores respectively, all significantly non-zero. When comparing both growth charts, Canadian children had significantly different weight and BMI z-scores (p 95th percentile) doubled from 8.6% to 16.0%. A significant age dependency was observed with higher WHO (2007) weight z-scores (>7 years) and higher BMI z-scores (7 to 13 years) and no significant difference was observed for height z-scores across all age groups. Gender differences were observed for weight z-scores (>9 years) and BMI (males: 9 - 11 years, p = 0.0118;11 - 13 years, p = 0.0069) whereas no significant difference was found in height z-scores across all age groups. Conclusion: Our results reveal substantial differences between both reference populations and thus interpretation needs be done with caution, especially when labelling results as abnormal.
文摘目的:通过比较肥胖青少年基础代谢率实测值与公式推测值的一致性,探讨以性别、年龄、身高和体重为主要参数的基础代谢率推测公式能否适用于中国肥胖青少年。方法:以66名中国肥胖青少年(男32人,女34人)为对象,晨起空腹进行相关人体测量,并采用便携式气体代谢分析仪测定受试者的基础代谢率,区分性别后分别比较采用Harris and Benedict公式、Schofield公式和Mifflin公式计算的基础代谢率与实测值的差异。结果:中国肥胖青少年基础代谢率采用Mifflin公式和Harris and Benedict公式的推测值与实测值相比,偏倚较小,Mifflin公式为-5.79 kcal/d(男)和-57.45 kcal/d(女),Harris and Benedict公式为-109.86 kcal/d(男)和-63.76 kcal/d(女),均在临床可接受的范围(-250 kcal/d,250 kcal/d)内。Harris and Benedict公式推测男女肥胖青少年基础代谢率的一致性界限分别为(男:-732.16 kcal/d,512.45 kcal/d)和(女:-595.01 kcal/d,467.49 kcal/d),Mifflin公式推测男女肥胖青少年基础代谢率的一致性界限分别为(男:-597.91 kcal/d,586.33 kcal/d)和(女:-603.01,531.84),均超出临床可接受范围。Schofield公式计算女性肥胖青少年基础代谢率的推测值与实测值相比,偏倚为-123.69 kcal/d,计算男性肥胖青少年基础代谢率的推测值与实测值的偏倚为-260.35 kcal/d,其一致性界限超出临床可接受范围。结论:Harris and Benedict公式、Schofield公式和Mifflin公式用于评估中国肥胖青少年基础代谢率时,其推测值与实测值的一致性界限均超出临床可接受范围,以上三个公式所得基础代谢率推测值与间接测热法实测值一致性较差,评估中国肥胖青少年基础代谢率的准确性不够。
