[ Objectives] This study was conducted to compare agrimophol contentsin Agrimonia pilosa Ledeb. at different harvest time, so as to select its best harvest time. [Methods] High performance liquid chromatography was us...[ Objectives] This study was conducted to compare agrimophol contentsin Agrimonia pilosa Ledeb. at different harvest time, so as to select its best harvest time. [Methods] High performance liquid chromatography was used for the determination of agfmophol in A. pilosa Ledeb. at different harvest time in Luzhou. [ Results ] The content of agrimophol could be detected by HPLC. Agrimophol had good linearity in 0.01 - 0.1 mg/ml （ r = 0.999 9 ）, the average recov- ery was 101.5%, and RSD was 1.10%. The content of agrimophol in A. pilosa Ledeb. in Luzhou was 0.010 8% in June, and 0.013 1% in July, much higher than any other months. [ Conclusions] This experiment established a method for detecting the content of agrimophol by HPLC, which is simple, with high precision, high accuracy, good repeatability and recovery. The reasonable harvest time of A. pilosa Ledeb. in Luzhou is June and July.展开更多
大鼠按8mg/kg静脉注射鹤草酚静脉乳,体内药物动力学特征呈现双室开放模型。α=1.771h^(-1),β=0.2535h^(-1),Cl=0.613ml/min,Clr=0.0268ml/min,AUC=50.336μg·h/ml,MRT=3.637h。稳态分布容积Vdss=132.233ml,本文采用非线性回归处...大鼠按8mg/kg静脉注射鹤草酚静脉乳,体内药物动力学特征呈现双室开放模型。α=1.771h^(-1),β=0.2535h^(-1),Cl=0.613ml/min,Clr=0.0268ml/min,AUC=50.336μg·h/ml,MRT=3.637h。稳态分布容积Vdss=132.233ml,本文采用非线性回归处理血药浓度数据,依据Akaike's判据(Akaike's information criterion,AIC).τ_1~2值比较和F-检验选择较佳的拟合模型。模型分析结果表明,鹤草酚主要经肝脏消除,肾脏排泄量仅占静注剂量的4.4%,体内主要分布于血流丰富的大循环和组织。双室模型计算的AUC和MRT与非房室处理的结果之间无明显差异。展开更多
文摘[ Objectives] This study was conducted to compare agrimophol contentsin Agrimonia pilosa Ledeb. at different harvest time, so as to select its best harvest time. [Methods] High performance liquid chromatography was used for the determination of agfmophol in A. pilosa Ledeb. at different harvest time in Luzhou. [ Results ] The content of agrimophol could be detected by HPLC. Agrimophol had good linearity in 0.01 - 0.1 mg/ml （ r = 0.999 9 ）, the average recov- ery was 101.5%, and RSD was 1.10%. The content of agrimophol in A. pilosa Ledeb. in Luzhou was 0.010 8% in June, and 0.013 1% in July, much higher than any other months. [ Conclusions] This experiment established a method for detecting the content of agrimophol by HPLC, which is simple, with high precision, high accuracy, good repeatability and recovery. The reasonable harvest time of A. pilosa Ledeb. in Luzhou is June and July.
文摘大鼠按8mg/kg静脉注射鹤草酚静脉乳,体内药物动力学特征呈现双室开放模型。α=1.771h^(-1),β=0.2535h^(-1),Cl=0.613ml/min,Clr=0.0268ml/min,AUC=50.336μg·h/ml,MRT=3.637h。稳态分布容积Vdss=132.233ml,本文采用非线性回归处理血药浓度数据,依据Akaike's判据(Akaike's information criterion,AIC).τ_1~2值比较和F-检验选择较佳的拟合模型。模型分析结果表明,鹤草酚主要经肝脏消除,肾脏排泄量仅占静注剂量的4.4%,体内主要分布于血流丰富的大循环和组织。双室模型计算的AUC和MRT与非房室处理的结果之间无明显差异。
