This study aims to assess and compare levels of particulate matter(PM10 and PM2.5)in urban and industrial areas in Malaysia during haze episodes,which typically occur in the south west monsoon season.The high concentr...This study aims to assess and compare levels of particulate matter(PM10 and PM2.5)in urban and industrial areas in Malaysia during haze episodes,which typically occur in the south west monsoon season.The high concentrations of atmospheric particles are mainly due to pollution from neighbouring countries.Daily PM concentrations were analysed for urban and industrial areas including Alor Setar,Tasek,Shah Alam,Klang,Bandaraya Melaka,Larkin,Balok Baru,and Kuala Terengganu in 2018 and 2019.The analysis employed spatiotemporal to examine how PM levels were distributed.The data summary revealed that PM levels in all study areas were right-skewed,indicating the occurrence of high particulate events.Significant peaks in PM concentrations during haze events were consistently observed between June and October,encompassing the south west monsoon and inter-monsoon periods.The study on acute respiratory illnesses primarily focused on Selangor.Analysis revealed that Klang had the highest mean number of inpatient cases for acute exacerbation of bronchial asthma(AEBA)and acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with values of 260.500 and 185.170,respectively.Similarly,for outpatient cases of AEBA and AECOPD,Klang had the highest average values of 41.67 and 14.00,respectively.Shah Alam and Sungai Buloh did not show a significant increase in cases during periods of biomass burning.The statistical analysis concluded that higher concentrations of PM were associated with increased hospital admissions,particularly from June to September,as shown in the bar diagram.Haze episodes were associated with more healthcare utilization due to haze-related respiratory illnesses,seen in higher inpatient and outpatient visits(p<0.05).However,seasonal variability had minimal impact on healthcare utilization.These findings offer a comprehensive assessment of PM levels during historic haze episodes,providing valuable insights for authorities to develop policies and guidelines for effective monitoring and mitigation of the negative impacts of haze events.展开更多
This work mainly focuses on the mineralogical study of particulate matter(PM10) in Beijing. Samples were collected on polycarbonate filter from April, 2002 to March, 2003 in Beijing urban area. Scanning electronic m...This work mainly focuses on the mineralogical study of particulate matter(PM10) in Beijing. Samples were collected on polycarbonate filter from April, 2002 to March, 2003 in Beijing urban area. Scanning electronic microscopy coupled with energy dispersive X-ray(SEM/EDX) was used to investigate individual mineral particles in Beijing PM10. 1454 individual mineral particulates from 48 samples were analysed by SEM/EDX. The results revealed that mineral particulates were complex and heterogeneous. 38 kinds of minerals in PM10 were identified. The clay minerals, of annual average percentage of 30.1%, were the main composition among the identified minerals, and illite/smectite was the main composition in clay minerals, reaching up to 35%. Annual average percentage of quartz, calcite, compound particulates, carbonates were 13.5%, 10.9%, 11.95%, 10.31%, respectively. Annual average percentage less than 10% were gypsum, feldspar, dolomite, and so on. Fluorite, apatite, halite, barite and chloridize zinc(ZnCl2) were firstly identified in Beijing PM10. Sulfurization was found on surface of mineral particles, suggested extensive atmospheric reaction in air during summer.展开更多
Urban particulate matter 2.5(PM2.5)pollution and public health are closely related,and concerns regarding PM2.5 are widespread.Of the underlying factors,the urban morphology is the most manageable.Therefore,investigat...Urban particulate matter 2.5(PM2.5)pollution and public health are closely related,and concerns regarding PM2.5 are widespread.Of the underlying factors,the urban morphology is the most manageable.Therefore,investigations of the impact of urban three-dimensional(3D)morphology on PM2.5 concentration have important scientific significance.In this paper,39 PM2.5 monitoring sites of Beijing in China were selected with PM2.5 automatic monitoring data that were collected in 2013.This data set was used to analyze the impacts of the meteorological condition and public transportation on PM2.5 concentrations.Based on the elimination of the meteorological conditions and public transportation factors,the relationships between urban 3D morphology and PM2.5 concentrations are highlighted.Ten urban 3D morphology indices were established to explore the spatial-temporal correlations between the indices and PM2.5 concentrations and analyze the impact of urban 3D morphology on the PM2.5 concentrations.Results demonstrated that road length density(RLD),road area density(RAD),construction area density(CAD),construction height density(CHD),construction volume density(CVD),construction otherness(CO),and vegetation area density(VAD)have positive impacts on the PM2.5 concentrations,whereas water area density(WAD),water fragmentation(WF),and vegetation fragmentation(VF)(except for the 500 m buffer)have negative impacts on the PM2.5 concentrations.Moreover,the correlations between the morphology indices and PM2.5 concentrations varied with the buffer scale.The findings could lay a foundation for the high-precision spatial-temporal modelling of PM2.5 concentrations and the scientific planning of urban 3D spaces by authorities responsible for controlling PM2.5 concentrations.展开更多
[ Objective] The research aimed to analyze characteristics of the atmospheric particulate pollutants ( PMlo and PM2.s) in Wenzhou City. [Method] We analyzed interannual change rule of the dust haze in Wenzhou during...[ Objective] The research aimed to analyze characteristics of the atmospheric particulate pollutants ( PMlo and PM2.s) in Wenzhou City. [Method] We analyzed interannual change rule of the dust haze in Wenzhou during 1978 -2008. Moreover, we respectively set monitoring points in urban district, industrial park and beauty spot of Wenzhou in summer and winter of 2010. Element, ion and polycyclic aromatic hydrocarbon com- positions and morphology of the particulate matter were analyzed. [ Result] Dust haze in Wenzhou City mainly appeared in winter and spring, which was related to local meteorological condition. In summer and winter, both PMlo and PM2.s concentrations presented the characteristic of industrial park 〉 commercial area 〉 beauty spot. Chain-like particle aggregates and ultrafine particles were main composition of the atmospheric particulate matter in Wenzhou. Contribution rate of the spherical particle amount was smaller than metropolis, which was related to local industry and traffic. Fe element had the most content in particulate matter. Mass concentration was mainly composed of 6 elements, such as Na, Si, S, K, Ca and Fe. Total concentration of the six elements occupied 70% -80% of the 16 elements. SO^- and NH4* in particulate matter were higher. They were mainly from human activity. Main compositions of the polycyclic aromatic hydrocarbon were naphthalene, anthracene, benzo (b) fluoranthene, indeno (1,2, 3-cd) pyrene and benzo (g, h, i) perylene, which was related to abrupt increase of the motor vehicle. [ Condusion] The research provided scientific basis and technology support for controlling atmospheric particulate matter pollution in Wenzhou City by government and related department.展开更多
In this study, PM10 and PM2.5 were measured in seven sites representing different activities (the same sites of EEAA monitoring stations) in addition to eighth site that used as a background. All results were higher t...In this study, PM10 and PM2.5 were measured in seven sites representing different activities (the same sites of EEAA monitoring stations) in addition to eighth site that used as a background. All results were higher than AQLs of EEAA, US/EPA, and EC although PM10 and PM2.5 are considered to be a direct cause of cardiovascular diseases as well as lead to death and it may be a reason for a number of chest diseases in short-term as well as long-term. Results were compared to the Air Quality Forecast system which developed by EEAA and AQI which created by US/EPA was calculated for some PM10 and PM2.5. Probable potential anthropogenic sources for such high concentrations of PM included unpaved roads, indiscriminate demolition and construction work, industrial activities, and solid wastes. This study resulted in a number of suggestions and recommendations include: 1) Implementation of integrated ISO 26000 and ISO 14001, 2) EIMP/EEAA monitoring stations need restructuring plan to cover all areas in Alexandria, 3) EIMP/EEAA must be supported with PM2.5 monitors, 4) PM control systems must be used in all industrial activities to reduce PM pollution from the source, 5) AQL of PM2.5 in the ambient environment must be reduced and it must be included in the working environment parameters, 6) Environmental law must be applied strictly, and 7) Multidisciplinary co-operation especially between environment and public health specialists must be increased.展开更多
The Tongon mine, the largest gold mine in C?te d’Ivoire, has been in operation since April 2010. However, to our knowledge to date, no study has been conducted on metallic contamination in suspended particulate matte...The Tongon mine, the largest gold mine in C?te d’Ivoire, has been in operation since April 2010. However, to our knowledge to date, no study has been conducted on metallic contamination in suspended particulate matter (PM<sub>10</sub> and PM<sub>2.5</sub>) where there is a lack of information on the carcinogenic and non-carcinogenic risk to human health associated with the exposure of populations in the Tongon area to these pollutants. The general objective of this study is to evaluate the level of contamination of PM<sub>10</sub>;PM<sub>2.5</sub> by heavy metals and their impact on the health of populations exposed to these pollutants in the Tongon gold mine area. The sampling and measurement of suspended particulate matter (PM<sub>10</sub> and PM<sub>2.5</sub>) were done using a MiniVol TAS passive air sampler. Heavy metal concentrations were determined by inductively coupled plasma mass spectroscopy (Nex ION 2000 ICP-MS, USA). The results indicate that the average concentrations of suspended particles (PM<sub>2.5</sub> and PM<sub>10</sub>) obtained are all above the recommended exposure limits. In addition, among the heavy metals contained in the suspended particles, the concentrations of arsenic and nickel are high and all above the standard limit values. The assessment of the health risks related to the inhalation of PM<sub>10</sub> particles reveals that their inhalation over a long period could cause a carcinogenic risk.展开更多
AIM To examine the accuracy of machine learning to relate particulate matter(PM) 2.5 and PM10 concentrations to upper respiratory tract infections(URIs).METHODS Daily nationwide and regional outdoor PM2.5 and PM10 con...AIM To examine the accuracy of machine learning to relate particulate matter(PM) 2.5 and PM10 concentrations to upper respiratory tract infections(URIs).METHODS Daily nationwide and regional outdoor PM2.5 and PM10 concentrations collected over 30 consecutive days obtained from the Taiwan Environment Protection Administration were the inputs for machine learning, using multilayer perceptron(MLP), to relate to the subsequent one-week outpatient visits for URIs. TheURI data were obtained from the Centers for Disease Control datasets in Taiwan between 2009 and 2016. The testing used the middle month dataset of each season(January, April, July and October), and the training used the other months' datasets. The weekly URI cases were classified by tertile as high, moderate, and low volumes.RESULTS Both PM concentrations and URI cases peak in winter and spring. In the nationwide data analysis, MLP machine learning can accurately relate the URI volumes of the elderly(89.05% and 88.32%, respectively) and the overall population(81.75% and 83.21%, respectively) with the PM2.5 and PM10 concentrations. In the regional data analyses, greater accuracy is found for PM2.5 than for PM10 for the elderly, particularly in the Central region(78.10% and 74.45%, respectively), whereas greater accuracy is found for PM10 than for PM2.5 for the overall population, particularly in the Northern region(73.19% and 63.04%, respectively).CONCLUSION Short-term PM2.5 and PM10 concentrations were accurately related to the subsequent occurrence of URIs by using machine learning. Our findings suggested that the effects of PM2.5 and PM10 on URI may differ by age, and the mechanism needs further evaluation.展开更多
Since 1991, air pollution has gained special attention in Taiwan after a petrochemical complex was constructed in Mailiao Township, Yunlin County. We explored the association between the magnitude of PM2.5 and meteoro...Since 1991, air pollution has gained special attention in Taiwan after a petrochemical complex was constructed in Mailiao Township, Yunlin County. We explored the association between the magnitude of PM2.5 and meteorological factors during 2012-2016. Our findings revealed that 1) mean PM2.5 levels gradually decreased from 30.70 μg/m3 in 2013 to 25.36 μg/m3 in 2016;2) wind speed is the main determinant of air quality—air quality significantly improved when it was faster than 4 m/sec;and 3) wind direction is another determinant of air quality—when the wind direction was southerly, air quality improved. Elevated PM2.5 levels were defined as those hourly levels higher than the third quartile (36 μg/m3). The significantly negative predictive factors for elevated PM2.5 levels were the summer or autumn seasons, rainfall, increased wind speed, and wind direction from 150° to 230° from the north. The significantly positive predictive factors for elevated PM2.5 levels were working hours from 6 a.m. to 2 p.m., a temperature between 11°C and 25°C, relative humidity between 40% and 68%, and wind direction (e.g., northerly wind, northeasterly wind, and easterly wind). The predictive formula is attached in the Appendix. Therefore, people should protect themselves on these high-risk days.展开更多
Objective To evaluate the antagonistic effects of N-acetylcysteine(NAC)on mitogen-activated protein kinases(MAPK)pathway activation,oxidative stress and inflammatory responses in rats with lung injury induced by fine ...Objective To evaluate the antagonistic effects of N-acetylcysteine(NAC)on mitogen-activated protein kinases(MAPK)pathway activation,oxidative stress and inflammatory responses in rats with lung injury induced by fine particulate matter(PM2.5).Methods Forty eight male Wistar rats were randomly divided into six groups:blank control group(C1),water drip control group(C2),PM2.5 exposed group(P),low-dose NAC treated and PM2.5 exposed group(L),middle-dose NAC treated and PM2.5 exposed group(M),and high-dose NAC treated and PM2.5 exposed group(H).PM2.5 suspension(7.5 mg/kg)was administered tracheally once a week for four times.NAC of 125 mg/kg,250 mg/kg and 500 mg/kg was delivered intragastrically to L,M and H group respectively by gavage(10 ml/kg)for six days before PM2.5 exposure.The histopathological changes and human mucin 5 subtype AC(MUC5AC)content in lung tissue of rats were evaluated.We investigated IL-6 in serum and bronchoalveolar lavage fluid(BALF)by Enzyme-linked immunosorbent assay(ELISA),MUC5AC in lung tissue homogenate by ELISA,glutathione peroxidase(GSH-PX)in serum and BALF by spectrophotometry,and the expression of p-ERK1/2,p-JNK1/2 and p-p38 proteins by Western blot.All the measurements were analyzed and compared statistically.Results Lung tissue of rats exposed to PM2.5 showed histological destruction and increased mucus secretion of bronchial epithelial cells.Rats receiving NAC treatment showed less histological destruction and mucus secretion.Of P,L,M and H group,MUC5AC in lung tissue,IL-6 in serum and BALF were higher than controls(C1 and C2)(all P<0.05),with the highest levels found in the P group and a decreasing trend with increase of NAC dose.The activity of GSH-PX in serum and BALF of PM2.5 exposed rats(P,L,M and H)was lower than that of controls(all P<0.05),with higher activities found in NAC treated rats(L,M,and H),and an increasing trend with increase of NAC dose.The expressions of p-ERK1/2,p-JNK1/2 and p-p38 proteins in PM2.5 exposed lung tissue(P,L,M and H)was higher than controls(all P<0.05),with decreased levels and dose dependent downregulation found in NAC treated rats.Conclusion NAC can antagonize major MAPK pathway activation,lung oxidative stress and inflammatory injury induced by PM2.5 in rats.展开更多
文摘This study aims to assess and compare levels of particulate matter(PM10 and PM2.5)in urban and industrial areas in Malaysia during haze episodes,which typically occur in the south west monsoon season.The high concentrations of atmospheric particles are mainly due to pollution from neighbouring countries.Daily PM concentrations were analysed for urban and industrial areas including Alor Setar,Tasek,Shah Alam,Klang,Bandaraya Melaka,Larkin,Balok Baru,and Kuala Terengganu in 2018 and 2019.The analysis employed spatiotemporal to examine how PM levels were distributed.The data summary revealed that PM levels in all study areas were right-skewed,indicating the occurrence of high particulate events.Significant peaks in PM concentrations during haze events were consistently observed between June and October,encompassing the south west monsoon and inter-monsoon periods.The study on acute respiratory illnesses primarily focused on Selangor.Analysis revealed that Klang had the highest mean number of inpatient cases for acute exacerbation of bronchial asthma(AEBA)and acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with values of 260.500 and 185.170,respectively.Similarly,for outpatient cases of AEBA and AECOPD,Klang had the highest average values of 41.67 and 14.00,respectively.Shah Alam and Sungai Buloh did not show a significant increase in cases during periods of biomass burning.The statistical analysis concluded that higher concentrations of PM were associated with increased hospital admissions,particularly from June to September,as shown in the bar diagram.Haze episodes were associated with more healthcare utilization due to haze-related respiratory illnesses,seen in higher inpatient and outpatient visits(p<0.05).However,seasonal variability had minimal impact on healthcare utilization.These findings offer a comprehensive assessment of PM levels during historic haze episodes,providing valuable insights for authorities to develop policies and guidelines for effective monitoring and mitigation of the negative impacts of haze events.
基金The National Natural Science Foundation of China(No.40275040) and the Shanghai Leading Academic Disciplines(No. T0105)
文摘This work mainly focuses on the mineralogical study of particulate matter(PM10) in Beijing. Samples were collected on polycarbonate filter from April, 2002 to March, 2003 in Beijing urban area. Scanning electronic microscopy coupled with energy dispersive X-ray(SEM/EDX) was used to investigate individual mineral particles in Beijing PM10. 1454 individual mineral particulates from 48 samples were analysed by SEM/EDX. The results revealed that mineral particulates were complex and heterogeneous. 38 kinds of minerals in PM10 were identified. The clay minerals, of annual average percentage of 30.1%, were the main composition among the identified minerals, and illite/smectite was the main composition in clay minerals, reaching up to 35%. Annual average percentage of quartz, calcite, compound particulates, carbonates were 13.5%, 10.9%, 11.95%, 10.31%, respectively. Annual average percentage less than 10% were gypsum, feldspar, dolomite, and so on. Fluorite, apatite, halite, barite and chloridize zinc(ZnCl2) were firstly identified in Beijing PM10. Sulfurization was found on surface of mineral particles, suggested extensive atmospheric reaction in air during summer.
基金Under the auspices of National Key Research and Development Program of China(No.2016YFB0502504)Beijing Excellent Youth Talent Program(No.2015400018760G294)National Natural Science Foundation of China(No.41201443,41001267).
文摘Urban particulate matter 2.5(PM2.5)pollution and public health are closely related,and concerns regarding PM2.5 are widespread.Of the underlying factors,the urban morphology is the most manageable.Therefore,investigations of the impact of urban three-dimensional(3D)morphology on PM2.5 concentration have important scientific significance.In this paper,39 PM2.5 monitoring sites of Beijing in China were selected with PM2.5 automatic monitoring data that were collected in 2013.This data set was used to analyze the impacts of the meteorological condition and public transportation on PM2.5 concentrations.Based on the elimination of the meteorological conditions and public transportation factors,the relationships between urban 3D morphology and PM2.5 concentrations are highlighted.Ten urban 3D morphology indices were established to explore the spatial-temporal correlations between the indices and PM2.5 concentrations and analyze the impact of urban 3D morphology on the PM2.5 concentrations.Results demonstrated that road length density(RLD),road area density(RAD),construction area density(CAD),construction height density(CHD),construction volume density(CVD),construction otherness(CO),and vegetation area density(VAD)have positive impacts on the PM2.5 concentrations,whereas water area density(WAD),water fragmentation(WF),and vegetation fragmentation(VF)(except for the 500 m buffer)have negative impacts on the PM2.5 concentrations.Moreover,the correlations between the morphology indices and PM2.5 concentrations varied with the buffer scale.The findings could lay a foundation for the high-precision spatial-temporal modelling of PM2.5 concentrations and the scientific planning of urban 3D spaces by authorities responsible for controlling PM2.5 concentrations.
基金Supported by Study on Formation Reason and Early Warning of the Dust Haze and Atmospheric Complex Pollution Control in Wenzhou City ( R20090124)
文摘[ Objective] The research aimed to analyze characteristics of the atmospheric particulate pollutants ( PMlo and PM2.s) in Wenzhou City. [Method] We analyzed interannual change rule of the dust haze in Wenzhou during 1978 -2008. Moreover, we respectively set monitoring points in urban district, industrial park and beauty spot of Wenzhou in summer and winter of 2010. Element, ion and polycyclic aromatic hydrocarbon com- positions and morphology of the particulate matter were analyzed. [ Result] Dust haze in Wenzhou City mainly appeared in winter and spring, which was related to local meteorological condition. In summer and winter, both PMlo and PM2.s concentrations presented the characteristic of industrial park 〉 commercial area 〉 beauty spot. Chain-like particle aggregates and ultrafine particles were main composition of the atmospheric particulate matter in Wenzhou. Contribution rate of the spherical particle amount was smaller than metropolis, which was related to local industry and traffic. Fe element had the most content in particulate matter. Mass concentration was mainly composed of 6 elements, such as Na, Si, S, K, Ca and Fe. Total concentration of the six elements occupied 70% -80% of the 16 elements. SO^- and NH4* in particulate matter were higher. They were mainly from human activity. Main compositions of the polycyclic aromatic hydrocarbon were naphthalene, anthracene, benzo (b) fluoranthene, indeno (1,2, 3-cd) pyrene and benzo (g, h, i) perylene, which was related to abrupt increase of the motor vehicle. [ Condusion] The research provided scientific basis and technology support for controlling atmospheric particulate matter pollution in Wenzhou City by government and related department.
文摘In this study, PM10 and PM2.5 were measured in seven sites representing different activities (the same sites of EEAA monitoring stations) in addition to eighth site that used as a background. All results were higher than AQLs of EEAA, US/EPA, and EC although PM10 and PM2.5 are considered to be a direct cause of cardiovascular diseases as well as lead to death and it may be a reason for a number of chest diseases in short-term as well as long-term. Results were compared to the Air Quality Forecast system which developed by EEAA and AQI which created by US/EPA was calculated for some PM10 and PM2.5. Probable potential anthropogenic sources for such high concentrations of PM included unpaved roads, indiscriminate demolition and construction work, industrial activities, and solid wastes. This study resulted in a number of suggestions and recommendations include: 1) Implementation of integrated ISO 26000 and ISO 14001, 2) EIMP/EEAA monitoring stations need restructuring plan to cover all areas in Alexandria, 3) EIMP/EEAA must be supported with PM2.5 monitors, 4) PM control systems must be used in all industrial activities to reduce PM pollution from the source, 5) AQL of PM2.5 in the ambient environment must be reduced and it must be included in the working environment parameters, 6) Environmental law must be applied strictly, and 7) Multidisciplinary co-operation especially between environment and public health specialists must be increased.
文摘The Tongon mine, the largest gold mine in C?te d’Ivoire, has been in operation since April 2010. However, to our knowledge to date, no study has been conducted on metallic contamination in suspended particulate matter (PM<sub>10</sub> and PM<sub>2.5</sub>) where there is a lack of information on the carcinogenic and non-carcinogenic risk to human health associated with the exposure of populations in the Tongon area to these pollutants. The general objective of this study is to evaluate the level of contamination of PM<sub>10</sub>;PM<sub>2.5</sub> by heavy metals and their impact on the health of populations exposed to these pollutants in the Tongon gold mine area. The sampling and measurement of suspended particulate matter (PM<sub>10</sub> and PM<sub>2.5</sub>) were done using a MiniVol TAS passive air sampler. Heavy metal concentrations were determined by inductively coupled plasma mass spectroscopy (Nex ION 2000 ICP-MS, USA). The results indicate that the average concentrations of suspended particles (PM<sub>2.5</sub> and PM<sub>10</sub>) obtained are all above the recommended exposure limits. In addition, among the heavy metals contained in the suspended particles, the concentrations of arsenic and nickel are high and all above the standard limit values. The assessment of the health risks related to the inhalation of PM<sub>10</sub> particles reveals that their inhalation over a long period could cause a carcinogenic risk.
基金Supported by Hualien Armed Forces General Hospital,No.805-C107-14Ministry of Science and Technology,Taiwan,R.O.C.,No.MOST 107-2221-E-899-002-MY3
文摘AIM To examine the accuracy of machine learning to relate particulate matter(PM) 2.5 and PM10 concentrations to upper respiratory tract infections(URIs).METHODS Daily nationwide and regional outdoor PM2.5 and PM10 concentrations collected over 30 consecutive days obtained from the Taiwan Environment Protection Administration were the inputs for machine learning, using multilayer perceptron(MLP), to relate to the subsequent one-week outpatient visits for URIs. TheURI data were obtained from the Centers for Disease Control datasets in Taiwan between 2009 and 2016. The testing used the middle month dataset of each season(January, April, July and October), and the training used the other months' datasets. The weekly URI cases were classified by tertile as high, moderate, and low volumes.RESULTS Both PM concentrations and URI cases peak in winter and spring. In the nationwide data analysis, MLP machine learning can accurately relate the URI volumes of the elderly(89.05% and 88.32%, respectively) and the overall population(81.75% and 83.21%, respectively) with the PM2.5 and PM10 concentrations. In the regional data analyses, greater accuracy is found for PM2.5 than for PM10 for the elderly, particularly in the Central region(78.10% and 74.45%, respectively), whereas greater accuracy is found for PM10 than for PM2.5 for the overall population, particularly in the Northern region(73.19% and 63.04%, respectively).CONCLUSION Short-term PM2.5 and PM10 concentrations were accurately related to the subsequent occurrence of URIs by using machine learning. Our findings suggested that the effects of PM2.5 and PM10 on URI may differ by age, and the mechanism needs further evaluation.
文摘Since 1991, air pollution has gained special attention in Taiwan after a petrochemical complex was constructed in Mailiao Township, Yunlin County. We explored the association between the magnitude of PM2.5 and meteorological factors during 2012-2016. Our findings revealed that 1) mean PM2.5 levels gradually decreased from 30.70 μg/m3 in 2013 to 25.36 μg/m3 in 2016;2) wind speed is the main determinant of air quality—air quality significantly improved when it was faster than 4 m/sec;and 3) wind direction is another determinant of air quality—when the wind direction was southerly, air quality improved. Elevated PM2.5 levels were defined as those hourly levels higher than the third quartile (36 μg/m3). The significantly negative predictive factors for elevated PM2.5 levels were the summer or autumn seasons, rainfall, increased wind speed, and wind direction from 150° to 230° from the north. The significantly positive predictive factors for elevated PM2.5 levels were working hours from 6 a.m. to 2 p.m., a temperature between 11°C and 25°C, relative humidity between 40% and 68%, and wind direction (e.g., northerly wind, northeasterly wind, and easterly wind). The predictive formula is attached in the Appendix. Therefore, people should protect themselves on these high-risk days.
文摘Objective To evaluate the antagonistic effects of N-acetylcysteine(NAC)on mitogen-activated protein kinases(MAPK)pathway activation,oxidative stress and inflammatory responses in rats with lung injury induced by fine particulate matter(PM2.5).Methods Forty eight male Wistar rats were randomly divided into six groups:blank control group(C1),water drip control group(C2),PM2.5 exposed group(P),low-dose NAC treated and PM2.5 exposed group(L),middle-dose NAC treated and PM2.5 exposed group(M),and high-dose NAC treated and PM2.5 exposed group(H).PM2.5 suspension(7.5 mg/kg)was administered tracheally once a week for four times.NAC of 125 mg/kg,250 mg/kg and 500 mg/kg was delivered intragastrically to L,M and H group respectively by gavage(10 ml/kg)for six days before PM2.5 exposure.The histopathological changes and human mucin 5 subtype AC(MUC5AC)content in lung tissue of rats were evaluated.We investigated IL-6 in serum and bronchoalveolar lavage fluid(BALF)by Enzyme-linked immunosorbent assay(ELISA),MUC5AC in lung tissue homogenate by ELISA,glutathione peroxidase(GSH-PX)in serum and BALF by spectrophotometry,and the expression of p-ERK1/2,p-JNK1/2 and p-p38 proteins by Western blot.All the measurements were analyzed and compared statistically.Results Lung tissue of rats exposed to PM2.5 showed histological destruction and increased mucus secretion of bronchial epithelial cells.Rats receiving NAC treatment showed less histological destruction and mucus secretion.Of P,L,M and H group,MUC5AC in lung tissue,IL-6 in serum and BALF were higher than controls(C1 and C2)(all P<0.05),with the highest levels found in the P group and a decreasing trend with increase of NAC dose.The activity of GSH-PX in serum and BALF of PM2.5 exposed rats(P,L,M and H)was lower than that of controls(all P<0.05),with higher activities found in NAC treated rats(L,M,and H),and an increasing trend with increase of NAC dose.The expressions of p-ERK1/2,p-JNK1/2 and p-p38 proteins in PM2.5 exposed lung tissue(P,L,M and H)was higher than controls(all P<0.05),with decreased levels and dose dependent downregulation found in NAC treated rats.Conclusion NAC can antagonize major MAPK pathway activation,lung oxidative stress and inflammatory injury induced by PM2.5 in rats.