Objective\ To test the effect of hypothermia on Na+/H+ exchange, activated by shrinkage and cytoplasmic acidosis. Method\ Amiloride-sensitive Na+ influx in guinea pig red cells was traced with isotope 22Na an...Objective\ To test the effect of hypothermia on Na+/H+ exchange, activated by shrinkage and cytoplasmic acidosis. Method\ Amiloride-sensitive Na+ influx in guinea pig red cells was traced with isotope 22Na and intracellular Na+ concentration was measured by emission flame photometry. Result\ Amiloride-sensitive Na+ influx decreased linearly as a function of temperatures (about 37℃) in shrunken cells, but increased in acidified cells. The up-regulation of acid-induced Na+/H+ exchange by elevated temperature was enhanced by hypo-osmolarity. Less sensitivity of intracellular H+ site at 41℃ may be the mechanism for the inhibition of shrinkage-induced Na+/H+ exchange by elevated temperature. Heating-mediated explosive increase in the activity of acid-induced Na+/H+ exchange may be due to enhanced extracellular Na+ sensitivity and lower intracellular pH caused by acidic metabolites. Acid-induced Na+/H+ ewxchange contributes to cytoplasmic Na+ accumulation. Conclusion\ These two modes of Na+/H+ exchange with different response to elevated temperature may play different roles in the cellular pathogenesis of heatstroke.展开更多
S Zorb装置在长期低负荷运行中出现进料换热器偏流、反应器底部分配盘泡罩磨损严重、精制汽油产品带水、吸附剂循环故障等问题,不能满足装置在特殊情况下需要长期维持低负荷运行的需求。对S Zorb装置在长期低负荷运行中出现的问题进行...S Zorb装置在长期低负荷运行中出现进料换热器偏流、反应器底部分配盘泡罩磨损严重、精制汽油产品带水、吸附剂循环故障等问题,不能满足装置在特殊情况下需要长期维持低负荷运行的需求。对S Zorb装置在长期低负荷运行中出现的问题进行了分析,并通过控制氢油比,控制吸附剂硫、碳含量,控制稳定塔汽提效果等措施,使装置能够在65%的低负荷下控制辛烷值损失小于0.5单位,烯烃损失小于1.0%,并维持长期稳定运行。展开更多
This research evaluates the performance of a Phase Change Material(PCM)battery integrated into the climate system of a new transparent meeting center.The main research questions are:a.“Can the performance of the batt...This research evaluates the performance of a Phase Change Material(PCM)battery integrated into the climate system of a new transparent meeting center.The main research questions are:a.“Can the performance of the battery be calculated?”and b.“Can the battery reduce the heating and cooling energy demand in a significant way?”The first question is answered in this document.In order to be able to answer the second question,especially the way the heat loading in winter should be improved,then more research is necessary.In addition to the thermal battery,which consists of Phase Change Material plates,the climate system has a cross-flow heat exchanger and a heat pump.The battery should play a central role in closing the thermal balance of the lightweight building,which can be loaded with hot return or cold outdoor air.The temperature of the battery plates is monitored by multi-sensors and simulated by the use of PHOENICS(Computational Fluid Dynamics)and MATLAB.This paper reports reasonable agreement between the numerical predictions and the measurements,with a maximum variance of 10%.The current coefficient of performance for heating and cooling is already high,more than 27.There is scope for increasing this much further by making use of the very low-pressure difference of the battery(below 25 Pascal),low pressure fans and the ventilation system as a whole.展开更多
文摘Objective\ To test the effect of hypothermia on Na+/H+ exchange, activated by shrinkage and cytoplasmic acidosis. Method\ Amiloride-sensitive Na+ influx in guinea pig red cells was traced with isotope 22Na and intracellular Na+ concentration was measured by emission flame photometry. Result\ Amiloride-sensitive Na+ influx decreased linearly as a function of temperatures (about 37℃) in shrunken cells, but increased in acidified cells. The up-regulation of acid-induced Na+/H+ exchange by elevated temperature was enhanced by hypo-osmolarity. Less sensitivity of intracellular H+ site at 41℃ may be the mechanism for the inhibition of shrinkage-induced Na+/H+ exchange by elevated temperature. Heating-mediated explosive increase in the activity of acid-induced Na+/H+ exchange may be due to enhanced extracellular Na+ sensitivity and lower intracellular pH caused by acidic metabolites. Acid-induced Na+/H+ ewxchange contributes to cytoplasmic Na+ accumulation. Conclusion\ These two modes of Na+/H+ exchange with different response to elevated temperature may play different roles in the cellular pathogenesis of heatstroke.
基金The project is financed via a public grant of the Rijksdienst Voor Ondernemend Nederland(RVO,https://www.rvo.nl/)within the Urban Energy 2018 Research-Line with Grant No.TEUE318008.The grant is awarded to the following consortium:The Delft University of Technology(https://www.tudelft.nl/en),Van Dorp B.V.,Hunter Douglas Europe B.V.(https://www.hunterdouglasarchitectural.eu/),Priva B.V.(https://www.priva.com/nl)and the Green Village Foundation(https://www.thegreenvillage.org/en/).
文摘This research evaluates the performance of a Phase Change Material(PCM)battery integrated into the climate system of a new transparent meeting center.The main research questions are:a.“Can the performance of the battery be calculated?”and b.“Can the battery reduce the heating and cooling energy demand in a significant way?”The first question is answered in this document.In order to be able to answer the second question,especially the way the heat loading in winter should be improved,then more research is necessary.In addition to the thermal battery,which consists of Phase Change Material plates,the climate system has a cross-flow heat exchanger and a heat pump.The battery should play a central role in closing the thermal balance of the lightweight building,which can be loaded with hot return or cold outdoor air.The temperature of the battery plates is monitored by multi-sensors and simulated by the use of PHOENICS(Computational Fluid Dynamics)and MATLAB.This paper reports reasonable agreement between the numerical predictions and the measurements,with a maximum variance of 10%.The current coefficient of performance for heating and cooling is already high,more than 27.There is scope for increasing this much further by making use of the very low-pressure difference of the battery(below 25 Pascal),low pressure fans and the ventilation system as a whole.
