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Impact of Selenium on Microtubules Polymarisation of Spermatozoa of Endosulfan Exposed Swiss Albino Mice
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作者 Ranjit Kumar Jitendra Kumar Singh Mohammad Ali Arun Kumar 《Journal of Life Sciences》 2011年第2期132-135,共4页
Pesticide plays a vital role in agricultural, industrial and residemial pest control. In recent years the ‘pesticide problem' has been the focus of public interest because these chemicals have a very important role ... Pesticide plays a vital role in agricultural, industrial and residemial pest control. In recent years the ‘pesticide problem' has been the focus of public interest because these chemicals have a very important role in agriculture but these chemicals also act like endocrine disruptor. Experiments were carried out on 12 weeks old mice with 30 ± 2 gm. b.w. Endosulfan were administered at 3 mg/kg b.w daily by gavage method for five weeks followed by selenium treatment at 10 μg/kg.b.w./day for five weeks. 9 + 2 arrangment were clearly observed in control group mice with well structured dynein and nexin arm while Endosulfan treated group show depolymerised microtubule and 9 + 1 arrangment with degenerated mitochondria. While selenium treated group shows restoration of 9 + 2 arrangement of microtubule. It is evident from study that endosulfan causes depolymerisation of microtubule while selenium administered group show normal polymerized microtubule and restores normal fertility in mice. 展开更多
关键词 SPERMATOZOA SELENIUM MICROTUBULES dynein arm nexin AXONEME depolymerisation Swiss albino mice
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Bioassay of Eucalyptus extracts for anticancer activity against Ehrlich ascites carcinoma(eac) cells in Swiss albino mice 被引量:1
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作者 Farhadul Islam Hasina Khatun +2 位作者 Soby Ghosh MM Ali JA Khanam 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第5期394-398,共5页
Objective:To evaluate the antineoplastic activity of Eucalyptus extract(EUE) against Ehrlich ascites carcinoma(EAC)in Swiss albino mice.Methods:Preliminary examination of four plant extracts(namely Eucalyptus,Costus,A... Objective:To evaluate the antineoplastic activity of Eucalyptus extract(EUE) against Ehrlich ascites carcinoma(EAC)in Swiss albino mice.Methods:Preliminary examination of four plant extracts(namely Eucalyptus,Costus,Azadirachla.Feroniai has been done by observing the reduction ability of number of EAC cells in previously inoculated Swiss alliino mice.Among them as EuE showed maximum capability,the whole study has been conducted with EuE only. Important parameters viz.enhancement of life span,reduction of average tumor weight etc.have been studied.In addition the effects of EuE on hematological parameters in both normal and EAC inoculated mice have been measured.Effect of EuE on normal peritoneal cells has also been studied.Results:EuE reduced tumor burden remarkably.It reduced the tumor growth rate and enhanced the life span of EAC bearing mice noticeably.It reversed back the hematological parameters towards normal,reduced the Irasplanlability of EAC cells and enhanced the immunomodulatory effects in mice.The host toxic effect of EuE in mice is minimum and mostly reversible with time.All such data have been compared with those obtained by running parallel experiments with bleomycin at dose 0.3 mg/kg(i.p.).Conclusions:The Eucalyptus extract may be considered as a potent anticancer agent for advanced researches. 展开更多
关键词 ANTINEOPLASTIC activity EUCALYPTUS extract Ehrlich ASCITES carcinoma CELLS SWISS albino mice
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Assessments of Immunological Activity of Achillea Millefolium Methanolic Extract on Albino Male Mice 被引量:1
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作者 Ruqaya Mohammed Al-Ezzy Rafal S. A. Al Anee Niran A. Ibrahim 《Journal of Pharmacy and Pharmacology》 2018年第6期563-569,共7页
Achillea millefolium (Asteraceae) is a permanent herb highly recognized in traditional medicine for its anti-oxidant and anti-inflammation properties. However, studies on phytochemical constituents of A. millefoli... Achillea millefolium (Asteraceae) is a permanent herb highly recognized in traditional medicine for its anti-oxidant and anti-inflammation properties. However, studies on phytochemical constituents of A. millefolium underlying these properties are scarce. The present work focuses on examining the effect of methanol extract of A. millefolium L. on total and differential blood cells account on albino male mice. The results showed the methanol extract increased the account of lymphocyte, and monocyte cells, and total account as well as this extract showed high decrease in the oxidative stress of MTX after the interfere between the extract and MTX due to increase in the leucocyte cells compared with controls. Concluded from these results that methanol extract of A. millefolium has ability enhancement in leucocyte cells in the blood and it has detoxification effect of MTX. 展开更多
关键词 Achillea millefolium white blood cells methanol extract total account differential account and albino male mice.
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Pumpkin seed ethanolic extract protects against escitalopram-induced reproductive toxicity in male mice
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作者 Agrawal Karuna Shahani Lata Bhatnagar Pradeep 《Asian pacific Journal of Reproduction》 2023年第2期71-80,共10页
Objective:To investigate the protective role of pumpkin seed ethanolic extract against escitalopram-induced reproductive toxicity in male mice.Methods:Swiss albino male mice were randomly divided into five groups with... Objective:To investigate the protective role of pumpkin seed ethanolic extract against escitalopram-induced reproductive toxicity in male mice.Methods:Swiss albino male mice were randomly divided into five groups with six mice in each group.Group Ⅰreceived normal water orally,Group Ⅱ,Ⅲ,Ⅳand Ⅴreceived escitalopram oxalate(10 mg/kg),pumpkin seed extract(300 mg/kg)plus escitalopram oxalate(10 mg/kg),escitalopram oxalate(20 mg/kg),and pumpkin seed extract(300 mg/kg)plus escitalopram oxalate(20 mg/kg),respectively.All test doses were continuously administered orally once daily per animal body weight for 30 days and 60 days.Body weight and sexual organ weight were evaluated on day 31 and 61.Effects of pumpkin seed extract on sperm parameters,biochemical parameters and histology of testis were also investigated.Results:Escitalopram 10 or 20 mg/kg caused reproductive toxicity in male mice after 30 and 60 days of treatment.However,simultaneous administration of escitalopram oxalate(10 or 20 mg/kg)with pumpkin seed extract(300 mg/kg)attenuated escitalopram-induced testicular toxicity.Significant increase in the body weight and relative organ weight was observed.Sperm count,sperm motility and viability significantly increased(P<0.05).The histopathological alterations caused by escitalopram was also ameliorated.Conclusions:Ethanolic extract of pumpkin seeds(300 mg/kg body weight)protects again reproductive toxicity induced by escitalopram.Therefore,dietary intake of pumpkin seed extract might be useful for male patients who expose to antidepressant drug due to depression. 展开更多
关键词 Escitalopram oxalate Pumpkin seeds Testicular toxicity Sperm parameters Male Swiss albino mice
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In <i>Vivo</i>Hypoglycemic Activity of Aqueous Extracts of <i>Chasmanthera dependens</i>in Alloxan Induced Diabetic Mice
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作者 Dinah J. Sawe Eliud N. M. Njagi +1 位作者 Alice N. Muchugi Moses Ndiema 《Open Journal of Applied Sciences》 2021年第7期832-845,共14页
The plant <i>Chasmanthera dependens </i>(Hochst) have been used to manage many diseases including diabetes mellitus without scientific evaluation of its efficacy and safety. The main objective of the proje... The plant <i>Chasmanthera dependens </i>(Hochst) have been used to manage many diseases including diabetes mellitus without scientific evaluation of its efficacy and safety. The main objective of the project was to determine the antidiabetic activity of <i>Chasmanthera dependens</i> plant in a rat model. Experimental design was used where<b> </b>the stem of the plant was collected, dried, crashed into fine powder, extracted with distilled water at 60<span lang="EN-US">°C and lyophilized using a Freeze Dryer, packaged in air tight container and stored at -20°C ready for use. The extract was orally and intraperitoneally screened in alloxan induced diabetic mice for its hypoglycemic activity at doses of 25, 48.4, 93.5, 180.9 and 350 mg per kg body weight. Diabetes in mice was induced using 186.9 mg/kg of alloxan monohydrate. Negative controls included normal and diabetic rats orally and intraperitoneally administered with physiological saline while positive controls included diabetic rats administered with glibenclamide as oral and insulin as intraperitoneal reference drug. The results revealed hypoglycemic activity in <i>Chasmanthera dependens </i>at the five different doses when given either orally or intraperitoneally. In conclusion, the medicinal plant at the various doses demonstrated significant (<i>ρ</i> ≤ 0.05) hypoglycemic activity. The author’s recommendation is continued use of the plant extracts at low therapeutic doses. Consideration should be made to carry out the same studies using higher animals including man.</span> 展开更多
关键词 DIABETES HYPOGLYCEMIA Plant Extract Chasmanthera dependens albino mice
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In vivo study of pomegranate(Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice 被引量:3
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作者 Wafa Abdullah Al-Megrin 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2017年第1期59-63,共5页
Objective: To investigate the efficacy of pomegranate(Punica granatum) peel extract as an alternative treatment on the white laboratory mice against giardiasis.Methods: Experimental animals were divided into five grou... Objective: To investigate the efficacy of pomegranate(Punica granatum) peel extract as an alternative treatment on the white laboratory mice against giardiasis.Methods: Experimental animals were divided into five groups, including Group A:control(infected untreated), Group B: infected and fed with pectin 7 days before infection, Group C: infected and fed with pectin starting from 7th day of infection,Group D: infected and fed with pomegranate peel extract 7 days before infection, and Group E: infected and fed with pomegranate peel extract starting from 7th day of infection.Results: Results from this study revealed that the prevention rate in the experimental groups reached approximately 50% by the 10 th day of using pomegranate peel extract.Moreover, stool cyst counts of groups showed a significant reduction in the shedding of cysts approximately 75.6% by day 20 post-infection. ELISA test showed a reduction in Giardia antigen in the stools of the experimental groups which received pomegranate peel extract. The cure rate of these groups was approximately 97.4% by 28 th day of infection.Conclusions: Our present findings indicated that the pomegranate peel extract proved to be valuable in prevention and treatment of Giardia lamblia infection. Further studies are required to determine the effective dose of pomegranate peel extract against Giardia lamblia infection. 展开更多
关键词 POMEGRANATE GIARDIA LAMBLIA Swiss albino mice Saudi ARABIA
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中草药促排卵汤对小鼠胚泡数量的影响 被引量:11
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作者 李桂娴 张亚滨 +2 位作者 史小林 许晴 路欣 《首都医学院学报》 1994年第3期194-196,共3页
用中草药促排卵汤给生育期雌性小鼠灌胃,并于其受孕后第8d处死,观察子宫内胚泡形成的数量。实验结果表明,服用与人等倍剂量药物小鼠的胚泡数比对照组显著增加(P<0.05),增加药物剂量(相当人5倍量)效果与服用等倍量组相... 用中草药促排卵汤给生育期雌性小鼠灌胃,并于其受孕后第8d处死,观察子宫内胚泡形成的数量。实验结果表明,服用与人等倍剂量药物小鼠的胚泡数比对照组显著增加(P<0.05),增加药物剂量(相当人5倍量)效果与服用等倍量组相同,增加药物剂量直至50倍量未见药物有毒副作用。证明中草药促排卵汤有效、安全、能提高小鼠生殖机能。 展开更多
关键词 促排卵汤 胚泡 小鼠 中草药
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长期饲喂三氧化二砷对小白鼠的影响 被引量:1
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作者 张富梅 闫贵龙 +2 位作者 孙全文 杜建华 李世芳 《畜牧兽医杂志》 2000年第6期5-6,共2页
试验选择 4 0日龄昆明种小白鼠 80只 ,公母各半 ,随机分为两组 ,对照组饲喂基础日粮 ,试验组日粮中添加 1 .4 mg/ kg的 AS2 O3。选 F1 代小白鼠生产的三窝小白鼠进行观察 ,记录每窝出生数 ,测定体增重 ,观察有无畸形个体出现。结果表明 ... 试验选择 4 0日龄昆明种小白鼠 80只 ,公母各半 ,随机分为两组 ,对照组饲喂基础日粮 ,试验组日粮中添加 1 .4 mg/ kg的 AS2 O3。选 F1 代小白鼠生产的三窝小白鼠进行观察 ,记录每窝出生数 ,测定体增重 ,观察有无畸形个体出现。结果表明 ,长期饲喂小剂量 AS2 O3对不同窝次小白鼠不仅不产生毒性作用 ,而且可增强生活力 。 展开更多
关键词 三氧化二砷 生长 死亡率 畸形 小白鼠 剂量 毒性
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Experiment of Hydatid Cyst in Two Strains (Camels and Goats) in Saudi Arabia
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作者 Areej O. Bakhraibah Muslimah N. Alsulami +1 位作者 Fawzia H. Toulah Amal A. El Shafi 《Open Journal of Animal Sciences》 2019年第1期76-87,共12页
Hydatid cyst disease is one of the most parasitic diseases transmitted from carnivores animals (such as dogs) to humans and causes a deterioration in the general health. Its transmission to herbivores animals led to a... Hydatid cyst disease is one of the most parasitic diseases transmitted from carnivores animals (such as dogs) to humans and causes a deterioration in the general health. Its transmission to herbivores animals led to a substantial economic loss in the meat productivity and reduced its quality. The increase of acquisition of dogs at homes nowadays led to an increase in the risk of infection with many parasitic diseases such as hydatid cyst disease. The present study was conducted to provide a modern view on the current status of hydatid cyst disease among slaughtered animals in Jeddah through periodic visiting to a slaughter house in North Jeddah. The mice prepared have been infected in the peritoneal membrane with 0.2 ml of hydatid cyst fluid containing ±2000 protoscoleces from fertile cysts obtained from an infected goat’s liver which resulted in a 75% infection rate. Mice infected with hydatid fluid from fertile cysts obtained from an infected camel’s lungs showed a result of 11.1% infection rate. The cysts appeared in the peritoneal and abdominal cavity. 展开更多
关键词 E. granulosus Swiss albino mice Protoscoleces HYDATID CYST Disease HYDATID CYSTS VIRULENCE of Scoleces
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The role of vitamin C in alteration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse
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作者 Zaina Zuhair Hasan AL-amri 《Advances in Biological Chemistry》 2011年第2期15-23,共9页
Tamoxifen is a synthetic non-steroidal ant estrogen. It was suggested to study the role of vitamin C in alte- ration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse. The eff... Tamoxifen is a synthetic non-steroidal ant estrogen. It was suggested to study the role of vitamin C in alte- ration of enzymes responsible of energy metabolism induced by administration of tamoxifen to mouse. The effect of tamoxifen and tamoxifen with vitamin C on some activity of enzymes in the mice representing gly- colytic, gluconeogenic and glycogenolytic pathway and also, liver function enzymes represented by aspartate aminotransferase (AST), alanine amino-transferase (ALT), acid phosphatase (ACP) and alkaline phos- phatase (ALP) were studied. The present results showed that a significant (p < 0.001) increase in glycolytic enzymes (HK, PK, GPI and PFK), glu- coneogenic enzymes, G-6-Pase, acid phosphatase (ACP), alkaline phosphatase (ALP) and glucose, were observed in treated groups, while LDH, glycogen phos- phorylase, AST and ALT enzymes activities showed significant (p < 0.01) reduction. The present results also, showed that significant reduction in glycogen, total protein, total cholesterol, uric acid, urea, and creatinine in treated mice as compared to the normal healthy control group. However, normal control mice treated with tamoxifen and vitamin C showed no side effects of most parameters compared to the normal healthy control group. It was concluded that vitamin C may prevent tamoxifen-induced testes toxicity in mice. 展开更多
关键词 Adult Male albino mice TAMOXIFEN VITAMIN C Liver Tissue Homogenates
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In vivo antiplasmodial potential of three herbal methanolic extracts in mice infected with Plasmodium berghei NK65
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作者 Pachiyappan Rajiv Gandhi Chinnaperumal Kamaraj +1 位作者 Elangovan Vimalkumar Selvaraj Mohana Roopan 《Chinese Herbal Medicines》 CAS 2019年第3期299-307,共9页
Objective: The present study deals with the investigation of antiplasmodial potential of leaf methanolic extract of Aegle marmelos, Aristolochia indica and Cassia auriculata against Plasmodium berghei(NK65)infected mi... Objective: The present study deals with the investigation of antiplasmodial potential of leaf methanolic extract of Aegle marmelos, Aristolochia indica and Cassia auriculata against Plasmodium berghei(NK65)infected mice.Methods: The chloroquine-sensitive parasites P. berghei(1 × 106) were inoculated into Swiss albino mice intraperitoneally. The methanol extracts of three herbal plants were orally administered in P. berghei infected mice which were further assessed using the four-day suppressive test at different doses of 150, 300 and 600 mg/kg per day. Chloroquine(CQ) was used as the standard drug with of 1.25, 2.5 and 5 mg/kg concentrations and was orally administered.Results: The leaves of A. marmelos, A. indica, and C. auriculata were found to suppress P. berghei parasitaemia in Swiss albino mice by(67.0 ± 4.02)%,(72.0 ± 8.44)% and(52.7 ± 2.06)% at 600 mg/kg/d with ED50 values of 284.73, 233.77 and 562.48 mg/kg, respectively. These herbal plants increased the mean survival time of infected mice and prevented body weight loss. GC-MS analysis revealed the presence of hentriacontan-16-one(C31 H62 O) in A. indica extract. The histopathology study showed non-toxic to kidney and liver at 600 mg/kg/body weight.Conclusions: Overall results revealed that herbal plants may be active in the development of novel and cheap antimalarial compounds. 展开更多
关键词 Aegle marmelos L. ARISTOLOCHIA indica L. Cassia auriculata L. GC-MS histopathology in vivo ANTIPLASMODIAL POTENTIAL Plasmodium berghei(NK65) Swiss albino mice
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