Reaction of Cp2TiCl2-Mg synthetic equivalent of practical Ti(II) reagent with propargyl alcohol derivatives affords allenyl titanium compounds in good yields.thus, providing an efficient and practical methods for synt...Reaction of Cp2TiCl2-Mg synthetic equivalent of practical Ti(II) reagent with propargyl alcohol derivatives affords allenyl titanium compounds in good yields.thus, providing an efficient and practical methods for synthesis of both allenyl and homopropargyl alcohols by the successive treatment with aldehydes and ketones.展开更多
Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivative...Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.展开更多
Phytochemical investigation of the roots of Ligularia nelumbifolia afforded three new sinapyl alcohol derivatives together with two other novel constituents.Their structures were elucidated by high field 1D and 2D NMR...Phytochemical investigation of the roots of Ligularia nelumbifolia afforded three new sinapyl alcohol derivatives together with two other novel constituents.Their structures were elucidated by high field 1D and 2D NMR techniques and chemical transformations.展开更多
A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Mos...A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.展开更多
A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis ...A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.展开更多
A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone...A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone and 4,5-dihydrobenzo[b]-thiophen-5（4H）-one as intermediates and Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by ^1H NMR, ^13C NMR IR and HRMS. Their characterization as sphirtgosine 1-phosphate（S 1P） receptor agonists was reported.展开更多
Objective:To isolate and characterize chemical constituents of the roots of Zanthoxylumchalybeum(Z.chalybeum).Methods:A number of phytochemical tests were applied to identify the class of compounds present in the CH_(...Objective:To isolate and characterize chemical constituents of the roots of Zanthoxylumchalybeum(Z.chalybeum).Methods:A number of phytochemical tests were applied to identify the class of compounds present in the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract.Column chromatographic separation technique was applied to separate the constituents of the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract and various spectroscopic techniques[UV-vis,infrared radiation,nuclear magnetic resonance(NMR)(^(1)H-NMR,^(13)C NMR,DEPT-135,COSY,gHSQC and gHMBC)]were used to determine the structures of pure compounds.Results:Phytochemical screening of the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract of Z.chalybeum revealed the presence of alkaloids,flavonoids,terpenoids,tannins and anthraquinones.Column chromatographic separation of the extract yielded a new coniferyl alcohol derivative,2,3-epoxy-6,7-methylenedioxyconiferyl alcohol(1)together with the known alkaloid,dihydrochelerythrine(2).Conclusions:The present work conducted on the CH2Cl2:CH3OH(1:1)root extract of Z.chalybeum identified various class of compounds present in the root extract.Complete characterization of two compounds were done using spectroscopic techniques of which a coniferyl alcohol derivative(1)was identified for the first time.展开更多
文摘Reaction of Cp2TiCl2-Mg synthetic equivalent of practical Ti(II) reagent with propargyl alcohol derivatives affords allenyl titanium compounds in good yields.thus, providing an efficient and practical methods for synthesis of both allenyl and homopropargyl alcohols by the successive treatment with aldehydes and ketones.
基金This work is financially supported by the Life Science Special Fund of Chinese Academy of Sciences Supported by the Ministry of Finance (STZ-00-24), the Yunnan Province Foundation of Applied and Basic Research (2000C0072M), the Foundation for Visiting Pr
文摘Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.
基金①This work was supported by the National Natural Science Foundation of China and the doctoral programmc from State Education Commission of China.
文摘Phytochemical investigation of the roots of Ligularia nelumbifolia afforded three new sinapyl alcohol derivatives together with two other novel constituents.Their structures were elucidated by high field 1D and 2D NMR techniques and chemical transformations.
基金Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co.Ltd
文摘A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.
文摘A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.
文摘A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone and 4,5-dihydrobenzo[b]-thiophen-5（4H）-one as intermediates and Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by ^1H NMR, ^13C NMR IR and HRMS. Their characterization as sphirtgosine 1-phosphate（S 1P） receptor agonists was reported.
文摘Objective:To isolate and characterize chemical constituents of the roots of Zanthoxylumchalybeum(Z.chalybeum).Methods:A number of phytochemical tests were applied to identify the class of compounds present in the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract.Column chromatographic separation technique was applied to separate the constituents of the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract and various spectroscopic techniques[UV-vis,infrared radiation,nuclear magnetic resonance(NMR)(^(1)H-NMR,^(13)C NMR,DEPT-135,COSY,gHSQC and gHMBC)]were used to determine the structures of pure compounds.Results:Phytochemical screening of the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract of Z.chalybeum revealed the presence of alkaloids,flavonoids,terpenoids,tannins and anthraquinones.Column chromatographic separation of the extract yielded a new coniferyl alcohol derivative,2,3-epoxy-6,7-methylenedioxyconiferyl alcohol(1)together with the known alkaloid,dihydrochelerythrine(2).Conclusions:The present work conducted on the CH2Cl2:CH3OH(1:1)root extract of Z.chalybeum identified various class of compounds present in the root extract.Complete characterization of two compounds were done using spectroscopic techniques of which a coniferyl alcohol derivative(1)was identified for the first time.
