Citrinal A （1）, a novel tricyclic compound with a rare tetrahydro-2H-benzofuro[7-b] [ 1,4]dioxin-9（3H）-one skeleton, along with two known related compounds, citrinin （2） and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dih...Citrinal A （1）, a novel tricyclic compound with a rare tetrahydro-2H-benzofuro[7-b] [ 1,4]dioxin-9（3H）-one skeleton, along with two known related compounds, citrinin （2） and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran （3） were isolated from an algicolous fungus Penicillium sp. i-1-1. The structure and stereochemistry of 1 were determined by comprehensive spectral and biogenic analysis. Its cytotoxic effects on the A-549 and HL-60 cell lines were evaluated. ？2009 Qian Qun Gu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
Marine algicolous fungi refer to the fungi inhabiting or associated with marine algae,which have attracted a great attention for natural product researchers due to their chemical diversity and biological activity duri...Marine algicolous fungi refer to the fungi inhabiting or associated with marine algae,which have attracted a great attention for natural product researchers due to their chemical diversity and biological activity during the past two decades.Up to the end of 2014,a total of 366 new natural products,including polyketides,terpenoids,polyketide-terpenoids,peptides,alkaloids,and shikimate derivatives,have been characterized from them.Among these metabolites,240 compounds feature cytotoxic,antibacterial,antifungal,antimicroalgal,zooplankton-toxic,antiprotozoal,antioxidative,enzyme-modulatory,and/or some other activities.This review gives a comprehensive coverage of both chemical and biological aspects of the secondary metabolites from marine algicolous fungi.展开更多
基金supported by the Shandong Province Naturfl Science Fund(No.Z2006C 1 3)The anfitumor assay was performed at the Shanghai Institute of Matena Medica,Chinese Academy of Sciences.
文摘Citrinal A （1）, a novel tricyclic compound with a rare tetrahydro-2H-benzofuro[7-b] [ 1,4]dioxin-9（3H）-one skeleton, along with two known related compounds, citrinin （2） and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran （3） were isolated from an algicolous fungus Penicillium sp. i-1-1. The structure and stereochemistry of 1 were determined by comprehensive spectral and biogenic analysis. Its cytotoxic effects on the A-549 and HL-60 cell lines were evaluated. ？2009 Qian Qun Gu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金The preparation of this review and our related research were financially supported by the Natural Science Foundation of China(41106136 and 31330009).
文摘Marine algicolous fungi refer to the fungi inhabiting or associated with marine algae,which have attracted a great attention for natural product researchers due to their chemical diversity and biological activity during the past two decades.Up to the end of 2014,a total of 366 new natural products,including polyketides,terpenoids,polyketide-terpenoids,peptides,alkaloids,and shikimate derivatives,have been characterized from them.Among these metabolites,240 compounds feature cytotoxic,antibacterial,antifungal,antimicroalgal,zooplankton-toxic,antiprotozoal,antioxidative,enzyme-modulatory,and/or some other activities.This review gives a comprehensive coverage of both chemical and biological aspects of the secondary metabolites from marine algicolous fungi.
