Six new aliphatic alcohol and ester compounds of n-octacos-9-enyl propionate （1）, 4-（3-formylheptyl）cyclohexyl 4-（cyclohexylcarbonyloxymethyl）cyclohexyl-carboxylate （2）, n-hentriacont-25-en-5α-ol （3）, n-hex...Six new aliphatic alcohol and ester compounds of n-octacos-9-enyl propionate （1）, 4-（3-formylheptyl）cyclohexyl 4-（cyclohexylcarbonyloxymethyl）cyclohexyl-carboxylate （2）, n-hentriacont-25-en-5α-ol （3）, n-hexetriacont-9,26-dien-8α,11β,23α-triol （4）, n-tetracontan-15α-ol （5） and n-tritetracontan-5α-ol （6） were isolated from the hulls of Oryza sativa. The structures were established on the basis of spectroscopic analysis.展开更多
Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery.In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library,a pa...Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery.In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library,a pathogenic fungus,Fusarium proliferatum strain 13294(FP13294),was selected for chemical investigation.Two novel aliphatic unsaturated alcohols named fusariumnols A and B(1 and 2),together with one previously characterized sesquiterpenoid lignoren(3)were identified.Structures of 1-3 were assigned by mass spectrometry and NMR spectroscopy.Their bioactivities were assessed against Staphylococcus epidermidis,S.aureus,and Methicillin-resistant S.aureus(MRSA).Compounds 1 and 2 exhibited weak antibacterial activity against S.epidermidis(MIC=100μM).展开更多
文摘Six new aliphatic alcohol and ester compounds of n-octacos-9-enyl propionate （1）, 4-（3-formylheptyl）cyclohexyl 4-（cyclohexylcarbonyloxymethyl）cyclohexyl-carboxylate （2）, n-hentriacont-25-en-5α-ol （3）, n-hexetriacont-9,26-dien-8α,11β,23α-triol （4）, n-tetracontan-15α-ol （5） and n-tritetracontan-5α-ol （6） were isolated from the hulls of Oryza sativa. The structures were established on the basis of spectroscopic analysis.
基金This work was supported by the National Key Research and Development Program of China(2020YFA0907200,2019YFA0906200,and 2020YFA0907800)the National Natural Science Foundation of China(21877038,21907031,21977029,31720103901,and 81903529)+1 种基金Shanghai Rising-Star Program(20QA1402800)the Open Project Funding of the State Key Laboratory of Bioreactor Engineering,and the 111 Project(B18022).
文摘Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery.In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library,a pathogenic fungus,Fusarium proliferatum strain 13294(FP13294),was selected for chemical investigation.Two novel aliphatic unsaturated alcohols named fusariumnols A and B(1 and 2),together with one previously characterized sesquiterpenoid lignoren(3)were identified.Structures of 1-3 were assigned by mass spectrometry and NMR spectroscopy.Their bioactivities were assessed against Staphylococcus epidermidis,S.aureus,and Methicillin-resistant S.aureus(MRSA).Compounds 1 and 2 exhibited weak antibacterial activity against S.epidermidis(MIC=100μM).
