Screen-and-Treat Approach in Secondary Prevention of Cervical Cancer among HIV-Infected Women in Faith Alive Hospital, Jos Nigeria

Background: Cervical cancer is the fourth most common cancer among women globally, the second most common cancer in Nigeria and the most common cause of cancer-related death in Africa. In 2020, World Health Organization in its updated guidelines recommended cervical cancer screening using HPV DNA, HPV mRNA tests and subsequent treatment as appropriate. However, in resource-poor settings, Visual Inspections with Acetic Acid (VIA), Lugol’s Iodine (VILI) and subsequent treatment of precancerous lesions with thermal ablation remain the practical approaches. Objectives: To determine the prevalence of precancerous cervical lesions and associated risk factors among Women Living with HIV (WLHIV). Methods: A retrospective study on sexually active WLHIV aged 16 - 55 years screened for cervical cancer using VIA and VILI within 16 months period in Faith Alive Hospital Jos. Data were analyzed using IBM-SPSS 26. Sociodemographic characteristics of the study participants and the screening results were presented in frequency tables, and logistic regression was performed to determine risk factors of pre-cancerous lesions. Results: 1113 women were screened for cervical cancer using VIA/VILI. 994 (89.3%) were negative, 101 (9.1%) were positive for precancerous lesions, and 18 (1.6%) were suspicious of cervical cancer. The mean age of clients with pre-cancerous lesions was 41.32 ± 9.89 years. A higher positivity yield (69.4%) was found in ages between 36 and ≥55 years while a less positivity yield (30.6%) was found in age’s ≤ 35 years. History of STI had 1.64 fold risk association with precancerous lesions. Conclusion: Our study demonstrated a high prevalence of precancerous cervical lesions among WLHIV;bimodal age distribution for cancer-suspicious lesions and risk associated with STI. Thus, a “screen-and-treat” approach to cervical cancer prevention by VIA and thermal ablation in resource-poor settings should be undertaken until widespread HPV testing to triage clients is feasible.

SIP终端Keep Alive实现机制的分析

对电信级的软交换和IP多媒体子系统(IMS)而言,终端与相关的软交换服务器之间保持实时Keep Alive是非常重要和必要的。会话发起协议(SIP)作为软交换系统和IMS系统的主要信令协议之一,在下一代网络(NGN)系统中有着重要作用,但是SIP协议本身没有明确定义网络实体之间的Keep Alive机制。目前在SIP系统的实现中,存在着一些比较常见的Keep Alive机制实现方式,IETF的SIP工作组也正致力于这方面的研究和讨论。文章对一些常见的SIP的Keep Alive机制和SIP工作组提出的Keep Alive方案进行了分析和比较,并对应用前景进行了简要分析。

Polymorphism of mitochondrial tRNA genes associated with the number of pigs born alive

Background: Mutations in mitochondrial tRNA genes have been widely reported association with human reproductions.It is also important to explore the effect on the number of piglets born alive(NBA).Here,1017 sows were used to investigate the association between polymorphisms in mitochondrial tRNA genes and NBA.Results: In total,16 mutations were found in mitochondrial tRNA genes,of which 13 mutations were significantly associated with NBA(P < 0.05).The reproductions of mutant carriers were significantly greater than that of wild carriers by 0.989 piglets born alive/sow farrowing.To test whether the mutations altered the structure of mitochondrial tRNAs,the secondary and tertiary structures were predicted.In result,C2255 T changed the secondary structure of t RNA-Val by elongating the T stem and shrinking the T loop,and C2255 T and G2259 A in the tRNA-Val gene,C6217 T and T6219 C in the tRNA-Ala gene,and T15283 C in the tRNA-Glu gene altered the tertiary structure of their tRNAs,respectively by changing the folding form of the T arm,and C16487 T in the tRNA-Thr gene changed the tertiary structure of mitochondrial tRNA-Thr by influencing the folding form of the acceptor arm.Conclusions: Results highlight the effect of mitochondrial tRNA genes on the number of piglets born alive,and suggest that polymorphic sites of the tRNA genes be genetic markers for selection of pig reproduction.

浅析living,live,alive

形容词 living,live,alive 都可表示“活的,有生命的,活着的”,反义词均为 dead。但用法不相同,常易混淆,现作简要辨析。1.living:“活的、有生命的、现存的”。强调现在活着的,存在着的人或物,在句中作定语和表语。转义表示生机勃勃的,发挥作用的,常作“当代的、活泼的、非常的、维妙维肖的”解。They didn’t find any living things on the moon,did they?他们在月球上没有发现任何有生命的东西,是吗?

HIV Prevalence amongst Pregnant Women Clients Attending Antenatal Clinic at the Faith Alive Foundation and PMTCT Centre, Jos Plateau State

Introduction: HIV infection and AIDS is a public health problem worldwide, particularly affecting the populace in resource challenged setting like sub-saharan Africa. Women of reproductive age are mostly affected and infected with the HIV disease. Methodology: A cross-sectional study of 216 randomly selected women that booked for antenatal care at the Faith Alive Foundation and PMTCT centre Jos between 1st July to 31st December, 2014 was carried out. Information regarding age, parity, gestational age at booking, educational status and HIV sero-status of the clients was analysed. Screening test was conducted in a serial two step approval using determine and UNIGOLD as the confirmatory test, while STAT-PAK was the tie-beaker with discordant result as per the national algorithm. Positive samples were confirmed by western blot method. Result: A total of 18 women out of the 216 women studied were positive giving a sero-prevalence rate of 8.3%. The highest sero-prevalent rate was amongst 25 - 29 years age group (31.5%). Women of parity 1 - 4 constituted the highest group of 62.9%. Majority of the women 65.7% booked in the second trimester while 26.9% booked in the 3rd trimester. Most of the women 47.2% had secondary school education while only 5.6% of them had no form of education. Conclusion: HIV infection prevalence rate among antenatal attendants at Faith Alive Foundation and PMTCT centre Jos is still high. Multisectorial approach and intervention strategies should be further scaled up for the prevention of vertical transmission of the virus. However, it is worth noting that it is mainly an HIV/AIDS hospital which should have affected the outcome.

《no one here gets out alive》

这本书是《滚石》记者关于美国著名摇滚歌星大门乐队JIM MORRISON 的传记。JIM MORRISON 一生都在寻找灵魂归属地,他纵欲、酗酒、吸毒、挑动骚乱,在公众场合展示身体和关键部位。他拥护多妻制。

Dead or Alive 笔记本电脑次世代謎团解析

2007年9月5日,Palm总裁Ed Colligan在Palm公司的官方Blog上宣布,决定取消Foleo的市场汁划,"暂时"将这款"商务移动笔记本电脑"搁置。比起Palm在5月底发布Foleo的风光炒作来说,这次的取消显得非常低调——不仅将这个产品迅速从palm的产品目录中去除,就连取消之事在官方网站也不见报道,只是用了官方Blog来发布消息。尽管这样,但Foleo这个设计独特的新概念产品尚未出世便已夭折却是不争的事实。无独有偶,笔记本电脑大厂华硕(Asus)也在暑期曝光了它所研发的一款功能接近Foleo,但在设计上却另辟蹊径的新产品Eee PC。Foleo的早夭和Eee PC的新生,拉开了笔记本电脑市场的一个新时代序幕。

“We'd both be alive”

Two guys,Jimmy and Johnny,were standing at heaven’sgate ,waiting to be interviewed by St.Peter.Jimmy:“How did you get here?”Johnny:“Hypothermia(体温过低).You?”Jimmy:“You won’t believe it.I was sure my wife wascheating on me,so I came home early one day hoping to findthe guy.I accused my wife of unfaithfulness and searched

DEAD or ALIVE WCG首款格斗游戏

今年WCG最大的革命是首次引入了格斗游戏(FTG)项目,作为当前家用游戏机3D格斗游戏代表之一的《Dead or Alive》意外的成为幸运儿。由于格斗游戏的起源和竞技化几乎都离不开大型街机机体和街机游戏．所以此次WCG选择XBOX上的《DOA 2：Ultimate》(中译《生死格斗2：终极版》,以下简称DOAU 2)也让广大格斗游戏玩家大惑不解。

Transport Corridor Alive With Possibilities

New Lamu Port infrastructure initiative has potential to improve the economies of East Africa East africa is gearing up to construct a trade lifeline that is set to be one of the largest transport projects in africa. In early February, Kenya, Ethiopia and south sudan launched construction of

Alive and Kicking

Kenya builds East Africa’s biggest kungfu academy as Chinese martial arts gain popularity KUNGFU has been a life-long passion for 21-year-old Kamau Mutunga who recently signed up for martial arts classes after a violent attack left him shaken and distressed.

Snake’s Alive!

A Temple Fair snake charmer responds to taunts from the Chinese New Year crowd that the snake is fake,by showing them the slithery serpent up close and personal. People’s expressions shift through

Alive and Well

On Christmas Eve a few years ago an English couple received a very special call. It was only a 20-second call but it was very important. The Haydens’ 15-year-old daughter had disappeared for six months.

Alive with Possibilities

THE 19th National Congress of the Communist Party of China, held in Beijing on October 18-24, set out the guiding principles for ChinEs major-country diplomacy with Chinese characteristics at the top level. The congress put forward that China will pursue a new form of international relations featuring mutual respect, fairness, justice, and win-win cooperation.

Alive With Art

Lovers of art who settle in Beijing have a wide set of options as local art museums featuring the best in home-grown and international art are trending right now.The National Art Museum of China and the CAFA (Central Academy of Fine Arts) Art Museum are two of the most important institutions available to feed the art itch.

Bringing History Alive

Beijing is home to about 130 museums dedicated to a myriad of interests,ranging from art,literature and urbanism to apiculture, tap water and watermelon.The two biggest and most important museums in the capital city are the Palace Museum and the National Museum of China. The Palace Museum The numbers give you an idea of the magnitude of this Ming Dynasty(1368-1644) masterpiece:1 million laborers to build it,14 years to complete it, about 8,700 rooms spreading over 720,000 square meters.

Relics Come Alive

Museums embrace modern technology to help visitors access China’s national treasuresBorn in England,25-year-old Laurence Coulton has always taken a keen interest in the cultures of the world.However,it was at university that he real-

美国戏剧教育项目设置与启示——浅析ALIVE项目的教育意义与价值

带有疗愈价值的戏剧教育活动在美国中小学的开展已有40余年历史,对于学生的压力分享、关系认知、个人成长、团队信任等方面有重要的促进作用和教育意义。此类戏剧教育旨在利用戏剧游戏、情景演绎、角色扮演等一系列颇具趣味性的戏剧活动,深入了解学生的成长环境和个性发展,在活动过程中强调疏导负向情绪,并对学生进行一系列的安全与成长教育,促进其人格的健康、全面发展。文章以ALIVE这一具体的戏剧教育项目在美国公立小学的开展为例,浅析该形式对于我国戏剧教育的启示与价值。