Objective:To observe the characteristics of indocyanine green angiography(ICGA)in exudative age-related macular degeneration(AMD).Methods:Thirty-one cases(39 eyes)were diagnosed as exudative AMD by ocular examination,...Objective:To observe the characteristics of indocyanine green angiography(ICGA)in exudative age-related macular degeneration(AMD).Methods:Thirty-one cases(39 eyes)were diagnosed as exudative AMD by ocular examination,fundus color photography,fundus fluorescein angiography(FFA)and ICGA.Their ages ranged from 50 to 82 years and visual acuities from FC/30cm to 0.7.We analyzed and compared the characteristics of ICGA and FFA in these patients.Results:of 26 eyes with ccult choroidal neovascularization (CNV)by FFA,15(57.7%)had classic CNV by ICGA.Of 4 eyes with serous retinal pigment epithelial detachment(PED)without CNV by FFA,1 had serous PED with classic CNV by ICGA.The hyperfluorescence of the scar staining was detecfed by ICGA.Conclusion:ICGA adds clinically useful information and is an important adjunct in the evaluation,classification,and laser treatment of patients with occult CNV in AMD.展开更多
Objective Epidemiology studies indicate that green tea polyphenols(GTP)perform a protective effect on cardiovascular diseases,but the underlying mechanisms are complex.The present study aimed to investigate the effect...Objective Epidemiology studies indicate that green tea polyphenols(GTP)perform a protective effect on cardiovascular diseases,but the underlying mechanisms are complex.The present study aimed to investigate the effect of GTP on high-fat diets(HFD)induced-early vascular aging.Methods Six-week young adult Wistar rats were fed with standard chow or HFD in the presence and absence of GTP(200 mg/kg body weight)for 18 weeks.In vitro experiment,human umbilical vascular endothelial cells(HUVECs)were treated with palmitic acid(PA)and GTP.Results The results showed that GTP alleviated the disorganized arterial wall and the increased intima-media thickness induced by HFD.In addition,the vascular oxidative injury was suppressed following GTP treatment.Furthermore,GTP elevated the ratio of LC3-II/LC3-I and suppressed expression of p62/SQSTM1,and restored SIRT3 expression in the aorta of HFD rats.Consistently,in cultured HUVECs,GTP inhibited cell senescence indicated by SA-β-gal and promoted endothelial autophagy compared with the PA treatment group.The activity of SIRT3 was specifically inhibited by 3-TYP,and the protective effect of GTP was consequently abolished.Conclusion The findings indicated that GTP protected against early vascular senescence in young HFD rats via ameliorating oxidative injury and promoting autophagy which was partially regulated by the SIRT3 pathway.展开更多
Silver nanoparticles were synthesized using an aqueous extract of cinnamon berks (cinnamon cassia) as a reducer and stabilizer. The synthesized silver nanoparticles were characterized using UV-Vis spectrometry and Tra...Silver nanoparticles were synthesized using an aqueous extract of cinnamon berks (cinnamon cassia) as a reducer and stabilizer. The synthesized silver nanoparticles were characterized using UV-Vis spectrometry and Transmission Electron Microscopy (TEM), which revealed the nano nature of the particles. Nonlinear absorption and nonlinear refraction were measured using a Z-scan technique at different wavelengths with CW lasers. The third order nonlinear susceptibility was found to be between (1.5 to 22) ×10-14 m2/V2. The nonlinear property of the synthesized silver nanoparticles was used to demonstrate optical limiting and all-optical switching. An optical limiting threshold was found to be 0.1 mW at 632.8 nm.展开更多
Synthesis of bimetallic nanoparticles has employed many applications especially as larvicidal agents, these bimetallic nanoparticles therefore need to be produced via a cost-effective and eco-friendly route. Here, gre...Synthesis of bimetallic nanoparticles has employed many applications especially as larvicidal agents, these bimetallic nanoparticles therefore need to be produced via a cost-effective and eco-friendly route. Here, green synthesis of Ag-Co hybrid nanoparticles obtained from aqueous root extract of palmyra palm was reported. The hybrid nanoparticles formation was noticed by a colour change from light pink to light brown and further studied using UV-Vis and FT-IR spectrophotometers. The maximum absorption wavelength, λmax as determined by the UV-Visible Spectrophotometer was found to be 420 nm. The FT-IR showed the formation and stabilization of the BMNPs. The nanolarvicidal potency was evaluated by the application of varying concentration ranging from 5 to 50 mg/L against first to fourth instars of larvae and recording the percentage mortality after 24 hours. Probit analysis showed the LC50 and LC90 for 1st instar to be 5.237 mg/L and 49.240 mg/L, 9.310 mg/L and 94.969 mg/L for 2nd instar, 13.626 mg/L and 105.542 mg/L for 3rd/4th instars respectively. This result therefore suggests that the nanoparticles can be used as potential control for larval population growth.展开更多
文摘Objective:To observe the characteristics of indocyanine green angiography(ICGA)in exudative age-related macular degeneration(AMD).Methods:Thirty-one cases(39 eyes)were diagnosed as exudative AMD by ocular examination,fundus color photography,fundus fluorescein angiography(FFA)and ICGA.Their ages ranged from 50 to 82 years and visual acuities from FC/30cm to 0.7.We analyzed and compared the characteristics of ICGA and FFA in these patients.Results:of 26 eyes with ccult choroidal neovascularization (CNV)by FFA,15(57.7%)had classic CNV by ICGA.Of 4 eyes with serous retinal pigment epithelial detachment(PED)without CNV by FFA,1 had serous PED with classic CNV by ICGA.The hyperfluorescence of the scar staining was detecfed by ICGA.Conclusion:ICGA adds clinically useful information and is an important adjunct in the evaluation,classification,and laser treatment of patients with occult CNV in AMD.
基金supported by grants from the National Natural Science Foundation of China(No.81373007)Fundamental Research Funds for the Central Universities(HUST:No.2016YXMS222).
文摘Objective Epidemiology studies indicate that green tea polyphenols(GTP)perform a protective effect on cardiovascular diseases,but the underlying mechanisms are complex.The present study aimed to investigate the effect of GTP on high-fat diets(HFD)induced-early vascular aging.Methods Six-week young adult Wistar rats were fed with standard chow or HFD in the presence and absence of GTP(200 mg/kg body weight)for 18 weeks.In vitro experiment,human umbilical vascular endothelial cells(HUVECs)were treated with palmitic acid(PA)and GTP.Results The results showed that GTP alleviated the disorganized arterial wall and the increased intima-media thickness induced by HFD.In addition,the vascular oxidative injury was suppressed following GTP treatment.Furthermore,GTP elevated the ratio of LC3-II/LC3-I and suppressed expression of p62/SQSTM1,and restored SIRT3 expression in the aorta of HFD rats.Consistently,in cultured HUVECs,GTP inhibited cell senescence indicated by SA-β-gal and promoted endothelial autophagy compared with the PA treatment group.The activity of SIRT3 was specifically inhibited by 3-TYP,and the protective effect of GTP was consequently abolished.Conclusion The findings indicated that GTP protected against early vascular senescence in young HFD rats via ameliorating oxidative injury and promoting autophagy which was partially regulated by the SIRT3 pathway.
文摘Silver nanoparticles were synthesized using an aqueous extract of cinnamon berks (cinnamon cassia) as a reducer and stabilizer. The synthesized silver nanoparticles were characterized using UV-Vis spectrometry and Transmission Electron Microscopy (TEM), which revealed the nano nature of the particles. Nonlinear absorption and nonlinear refraction were measured using a Z-scan technique at different wavelengths with CW lasers. The third order nonlinear susceptibility was found to be between (1.5 to 22) ×10-14 m2/V2. The nonlinear property of the synthesized silver nanoparticles was used to demonstrate optical limiting and all-optical switching. An optical limiting threshold was found to be 0.1 mW at 632.8 nm.
文摘Synthesis of bimetallic nanoparticles has employed many applications especially as larvicidal agents, these bimetallic nanoparticles therefore need to be produced via a cost-effective and eco-friendly route. Here, green synthesis of Ag-Co hybrid nanoparticles obtained from aqueous root extract of palmyra palm was reported. The hybrid nanoparticles formation was noticed by a colour change from light pink to light brown and further studied using UV-Vis and FT-IR spectrophotometers. The maximum absorption wavelength, λmax as determined by the UV-Visible Spectrophotometer was found to be 420 nm. The FT-IR showed the formation and stabilization of the BMNPs. The nanolarvicidal potency was evaluated by the application of varying concentration ranging from 5 to 50 mg/L against first to fourth instars of larvae and recording the percentage mortality after 24 hours. Probit analysis showed the LC50 and LC90 for 1st instar to be 5.237 mg/L and 49.240 mg/L, 9.310 mg/L and 94.969 mg/L for 2nd instar, 13.626 mg/L and 105.542 mg/L for 3rd/4th instars respectively. This result therefore suggests that the nanoparticles can be used as potential control for larval population growth.
