Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud....Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud. Using modern NMR techniques including NOESY and 1H_NMR line broadening effect experiments, CD spectra and MS analysis as well as chemical methods, their structures were identified as (13aR)_6_hydroxy_3,7_dimethoxy_phenanthroindolizidine (1), (13aS,14R)_14_hydroxy_3,6,7_trimethoxy_phenanthro_indolizidine (2), (13aS,14S)_14_hydroxy_3,6,7_trimethoxy_phenanthroindolizidine (3), and (13aS,14S)_6,14_dihydroxy_3,7_dimethoxy_phenanthroindolizidine (4) respectively. Compound 1 is a new compound, compounds 2-4 are obtained from this plant for the first time. Compounds 1, 3 and 4 showed strong antitumor activities.展开更多
Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analog...Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed.展开更多
Four new diterpenoid alkaloids,nagaconitines A-D（1-4）,were isolated from the roots of Aconitum nagarum var.heterotrichum.Their structures were elucidated as 8-（4＇-hydroxylbutyryl） aconitine（1）,15-oxo-13-deoxylu...Four new diterpenoid alkaloids,nagaconitines A-D（1-4）,were isolated from the roots of Aconitum nagarum var.heterotrichum.Their structures were elucidated as 8-（4＇-hydroxylbutyryl） aconitine（1）,15-oxo-13-deoxyludaconitine（2）,15-hydroxyldelphisine（3）,and 14-hydroxyl-2- acetoxyspiradine C（4）based on extensive UV,IR,MS,1D NMR and 2D NMR analyses.Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31%（IC_（50） 43.78 μmol/L） and 24%（IC_（50） 32.14 μmol/L）,respectively.展开更多
Nitidine chloride and oxynitidine were isolated from zanthoxylum nitidum by HUANG Zhi-xun et al. in 1980. Nitidine chloride exhibits good antitumor activity but oxynitidine does not. Recently we carried out a reaction...Nitidine chloride and oxynitidine were isolated from zanthoxylum nitidum by HUANG Zhi-xun et al. in 1980. Nitidine chloride exhibits good antitumor activity but oxynitidine does not. Recently we carried out a reaction in which the mixture of some nitidine chloride powder and NaOH aqueous solution was exposed to air and heated展开更多
文摘Four phenanthroindolizidine alkaloids, named tylophoridicine A (1), tylophorinine (2), O_methyl tylophorinidine (3) and tylophorinidine (4), were isolated from the roots of Tylophora ovata (Lindl.) Hook. ex Steud. Using modern NMR techniques including NOESY and 1H_NMR line broadening effect experiments, CD spectra and MS analysis as well as chemical methods, their structures were identified as (13aR)_6_hydroxy_3,7_dimethoxy_phenanthroindolizidine (1), (13aS,14R)_14_hydroxy_3,6,7_trimethoxy_phenanthro_indolizidine (2), (13aS,14S)_14_hydroxy_3,6,7_trimethoxy_phenanthroindolizidine (3), and (13aS,14S)_6,14_dihydroxy_3,7_dimethoxy_phenanthroindolizidine (4) respectively. Compound 1 is a new compound, compounds 2-4 are obtained from this plant for the first time. Compounds 1, 3 and 4 showed strong antitumor activities.
基金This work was supported by the National Natural Science Foundationof China(No.82173715).
文摘Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed.
基金supported by the National Natural Science Foundation of China (Nos. 21362045, 81560622)the project of Sciences and Technology Department of Yunnan Province (No. 2012CG007)
文摘Four new diterpenoid alkaloids,nagaconitines A-D（1-4）,were isolated from the roots of Aconitum nagarum var.heterotrichum.Their structures were elucidated as 8-（4＇-hydroxylbutyryl） aconitine（1）,15-oxo-13-deoxyludaconitine（2）,15-hydroxyldelphisine（3）,and 14-hydroxyl-2- acetoxyspiradine C（4）based on extensive UV,IR,MS,1D NMR and 2D NMR analyses.Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31%（IC_（50） 43.78 μmol/L） and 24%（IC_（50） 32.14 μmol/L）,respectively.
基金Project supported by the Science Foundation of Fujian Province
文摘Nitidine chloride and oxynitidine were isolated from zanthoxylum nitidum by HUANG Zhi-xun et al. in 1980. Nitidine chloride exhibits good antitumor activity but oxynitidine does not. Recently we carried out a reaction in which the mixture of some nitidine chloride powder and NaOH aqueous solution was exposed to air and heated
