Alkylating agents represent an important class of anticancer drugs.The occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics.A detailed understand...Alkylating agents represent an important class of anticancer drugs.The occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics.A detailed understanding of the mechanisms of activity of alkylating drugs is essential in order to overcome drug resistance.In particular,the role of non-coding microRNAs concerning alkylating drug activity and resistance in various cancers is highlighted in this review.Both synthetic and natural alkylating agents,which are approved for cancer therapy,are discussed concerning their interplay with microRNAs.展开更多
Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) ...Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) to afford α,α'-bis(substituted benzylidene) cycloalkanones in good yields.展开更多
DNA direct reversal repair(DRR)is unique in that no DNA synthesis is required to correct the error and therefore repair via such mechanisms are error-free.In humans,DRR is carried out by two different pathways:the O6-...DNA direct reversal repair(DRR)is unique in that no DNA synthesis is required to correct the error and therefore repair via such mechanisms are error-free.In humans,DRR is carried out by two different pathways:the O6-methylguanine-DNA methyltransferase(MGMT)and the alkylated DNA repair protein B(AlkB)homologs.The use of alkylating agents is the standard of care for many cancers.However,the use of those drugs is usually halted when resistance develops.This review will examine repair of alkylating agent damage mediated by DRR,resistance mechanisms and potential ways to overcome such resistance.展开更多
文摘Alkylating agents represent an important class of anticancer drugs.The occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics.A detailed understanding of the mechanisms of activity of alkylating drugs is essential in order to overcome drug resistance.In particular,the role of non-coding microRNAs concerning alkylating drug activity and resistance in various cancers is highlighted in this review.Both synthetic and natural alkylating agents,which are approved for cancer therapy,are discussed concerning their interplay with microRNAs.
文摘Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) to afford α,α'-bis(substituted benzylidene) cycloalkanones in good yields.
基金California Tobacco-Related Disease Research Program Grant:Combined genotoxic effects of alternative tobacco products and alcohol use(No.28IR-0050,TRO)。
文摘DNA direct reversal repair(DRR)is unique in that no DNA synthesis is required to correct the error and therefore repair via such mechanisms are error-free.In humans,DRR is carried out by two different pathways:the O6-methylguanine-DNA methyltransferase(MGMT)and the alkylated DNA repair protein B(AlkB)homologs.The use of alkylating agents is the standard of care for many cancers.However,the use of those drugs is usually halted when resistance develops.This review will examine repair of alkylating agent damage mediated by DRR,resistance mechanisms and potential ways to overcome such resistance.
